CN113766923A - 益生菌生物膜组合物及其制备方法 - Google Patents

益生菌生物膜组合物及其制备方法 Download PDF

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Publication number
CN113766923A
CN113766923A CN202080031956.1A CN202080031956A CN113766923A CN 113766923 A CN113766923 A CN 113766923A CN 202080031956 A CN202080031956 A CN 202080031956A CN 113766923 A CN113766923 A CN 113766923A
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Prior art keywords
biofilm
bacteria
composition
lactobacillus
bacterial
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Pending
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CN202080031956.1A
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English (en)
Chinese (zh)
Inventor
D·达布什
D·罗茨纳
S·科恩
H·埃利亚胡
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Mybiotics Pharma Ltd
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Mybiotics Pharma Ltd
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Priority claimed from US16/368,030 external-priority patent/US10709744B1/en
Application filed by Mybiotics Pharma Ltd filed Critical Mybiotics Pharma Ltd
Publication of CN113766923A publication Critical patent/CN113766923A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN202080031956.1A 2019-03-28 2020-03-29 益生菌生物膜组合物及其制备方法 Pending CN113766923A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16/368,030 US10709744B1 (en) 2019-03-28 2019-03-28 Probiotic biofilm suppositories
US16/368,030 2019-03-28
US201962827931P 2019-04-02 2019-04-02
US62/827,931 2019-04-02
PCT/IL2020/050380 WO2020194319A1 (en) 2019-03-28 2020-03-29 Probiotic biofilm compositions and methods of preparing same

Publications (1)

Publication Number Publication Date
CN113766923A true CN113766923A (zh) 2021-12-07

Family

ID=72610340

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080031956.1A Pending CN113766923A (zh) 2019-03-28 2020-03-29 益生菌生物膜组合物及其制备方法

Country Status (11)

Country Link
EP (1) EP3946392A4 (cg-RX-API-DMAC10.html)
JP (1) JP2022535323A (cg-RX-API-DMAC10.html)
KR (1) KR20220016042A (cg-RX-API-DMAC10.html)
CN (1) CN113766923A (cg-RX-API-DMAC10.html)
AU (1) AU2020250170A1 (cg-RX-API-DMAC10.html)
BR (1) BR112021019437A2 (cg-RX-API-DMAC10.html)
CA (1) CA3131165A1 (cg-RX-API-DMAC10.html)
IL (1) IL286704A (cg-RX-API-DMAC10.html)
MX (1) MX2021011628A (cg-RX-API-DMAC10.html)
SG (1) SG11202110741YA (cg-RX-API-DMAC10.html)
WO (1) WO2020194319A1 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023195008A1 (en) * 2022-04-05 2023-10-12 Mybiotics Pharma Ltd. Bacterial compositions and methods for growing bacteria on particles

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025532188A (ja) * 2021-09-27 2025-09-29 マイバイオティクス ファーマ リミテッド 微生物組成物、その調製方法およびその使用

Citations (6)

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WO2010103374A2 (en) * 2009-03-09 2010-09-16 Probiotical S.P.A. Oily suspension containing probiotic bacteria for paediatric uses
US20120247993A1 (en) * 2008-11-14 2012-10-04 Unistraw Patent Holdings Limited Probiotic Compositions, Methods and Apparatus for Their Administration
US20140370107A1 (en) * 2012-02-01 2014-12-18 Probiotical North America Inc. Multilayer microincapuslated probiotic bacteria
WO2015134808A2 (en) * 2014-03-06 2015-09-11 Research Institute At Nationwide Children's Hospital Probiotic formulations and methods for use
WO2017208237A1 (en) * 2016-05-29 2017-12-07 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Method of generating bacterial compositions
CN108883127A (zh) * 2016-05-10 2018-11-23 夏友动天有限公司 用于预防和治疗阴道病的包含乳酸菌的组合物及其用途

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EP1776877A1 (en) * 2005-10-21 2007-04-25 N.V. Nutricia Method for stimulating the intestinal flora
WO2009092810A2 (en) * 2008-01-24 2009-07-30 Bacterfield Oü Single pharmaceutical composition containing antibiotics and probiotics
CN106232578B (zh) * 2014-03-28 2019-06-07 帝斯曼知识产权资产管理有限公司 从生产类胡萝卜素的生物有机体分离类胡萝卜素的方法
CA2985729C (en) * 2015-05-11 2023-05-09 Mybiotics Pharma Ltd Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut
AU2016353091B2 (en) * 2015-11-10 2022-07-14 Probiotech Llc Probiotic delivery systems
WO2017095968A1 (en) * 2015-11-30 2017-06-08 Imagilin Technology Llc Compositions comprising probiotics and methods of use thereof
KR102380134B1 (ko) * 2016-05-25 2022-03-29 마이바이오틱스 파마 엘티디. 미생물총 치료를 위한 조성물 및 방법
WO2018013583A2 (en) * 2016-07-11 2018-01-18 The Brigham And Women's Hospital, Inc. Medicinal vaginal lactobacillus cocktail
EP3388069B1 (en) * 2017-04-12 2019-05-01 ETH Zurich Consortia of living bacteria useful for treatment of microbiome dysbiosis
WO2019136391A1 (en) * 2018-01-05 2019-07-11 Human Longevity, Inc. Probiotic compositions comprising bacteria from bacteroids and firmicutes phyla

Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
US20120247993A1 (en) * 2008-11-14 2012-10-04 Unistraw Patent Holdings Limited Probiotic Compositions, Methods and Apparatus for Their Administration
WO2010103374A2 (en) * 2009-03-09 2010-09-16 Probiotical S.P.A. Oily suspension containing probiotic bacteria for paediatric uses
US20140370107A1 (en) * 2012-02-01 2014-12-18 Probiotical North America Inc. Multilayer microincapuslated probiotic bacteria
WO2015134808A2 (en) * 2014-03-06 2015-09-11 Research Institute At Nationwide Children's Hospital Probiotic formulations and methods for use
US20170209504A1 (en) * 2014-03-06 2017-07-27 Research Institute At Nationwide Children's Hospital Probiotic formulations and methods for use
CN108883127A (zh) * 2016-05-10 2018-11-23 夏友动天有限公司 用于预防和治疗阴道病的包含乳酸菌的组合物及其用途
WO2017208237A1 (en) * 2016-05-29 2017-12-07 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Method of generating bacterial compositions
US20190216124A1 (en) * 2016-05-29 2019-07-18 The State of Israel Ministry of Agricult & Rural Develop Agricul Resear Organiz (ARO)(Volcani Cent) Method of generating bacterial compositions

Non-Patent Citations (1)

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刘 蕾等: ""益生菌生物被膜的研究进展"", 《食品科学》, vol. 37, no. 9, pages 214 - 219 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023195008A1 (en) * 2022-04-05 2023-10-12 Mybiotics Pharma Ltd. Bacterial compositions and methods for growing bacteria on particles

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MX2021011628A (es) 2021-12-10
EP3946392A4 (en) 2022-12-07
CA3131165A1 (en) 2020-10-01
WO2020194319A1 (en) 2020-10-01
KR20220016042A (ko) 2022-02-08
EP3946392A1 (en) 2022-02-09
JP2022535323A (ja) 2022-08-08
BR112021019437A2 (pt) 2021-11-30
IL286704A (en) 2021-10-31
AU2020250170A1 (en) 2021-10-28
SG11202110741YA (en) 2021-10-28

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