JP3779735B2

JP3779735B2 - Treatment for bed slippage from rice

Info

Publication number: JP3779735B2
Application number: JP30699293A
Authority: JP
Inventors: 孝徳山
Original assignee: 株式会社創研
Priority date: 1993-11-15
Filing date: 1993-11-15
Publication date: 2006-05-31
Anticipated expiration: 2021-05-31
Also published as: JPH07138172A

Description

【０００１】
【産業上の利用分野】
本発明は、米または発芽させた米を原料として得られる抗菌効果等をもつ優れた床ずれ防止治療剤に関するものである。
【０００２】
【従来の技術】
現在、日本は高齢化社会といわれ、１０年後には３人に１人が６５才以上という超高齢化社会をむかえようとしている。寝たきりの年寄りも急増しており、それに伴って生じる床ずれに苦しむ人も多い。
床ずれは、長い間床につくことにより、体の重みがかかって皮膚は皮下組織が持続的な圧迫を受けるため、血液の流れが悪くなり、栄養も滞ることから起こるもので、老人は特に皮下脂肪が少なく、骨の部分が突き出ている場合が多いので、そこが圧迫されやすく、床ずれができやすくなり、さらに、雑菌により病症はさらに悪化する。そこで、床ずれの予防としては、ひんぱんに姿勢をかえたり、エアマットを用いるなどして血行をよくするか、あるいは常に清潔に保つしかなく、床ずれの予防に対して有効で、しかも、副作用がなく安全な床ずれ防止剤は、未だ開発されていないのが現状である。
一方、米は主食以外に、清酒、焼酎、みりん、酢、麹などとして用途開発され、古くから生活に欠かせないものとなっている。このほかには、美容的用途として糠袋が知られている。これらは米を単なる主食であると見るか、またはせいぜい澱粉源としてしか見ていなかったということによるものであると思われる。また、糠袋にしても、皮膚によいとされ、慣例的にそのまま使用されてきたのみであり、有効成分という概念もなければ、その有効成分を利用するという考え方も全くなかったのである。
【０００３】
【発明が解決しようとする課題】
現在、薬剤の人体に対する副作用が問題となっており、全く副作用がなく、しかも、長期間常用しても十分に安全な床ずれ防止剤が要求されている。
本発明は、安全で安価であり、原料供給が安定しており、容易に加工ができ、長期間常用しても全く安全な米からの床ずれ防止治療剤を提供することを目的とするものである。
【０００４】
【課題を解決するための手段】
本発明者らは、動植物合和すの観点から、主食である米を中心に種々の植物成分の研究を進めてきた。その過程で、米には今まで予測できなかった数多くの可能性および効果があることが判明してきた。そこで、主食として用いられ、安全性が最も高いことが実証されている米をテーマとして取り上げ、米の総合利用研究を行ってきた。そのうちの一つのテーマとして、米からの床ずれ防止治療剤について鋭意研究を重ねてきたのであるが、その過程で、米および発芽させた米には、床ずれ防止治療効果を有する成分が含有されていることを見出し、本発明を完成するに至った。
即ち、本発明（１）は、白米の粉砕物を有効成分として含有する床ずれ防止治療剤である。
本発明（２）は、白米の抽出物を有効成分として含有する床ずれ防止治療剤である。
本発明（３）は、白米の加水物を酵素分解または麹を作用させたものを有効成分として含有する床ずれ防止治療剤である。
本発明（４）は、白米を抽出するに当たり、その抽出前、抽出と同時または抽出後に酵素分解または麹を作用させたものを有効成分として含有する床ずれ防止治療剤である。
本発明（５）は、白米の抽出物あるいは酵素分解または麹を作用させたものに、アルコール発酵あるいは有機酸発酵を行ったものを有効成分として含有する床ずれ防止治療剤である。
本発明（６）は、白米を、白米、玄米または発芽米の形態で用いる、前記発明（１）〜（５）のいずれか一つの床ずれ防止治療剤である。
【０００５】
本発明において、米および発芽させた米に含有されている床ずれ防止治療する効果を有する成分は、未だ解明するに至っていないが、米および発芽させた米を、下記のように処理したものには、床ずれに対する防止治療効果を示すことが判明した。
▲１▼ 米または発芽させた米の粉砕物をそのまま、あるいはこれを含有してなるもの。
▲２▼ 米または発芽させた米の抽出物をそのまま、あるいはこれを含有してなるもの。
▲３▼ 米および発芽させた米の加水物を酵素分解または麹を作用させたものをそのまま、あるいはこれを含有してなるもの。
▲４▼ 米または発芽させた米を抽出するに当り、その抽出前、抽出と同時または抽出後に酵素分解または麹を作用させたものをそのまま、あるいはこれを含有してなるもの。
▲５▼ 米または発芽させた米の抽出物あるいは麹を作用させたものに、アルコール発酵あるいは有機酸発酵を行なったものをそのまま、あるいはこれを含有してなるもの。
【０００６】
本発明で使用される米とは、ジャポニカ、インディカ米を問わず、うるち米、および餅米等の玄米および白米を指し、品種、種類は問わない。さらに、精白時に出てくる９２％以上の赤糠、あるいは９２％以下の白糠を使用してもよく、安価で経済的である。また、発芽させた米が使用される。なお、有効成分は、熱および光に対して安定であるため、上記の原料は、浸漬、蒸煮、焙煎（砂焙り、網焙り、熱風焙煎等全てを指す）、蒸煮焙煎、凍結乾燥等の表面変性、ＵＶ照射等の光変性、パットライス等の加圧焙煎、揚げる等の原料処理をしてもよく、また、効果も変わらなかった。
米および発芽させた米は、そのまま用いても有効であるが、実用上の面から粉砕して用いるのが好ましい。米および発芽させた米を粉砕して粉体化するには、粉砕機または精米機を用い一般的な方法で行なえばよい。
【０００７】
米を発芽させる場合、胚芽のついた米を水に浸漬あるいは水を噴霧して発芽させる。発芽させる時の温度は５〜７０℃である。ただし、発芽さえすれば、温度および時間は問わない。また、発芽中に水が腐敗する危険性がある場合は、腐敗しないように水を取り替えるか、何らかの防腐を行うのが好ましい。ここで、発芽とは、発芽する直前から発芽したものまで全てを指す。この発芽させた米を良く洗浄して用いる。この時、乾燥して用いてもよい。
米または発芽させた米を抽出、あるいは酵素分解または麹を作用させる場合、原料の米を粉砕して顆粒あるいは粉体化すると、表面積が大きくなるため効率がよくなる。粉砕しなくてもよいが、この場合には、米組織の分解および抽出に長時間を要する。
米または発芽させた米を水抽出する場合、抽出温度は、高温が効率的であるが、低温でも十分に抽出を行うことができる。ただし、４０℃以下の低温の場合は、ＰＨを酸性あるいはアルカリ性にするか、防腐剤あるいはアルコールを加えて、米が腐敗しないように処理することが望ましい。抽出時間は、有効成分さえ抽出できれば、長くても短くてもよく、抽出温度、抽出時間により定めればよい。また、抽出は、加圧下または常圧下で行っても、減圧下で行ってもよい。
【０００８】
水抽出の場合、最も問題になるのは糊化現象である。糊状になれば、抽出効率が悪くなるばかりでなく、実作業においては困難を極める。これを防ぐためには、アミラーゼを加えて反応させるか、塩酸などで酸性にして澱粉を切ってやればよく、この方法を用いることにより、十分に解決でき、実用上も全く問題はない。
抽出物中の有効成分は、酸、アルカリに安定であるためか、酸分解抽出あるいはアルカリ分解抽出を行うのも有効である。この場合、必要により中和、脱塩を行う。
有機溶媒で抽出する場合も、米はなるべく微粉砕または粉体化して抽出することが望ましい。有機溶媒はアルコール、アセトン、ｎ−ヘキサン、メタノール等の一般的な有機溶媒でよいが、人体に対して有害なものは抽出後、溶媒を完全に除去する必要があるので安全なものがよい。
【０００９】
また、米あるいは発芽させた米を酵素分解、または麹を作用させてもよい。ここで言う酵素分解とは、澱粉分解酵素、蛋白分解酵素、脂肪分解酵素、繊維分解酵素、リグニン分解酵素、ペクチン分解酵素等米に働く酵素全てを指し、これらを１種または２種以上作用させることをいう。また、麹とは麹菌の種類および米の品種、種類は問わない。
さらに、前記の抽出を行うに当り、抽出の前、抽出と同時または抽出後に、上記の酵素分解および麹を作用させてもよい。
本発明においては、さらに上記の処理を行なうと同時または処理後、アルコール発酵あるいは乳酸発酵、酢酸発酵等の有機酸発酵を行うと、次のような点でも有効である。
アルコール発酵を行なえば、塗布時にベタツキがないばかりか、濃縮がしやすく、有効成分の濃縮が容易になる。
また、９２％以上の赤糠部分を調べてみたところ、効果はあるが、弱いことが判明した。
【００１０】
以上のようにして得られた本発明品は、残渣を分離することなく、そのまま、あるいは圧搾、濾過して用いる。そのまま用いるときは、殺菌あるいは除菌をして製品にする。なお、本発明品を配合する場合は、実際の用途に応じ、常法にしたがってクリーム、洗顔料、乳液、化粧水、クレンジング、パック、石鹸などの化粧料、軟膏剤、パスタ剤、ローション剤、チンキ剤、リエメント剤、ゼリー剤、エアゾール剤などの外用医薬品のような剤型にする。他の配合成分は、通常用いられるものいずれでもよく、さらに、他の薬効剤を併用してもよい。
本発明品の床ずれ改善の効果を調べた結果について下記に示す。
まず、床ずれのパネラーに本発明品を毎日朝晩２回、床ずれの患部に１ケ月間継続的に塗布をし、その経過を診断し、本発明品の有効性を判断した。その結果を表１に示した。
なお、パネラーは各本発明品に対して１０名で行った。判定は著明改善、有用、やや有用、どちらともいえない、中止に別け、有用率（著明改善＋有用＋やや有用の全体の割合）で出した。また、判定は専門の医師により行なった。また、対照としては、本発明品の代りに水を塗布させた。
【００１１】
【表１】

【００１２】
表１から分かるように、本発明品全てにおいて、床ずれ防止、治療効果があることが判明した。また、実施例４と５を比較して明らかなように米を発芽させることにより、さらに有効になることが判明した。
そこで、これらを化学的に実証するために、本発明品の抗菌性について調べた。試験方法は、使用菌株ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍａｃｎｅｓＡＴＣＣ６９１９株をＧＡＭブイヨン培地で培養し、その時得られた培養液を液体培地とし、本発明品と等量混合した。その後、３７℃で静置培養し、４８時間後に増殖の有無を培養液の濁度（６６０ｎｍにおける吸光度）で判定した。その結果を表２に記載する。
なお、対照としては本発明品の代りに水を用いて行なった。
【００１３】
【表２】

【００１４】
表２から分かるように、本発明品全てにおいて、明らかに抗菌性があることが判明した。ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍａｃｎｅｓＡＴＣＣ６９１９株は皮膚上でも増殖する菌である。このような菌に対して優れた抗菌性があるので、化学的に本発明品が床ずれに対して有効なものであると実証されたのである。
なお、実施例およびそれに伴うデータは玄米の場合について記載したが、白糠および９２％以下の白糠の場合も同様の効果が認められた。
【００１５】
【実施例】
（実施例１）
胚芽のついたままの米１ｋｇを２５℃の水につけ、３日間浸漬させ、米を発芽させた。この発芽米をよく洗浄した後、５０℃で２４時間乾燥し、その後、細かく微粉砕し、本発明品９９０ｇを得た。
（実施例２）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物に水１５００ｍｌを添加、塩酸でＰＨを落とし１０日間放置した。その後、絞り機で絞り、得た清澄液を中和して、本発明品１２００ｍｌと残渣７６０ｇを得た。
（実施例３）
実施例１で得られた本発明品５００ｇを用いて、実施例３と同様の操作を行い、別の本発明品１１９０ｍｌを得た。
【００１６】
（実施例４）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物に液化酵素１０ｇと水１５００ｍｌを添加した。その後、徐々に温度を上げていき、５分間煮沸抽出した後、冷却した。その後、絞り機で絞り、本発明品１４２０ｍｌと残渣５６０ｇを得た。
（実施例５）
実施例１で得られた本発明品５００ｇを用いて、実施例４と同様の操作を行い、別の本発明品１４００ｍｌを得た。
（実施例６）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物に２Ｎ−ＮａＯＨ１５００ｍｌを添加して５日間放置した。その後、絞り機で絞り、清澄液１３５０ｍｌと残渣６５０ｇを得た。この清澄液を１０Ｎ−ＨＣｌで中和して、本発明品１４８０ｍｌを得た。
【００１７】
（実施例７）
実施例１で得られた本発明品５００ｇを用いて、実施例６と同様の操作を行い、別の本発明品１４９０ｍｌを得た。
（実施例８）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物に９５％エタノール１５００ｍｌを添加して、５日間放置した。その後、絞り機で絞り、清澄液１３００ｍｌと残渣６５０ｇを得た。この清澄液に水２０００ｍｌを添加し、ロータリーエバプレーターで濃縮し、本発明品１５００ｍｌを得た。
（実施例９）
実施例１で得られた本発明品５００ｇを用いて、実施例８と同様の操作を行い、別の本発明品１５００ｍｌを得た。
【００１８】
（実施例１０）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物に麹３００ｇ、水１５００ｍｌを加え、５５℃で２０時間放置した。その後、絞り機で絞り、本発明品１２３０ｍｌと残渣１０００ｇを得た。
（実施例１１）
実施例１で得られた本発明品５００ｇを用いて、実施例１０と同様の操作を行い、別の本発明品１２１０ｍｌを得た。
（実施例１２）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物に蛋白分解酵素２ｇと水１５００ｍｌを加え、５０℃で２０時間放置した。その後、絞り機で絞り、本発明品１３１０ｍｌと残渣６７０ｇを得た。
【００１９】
（実施例１３）
実施例１で得られた本発明品５００ｇを用いて、実施例１２と同様の操作を行い、別の本発明品１３８０ｍｌを得た。
（実施例１４）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物に脂肪分解酵素２ｇと水１５００ｍｌを加え、５０℃で２０時間放置した。その後、絞り機で絞り、本発明品１２９０ｍｌと残渣６８０ｇを得た。
（実施例１５）
実施例１で得られた本発明品５００ｇを用いて、実施例１４と同様の操作を行い、別の本発明品１３６０ｍｌを得た。
【００２０】
（実施例１６）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物に繊維分解酵素２ｇと水１５００ｍｌを加え、５０℃で２０時間放置した。その後、絞り機で絞り、本発明品１３３０ｍｌと残渣６５０ｇを得た。
（実施例１７）
実施例１で得られた本発明品５００ｇを用いて、実施例１６と同様の操作を行い、別の本発明品１３７０ｍｌを得た。
（実施例１８）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物に澱粉分解酵素２ｇと水１５００ｍｌを加え、５５℃で２０時間放置した。その後、絞り機で絞り、本発明品１３８０ｍｌと残渣６００ｇを得た。
【００２１】
（実施例１９）
実施例１で得られた本発明品５００ｇを用いて、実施例１８と同様の操作を行い、別の本発明品１４００ｍｌを得た。
（実施例２０）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物にペクチン分解酵素２ｇと水１５００ｍｌを加え、５０℃で２０時間放置した。その後、絞り機で絞り、本発明品１３２０ｍｌと残渣６６０ｇを得た。
（実施例２１）
実施例１で得られた本発明品５００ｇを用いて、実施例２０と同様の操作を行い、別の本発明品１３００ｍｌを得た。
【００２２】
（実施例２２）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物に蛋白分解酵素２ｇ、脂肪分解酵素２ｇ、繊維分解酵素２ｇ、澱粉分解酵素２ｇ、ペクチン分解酵素２ｇと水１５００ｍｌを加え、５０℃で２０時間放置した。その後、絞り機で絞り、本発明品１４２０ｍｌと残渣５６０ｇを得た。
（実施例２３）
実施例１で得られた本発明品５００ｇを用いて、実施例２２と同様の操作を行い、別の本発明品１４４０ｍｌを得た。
（実施例２４）
実施例２２と同様の操作をして、米の酵素分解物２０００ｇを得た。その後、徐々に温度を上げていき、５分間煮沸抽出した後、冷却した。その後、絞り機で絞り、本発明品１４００ｍｌと残渣５５０ｇを得た。
【００２３】
（実施例２５）
実施例１で得られた本発明品５００ｇを用いて、実施例２４と同様の操作を行い、別の本発明品１４２０ｍｌを得た。
（実施例２６）
玄米を粉砕機にかけ、玄米の粉砕物５００ｇを得た。この粉砕物に麹３００ｇと４０％エタノール１５００ｍｌを加え、５５℃で４８時間放置した。その後、絞り機で絞り、清澄液１３００ｍｌと残渣８５０ｇを得た。その後、清澄液に１０００ｍｌの水を加水し、ロータリーエバプレーターで濃縮し、本発明品１３００ｍｌを得た。
（実施例２７）
実施例１で得られた本発明品５００ｇを用いて、実施例２６と同様の操作を行い、別の本発明品１３００ｍｌを得た。
【００２４】
（実施例２８）
実施例４と同様にして、米の抽出物２０００ｇを得た。この抽出物に蛋白分解酵素２ｇ、脂肪分解酵素２ｇ、繊維分解酵素２ｇ、澱粉分解酵素２ｇ、ペクチン分解酵素２ｇを添加し、５０℃で２４時間放置した。その後、絞り機で絞り、本発明品１４００ｍｌと残渣５２０ｇを得た。
（実施例２９）
実施例１で得られた本発明品５００ｇを用いて、実施例２８と同様の操作を行い、別の本発明品１３９０ｍｌを得た。
（実施例３０）
実施例２２と同様にして、米の酵素分解抽出物２０００ｇを得た。この酵素分解抽出物に酵母を添加し、１６日間アルコール発酵した。その後、絞り機で絞り、本発明品１８８０ｍｌと残渣８０ｇを得た。
【００２５】
（実施例３１）
実施例１で得られた本発明品５００ｇを用いて、実施例３０と同様の操作を行い、別の本発明品１８００ｍｌを得た。
（実施例３２）
実施例２２と同様にして、米の酵素分解抽出物２０００ｇを得た。この酵素分解抽出物を煮沸殺菌した後、３７℃まで冷却し、前もって乳酸菌を培養したスターター２００ｍｌを添加後、よく攪拌密閉し、３７℃で２日間乳酸発酵を行った。その後、絞り機で絞り、本発明品１３８０ｍｌと残渣５９０ｇを得た。
（実施例３３）
実施例１で得られた本発明品５００ｇを用いて、実施例３２と同様の操作を行い、別の本発明品１４００ｍｌを得た。
【００２６】
（実施例３４）
実施例２２で得られた本発明品１０００ｍｌに９５％エタノール８０ｍｌを添加し、２０日間酢酸発酵を行った。その後、濾過をし、本発明品９９０ｍｌを得た。
（実施例３５）
実施例１で得られた本発明品５００ｇを用いて、実施例３４と同様の操作を行い、別の本発明品１０００ｍｌを得た。
以上の実施例で得た本発明品は、用途に応じて適宜に使用されるが、本発明品を配合して化粧水および乳液とする場合の実施例について、次に記載する。なお、配合例は以下の実施例に限定されるものではない。
【００２７】
（実施例３６）化粧水
実施例２２で得られた本発明品１０．０重量％
ソルビトール３．０重量％
グリセリン５．０重量％
精製水７６．４重量％
アラントイン０．１重量％
ポリオキシエチレンヒマシ油誘導体０．５重量％
エタノール５重量％
以上の配合材料を常法により混合溶解し、化粧水を得た。
【００２８】
（実施例３７）乳液

精製水にジプロピレンクリコールを加え、加熱攪拌し、温度を７０℃に保持し、これに本発明品、クイカスシード抽出液、香料、エタノール以外の原料を加えて攪拌し、次に、ホモジナイザーで均一に乳化させる。得られた乳化液を冷却しながら攪拌下に、残りのものを徐々に加え、室温に冷却して乳液を得た。
【００２９】
【発明の効果】
本発明によれば、床ずれのできやすい背中、腰、肩、肘など、皮下に触れる部分に塗布することにより、簡単に、全く安全で、しかも、床ずれを防止する効果を持つ優れた床ずれ防止剤が得られる。
米は今まで主食であったため、食以外の新規な分野での製法、利用用途はほとんど開発されていなかった。さらに、米は今まで主食とされてきたものであり、安全性も十分に実証されているものである。すなわち、本発明は、非常に優れた床ずれ防止効果を見出したばかりでなく、米の過剰生産といわれる現在、新たな利用用途を見出したこと、および米のイメージアップによる消費拡大を図り得ることは、極めて有意義なことである。[0001]
[Industrial application fields]
The present invention relates to an excellent treatment for preventing bedsores having an antibacterial effect and the like obtained from rice or germinated rice as a raw material.
[0002]
[Prior art]
At present, Japan is said to be an aging society, and in 10 years, one out of three people is going to become a super-aging society where 65 years old or older. The number of bedridden elderly is also increasing rapidly, and many people suffer from bedsores.
Bed slipping occurs because the body weight is applied to the skin for a long time and the skin receives continuous pressure on the subcutaneous tissue, resulting in poor blood flow and poor nutrition. Since there are few fats and the bone part has protruded in many cases, it is easy to be pressed and it becomes easy to carry out bed slipping, and various diseases will make the disease worse. In order to prevent bedsores, the only way to prevent bedsores is to change the posture frequently, improve the blood circulation by using an air mat, or keep them clean at all times. The current situation is that no bed slip prevention agent has been developed yet.
Rice, on the other hand, has been developed for sake, shochu, mirin, vinegar, koji, etc. in addition to staple foods, and has been indispensable for daily life. In addition, a bag is known as a cosmetic use. These may be due to seeing rice as a staple food, or at best only as a source of starch. Moreover, even if it is a bag, it is said that it is good for skin, and it has been used conventionally as it is, and there was no concept of an active ingredient, and there was no idea of using the active ingredient at all.
[0003]
[Problems to be solved by the invention]
Currently, side effects of drugs on the human body have become a problem, and there is a need for a bed slip prevention agent that has no side effects at all and that is sufficiently safe even when used for a long period of time.
An object of the present invention is to provide a therapeutic agent for preventing bed slippage from rice, which is safe and inexpensive, has a stable raw material supply, can be easily processed, and is completely safe even after regular use over a long period of time. is there.
[0004]
[Means for Solving the Problems]
The inventors of the present invention have been researching various plant components, mainly rice, which is a staple food, from the viewpoint of combining plants and animals. In the process, it has been found that rice has many possibilities and benefits that could not have been predicted before. Therefore, we have taken up the theme of rice, which is used as a staple food and has proven to be the safest, and has conducted comprehensive rice research. As one of the themes, we have been intensively researching the therapeutic agent for bedsores from rice. In the process, the rice and the germinated rice contain ingredients that have a therapeutic effect on bedsores. As a result, the present invention has been completed.
That is, the present invention (1) is a therapeutic agent for preventing bedsores containing pulverized white rice as an active ingredient.
This invention (2) is a bed slip prevention therapeutic agent which contains the extract of white rice as an active ingredient.
The present invention (3) is a therapeutic agent for preventing bedsores containing, as an active ingredient, a hydrolyzed white rice hydrolyzed or koji-treated substance.
The present invention (4) is a therapeutic agent for preventing bedsores containing, as an active ingredient, an enzyme-decomposed or rice bran acted before, simultaneously with or after extraction of white rice.
The present invention (5) is a therapeutic agent for preventing bedsores containing, as an active ingredient, a product obtained by subjecting an extract of white rice or enzymatic degradation or koji to alcohol fermentation or organic acid fermentation.
The present invention (6) is the therapeutic agent for preventing bed slip according to any one of the inventions (1) to (5), wherein white rice is used in the form of white rice, brown rice or germinated rice.
[0005]
In the present invention, the ingredients having the effect of preventing bed slippage contained in rice and germinated rice have not yet been elucidated, but rice and germinated rice treated as follows It has been found that it has a preventive and therapeutic effect against bedsores.
(1) Rice or germinated rice pulverized product as it is or containing it.
(2) Rice or germinated rice extract as it is or containing it.
(3) Rice or germinated rice hydrolyzate that has been subjected to enzymatic degradation or koji action or contains this as it is.
{Circle around (4)} Extracting rice or germinated rice as it is, or containing it, that has been subjected to enzymatic degradation or koji before, simultaneously with or after extraction.
(5) A product obtained by subjecting rice or germinated rice extract or rice cake to alcohol fermentation or organic acid fermentation as it is or containing it.
[0006]
The rice used in the present invention refers to brown rice and white rice such as sticky rice and brown rice, regardless of japonica and indica rice, regardless of the variety and type. Furthermore, it is possible to use 92% or more of red cocoon that appears during whitening, or 92% or less of white cocoon, which is inexpensive and economical. In addition, germinated rice is used. In addition, since the active ingredient is stable to heat and light, the above-mentioned raw materials are dipping, steaming, roasting (pointing to all of sand roasting, net roasting, hot air roasting, etc.), steaming roasting, freeze drying Material treatment such as surface modification such as UV irradiation, photo modification such as UV irradiation, pressure roasting such as Patrice, frying, etc., and the effect was not changed.
Rice and germinated rice are effective when used as they are, but are preferably pulverized for practical use. In order to pulverize rice and germinated rice into powder, a general method may be used using a pulverizer or a rice mill.
[0007]
When germinating rice, the germinated rice is immersed in water or sprayed with water. The temperature at the time of germination is 5-70 degreeC. However, the temperature and time are not limited as long as germination occurs. In addition, when there is a risk of water rot during germination, it is preferable to replace the water so that it does not rot or to perform some preservative. Here, germination refers to everything from just before germination to germination. The germinated rice is washed thoroughly before use. At this time, you may dry and use.
When rice or germinated rice is extracted or subjected to enzymatic degradation or koji, if the raw rice is pulverized into granules or powders, the surface area increases and efficiency increases. Although it is not necessary to grind, in this case, it takes a long time to decompose and extract the rice tissue.
When rice or germinated rice is extracted with water, a high extraction temperature is efficient, but sufficient extraction can be performed even at a low temperature. However, in the case of a low temperature of 40 ° C. or less, it is desirable to make the pH acidic or alkaline, or add a preservative or alcohol so that the rice is not spoiled. The extraction time may be long or short as long as the active ingredient can be extracted, and may be determined by the extraction temperature and the extraction time. The extraction may be performed under pressure, normal pressure, or reduced pressure.
[0008]
In the case of water extraction, the most serious problem is the gelatinization phenomenon. If it becomes paste-like, not only extraction efficiency will worsen but it will be extremely difficult in actual work. In order to prevent this, the reaction may be performed by adding amylase or acidifying with hydrochloric acid or the like to cut the starch. By using this method, the problem can be solved sufficiently and there is no problem in practical use.
It is also effective to perform acid decomposition extraction or alkali decomposition extraction because the active ingredient in the extract is stable to acid and alkali. In this case, neutralization and desalting are performed as necessary.
Also when extracting with an organic solvent, it is desirable to extract rice by pulverizing or pulverizing it as much as possible. The organic solvent may be a common organic solvent such as alcohol, acetone, n-hexane, methanol or the like, but those that are harmful to the human body are preferably safe because the solvent must be completely removed after extraction.
[0009]
In addition, rice or germinated rice may be subjected to enzymatic degradation, or koji. Enzymatic degradation as used herein refers to all enzymes acting on rice, such as starch degrading enzymes, proteolytic enzymes, lipolytic enzymes, fiber degrading enzymes, lignin degrading enzymes, pectin degrading enzymes, and one or more of these act on them. That means. In addition, koji is not limited to the type of koji mold and the variety and type of rice.
Furthermore, in performing the above-described extraction, the above-described enzymatic degradation and soot may be allowed to act before, simultaneously with or after extraction.
In the present invention, when the above-described treatment is further performed, or when the organic acid fermentation such as alcohol fermentation, lactic acid fermentation, or acetic acid fermentation is performed simultaneously or after the treatment, the following points are also effective.
When alcoholic fermentation is performed, not only is there no stickiness at the time of application, but it is easy to concentrate and the active ingredient is easily concentrated.
In addition, when the red cocoon portion of 92% or more was examined, it was found that although there was an effect, it was weak.
[0010]
The product of the present invention obtained as described above is used as it is or after being squeezed and filtered without separating the residue. When it is used as it is, it is sterilized or sterilized to make a product. In addition, when blending the product of the present invention, according to the actual application, cosmetics such as creams, face wash, milky lotion, skin lotion, cleansing, pack, soap, etc., ointment, pasta agent, lotion agent, Make the dosage form like external medicines such as tincture, rimentation, jelly and aerosol. Any other commonly used ingredients may be used, and other medicinal agents may be used in combination.
The results of examining the effect of improving the floor slip of the product of the present invention are shown below.
First, the product of the present invention was applied twice a day in the morning and night to the bed slipper and continuously applied to the affected part of the bed slip for one month, the progress was diagnosed, and the effectiveness of the product of the present invention was judged. The results are shown in Table 1.
The panelists were 10 persons for each product of the present invention. Judgment was made at the rate of usefulness (significantly improved + useful + slightly useful overall rate), with or without discontinuation, marked improvement, useful or slightly useful. The determination was made by a specialist doctor. As a control, water was applied instead of the product of the present invention.
[0011]
[Table 1]

[0012]
As can be seen from Table 1, it was found that all the products of the present invention have a bed slip prevention and therapeutic effect. Moreover, it became clear that it became still more effective by germinating rice so that Example 4 and 5 might be compared.
Therefore, in order to chemically verify these, the antibacterial properties of the products of the present invention were examined. In the test method, the used strain propionibacterium acnes ATCC 6919 was cultured in a GAM bouillon medium, and the culture medium obtained at that time was used as a liquid medium and mixed with the product of the present invention in an equal amount. Thereafter, the culture was allowed to stand at 37 ° C., and after 48 hours, the presence or absence of growth was determined by the turbidity of the culture (absorbance at 660 nm). The results are listed in Table 2.
As a control, water was used instead of the product of the present invention.
[0013]
[Table 2]

[0014]
As can be seen from Table 2, all the products of the present invention were clearly found to have antibacterial properties. Propionibacterium acnes ATCC 6919 is a fungus that also grows on the skin. Since it has an excellent antibacterial property against such bacteria, the product of the present invention has been chemically demonstrated to be effective against bed slip.
In addition, although the Example and the data accompanying it were described about the case of brown rice, the same effect was recognized also in the case of the white rice bran and 92% or less of white rice.
[0015]
【Example】
Example 1
1 kg of rice with germs was placed in water at 25 ° C. and immersed for 3 days to germinate the rice. After thoroughly washing the germinated rice, it was dried at 50 ° C. for 24 hours, and then finely pulverized to obtain 990 g of the product of the present invention.
(Example 2)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. To this pulverized product, 1500 ml of water was added, pH was dropped with hydrochloric acid, and the mixture was allowed to stand for 10 days. Thereafter, the clarified liquid obtained by squeezing with a squeezer was neutralized to obtain 1200 ml of the present product and 760 g of a residue.
Example 3
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 3 was performed to obtain 1190 ml of another product of the present invention.
[0016]
(Example 4)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. 10 g of liquefied enzyme and 1500 ml of water were added to this pulverized product. Thereafter, the temperature was gradually increased, followed by boiling extraction for 5 minutes and then cooling. Thereafter, the product was squeezed with a squeezer to obtain 1420 ml of the product of the present invention and 560 g of residue.
(Example 5)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 4 was performed to obtain 1400 ml of another product of the present invention.
(Example 6)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. To this pulverized product, 1500 ml of 2N-NaOH was added and left for 5 days. Then, it squeezed with the squeezer and obtained 1350 ml of clarified liquids, and 650 g of residue. The clear solution was neutralized with 10N HCl to obtain 1480 ml of the product of the present invention.
[0017]
(Example 7)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 6 was performed to obtain another 1490 ml of the product of the present invention.
(Example 8)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. To this pulverized product, 1500 ml of 95% ethanol was added and left for 5 days. Then, it squeezed with the squeezer and 1300 ml of clarified liquids and 650 g of residue were obtained. To this clarified liquid, 2000 ml of water was added and concentrated with a rotary evaporator to obtain 1500 ml of the product of the present invention.
Example 9
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 8 was performed to obtain 1500 ml of another product of the present invention.
[0018]
(Example 10)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. To this pulverized product, 300 g of candy and 1500 ml of water were added, and the mixture was left at 55 ° C. for 20 hours. Then, it squeezed with the squeezer and obtained 1230 ml of this invention products and 1000 g of residue.
(Example 11)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 10 was performed to obtain 1210 ml of another product of the present invention.
(Example 12)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. To this pulverized product, 2 g of proteolytic enzyme and 1500 ml of water were added and left at 50 ° C. for 20 hours. Then, it squeezed with the squeezer and obtained 1310 ml of this invention products and 670 g of residue.
[0019]
(Example 13)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 12 was performed to obtain 1380 ml of another product of the present invention.
(Example 14)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. To this pulverized product, 2 g of lipolytic enzyme and 1500 ml of water were added and left at 50 ° C. for 20 hours. Thereafter, the product was squeezed with a squeezer to obtain 1290 ml of the product of the present invention and 680 g of residue.
(Example 15)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 14 was performed to obtain 1360 ml of another product of the present invention.
[0020]
(Example 16)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. To this pulverized product, 2 g of a fiber-degrading enzyme and 1500 ml of water were added and left at 50 ° C. for 20 hours. Thereafter, the product was squeezed with a squeezer to obtain 1330 ml of the present product and 650 g of a residue.
(Example 17)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 16 was performed to obtain 1370 ml of another product of the present invention.
(Example 18)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. To this pulverized product, 2 g of amylolytic enzyme and 1500 ml of water were added and left at 55 ° C. for 20 hours. Thereafter, the product was squeezed with a squeezer to obtain 1380 ml of the product of the present invention and 600 g of residue.
[0021]
(Example 19)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 18 was performed to obtain 1400 ml of another product of the present invention.
(Example 20)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. To this pulverized product, 2 g of pectin-degrading enzyme and 1500 ml of water were added and left at 50 ° C. for 20 hours. Thereafter, the product was squeezed with a squeezer to obtain 1320 ml of the product of the present invention and 660 g of residue.
(Example 21)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 20 was performed to obtain 1300 ml of another product of the present invention.
[0022]
(Example 22)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. To this pulverized product, 2 g of proteolytic enzyme, 2 g of lipolytic enzyme, 2 g of fiber degrading enzyme, 2 g of starch degrading enzyme, 2 g of pectin degrading enzyme and 1500 ml of water were added and left at 50 ° C. for 20 hours. Thereafter, the product was squeezed with a squeezer to obtain 1420 ml of the product of the present invention and 560 g of residue.
(Example 23)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 22 was performed to obtain 1440 ml of another product of the present invention.
(Example 24)
The same operation as in Example 22 was performed to obtain 2000 g of an enzymatic degradation product of rice. Thereafter, the temperature was gradually increased, followed by boiling extraction for 5 minutes and then cooling. Then, it squeezed with the squeezer and obtained 1400 ml of this invention products and 550 g of residue.
[0023]
(Example 25)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 24 was performed to obtain 1420 ml of another product of the present invention.
(Example 26)
Brown rice was put into a pulverizer to obtain 500 g of pulverized brown rice. To this pulverized product, 300 g of koji and 1500 ml of 40% ethanol were added and left at 55 ° C. for 48 hours. Then, it squeezed with the squeezer and 1300 ml of clarified liquids and 850 g of residue were obtained. Thereafter, 1000 ml of water was added to the clarified liquid and concentrated with a rotary evaporator to obtain 1300 ml of the product of the present invention.
(Example 27)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 26 was performed to obtain 1300 ml of another product of the present invention.
[0024]
(Example 28)
In the same manner as in Example 4, 2000 g of rice extract was obtained. To this extract, 2 g of proteolytic enzyme, 2 g of lipolytic enzyme, 2 g of fiber degrading enzyme, 2 g of starch degrading enzyme and 2 g of pectin degrading enzyme were added and left at 50 ° C. for 24 hours. Thereafter, the product was squeezed with a squeezer to obtain 1400 ml of the present product and 520 g of a residue.
(Example 29)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 28 was performed to obtain another 1390 ml of the product of the present invention.
(Example 30)
In the same manner as in Example 22, 2000 g of enzymatic decomposition extract of rice was obtained. Yeast was added to this enzymatic degradation extract, and alcohol fermentation was performed for 16 days. Thereafter, the product was squeezed with a squeezer to obtain 1880 ml of the product of the present invention and 80 g of residue.
[0025]
(Example 31)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 30 was performed to obtain 1800 ml of another product of the present invention.
(Example 32)
In the same manner as in Example 22, 2000 g of enzymatic decomposition extract of rice was obtained. The enzyme-degraded extract was sterilized by boiling, cooled to 37 ° C., added with 200 ml of a starter in which lactic acid bacteria had been cultured in advance, sealed well, and subjected to lactic acid fermentation at 37 ° C. for 2 days. Thereafter, the product was squeezed with a squeezer to obtain 1380 ml of the present product and 590 g of a residue.
(Example 33)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 32 was performed to obtain 1400 ml of another product of the present invention.
[0026]
(Example 34)
To 1000 ml of the product of the present invention obtained in Example 22, 80 ml of 95% ethanol was added, and acetic acid fermentation was performed for 20 days. Thereafter, filtration was performed to obtain 990 ml of the present product.
(Example 35)
Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 34 was performed to obtain 1000 ml of another product of the present invention.
The product of the present invention obtained in the above examples is appropriately used depending on the application. Examples of the case where the product of the present invention is blended into a lotion and an emulsion are described below. In addition, a compounding example is not limited to a following example.
[0027]
(Example 36) The product of the present invention obtained in the lotion Example 22 10.0% by weight
Sorbitol 3.0% by weight
Glycerin 5.0% by weight
76.4% by weight of purified water
Allantoin 0.1% by weight
Polyoxyethylene castor oil derivative 0.5% by weight
Ethanol 5% by weight
The above blended materials were mixed and dissolved by a conventional method to obtain a lotion.
[0028]
(Example 37) Latex

Dipropylene glycol is added to purified water, heated and stirred, and the temperature is maintained at 70 ° C. The ingredients other than the product of the present invention, quicus seed extract, fragrance, and ethanol are added and stirred, and then uniformly with a homogenizer To emulsify. The remaining emulsion was gradually added with stirring while cooling the obtained emulsion, and cooled to room temperature to obtain an emulsion.
[0029]
【The invention's effect】
According to the present invention, an excellent floor slip prevention agent having an effect of preventing bedsores simply, completely safe by applying to the part touching the skin such as back, waist, shoulder, elbow, etc. Is obtained.
Since rice has been a staple food until now, there has been almost no development of methods and uses in new fields other than food. Furthermore, rice has been regarded as a staple food until now, and its safety has been fully demonstrated. That is, the present invention has not only found a very excellent bed slip prevention effect, but has now found a new use application, which is said to be overproduction of rice, and can increase consumption by improving the image of rice. This is extremely meaningful.

Claims

Prevent bedsores therapeutic agent containing white rice hydrolyzate as an active ingredient that is enzymatic degradation.

A therapeutic agent for preventing bedsores containing, as an active ingredient, an enzyme-decomposed material before, simultaneously with or after extraction of white rice.

Furthermore, the therapeutic agent for preventing bedsores according to claim 1 or 2, which has been subjected to alcoholic fermentation or organic acid fermentation .