CN111467278A - Jinlian refreshing spray - Google Patents
Jinlian refreshing spray Download PDFInfo
- Publication number
- CN111467278A CN111467278A CN202010441017.6A CN202010441017A CN111467278A CN 111467278 A CN111467278 A CN 111467278A CN 202010441017 A CN202010441017 A CN 202010441017A CN 111467278 A CN111467278 A CN 111467278A
- Authority
- CN
- China
- Prior art keywords
- tropaeolum
- spray
- mouth
- sorbitol
- poloxamer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007921 spray Substances 0.000 title claims abstract description 40
- 241001312894 Trollius chinensis Species 0.000 claims abstract description 19
- 229930003935 flavonoid Natural products 0.000 claims abstract description 19
- 150000002215 flavonoids Chemical class 0.000 claims abstract description 19
- 235000017173 flavonoids Nutrition 0.000 claims abstract description 19
- 241000208241 Tropaeolum Species 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 13
- 241000612118 Samolus valerandi Species 0.000 claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 52
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 244000269722 Thea sinensis Species 0.000 claims description 21
- 235000009569 green tea Nutrition 0.000 claims description 21
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 20
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 18
- 239000000600 sorbitol Substances 0.000 claims description 18
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 17
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 17
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 16
- 239000004359 castor oil Substances 0.000 claims description 16
- 235000019438 castor oil Nutrition 0.000 claims description 16
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 16
- 229940069338 potassium sorbate Drugs 0.000 claims description 16
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- 229960002920 sorbitol Drugs 0.000 claims description 16
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 14
- 229940041616 menthol Drugs 0.000 claims description 14
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- 239000002994 raw material Substances 0.000 claims description 13
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- 239000008367 deionised water Substances 0.000 claims description 11
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- 238000012360 testing method Methods 0.000 description 36
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- 206010061218 Inflammation Diseases 0.000 description 5
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- 229920001817 Agar Polymers 0.000 description 4
- 241000228245 Aspergillus niger Species 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 4
- 208000007117 Oral Ulcer Diseases 0.000 description 4
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- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 229930003944 flavone Natural products 0.000 description 3
- 150000002212 flavone derivatives Chemical class 0.000 description 3
- 235000011949 flavones Nutrition 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 208000007565 gingivitis Diseases 0.000 description 3
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- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 241001530121 Trollius Species 0.000 description 2
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- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical compound CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
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- 229960004793 sucrose Drugs 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000006150 trypticase soy agar Substances 0.000 description 2
- 108010050327 trypticase-soy broth Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 230000037406 food intake Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
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- 231100000252 nontoxic Toxicity 0.000 description 1
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- 230000009965 odorless effect Effects 0.000 description 1
- 229940041678 oral spray Drugs 0.000 description 1
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- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
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- 125000000963 oxybis(methylene) group Chemical group [H]C([H])(*)OC([H])([H])* 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
The invention relates to a medicine or a cleaning agent, namely a tropaeolum mouth-refreshing spray, which is characterized in that: the spray is prepared from trollius chinensis total flavonoids and auxiliary materials. The beneficial effects are that: the oral liquid contains the active ingredients of the trollius chinensis bunge, has an inhibiting effect on a plurality of harmful bacteria such as bacillus subtilis, pseudomonas aeruginosa and the like, can reduce the breeding of oral bacteria, relieve dental ulcer and gum swelling and pain, eliminate oral peculiar smell, keep fresh breath, obviously improve the spirit and the life quality of a user, and has the advantages of convenient use, no toxic or side effect, no residual waste and very considerable application prospect.
Description
Technical Field
The invention relates to a medicine or a cleaning agent, in particular to a tropaeolum mouth-refreshing spray which is called as alateng mouth spray in Mongolia.
Background
The oral cavity is an important organ for people to breathe air, take food and communicate languages, and the oral cavity hygiene is one of the most important human body hygiene. Due to ingestion of food, the oral cavity is liable to produce harmful flora and bad smell, which brings negative effects on human health and social interaction. In order to solve the problem, people adopt articles such as toothpaste, spray, chewing gum and the like to clean the oral cavity. However, most of toothpaste is chemical products, which are not suitable for entering into body, and the toothpaste is inconvenient to use and can not be used at any time. Most of the spray is flavoring agent, and has no functions of disinfection, sterilization and oral health care. The chewing gum is not suitable for eating, and the residue pollutes the environment.
The Mongolian population mostly takes the milk meat as food, and is very easy to generate oral odor and various oral inflammations. Therefore, Mongolian people pay attention to oral hygiene, have rich experience on eliminating oral odor and various inflammations, and have a lot of Mongolian medicines for oral cleaning and health care. However, for historical reasons, the Mongolian medicines are mostly distributed in folk in the form of secret prescriptions, and are not utilized and transmitted, so that many prescriptions are distorted, varied and even lost in distribution. Therefore, the method has important significance for improving the health level and the life quality of people and promoting the civilization and progress of society by digging and arranging the precious heritage related to oral cleaning and health care of Mongolian medicines by using a modern technological means.
Disclosure of Invention
The invention aims to develop an oral spray which can kill or inhibit harmful bacteria, treat various oral inflammations, eliminate peculiar smell of oral cavity, is convenient to use, has no toxic or side effect and can be used for a long time by using modern technological means on the basis of collecting and arranging Mongolian medicine secret recipes.
The above purpose is realized by the following technical scheme: the developed tropaeolum mouth-refreshing spray is characterized by comprising the following components in parts by weight: the spray is prepared from trollius chinensis total flavonoids and auxiliary materials.
The auxiliary materials comprise ethanol, water and a freshener.
The aromatic agent is one or more of Mentholum, green tea, and fructus Citri Limoniae.
The auxiliary materials are added with glycerol, sorbitol, poloxamer 407, potassium sorbate and PEG-40 hydrogenated castor oil.
The total flavonoids of the trollius chinensis bunge are 0.09-0.5%, and the high-alcohol content edible ethanol with the alcohol content of more than 80% is 7-12%.
The dosage of one of the menthol, the green tea and the lemon is 0.01 to 0.02 percent, or the dosage of two of the menthol, the green tea and the lemon is 0.014 to 0.016 percent respectively, or the dosage of the three of the menthol, the green tea and the lemon is 0.008 to 0.01 percent respectively.
2-5% of glycerol, 2-5% of sorbitol, 0.04-0.08% of poloxamer 407, 0.06-0.2% of potassium sorbate and 0.1-0.4% of PEG-40 hydrogenated castor oil.
The spray is prepared from 1g of trollius chinensis total flavonoids, 0.14g of menthol, 100m L of 95% edible ethanol, 30m L of glycerol, 30m L of sorbitol, 4070.5g of poloxamer, 1g of potassium sorbate, 2.5g of PEG-40 hydrogenated castor oil and deionized water which is added to 1L, wherein the error of the raw materials is less than or equal to 5%.
The spray is prepared from 1g of trollius chinensis total flavonoids, 0.1g of green tea, 100m L of 95% edible ethanol, 30m L of glycerol, 30m L of sorbitol, 4070.5g of poloxamer, 1g of potassium sorbate, 2.5g of PEG-40 hydrogenated castor oil and deionized water added to 1L, wherein the error of the raw materials is less than or equal to 5%.
The spray is prepared from 1g of trollius chinensis total flavonoids, 0.1g of green tea, 100m L of 95% edible ethanol, 30m L of glycerol, 30m L of sorbitol, 4070.5g of poloxamer, 1g of potassium sorbate, 2.5g of PEG-40 hydrogenated castor oil and deionized water added to 1L, wherein the error of the raw materials is less than or equal to 5%.
The invention has the beneficial effects that: the oral liquid contains the active ingredients of the trollius chinensis bunge, has an inhibiting effect on a plurality of harmful bacteria such as bacillus subtilis, pseudomonas aeruginosa and the like, can reduce the breeding of oral bacteria, relieve dental ulcer and gum swelling and pain, eliminate oral peculiar smell, keep fresh breath, obviously improve the spirit and the life quality of a user, and has the advantages of convenient use, no toxic or side effect, no residual waste and very considerable application prospect.
Detailed Description
The first embodiment: a tropaeolum refreshing spray is prepared from tropaeolum total flavonoids and auxiliary materials. The adjuvants can be ethanol, water and aromatic. The ethanol is edible ethanol, the water is purified water, and the aromatic agent is one or more of Mentholum, green tea, and fructus Citri Limoniae.
The total flavonoids of the trollius chinensis bunge are active extracts of the traditional Mongolian medicinal material trollius chinensis bunge. The flos Trollii is flos Trollii of RanunculaceaeTrollius chinensisThe dry flower of Bge, Mongolian medicine called Alatan flower, its grid, also called Alteng flower, has the functions of healing wound, drying pus, stopping decay, stopping bleeding, clearing heat and removing toxic material, and can be used for curing the diseases of gold wound, traumatic infection, blood \ "Xiairi \" eye disease and throat heat, etc. Modern pharmacological research shows that the trollius chinensis bunge has the effects of resisting bacteria, inflammation, viruses and the like, and has a very wide application prospect in the field of medicines. The flos Trollii mainly contains chemical components such as flavonoids, organic acids, alkaloids, etc. The research considers that the flavonoid substances are the main components of the pharmacodynamic action of the trollius chinensis bunge.
The following experiment is specially performed to prove the bacteriostatic function of the trollius chinensis total flavonoids.
Sample name and source:
name: globeflower total flavone, 60% ethanol extract (dry extract powder), batch number: 20180109, production Unit: inner Mongolia institute of pharmaceutical engineering and technology.
And test articles:
2.1 strains for experiments: staphylococcus aureus [ cmcc (b)26003 ] number: JPW-3 (2)2) -4 Pseudomonas aeruginosa [ CMCC (B)10104 ] number T L W-3 (2)3) -6, bacillus subtilis [ cmcc (b)63501 ] no: KCW-3 (2)3) -8, escherichia coli [ cmcc (b)44102 ] no: DCW-3 (2)4) -3, candida albicans [ cmcc (f)98001 ] no: BNW-3 (2)1) -6, aspergillus niger [ cmcc (f)98003 ] no: HQW-3 (2)4）-6。
The 0 generation mother strains of the strains are all provided by China food and drug testing research institute.
Culture medium: trypticase soy peptone agar medium, lot No.: 20170623, respectively; saxise glucose agar medium, lot number: 20170225.
the culture medium is provided by Qingdao Gaokoubo Biotech Co., Ltd.
The instrument equipment comprises:
numbering the water-proof constant-temperature incubator: WSW-YQ-021; numbering the water-proof constant-temperature incubator: WSW-YQ-022; numbering the electric heating constant-temperature incubator: WSW-YQ-026; mould incubator number: WSW-YQ-023; mould incubator number: WSW-YQ-024; numbering the electrothermal blowing drying box: WSW-YQ-041; numbering the electrothermal blowing drying box: WSW-YQ-042; numbering of the vertical steam sterilizer: WSW-YQ-036; numbering of the vertical steam sterilizer: WSW-YQ-037; numbering of the vertical steam sterilizer: WSW-YQ-038; numbering of the biological safety cabinet: WSW-YQ-002; numbering of the biological safety cabinet: WSW-YQ-003; numbering of the biological safety cabinet: WSW-YQ-005; numbering of the biological safety cabinet: WSW-YQ-006; serial number of the flapping type sterile homogenizer: WSW-YQ-054; refrigerator numbering: WSW-YQ-032; numbering the electronic balance: WSW-YQ-122; numbering the induction cooker: WSW-YQ-084; numbering of a homogenizer: WSW-YQ-078.
And the test method comprises the following steps: and respectively counting microorganisms according to the colony numbers on the test sample group, the test group, the bacteria liquid control group and the negative control group, and calculating the recovery rate of each test bacterium, so as to investigate the inhibition capacity of the test sample on the test microorganisms.
The test basis is as follows: test of applicability of the counting method in examination of microbial limit of non-sterile products in the four parts 1105 of the "Chinese pharmacopoeia" 2015 edition.
Preparing bacterial liquid:
3.2.1 taking fresh cultures of staphylococcus aureus, pseudomonas aeruginosa, bacillus subtilis and escherichia coli which are cultured for 24 hours at 33 ℃, adding 20ml of 0.9% sterile sodium chloride solution (diluent) for elution to a sterile test tube, taking 1ml of the sterile test tube, adding 9ml of the diluent, and diluting by 10 times until each 1ml of test bacteria solution containing 5000-10000 cfu of bacteria is reserved.
And (3) taking a fresh culture of candida albicans and aspergillus niger cultured for 3-7 days at 23 ℃, adding 20ml of diluent, eluting into a sterile test tube, taking 1ml of diluent, adding 9ml of diluent, and diluting by 10 times until each 1ml of test bacterial liquid containing 5000-10000 cfu of bacteria is reserved.
Preparing a test solution: according to the test, a proper amount of the test sample is added into a homogenizing cup, dried and beaten for 2 minutes, and transferred into a homogenizing bag with a filtering membrane. Taking a proper amount of diluent, washing a homogenizing cup for 3 times, transferring flushing fluid into a homogenizing bag, beating the flushing fluid with a beating type sterile homogenizer for 2 minutes for uniform mixing, taking all filtrate, precipitating in a sterile large test tube for 10 minutes, taking supernatant, putting the supernatant in the sterile large test tube for uniform mixing, and preparing into 1: 10, and reserving the test solution for later use.
Total aerobic count method test general methods:
3.4.1 test group: taking 6 parts of 10ml of the test solution in 3.3, adding 0.1ml of test bacterial liquid in 3.2 respectively, shaking uniformly to prepare test bacterial liquid containing 50-100 cfu per ml, pouring 1ml of each test bacterial liquid into a flat dish, immediately pouring trypticase soy peptone agar medium at 45 ℃ and shaking uniformly, culturing in an incubator at 33 ℃ for 18-72 hours, and preparing 2 parallels, wherein the results are shown in table 1.
Bacteria liquid control group: 6 parts of 10ml of the diluted solution were added to 0.1ml of 3.2 of the test bacterial suspension in the same manner as 3.4.1, and the results are shown in Table 1.
3.4.3 control group of test article: 1ml of the test solution of 3.3 was poured into a dish, and immediately poured into trypticase Soy agar medium at 45 ℃ and shaken up in the same manner as 3.4.1, and the results are shown in Table 2.
Negative control group: 1ml of the dilution was poured into a plate and immediately poured into trypticase Soy agar medium at 45 ℃ and shaken up in the same manner as 3.4.1, and the results are shown in Table 2.
The results of the test groups on the recovery rate of infectious bacteria (%) = (average number of colonies in test group-average number of colonies in test sample control group) ÷ average number of colonies in bacterial liquid group × 100% are shown in table 2.
Table 1: colony counting and contamination recovery rate of test group and bacteria liquid control group
Table 2: colony count of test sample and negative control group
3.5 Total mold and Yeast count method test general methods
3.5.1 test groups: taking 10ml 2 parts of the test solution in 3.3, respectively adding 0.1ml 3.2.2 test bacterial solution to prepare test bacterial solution containing 50-100 cfu per 1ml, shaking up, taking 1ml each, pouring into a flat dish, immediately pouring into a 45 ℃ Sabouraud's dextrose agar culture medium, shaking up, culturing for 2-5 days at 23 ℃, preparing 2 parallels, and finding results (table 3).
3.5.2 bacterial liquid control group: 2 portions of 10ml of the diluted solution were added to 0.1ml of the test bacterial suspension of 3.2.2 by the same method as 3.5.1, and the results are shown in Table 3.
The test article control group: 1ml of the test solution in 3.3 was poured into a dish in the same manner as 3.5.1, and the results are shown in Table 3.
Negative control group: 1ml of the dilution was poured into a dish in the same manner as 3.5.1, and the results are shown in Table 3.
The recovery% of the tested infectious agents was determined in the same manner as 3.4.5, and the results are shown in Table 3.
Table 3: total number of mold and yeast counts
4. And (4) analyzing results:
from table 1, aerobic bacteria can be seen: the recovery rates of the bacillus subtilis and the pseudomonas aeruginosa are both below 50 percent; the recovery rates of staphylococcus aureus, escherichia coli, candida albicans and aspergillus niger are all between 50% and 200%.
From table 3, it can be seen that mold and yeast: the recovery rate of Candida albicans and Aspergillus niger is 50% -200%.
And conclusion:
the test sample has antibacterial effect on aerobic bacteria (Bacillus subtilis and Pseudomonas aeruginosa).
The globeflower total flavonoids and the auxiliary materials such as ethanol and the like are prepared into a spray, so that the bacteriostatic effect is more prominent. Because the mixture ratio range of the raw materials is wider, the embodiment only recommends one group of optimized formula: in the total weight of the product, the total flavonoids of the trollius chinensis bunge is 0.09-0.5%, and the edible ethanol with the alcohol content of more than 80% is 7-12%. And adding water to 100 percent to obtain the refreshing spray.
Further, a flavoring agent is added into the above raw materials, and the flavoring agent is one or more of menthol, green tea and lemon. If one of menthol, green tea and lemon is adopted, the dosage of the menthol, green tea and lemon is preferably 0.01 to 0.02 percent. If two of menthol, green tea and lemon are mixed, 0.014-0.016% of each is preferable. If the mixture of menthol, green tea and lemon is adopted, 0.008-0.01% of each is suitable. Finally adding water to 100%.
The spray prepared by the method is sprayed into the oral cavity when in use, has fragrant taste, and can eliminate or reduce the peculiar smell of the oral cavity instantly. Can also effectively kill or inhibit various bacteria in the oral cavity. Especially after tooth brushing or mouth rinsing, the effect is better, and the fragrance of the mouth can be kept for 1 to 2 hours.
The second embodiment: based on the first embodiment, glycerol, sorbitol, poloxamer 407, potassium sorbate and PEG-40 hydrogenated castor oil are added into auxiliary materials. The weight ratio is as follows: 2 to 5 percent of glycerol, 2 to 5 percent of sorbitol, 0.04 to 0.08 percent of poloxamer 407, 0.06 to 0.2 percent of potassium sorbate and 0.1 to 0.4 percent of PEG-40 hydrogenated castor oil. Finally adding purified water to 100 percent.
Glycerol, an organic substance, is named as English G L YCERO L, G L YCERINE, 1,2, 3-propanetriol, glycerin, chemical formula C3H8O3, molecular weight 92.09, colorless, odorless, sweet and clear and viscous liquid.
Sorbitol, also known as sorbitol. The English names Sorbitol, D-Glucitol, Sorbol and D-Sorbitol. Molecular formula C6H14O6And the molecular weight is 182.17. No odor, cool sweet taste, sweetness about half of that of cane sugar, and calorific value similar to that of cane sugar. This example is used primarily as a sweetener.
Poloxamer 407, the name Poloxamer 407 in Chinese, the English name is Poloxamer 407, the molecule HO (C2H4O) a (C3H6O) b (C2H4O) aH, and the molecular weight is 9840-14600. It is non-toxic and is used as disperser, emulsifier, solubilizer, lubricant and wetting agent. This example is used mainly as solubilizer and emulsifier.
Potassium sorbate, formula C6H7O2K, the molecular weight is 150.2, and the preservative is a preservative allowed to be used in China. Has strong function of inhibiting putrefying bacteria and mould, has far lower toxicity than other preservatives, and is widely used at present. This example is used primarily as a bacteriostatic.
The hydrogenated castor oil (CO-40, PEG-40) solubilizer is a viscous liquid or paste, and is an excellent nonionic solubilizer and emulsifier. This example is used mainly as an emulsifier.
Purified water refers to H free of impurities2O, Purified water or Purified water for short, and the foreign language named Purified water/deinized water is pure, clean and free of impurities or bacteria. This example is used primarily as a solvent and diluent. The pure water of this example includes ultrapure water, i.e., deionized water, which is a foreign language named deionized water and is purified water from which impurities in the form of ions are removed.
The using method comprises the following steps: the bottled product is sprayed into oral cavity, preferably directly onto the unsuitable part of oral cavity, 2-3 times per time and 4-6 times per day.
The spraying agent added with the auxiliary materials has obvious improvement on various indexes, has fragrant taste after being sprayed into oral cavity, and can eliminate or obviously reduce the peculiar smell in the oral cavity instantly. Can also effectively kill or inhibit various bacteria in the oral cavity. The bacteriostasis rate to bacillus subtilis and pseudomonas aeruginosa is not less than 70 percent. Has good curative effect on gingivitis, oral ulcer and other oral inflammations, especially has better effect when used after tooth brushing or mouth rinsing, and can keep fresh breath for 2 to 3 hours.
The third embodiment is that the spray is prepared by the following raw materials of 1g of trollius chinensis total flavone, 0.15g of menthol, 100m L of 95% edible ethanol, 30m L of glycerol, 30m L of sorbitol, 4070.5g of poloxamer, 1g of potassium sorbate, 2.5g of PEG-40 hydrogenated castor oil and deionized water added to 1L, wherein the error of the raw materials is less than or equal to 5%.
The using method comprises the following steps: the bottled product is sprayed into oral cavity, preferably directly onto the unsuitable part of oral cavity, 2-3 times per time and 4-6 times per day.
The use effect is as follows: the menthol crystal has the flavor, and the taste is fragrant and overflows after the menthol crystal is sprayed into the oral cavity, so that the peculiar smell in the oral cavity can be eliminated or remarkably reduced instantly. Can also effectively kill or inhibit various bacteria in the oral cavity. The bacteriostasis rate to bacillus subtilis and pseudomonas aeruginosa is not less than 70 percent. Especially after tooth brushing or mouth rinsing, the effect is better, and the fragrance of the mouth can be kept for 2 to 3 hours.
Since the year, after trial production by the inner Mongolia medicine engineering and technology research institute and strict toxicology experiments prove that the spray has no toxic or side effect, on the basis of volunteers, trial use is carried out in a plurality of hospitals, classrooms, restaurants and entertainment venues, and the trial users consistently think that the effect of improving the oral odor of the spray is better than that of chewing gum, and after the spray is used, the users are bought in a way of contact with each other. Wherein, a plurality of people feed back gingivitis, oral ulcer, pharyngitis and tonsillitis which are not cured for a long time and are frequently attacked can be cured or controlled. Only the inner Mongolia Mongolian institute of medical engineering and technology records that more than one hundred patients have effective oral cavity.
The fourth embodiment is that the spray is made from the following raw materials of 1g of trollius chinensis total flavone, 0.1g of green tea, 100m L of 95% edible ethanol, 30m L of glycerol, 30m L of sorbitol, 4070.5g of poloxamer, 1g of potassium sorbate, 2.5g of PEG-40 hydrogenated castor oil, and deionized water added to 1L, wherein the error of the raw materials is less than or equal to 5%.
The using method comprises the following steps: the bottled product is sprayed into oral cavity, preferably directly onto the unsuitable part of oral cavity, 2-3 times per time and 4-6 times per day.
The use effect is as follows: the green tea has the flavor of green tea, and the taste of the green tea is fragrant and overflows after the green tea is sprayed into the oral cavity, so that the peculiar smell in the oral cavity can be eliminated or remarkably reduced instantly. Can also effectively kill or inhibit various bacteria in the oral cavity. The bacteriostasis rate to bacillus subtilis and pseudomonas aeruginosa is not less than 70 percent. Especially after tooth brushing or mouth rinsing, the effect is better, and the fragrance of the mouth can be kept for 2 to 3 hours.
Since the year, after trial production by the inner Mongolia medicine engineering and technology research institute and strict toxicology experiments prove that the spray has no toxic or side effect, on the basis of volunteers, trial use is carried out in a plurality of hospitals, classrooms, restaurants and entertainment venues, and the trial users consistently think that the effect of improving the oral odor of the spray is better than that of chewing gum, and after the spray is used, the users are bought in a way of contact with each other. Wherein, a plurality of people feed back gingivitis, oral ulcer, pharyngitis and tonsillitis which are not cured for a long time and are frequently attacked can be cured or controlled. Only the inner Mongolian institute of medical engineering and technology records as many as 80 patients who are in effective use in the oral cavity.
In a fifth embodiment, the spray is prepared from 1g of trollius chinensis total flavonoids, 0.1g of lemons, 100m L of 95% edible ethanol, 30m L of glycerol, 30m L of sorbitol, 4070.5g of poloxamer, 1g of potassium sorbate, 2.5g of PEG-40 hydrogenated castor oil and deionized water added to 1L, wherein the error of the raw materials is less than or equal to 5%.
The using method comprises the following steps: the bottled product is sprayed into oral cavity, preferably directly onto the unsuitable part of oral cavity, 2-3 times per time and 4-6 times per day.
The use effect is as follows: the lemon flavor has fragrant and overflowing taste after being sprayed into oral cavity, and the peculiar smell in the oral cavity is eliminated or obviously reduced instantly. Can also effectively kill or inhibit various bacteria in the oral cavity. The bacteriostasis rate to bacillus subtilis and pseudomonas aeruginosa is not less than 70 percent. Especially after tooth brushing or mouth rinsing, the effect is better, and the fragrance of the mouth can be kept for 2 to 3 hours.
Since the year, after trial production by the inner Mongolia medicine engineering and technology research institute and strict toxicology experiments prove that the spray has no toxic or side effect, on the basis of volunteers, trial use is carried out in a plurality of hospitals, classrooms, restaurants and entertainment venues, and the trial users consistently think that the effect of improving the oral odor of the spray is better than that of chewing gum, and after the spray is used, the users are bought in a way of contact with each other. Wherein, a plurality of people feed back gingivitis, oral ulcer, pharyngitis and tonsillitis which are not cured for a long time and are frequently attacked can be cured or controlled. Only the inner Mongolian institute of medical engineering and technology records that more than one hundred patients have a valid mouth.
Claims (10)
1. The tropaeolum mouth-refreshing spray is characterized by comprising the following components in parts by weight: the spray is prepared from trollius chinensis total flavonoids and auxiliary materials.
2. The tropaeolum mouth-refreshing spray according to claim 1, which is characterized in that: the auxiliary materials comprise ethanol, water and a freshener.
3. The tropaeolum mouth-refreshing spray according to claim 2, which is characterized in that: the aromatic agent is one or more of Mentholum, green tea, and fructus Citri Limoniae.
4. The tropaeolum mouth-refreshing spray according to claim 2, which is characterized in that: the auxiliary materials are added with glycerol, sorbitol, poloxamer 407, potassium sorbate and PEG-40 hydrogenated castor oil.
5. The tropaeolum mouth-refreshing spray according to claim 1 or 2, which is characterized in that: according to weight, the total flavonoids of the trollius chinensis bunge are 0.09-0.5%, and the high-alcohol content edible ethanol with the alcohol content of more than 80% is 7-12%.
6. The tropaeolum mouth-refreshing spray according to claim 3, which is characterized in that: the amount of one of menthol, green tea and lemon is 0.01-0.02% by weight, or the amount of two of them is 0.014-0.016% respectively, or the amount of three of them is 0.008-0.01% respectively.
7. The tropaeolum mouth-refreshing spray according to claim 4, which is characterized in that: adding 2-5% of glycerol, 2-5% of sorbitol, 0.04-0.08% of poloxamer 407, 0.06-0.2% of potassium sorbate and 0.1-0.4% of PEG-40 hydrogenated castor oil by weight.
8. The tropaeolum mouth spray of claim 1, which is characterized by being prepared from 1g of tropaeolum total flavonoids, 0.14g of menthol, 100m L of 95% edible ethanol, 30m L of glycerol, 30m L of sorbitol, 4070.5g of poloxamer, 1g of potassium sorbate, 2.5g of PEG-40 hydrogenated castor oil and 1L of deionized water, wherein the error of the raw materials is less than or equal to 5%.
9. The tropaeolum mouth spray of claim 1, which is characterized by being prepared from 1g of total flavonoids of tropaeolum, 0.1g of green tea, 100m L of 95% edible ethanol, 30m L of glycerol, 30m L of sorbitol, 4070.5g of poloxamer, 1g of potassium sorbate, 2.5g of PEG-40 hydrogenated castor oil and 1L of deionized water, wherein the error of the raw materials is less than or equal to 5%.
10. The tropaeolum mouth spray of claim 1, which is characterized by being prepared from 1g of total flavonoids of tropaeolum, 0.1g of green tea, 100m L of 95% edible ethanol, 30m L of glycerol, 30m L of sorbitol, 4070.5g of poloxamer, 1g of potassium sorbate, 2.5g of PEG-40 hydrogenated castor oil and 1L of deionized water, wherein the error of the raw materials is less than or equal to 5%.
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