JPH07138172A - Bedsore preventive or treating agent - Google Patents

Abstract

PURPOSE:To obtain an inexpensive bedsore preventive and treating agent which is safe, even after it is applied for a long period of time, from the starting substances which can stably be supplied and has high processibility. CONSTITUTION:(1) Ground products of germinated rice grains, (2) extracts from rice grains or germinated rice grains, (3) hydrolytic products of rice of germinated rice grains or products by allowing KOJI (malted rice) to act on them, (4) products obtained by allowing enzyme or KOJI to act on rice or germinated rice grains before, on or after extraction and (5) products of alcoholic or organic acid fermentation on the enzymatic hydrolyzate or Koji treatment product from rice, germinated rice or rice extract can be directly used or formulated with other components into the objective bedsore preventive respectively.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an excellent anti-bedsore therapeutic agent having an antibacterial effect and the like obtained from rice or germinated rice as a raw material.

[0002]

2. Description of the Related Art At present, Japan is said to be an aging society.
One year out of three, one in three will be 65 years old or more, and they are trying to reach a super-aging society. The number of bedridden elderly people is increasing rapidly, and many people suffer from bed sores that accompany it. Bed sores are caused by the weight of the body being applied to the skin for a long time, and the subcutaneous tissue of the skin is continuously pressed, resulting in poor blood flow and poor nutrition, especially in the elderly. In many cases, there is little fat and the bone part is protruding, so that it is easy to be compressed and bed sores are easily caused, and further, various bacteria aggravate the disease. Therefore, to prevent bed sores, it is effective to prevent bed sores by frequently changing postures, using an air mat, etc. to improve blood circulation, or always keeping it clean. Anti-bed sores
The current situation is that it has not been developed yet. On the other hand, rice has been developed to be used as sake, shochu, mirin, vinegar, koji, etc., in addition to the staple food, and has been indispensable for daily life.
In addition to this, bran bags are known for cosmetic purposes.
It is believed that these were due to the fact that rice was viewed as merely a staple food, or at best as a source of starch. Also, even if it is a bran bag, it is said that it is good for the skin, and it has been customarily used as it is,
There was no concept of an active ingredient, and no idea of utilizing that active ingredient.

[0003]

At present, there is a problem of side effects of drugs on the human body, and there is a demand for a bed sore preventive agent which has no side effects and is sufficiently safe even if it is used for a long period of time. An object of the present invention is to provide a therapeutic agent for preventing bedsores from rice, which is safe and inexpensive, has a stable supply of raw materials, can be easily processed, and is completely safe even after long-term regular use. is there.

[0004]

[Means for Solving the Problems] From the viewpoint of animal and plant harmony, the present inventors have conducted research on various plant components centering on rice, which is a staple food. In the process, it has become clear that rice has a number of potential and benefits that were previously unpredictable. Therefore, we picked up rice, which is used as a staple food and proved to have the highest safety, as the theme,
I have conducted comprehensive utilization research on rice. As one of the themes, we have conducted intensive research on a therapeutic agent for preventing bedsores from rice, and in the process, rice and germinated rice contain ingredients that have a therapeutic effect on bedsores. This has led to the completion of the present invention.

In the present invention, the components contained in rice and germinated rice and having an effect of preventing and treating bed sores have not yet been elucidated, but rice and germinated rice were treated as follows. It was found that the product showed preventive and therapeutic effect on bed sores. Crushed rice or germinated rice as it is or containing it. Rice or germinated rice extract as it is or containing it. Enzyme-decomposed or hydrolyzed rice hydrolyzed as it is, or containing it. When extracting rice or sprouted rice, the one that has been subjected to enzymatic decomposition or koji before or at the same time as or after the extraction is used as it is or containing it. A product obtained by subjecting rice or germinated rice extract or koji which has been subjected to alcohol fermentation or organic acid fermentation to itself or containing it.

The rice used in the present invention is Japonica,
Regardless of indica rice, it refers to non-glutinous rice, brown rice such as sticky rice, and white rice, regardless of variety and type. Further, 92% or more of red rice bran or 92% or less of white rice bran, which appears during whitening, may be used, which is inexpensive and economical. Also,
Germinated rice is used. In addition, since the active ingredient is stable to heat and light, the above raw materials are dipping, steaming, roasting (all sand roasting, net roasting, hot air roasting, etc.),
The raw material treatment such as steam roasting, surface modification such as freeze-drying, photo-modification such as UV irradiation, pressure roasting such as Patrice, and frying may be performed, and the effect was not changed. Although rice and germinated rice are effective as they are, they are preferably crushed and used from the viewpoint of practical use. In order to pulverize the rice and the sprouted rice into powder, a pulverizer or a rice mill may be used by a general method.

When germinating rice, germinated rice is soaked in water or sprayed with water to germinate. The temperature for germination is 5 to 70 ° C. However, as long as it germinates,
Temperature and time do not matter. Further, when there is a risk of water spoiling during germination, it is preferable to replace the water so that it does not spoil, or to perform some kind of preservative. Here, germination refers to everything from just before germination to germinated ones.
The germinated rice is washed well before use. At this time, it may be dried before use. When extracting rice or sprouted rice, or subjecting it to enzymatic decomposition or koji, the raw material rice is pulverized into granules or powder to increase the surface area, resulting in higher efficiency. Although it is not necessary to grind, in this case, it takes a long time to decompose and extract the rice tissue. When extracting rice or germinated rice with water, a high extraction temperature is effective, but sufficient extraction can be performed even at a low temperature. However, in the case of a low temperature of 40 ° C. or lower, it is desirable to make PH acidic or alkaline, or add a preservative or alcohol to treat the rice so that it does not spoil. The extraction time may be long or short as long as the active ingredient can be extracted, and may be determined depending on the extraction temperature and the extraction time. The extraction may be carried out under pressure, at normal pressure, or under reduced pressure.

In the case of water extraction, the gelatinization phenomenon is the most problematic. If it becomes pasty, not only the extraction efficiency will deteriorate, but it will be extremely difficult in actual work. In order to prevent this, the reaction may be carried out by adding amylase or acidification may be carried out with hydrochloric acid or the like to cut the starch. By using this method, it can be sufficiently solved and there is no problem in practice.
Since the active ingredient in the extract is stable to acid and alkali, it is also effective to perform acid decomposition extraction or alkali decomposition extraction. In this case, neutralization and desalting are performed if necessary. Also when extracting with an organic solvent, it is desirable to pulverize or pulverize rice as much as possible before extracting. The organic solvent may be a general organic solvent such as alcohol, acetone, n-hexane, methanol, etc., but if it is harmful to the human body, after extraction,
A safe one is preferable because it is necessary to completely remove the solvent.

Alternatively, rice or germinated rice may be enzymatically decomposed or koji may be allowed to act on it. The term "enzymatic degradation" as used herein refers to all enzymes that act on rice, such as starch degrading enzymes, proteolytic enzymes, lipolytic enzymes, fiber degrading enzymes, lignin degrading enzymes, pectin degrading enzymes, and one or more of these are allowed to act. Say that. The koji mold may be any kind of koji mold, rice variety or kind. Further, in carrying out the above-mentioned extraction, the above-mentioned enzymatic decomposition and koji may be allowed to act before, simultaneously with or after the extraction. In the present invention, when the organic acid fermentation such as alcohol fermentation, lactic acid fermentation, or acetic acid fermentation is carried out simultaneously with or after the above treatment, the following points are also effective. If alcohol fermentation is carried out, not only there is no stickiness at the time of application, but also the concentration is easy and the active ingredient can be easily concentrated. Also, 9
When 2% or more of red rice bran was examined, it was found to be effective but weak.

The product of the present invention obtained as described above is used as it is, or after being squeezed and filtered without separating the residue. When used as is, sterilize or sterilize the product. When blending the product of the present invention,
Depending on the actual application, cosmetics such as cream, face wash, emulsion, lotion, cleansing, pack, soap, ointment, pasta, lotion, tincture, etc.
The dosage form should be similar to external medicines such as relief agents, jellies and aerosols. The other compounding ingredients may be any of those usually used, and further, other medicinal agents may be used in combination. The results of examining the effect of improving the bed sores of the product of the present invention are shown below. First, the product of the present invention was applied to a bed sore panelist twice daily in the morning and evening and continuously to the affected area of the bed sore for 1 month, and the progress was diagnosed to determine the effectiveness of the product of the present invention.
The results are shown in Table 1. The panelists were 10 people for each of the products of the present invention. Judgment was markedly improved, useful, rather useful, which can be said to be neither, discontinuation, and the useful rate (significant improvement + useful + slightly useful overall ratio). Also,
The judgment was made by a specialist doctor. As a control, water was applied instead of the product of the present invention.

[0011]

[Table 1]

As can be seen from Table 1, all of the products of the present invention were found to have the effect of preventing bedsores and treating them. Further, as is apparent from comparison between Examples 4 and 5, germination of rice was found to be more effective. Therefore, in order to chemically verify these, the antibacterial properties of the products of the present invention were examined. The test method is used strain propi
onibacterium acnes ATCC 6
The 919 strain was cultured in a GAM broth medium, and the culture solution obtained at that time was used as a liquid medium and mixed in an equal amount with the product of the present invention. After that, static culture was performed at 37 ° C., and after 48 hours, the presence or absence of proliferation was determined by the turbidity of the culture solution (absorbance at 660 nm). The results are shown in Table 2. As a control, water was used instead of the product of the present invention.

[0013]

[Table 2]

As can be seen from Table 2, it was found that all the products of the present invention have antibacterial properties. prop
Ionibacterium acnes ATCC
The 6919 strain is a bacterium that grows even on the skin. It has been proved chemically that the product of the present invention is effective against bed sores because it has excellent antibacterial properties against such bacteria. Although the examples and the data associated therewith are described for brown rice, the same effect was also observed for white rice bran and white rice bran with 92% or less.

[0015]

【Example】

(Example 1) 1 kg of rice without germ was soaked in water at 25 ° C for 3 days to germinate rice. After thoroughly washing the germinated rice, it is dried at 50 ° C. for 24 hours, and then,
The product was finely pulverized to obtain 990 g of the product of the present invention. (Example 2) Brown rice was crushed to obtain a crushed brown rice product 500
g was obtained. 1500 ml of water was added to this pulverized product, PH was dropped with hydrochloric acid, and the mixture was left for 10 days. Then, it was squeezed with a squeezing machine to neutralize the resulting clear liquid to obtain 1200 ml of the product of the present invention and 760 g of a residue. (Example 3) Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 3 was carried out to obtain another product of the present invention 11
90 ml was obtained.

Example 4 Brown rice was crushed to obtain 500 g of crushed brown rice. Liquefaction enzyme 10g and water 1500ml were added to this ground product. Then, the temperature was gradually raised, and the mixture was boiled and extracted for 5 minutes and then cooled. Then, it was squeezed with a squeezing machine to obtain 1420 ml of the product of the present invention and 560 g of a residue. (Example 5) Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 4 was carried out to obtain another product of the present invention 14
00 ml was obtained. (Example 6) Brown rice is crushed by a crusher to obtain crushed brown rice 500
g was obtained. 1500 ml of 2N-NaOH was added to this pulverized product and the mixture was left for 5 days. Then, it was squeezed with a squeezing machine to obtain 1350 ml of the clear liquid and 650 g of the residue. 1 of this clarified liquid
Neutralization with 0N-HCl gave 1480 ml of the product of the present invention.

(Example 7) Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 6 was carried out to obtain another 1490 ml of the product of the present invention. (Embodiment 8) Brown rice is crushed to obtain a crushed brown rice product 500
g was obtained. 1500 ml of 95% ethanol is added to this pulverized product.
Was added and left for 5 days. After that, squeeze with a wringer,
1300 ml of clear liquid and 650 g of residue were obtained. 2000 ml of water was added to this clarified liquid and concentrated by a rotary evaporator to obtain 1500 ml of the product of the present invention. (Example 9) Using 500 g of the present invention product obtained in Example 1, the same operation as in Example 8 was carried out to obtain another invention product 15
00 ml was obtained.

Example 10 Brown rice was crushed to obtain 500 g of crushed brown rice. 300 g of koji and 1500 ml of water were added to this pulverized product, and the mixture was left at 55 ° C. for 20 hours. Then, squeezing with a squeezing machine, 1230 ml of the present invention product and 100 residues
0 g was obtained. (Example 11) Using 500 g of the present invention product obtained in Example 1, the same operation as in Example 10 was carried out to obtain another 1210 ml of the present invention product. (Example 12) Brown rice is crushed to obtain a crushed brown rice product 50
0 g was obtained. 2 g of protease and 150 water
0 ml was added and the mixture was left at 50 ° C. for 20 hours. Then, the product was squeezed with a squeezing machine to obtain 1310 ml of the product of the present invention and 670 g of a residue.

(Example 13) Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 12 was carried out,
Another 1380 ml of the product of the present invention was obtained. (Example 14) Brown rice is crushed to obtain 50 crushed brown rice.
0 g was obtained. 2 g of lipolytic enzyme and 150 water
0 ml was added and the mixture was left at 50 ° C. for 20 hours. Then, it was squeezed with a squeezing machine to obtain 1290 ml of the product of the present invention and 680 g of a residue. (Example 15) The same operation as in Example 14 was carried out using 500 g of the product of the present invention obtained in Example 1 to obtain 1360 ml of another product of the present invention.

Example 16 Brown rice was crushed to obtain 500 g of crushed brown rice. Fiber-degrading enzyme 2 in this crushed product
g and 1500 ml of water were added, and the mixture was left at 50 ° C. for 20 hours. Then, the product was squeezed with a squeezing machine to obtain 1330 ml of the product of the present invention and 650 g of a residue. (Example 17) The same operation as in Example 16 was carried out using 500 g of the product of the present invention obtained in Example 1 to obtain 1370 ml of another product of the present invention. (Example 18) Brown rice was crushed to obtain a crushed brown rice product 50
0 g was obtained. 2g starch degrading enzyme and 150g water
0 ml was added and the mixture was left at 55 ° C. for 20 hours. Then, it was squeezed with a squeezing machine to obtain 1380 ml of the product of the present invention and 600 g of a residue.

(Example 19) Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 18 was carried out,
Another 1400 ml of the product of the present invention was obtained. (Example 20) Brown rice is crushed to obtain a crushed brown rice product 50
0 g was obtained. Add 2 g of pectin-degrading enzyme and 1 part of water to this ground product.
500 ml was added and left at 50 ° C. for 20 hours. After that, squeezing with a squeezing machine, 1320 ml of the present invention product and residue 660
g was obtained. (Example 21) Using 500 g of the present invention product obtained in Example 1, the same operation as in Example 20 was carried out to obtain another 1300 ml of the present invention product.

Example 22 Brown rice was crushed to obtain 500 g of crushed brown rice. Proteolytic enzyme 2 in this crushed product
g, lipolytic enzyme 2 g, fiber degrading enzyme 2 g, starch degrading enzyme 2 g, pectin degrading enzyme 2 g and 1500 ml of water were added, and the mixture was allowed to stand at 50 ° C. for 20 hours. Then, it was squeezed with a squeezing machine to obtain 1420 ml of the product of the present invention and 560 g of a residue. (Example 23) Using 500 g of the product of the present invention obtained in Example 1, the same operation as in Example 22 was carried out to obtain another 1440 ml of the product of the present invention. (Example 24) The same operation as in Example 22 was carried out to obtain 2000 g of an enzymatic decomposition product of rice. Then, the temperature was gradually raised, and the mixture was boiled and extracted for 5 minutes and then cooled. Then, it was squeezed with a squeezing machine to obtain 1400 ml of the product of the present invention and 550 g of a residue.

(Example 25) The same operation as in Example 24 was carried out using 500 g of the product of the present invention obtained in Example 1,
1420 ml of another product of the present invention was obtained. (Example 26) Brown rice was crushed to obtain a crushed brown rice product 50
0 g was obtained. To this crushed product, 300 g of koji and 1500 ml of 40% ethanol were added, and the mixture was left at 55 ° C. for 48 hours. After that, squeeze with a squeezing machine and clarified liquid 1300 ml and residue 850
g was obtained. Then, 1000 ml of water was added to the clarified solution and concentrated with a rotary evaporator to obtain the product of the present invention 13
00 ml was obtained. (Example 27) The same operation as in Example 26 was carried out using 500 g of the present invention product obtained in Example 1 to obtain another 1300 ml of the present invention product.

(Example 28) In the same manner as in Example 4, 2000 g of a rice extract was obtained. To this extract, 2 g of proteolytic enzyme, 2 g of lipolytic enzyme, 2 g of fiber degrading enzyme, 2 g of starch degrading enzyme, 2 g of pectin degrading enzyme were added, and the mixture was heated at 50 ° C for 2
It was left for 4 hours. After that, the product of the present invention 14
00 ml and 520 g of residue were obtained. (Example 29) The same operation as in Example 28 was carried out using 500 g of the present invention product obtained in Example 1 to obtain another 1390 ml of the present invention product. (Example 30) In the same manner as in Example 22, 2000 g of an enzyme-decomposed extract of rice was obtained. Yeast was added to this enzyme-decomposed extract, and alcoholic fermentation was carried out for 16 days. Then, it was squeezed with a squeezing machine to obtain 1880 ml of the product of the present invention and 80 g of a residue.

(Example 31) The same operation as in Example 30 was carried out using 500 g of the product of the present invention obtained in Example 1,
Another 1800 ml of the product of the present invention was obtained. (Example 32) In the same manner as in Example 22, 2000 g of an enzyme-decomposed extract of rice was obtained. The enzyme-decomposed extract was sterilized by boiling, cooled to 37 ° C., 200 ml of a starter in which lactic acid bacteria had been cultured in advance was added, and the mixture was well stirred and hermetically sealed.
Lactic acid fermentation was performed at 7 ° C for 2 days. Then, it was squeezed with a squeezing machine to obtain 1380 ml of the product of the present invention and 590 g of a residue. (Example 33) Using 500 g of the present invention product obtained in Example 1, the same operation as in Example 32 was carried out to obtain another 1400 ml of the present invention product.

(Example 34) To 1000 ml of the product of the present invention obtained in Example 22, 80 ml of 95% ethanol was added, and acetic acid fermentation was carried out for 20 days. Then, filtration was performed to obtain 990 ml of the product of the present invention. (Example 35) Using 500 g of the present invention product obtained in Example 1, the same operation as in Example 34 was carried out to obtain another 1000 ml of the present invention product. The products of the present invention obtained in the above examples,
Examples of the case where the product of the present invention is blended into a lotion and a milky lotion, which may be appropriately used depending on the application, will be described below. The formulation examples are not limited to the examples below.

(Example 36) Lotion A product of the present invention obtained in Example 22 10.0% by weight Sorbitol 3.0% by weight Glycerin 5.0% by weight Purified water 76.4% by weight Allantoin 0.1% by weight Polyoxyethylene castor oil derivative 0.5% by weight Ethanol 5% by weight The above ingredients were mixed and dissolved by a conventional method to obtain a lotion.

(Example 37) Emulsion Product of the present invention obtained in Example 2 20.0% by weight Stearic acid 1.3% by weight Cetanol 0.7% by weight Beeswax 2.0% by weight Polyoxyethylene (11) Mono Oleic acid ester 1.2% by weight Glycerin monostearate ester 0.8% by weight Quinceseed extract (5% aqueous solution) 15.0% by weight dipropylene glycol 5.0% by weight Ethanol 3.0% by weight Methylparaben 0.3 % By weight Perfume 0.3% by weight Purified water 50.4% by weight Dipropylene glycol is added to the purified water and heated and stirred,
The temperature is maintained at 70 ° C., the ingredients of the present invention, quicus seed extract, flavors and raw materials other than ethanol are added and stirred, and then uniformly emulsified with a homogenizer. While cooling the obtained emulsion, the rest of the emulsion was gradually added to the emulsion and cooled to room temperature to obtain an emulsion.

[0029]

EFFECTS OF THE INVENTION According to the present invention, by applying it to the parts of the back, waist, shoulders, elbows, etc. where it is easy to get a bed sore that it touches the skin, it is easy and completely safe, and has the effect of preventing a bed sore. An excellent anti-bed sore agent can be obtained. Since rice has been the staple food until now, little has been developed about its manufacturing method and use in new fields other than food. Furthermore, rice has been the staple food until now, and its safety has been well demonstrated. That is, the present invention not only finds a very excellent bed sore prevention effect, but is now said to be overproduction of rice, has found a new use application, and can increase consumption by improving the image of rice, It is extremely meaningful.

Claims (5)

[Claims] 1. A therapeutic agent for preventing bedsores, which comprises the crushed product of rice or sprouted rice as it is, or containing the same. 2. A therapeutic agent for preventing bedsores, which comprises rice or an extract of germinated rice as it is or contains it. 3. A therapeutic agent for preventing bedsores, which is obtained by enzymatically decomposing or hydrolyzing rice hydrolyzed with hydrolyzed rice, or containing it. 4. A therapeutic agent for preventing bedsores, which is obtained by extracting rice or sprouted rice with or without enzymatic decomposition or koji before extraction, at the same time as extraction, or after extraction. . 5. A therapeutic agent for preventing bedsores, which is obtained by subjecting rice or germinated rice extract or enzyme-decomposed or malted rice to alcohol fermentation or organic acid fermentation as it is, or containing the same. .