CN114558072A - Spray for treating pharyngitis and preparation method thereof - Google Patents
Spray for treating pharyngitis and preparation method thereof Download PDFInfo
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- CN114558072A CN114558072A CN202210195837.0A CN202210195837A CN114558072A CN 114558072 A CN114558072 A CN 114558072A CN 202210195837 A CN202210195837 A CN 202210195837A CN 114558072 A CN114558072 A CN 114558072A
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- 201000007100 Pharyngitis Diseases 0.000 title claims abstract description 42
- 239000007921 spray Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229920000136 polysorbate Polymers 0.000 claims abstract description 17
- 238000001914 filtration Methods 0.000 claims abstract description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 12
- 240000006365 Vitis vinifera Species 0.000 claims abstract description 12
- 235000014787 Vitis vinifera Nutrition 0.000 claims abstract description 12
- 244000274050 Platycodon grandiflorum Species 0.000 claims abstract description 11
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 11
- 240000004534 Scutellaria baicalensis Species 0.000 claims abstract description 11
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims abstract description 11
- 239000008367 deionised water Substances 0.000 claims abstract description 11
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 11
- 239000000706 filtrate Substances 0.000 claims abstract description 8
- 239000012982 microporous membrane Substances 0.000 claims abstract description 8
- 239000012452 mother liquor Substances 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 238000009835 boiling Methods 0.000 claims abstract description 3
- 238000000227 grinding Methods 0.000 claims abstract description 3
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 238000002791 soaking Methods 0.000 claims abstract description 3
- 241000406668 Loxodonta cyclotis Species 0.000 claims description 7
- 239000000839 emulsion Substances 0.000 claims description 7
- 229920000053 polysorbate 80 Polymers 0.000 claims description 7
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 12
- 238000011282 treatment Methods 0.000 abstract description 8
- 231100000331 toxic Toxicity 0.000 abstract description 6
- 230000002588 toxic effect Effects 0.000 abstract description 6
- 239000002904 solvent Substances 0.000 abstract description 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 2
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000002085 irritant Substances 0.000 abstract 1
- 231100000021 irritant Toxicity 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 24
- 210000003800 pharynx Anatomy 0.000 description 20
- 201000010099 disease Diseases 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
- 208000016150 acute pharyngitis Diseases 0.000 description 9
- 208000003251 Pruritus Diseases 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 7
- 206010011224 Cough Diseases 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 230000007794 irritation Effects 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 230000007803 itching Effects 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 206010058019 Cancer Pain Diseases 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 231100000956 nontoxicity Toxicity 0.000 description 2
- 210000002741 palatine tonsil Anatomy 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 206010050639 Allergic pharyngitis Diseases 0.000 description 1
- 240000006162 Chenopodium quinoa Species 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 206010060891 General symptom Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 201000008197 Laryngitis Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 206010033078 Otitis media Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010038776 Retching Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 235000021259 spicy food Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Otolaryngology (AREA)
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Abstract
The invention relates to the technical field of pharyngitis sprays, in particular to a spray for treating pharyngitis and a preparation method thereof. The preparation method comprises the following steps: mixing the scutellaria baicalensis, the platycodon grandiflorum and the grape vine according to the weight ratio of 31-40:20-41: 30-50; grinding by a ball mill, adding sterile deionized water, soaking at room temperature for 12-36 hours, and heating and boiling for 4-6 hours; decolorizing with activated carbon, performing hot coarse filtration for 2-4 times, and filtering the obtained hot filtrate with microporous membrane; the obtained mother liquor is prepared into 20 ten thousand mL; and adding an auxiliary material Tween into the hot water solution, wherein the dosage of Tween is controlled to be 1% -2%. The spray obtained by the invention has the advantages of good treatment effect and small toxic and side effects, the solvent used by the spray is sterile deionized water, the pharmaceutic adjuvant is non-toxic and non-irritant, the price of the raw materials of the medicine is low, the source of the raw materials of the medicine is wide, and the like.
Description
Technical Field
The invention relates to the technical field of pharyngitis sprays, in particular to a spray for treating pharyngitis and a preparation method thereof.
Background
Pharyngitis is one of the most common clinical diseases, and is often divided into chronic pharyngitis and acute pharyngitis. The clinical symptoms of the chronic pharyngitis are mainly dry cough with little phlegm, red swelling and pain in throat, easy fatigue of speech and easy nausea and retching, and simultaneously, the symptoms are accompanied by upper respiratory tract infection symptoms such as fever, cough and the like. In addition, the disease is often accompanied by general symptoms such as inappetence. The disease causes are complex, the symptoms are stubborn, the disease is easy to rebound and difficult to heal, and the life quality of the patient is greatly reduced. Acute pharyngitis is rapid in onset, recurrent in a short period, lingering and difficult to heal, and is easy to be complicated with other pathological changes, such as nasosinusitis, otitis media, laryngitis, pneumonia and the like. In recent years, the incidence of pharyngitis has been on a rising trend with changes in the living environment and dietary habits of people. At present, the treatment of pharyngitis in clinic is mainly started from symptom improvement, and western medicines such as antiviral medicines, antibiotics or glucocorticoids and the like are used. However, the treatment proposal has the defects of easy side effect and difficult radical treatment. The existing traditional Chinese medicine treatment scheme mainly uses multi-component traditional Chinese medicine combination treatment and mainly adopts oral administration. Therefore, the dosage for treating the disease is large, certain side effects exist, the compliance of patients is low, the drug effect is slow, the treatment period is long, and the like. In addition, some existing medicines for treating chronic pharyngitis are not good enough for treating acute pharyngitis. It is worth mentioning that the existing spray for treating acute pharyngitis uses ethanol as an auxiliary material and has large irritation. Therefore, in order to effectively treat the lingering and difficult-to-cure pharyngitis, the existing problems need to be solved.
In order to solve the problems of slow drug effect, large toxic and side effects of the drug, large irritation of auxiliary materials and the like, a pure natural traditional Chinese medicine spray with small toxic and side effects and good drug effect is developed. The scutellaria baicalensis, the platycodon grandiflorum, the grapevine and the like are fused to obtain extracts (wherein the grapevine is mainly used for obtaining the quinoa alcohol), and the extracts are prepared into a water-soluble spray, so that the administration route is convenient, and the chronic and polar pharyngitis can be effectively treated in a double-tube manner. .
Disclosure of Invention
The invention aims to provide a spray for treating pharyngitis and a preparation method thereof, which are used for solving the technical problems in the prior art: slow drug effect, great toxic and side effects of the drug, great irritation of auxiliary materials and the like.
In order to achieve the purpose, the invention adopts the following technical scheme:
the spray for treating pharyngitis comprises the following raw materials in parts by weight:
31-40 of scutellaria baicalensis, 20-41 of platycodon grandiflorum and 30-50 of grapevine;
also comprises Tween which accounts for 1 to 2 percent of the total mass of the spray.
Further preferably, the tween is tween 80 or tween 40.
A preparation method of a spray for treating pharyngitis comprises the following steps:
mixing the scutellaria baicalensis, the platycodon grandiflorum and the grape vine according to the weight ratio of 31-40:20-41: 30-50;
grinding by a ball mill, placing in a large container, adding sterile deionized water, soaking at room temperature for 12-36 hours, and boiling for 4-6 hours;
decolorizing with activated carbon, performing hot coarse filtration for 2-4 times, and filtering the obtained hot filtrate with microporous membrane;
the obtained mother liquor is prepared into 20 ten thousand mL;
adding Tween into the hot water solution, and controlling the dosage of Tween to be 1-2%;
finally, the obtained emulsion is subpackaged into an elephant nose rotary spray bottle for standby.
The invention has at least the following beneficial effects:
the spray obtained by the invention is suitable for a wide range of people including chronic disease patients, cancer pain patients and other people, and has the advantages of good treatment effect, small toxic and side effects, sterile deionized water as a solvent used by the spray, no toxicity and irritation of pharmaceutic adjuvants, cheap price and wide source of raw materials of medicines and the like. In addition, most importantly, the spray can be used for treating acute pharyngitis, chronic pharyngitis and other throat diseases.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1:
31 kg of scutellaria baicalensis, 20 kg of platycodon grandiflorum and 30 kg of grapevine are mixed, ground by means of a ball mill, placed in a large container, and then added with sterile deionized water, soaked at room temperature for 12 hours, and then heated and boiled for 4 hours. Then decolouring with medicinal active carbon, coarse filtering for 2 times, and further filtering the obtained hot filtrate with microporous membrane. The obtained mother liquor was prepared in an amount of 20 ten thousand mL. Adding Tween (80 or 40) into the hot water solution, wherein the amount of Tween is 1%. Finally, the obtained emulsion is subpackaged into an elephant nose rotary spray bottle for standby.
Example 2:
35 kg of scutellaria baicalensis, 30 kg of platycodon grandiflorum and 35 kg of grapevine are mixed, ground by means of a ball mill, placed in a large container, and then added with sterile deionized water, soaked for 16 hours at room temperature, and then heated and boiled for 5 hours. Then decolouring with medicinal active carbon, coarse filtering for 3 times, and further filtering the obtained hot filtrate with microporous membrane. The obtained mother liquor was prepared in an amount of 20 ten thousand mL. Adding Tween (80 or 40) into the hot water solution, and controlling the use amount of Tween to 1.5%. Finally, the obtained emulsion is subpackaged into an elephant nose rotary spray bottle for later use.
Example 3:
35 kg of scutellaria baicalensis, 35 kg of platycodon grandiflorum and 45 kg of grape vine are mixed, ground by a ball mill, placed in a large container, then added with sterile deionized water, soaked for 24 hours at room temperature and then heated and boiled for 6 hours. Then decolouring with medicinal active carbon, coarse filtering for 3 times, and further filtering the obtained hot filtrate with microporous membrane. The obtained mother liquor was prepared in an amount of 20 ten thousand mL. Adding Tween (80 or 40) into the hot water solution, and controlling the amount of Tween to 2%. Finally, the obtained emulsion is subpackaged into an elephant nose rotary spray bottle for later use.
Example 4:
40 kg of scutellaria baicalensis, 41 kg of platycodon grandiflorum and 50 kg of grape vine are mixed, ground by a ball mill, placed in a large container, then added with sterile deionized water, soaked for 24 hours at room temperature and then heated and boiled for 5 hours. Then decolouring with medicinal active carbon, coarse filtering for 2 times, and further filtering the obtained hot filtrate with microporous membrane. The obtained mother liquor was prepared in an amount of 20 ten thousand mL. Adding Tween (80 or 40) into the hot water solution, and controlling the amount of Tween to 2%. Finally, the obtained emulsion is subpackaged into an elephant nose rotary spray bottle for later use.
Example 5:
the preparation method comprises the following steps: 31 kg of scutellaria baicalensis, 35 kg of platycodon grandiflorum and 45 kg of grape vine are mixed, ground by a ball mill, placed in a large container, then added with sterile deionized water, soaked for 36 hours at room temperature and then heated and boiled for 5 hours. Then decolouring with medicinal activated carbon, coarse filtering for 3 times, and filtering the obtained hot filtrate with microporous membrane. The obtained mother liquor was prepared in an amount of 20 ten thousand mL. Adding Tween (80 or 40) into the hot water solution, and controlling the amount of Tween to 1.5%. Finally, the obtained emulsion is subpackaged into an elephant nose rotary spray bottle for standby.
It is noted that the entire procedure of examples 1-5 above is carried out in a sterile workshop.
To further illustrate the effects of the present application, the following exemplary cases are now provided:
the patient Cao is a man, 56 years old, a farmer is healthy, inhales soil for 30 years, and has at least 5 soil tobacco branches per day on average. In normal times, people like spicy food, in particular to chafing dish. Symptoms are: intermittent dry throat, itching throat, and intermittent cough at night. And (3) diagnosis: chronic pharyngitis. By using the spray, the throat is sprayed for an indefinite number of times every day, the pharyngalgia of a patient is obviously relieved after 3 days, the number of cough times at night is reduced, the pharynx is itchy, and other uncomfortable symptoms do not exist. The patient takes the medicine continuously, the pharyngitis symptom of the patient is obviously relieved after 1 week, the throat inflammation of the patient is followed up after one month, and discomfort is reported for follow-up diagnosis.
The traditional Chinese medicine composition is prepared from radix et rhizoma Rhei, women, 47, white collar, night shift for a long time, irregular life rhythm, greedy and black, suffers from chronic pharyngitis for more than one year, is accompanied with stomach illness, and relieves symptoms by taking medicines such as antibiotics for a long time. Symptoms are: foreign body sensation and slight pain in the throat often occur repeatedly. After 1 month of using the spray, the pain disappears and the foreign body sensation is obviously relieved. The disease is cured after 2 months, and no other discomfort occurs.
Some Tang Dynasty, women, 32, middle school teachers, long-term teaching tasks are heavy, excessive use of throat, after long lectures, pharynx itch, cough is caused, and symptoms are more than half a year. Curing: chronic pharyngitis. The symptoms are obviously relieved within 2 weeks after the spray is used, and the disease is cured after 2 months of follow-up visit.
A certain Liu, male and 23 students, in flowering season, has itching throat and slight pain in throat. Curing: allergic pharyngitis. After the spray is used, the symptoms are obviously relieved after about 1 week, and the disease is cured after 1 month.
Pengzhi, female, 12, student, acute pharyngitis. Symptoms are: it is manifested as sore throat, dry and burning throat, soreness and pain of limbs, thirst. After 1 day of using the spray, the symptoms are obviously relieved, and the disease is cured after one week.
Certain li, male, age 48, driver, symptoms: phlegm with little blood streak, cough, pain, bilateral tonsil swelling. Acute pharyngitis is the symptom. The product is sprayed for several times in the same day, the symptoms of pharyngalgia are relieved in the next day, and pharyngitis is cured and tonsils on both sides are normal after one week.
When a certain plum is aged 57 years old, a sanitationman is susceptible to cold, the immune function of the body is reduced, the long-term working environment is poor, and the people return to the morning and evening. Chronic pharyngitis is suffered for 2 and half years. Symptoms are: the secretion of throat is not easy to be coughed out, the throat is itchy and the throat is painful. After the spray is used, the itching of the throat is relieved and the secretion is reduced after 1 week. The disease heals after 3 months.
When a person is young, male, 62 years old, violin lovers have lowered body immunity, and chronic pharyngitis attacks repeatedly throughout the year. Symptoms are: itching and slight pain in the throat, and difficult expectoration of secretion. After the spray is used, the symptoms are relieved after one month, the throat is not itchy any more, and the pharyngitis is cured after one year.
Tan somebody, male, 34 years old, American group take-out person, healthy, high working pressure, too fast pace of life, irregular diet, and accidental acute pharyngitis. Symptoms are: dry, burning and painful throat with headache and soreness of the extremities. The spray can obviously relieve symptoms after being used, and can work normally after one day. And the culture is not performed after one week.
Zhou Shi, female, age 40, sold with dry or irritated throat, difficult discharge of secretions, sore throat. The long-term work causes the frequent recurrent attacks of the long-term speaking time and the long-term speaking time. After the spray is used, the symptoms are relieved after 1 day, and the disease is cured after one week. The frequency of relapse is obviously reduced after 1 year follow-up. Continue to take medicine and inform discomfort for follow-up diagnosis.
Thus, it can be seen that:
the spray obtained by the invention is suitable for a wide range of people including chronic disease patients, cancer pain patients and other people, and has the advantages of good treatment effect, small toxic and side effects, sterile deionized water as a solvent used by the spray, no toxicity and no irritation as a medicinal auxiliary material, cheap and wide sources of raw materials of the medicine and the like. In addition, most importantly, the spray can be used for treating acute pharyngitis, chronic pharyngitis and other throat diseases.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (3)
1. The spray for treating pharyngitis is characterized by comprising the following raw materials in parts by weight:
31-40 of scutellaria baicalensis, 20-41 of platycodon grandiflorum and 30-50 of grapevine;
also comprises Tween which accounts for 1 to 2 percent of the total mass of the spray.
2. The spray for treating pharyngitis according to claim 1, wherein the tween is tween 80 or tween 40.
3. The preparation method of the spray for treating pharyngitis is characterized by comprising the following steps:
mixing the scutellaria baicalensis, the platycodon grandiflorum and the grape vine according to the weight ratio of 31-40:20-41: 30-50;
grinding by a ball mill, placing in a large container, adding sterile deionized water, soaking at room temperature for 12-36 hours, and boiling for 4-6 hours;
decolorizing with activated carbon, performing hot coarse filtration for 2-4 times, and filtering the obtained hot filtrate with microporous membrane;
the obtained mother liquor is prepared into 20 ten thousand mL;
adding an auxiliary material Tween into the hot water solution, and controlling the using amount of Tween to be 1% -2%;
finally, the obtained emulsion is subpackaged into an elephant nose rotary spray bottle for standby.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210195837.0A CN114558072A (en) | 2022-03-02 | 2022-03-02 | Spray for treating pharyngitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210195837.0A CN114558072A (en) | 2022-03-02 | 2022-03-02 | Spray for treating pharyngitis and preparation method thereof |
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| CN114558072A true CN114558072A (en) | 2022-05-31 |
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| CN202210195837.0A Pending CN114558072A (en) | 2022-03-02 | 2022-03-02 | Spray for treating pharyngitis and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599273A (en) * | 2013-12-05 | 2014-02-26 | 哈药集团中药二厂 | Dry powder spray for throat and its preparation method |
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| CN107213272A (en) * | 2017-06-15 | 2017-09-29 | 洛阳旺草生物技术开发有限公司 | It is a kind of to treat external application Chinese medicine spray of pharyngitis and preparation method thereof |
| CN110302263A (en) * | 2019-08-06 | 2019-10-08 | 广东大鹏医药科技有限公司 | A kind for the treatment of spraying agent for ulcer of oral cavity of the ingredient containing trollflower and preparation method thereof |
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2022
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| CN104510778A (en) * | 2013-09-27 | 2015-04-15 | 青岛畅绿生物研究所 | Novel water lily throat-soothing spraying agent |
| CN103599273A (en) * | 2013-12-05 | 2014-02-26 | 哈药集团中药二厂 | Dry powder spray for throat and its preparation method |
| CN107213272A (en) * | 2017-06-15 | 2017-09-29 | 洛阳旺草生物技术开发有限公司 | It is a kind of to treat external application Chinese medicine spray of pharyngitis and preparation method thereof |
| CN110302263A (en) * | 2019-08-06 | 2019-10-08 | 广东大鹏医药科技有限公司 | A kind for the treatment of spraying agent for ulcer of oral cavity of the ingredient containing trollflower and preparation method thereof |
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Application publication date: 20220531 |