CN113713031A - 一种治疗幽门螺杆菌感染的中药组合物、制备方法和应用 - Google Patents
一种治疗幽门螺杆菌感染的中药组合物、制备方法和应用 Download PDFInfo
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Abstract
本发明涉及一种治疗幽门螺杆菌感染的中药组合物、制备方法和应用,属于中药制剂技术领域。所述治疗幽门螺杆菌感染的中药组合物由如下重量份数的原料制成:黄连10‑14份、黄芩14‑16份、蒲公英18‑22份、黄芪14‑16份、三七10‑14份、炒白术14‑16份、法半夏10‑14份、紫花地丁14‑16份、金荞麦14‑16份、茯苓18‑22份、白花蛇舌草10‑14份、柴胡18‑22份、厚朴8‑12份、陈皮14‑16份和炙甘草8‑12份。本发明还公开了上述治疗幽门螺杆菌感染的中药组合物的制备方法和应用。本发明治疗幽门螺杆菌感染的中药组合物具有祛邪培本、化瘀解毒、养胃和胃之功效,可用于治疗幽门螺杆菌感染。
Description
技术领域
本发明涉及一种治疗幽门螺杆菌感染的中药组合物、制备方法和应用,属于中药制剂技术领域。
背景技术
幽门螺杆菌(Helicobacter Pylori,HP)是一种全球广泛流行的革兰氏阴性微需氧人类致病菌,它生存在人体胃幽门部位,是最常见的细菌病原体之一,与慢性胃炎、消化性溃疡、胃癌、胃黏膜相关组织淋巴瘤、微量元素缺乏病及缺血性心脏病等疾病密切相关。幽门螺杆菌是Ⅰ类致癌因子,感染HP后可引起胃十二指肠炎症等多种疾病。
HP为疫热之邪,从口而入,结于胃部,正邪交争,热甚肉腐,化脓成痈,内则出现溃疡,糜烂,外则表现胃脘疼痛。邪结胃脘,则疼痛性质多端,故出现胀痛、刺痛、灼痛、剧痛、隐痛等。升降失调,耗气伤阴,胃失受纳,故出现食欲不振、恶心呕吐,嘈杂泛酸,嗳气等症。舌红、苔黄腻,脉滑数为HP感染之象。
目前,西医治疗幽门螺杆菌感染,存在耐药性高、疗效不持久、费用高、副作用高等缺点。中医虽然疗效显著,但存在原料复杂,治疗周期长等缺点。
综上,亟需开发一种新的治疗幽门螺杆菌感染的中药组合物、制备方法和应用,来弥补上述缺陷。
发明内容
本发明的目的之一,是提供一种治疗幽门螺杆菌感染的中药组合物。
本发明解决上述技术问题的技术方案如下:一种治疗幽门螺杆菌感染的中药组合物,由如下重量份数的原料制成:黄连10-14份、黄芩14-16份、蒲公英18-22份、黄芪14-16份、三七10-14份、炒白术14-16份、法半夏10-14份、紫花地丁14-16份、金荞麦14-16份、茯苓18-22份、白花蛇舌草10-14份、柴胡18-22份、厚朴8-12份、陈皮14-16份和炙甘草8-12份。
中药方解:
黄连,味苦,性寒,归心、脾、胃、肝、胆、大肠经,有清热燥湿、泻火解毒之功效。
黄芩,味苦,性寒,归肺、胆、脾、大肠、小肠经,有清热燥湿、泻火解毒、止血、安胎之功效。
蒲公英,味苦甘,性寒,归肝、胃经,有清热解毒、利尿散结之功效。
黄芪,味甘,性微温,归脾、肺经,有补气固表、托毒排脓、利尿、生肌之功效。
三七,味甘、微苦,性温,归心、肝、脾经,有化瘀止血、消肿止痛之功效。
炒白术,别名炙白术、蜜炙白术等,味苦、甘,性温,归脾、胃经,有健脾益气、燥湿利水、止汗、安胎之功效。
法半夏,为半夏的炮制加工品,味辛,性温,归脾、胃、肺经,有燥湿化痰之功效。
紫花地丁,味苦、辛,性寒,归心、肝经,有清热解毒、凉血消肿之功效。
金荞麦,味酸、苦,性寒,归肺、胃、肝经,有清热解毒、活血消痈、祛风除湿之功效。
茯苓,味甘、淡,性平,归心、肺、脾、肾经,有利水渗湿、健脾、宁心之功效。
白花蛇舌草,味苦、淡,性寒,归心、肝、脾经,有清热解毒、利湿通淋之功效。
柴胡,味辛、苦,性微寒,归肝、胆、肺经,有和解表里、疏肝解郁、升阳举陷、退热截疟之功效。
厚朴,味苦、辛,性温,归脾、胃、肺、大肠经,有燥湿、行气、消积、平喘之功效。
陈皮,味辛、苦,性温,归脾、胃、肺经,有理气和中、燥湿化痰、利水通便之功效。
炙甘草,是用蜜烘制的甘草滋阴养血,性温,味甘,归心、肺、胃、脾经,有补脾和胃、益气复脉之功效。
本发明的中药组合物来自于临床经验方,其理论依据是象思维。幽门螺旋杆菌为疫热之邪,经口而入,结于脾胃,壅塞中焦,升降失调,耗气伤阴,而成本虚标实之证。故中医治疗当以祛邪培本为主。方中黄连清热泻火,黄芩解毒散结,蒲公英泻热散结,黄芪健脾益气,三七散瘀止痛,白术健脾燥湿,法半夏降逆祛痰,紫花地丁清热凉血,金荞麦清热健脾,茯苓健脾渗湿,白花蛇舌草泻热散结,柴胡升阳,厚朴、陈皮理气,炙甘草调和诸药。现有技术中,并没有黄连、黄芩、蒲公英、黄芪、三七、炒白术、法半夏、紫花地丁、金荞麦、茯苓、白花蛇舌草、柴胡、厚朴、陈皮和炙甘草合用,用来治疗幽门螺杆菌感染的报道。本申请的发明人经过大量试验,惊喜且意外地发现,采用上述原料进行组合,可以达到祛邪培本、化瘀解毒、养胃和胃之功效,可用于治疗幽门螺杆菌感染。
本发明的治疗幽门螺杆菌感染的中药组合物的有益效果是:
1、本发明的治疗幽门螺杆菌感染的中药组合物具有祛邪培本、化瘀解毒、养胃和胃之功效,可用于治疗幽门螺杆菌感染。
2、本发明的治疗幽门螺杆菌感染的中药组合物不存在任何毒副作用,疗效确切,停药后不复发。
在上述技术方案的基础上,本发明还可以做如下改进。
进一步,由如下重量份数的原料制成:黄连10份、黄芩16份、蒲公英18份、黄芪16份、三七10份、炒白术16份、法半夏10份、紫花地丁16份、金荞麦14份、茯苓22份、白花蛇舌草10份、柴胡22份、厚朴8份、陈皮16份和炙甘草8份。
采用上述进一步的有益效果是:以上为最佳参数,得到的中药组合物的性能最佳。
进一步,由如下重量份数的原料制成:黄连12份、黄芩15份、蒲公英20份、黄芪15份、三七12份、炒白术15份、法半夏12份、紫花地丁15份、金荞麦15份、茯苓20份、白花蛇舌草12份、柴胡20份、厚朴10份、陈皮15份和炙甘草10份。
采用上述进一步的有益效果是:以上为最佳参数,得到的中药组合物的性能最佳。
进一步,由如下重量份数的原料制成:黄连14份、黄芩14份、蒲公英22份、黄芪14份、三七14份、炒白术14份、法半夏14份、紫花地丁14份、金荞麦16份、茯苓18份、白花蛇舌草14份、柴胡18份、厚朴12份、陈皮14份和炙甘草12份。
采用上述进一步的有益效果是:以上为最佳参数,得到的中药组合物的性能最佳。
本发明的目的之二,是提供上述治疗幽门螺杆菌感染的中药组合物的制备方法。
本发明解决上述技术问题的技术方案如下:上述治疗幽门螺杆菌感染的中药组合物的制备方法,包括如下步骤:
分别称取如下重量份数的原料:熟地黄14-16份、海螵蛸18-22份、沙参7-11份、麦冬14-16份、山茱萸8-10份、白芍14-16份、党参7-11份、白术10-14份、火麻仁28-32份、柏子仁18-22份、酸枣仁14-16份、玉竹8-10份、炙甘草4-8份、三七7-11份、龟板8-12份和知母4-6份,分别粉碎过筛后,再混合均匀,即得所述治疗幽门螺杆菌感染的中药组合物。
上述原料均为中药饮片合格品。上述过筛为过80-100目筛。
本发明的治疗幽门螺杆菌感染的中药组合物的制备方法的有益效果是:
本发明的治疗幽门螺杆菌感染的中药组合物的制备方法简单,操作容易,成本低廉,适合规模化推广应用。
本发明的目的之三,是提供上述治疗幽门螺杆菌感染的中药组合物的应用。
本发明解决上述技术问题的技术方案如下:上述治疗幽门螺杆菌感染的中药组合物单独或作为活性组分在制备治疗幽门螺杆菌感染的药物中的应用。
本发明的治疗幽门螺杆菌感染的中药组合物的应用的有益效果是:
上述治疗幽门螺杆菌感染的中药组合物可以单独或作为活性组分,用于制备治疗幽门螺杆菌感染的药物,开拓了新的用途。
本发明的目的之四,是提供一种治疗幽门螺杆菌感染的药物。
本发明解决上述技术问题的技术方案如下:一种治疗幽门螺杆菌感染的药物,取如上所述的治疗幽门螺杆菌感染的中药组合物,加入一种或多种药学上可接受的辅料,按常规工艺制成水丸剂、颗粒剂、片剂或胶囊剂。
本发明的治疗幽门螺杆菌感染的药物的有益效果是:
上述治疗幽门螺杆菌感染的中药组合物,可以加入药学上可接受的辅料,用于制备各种剂型的治疗幽门螺杆菌感染的药物,方便病人根据病情用药。
在上述技术方案的基础上,本发明还可以做如下改进。
进一步,所述辅料包括淀粉、微晶纤维素、可可豆脂、卡波姆、苯甲酸钠、泊洛沙姆和苯扎溴铵中的任意一种或多种。
具体实施方式
以下结合实施例对本发明的原理和特征进行描述,所举实例只用于解释本发明,并非用于限定本发明的范围。
实施例1
本实施例的治疗幽门螺杆菌感染的中药组合物,由如下重量的原料制成:黄连10g、黄芩16g、蒲公英18g、黄芪16g、三七10g、炒白术16g、法半夏10g、紫花地丁16g、金荞麦14g、茯苓22g、白花蛇舌草10g、柴胡22g、厚朴8g、陈皮16g和炙甘草8g。
上述治疗幽门螺杆菌感染的中药组合物的制备方法,包括如下步骤:
分别称取如下重量的原料:黄连10g、黄芩16g、蒲公英18g、黄芪16g、三七10g、炒白术16g、法半夏10g、紫花地丁16g、金荞麦14g、茯苓22g、白花蛇舌草10g、柴胡22g、厚朴8g、陈皮16g和炙甘草8g,分别粉碎过100筛后,再混合均匀,即得所述治疗幽门螺杆菌感染的中药组合物。
上述治疗幽门螺杆菌感染的中药组合物单独或作为活性组分在制备治疗幽门螺杆菌感染的药物中的应用。
一种治疗幽门螺杆菌感染的药物,取上述治疗幽门螺杆菌感染的中药组合物,加入一种或多种药学上可接受的辅料,按常规工艺制成颗粒剂。
实施例2
本实施例的治疗幽门螺杆菌感染的中药组合物,由如下重量的原料制成:黄连12g、黄芩15g、蒲公英20g、黄芪15g、三七12g、炒白术15g、法半夏12g、紫花地丁15g、金荞麦15g、茯苓20g、白花蛇舌草12g、柴胡20g、厚朴10g、陈皮15g和炙甘草10g。
上述治疗幽门螺杆菌感染的中药组合物的制备方法,包括如下步骤:
分别称取如下重量的原料:黄连12g、黄芩15g、蒲公英20g、黄芪15g、三七12g、炒白术15g、法半夏12g、紫花地丁15g、金荞麦15g、茯苓20g、白花蛇舌草12g、柴胡20g、厚朴10g、陈皮15g和炙甘草10g,分别粉碎过100筛后,再混合均匀,即得所述治疗幽门螺杆菌感染的中药组合物。
上述治疗幽门螺杆菌感染的中药组合物单独或作为活性组分在制备治疗幽门螺杆菌感染的药物中的应用。
一种治疗幽门螺杆菌感染的药物,取上述治疗幽门螺杆菌感染的中药组合物,加入一种或多种药学上可接受的辅料,按常规工艺制成水丸剂。
实施例3
本实施例的治疗幽门螺杆菌感染的中药组合物,由如下重量的原料制成:黄连14g、黄芩14g、蒲公英22g、黄芪14g、三七14g、炒白术14g、法半夏14g、紫花地丁14g、金荞麦16g、茯苓18g、白花蛇舌草14g、柴胡18g、厚朴12g、陈皮14g和炙甘草12g。
上述治疗幽门螺杆菌感染的中药组合物的制备方法,包括如下步骤:
分别称取如下重量的原料:黄连14g、黄芩14g、蒲公英22g、黄芪14g、三七14g、炒白术14g、法半夏14g、紫花地丁14g、金荞麦16g、茯苓18g、白花蛇舌草14g、柴胡18g、厚朴12g、陈皮14g和炙甘草12g,分别粉碎过100筛后,再混合均匀,即得所述治疗幽门螺杆菌感染的中药组合物。
上述治疗幽门螺杆菌感染的中药组合物单独或作为活性组分在制备治疗幽门螺杆菌感染的药物中的应用。
一种治疗幽门螺杆菌感染的药物,取上述治疗幽门螺杆菌感染的中药组合物,加入一种或多种药学上可接受的辅料,按常规工艺制成片剂。
临床观察:
1、病例选择:本组58例,年龄为48-68岁,均为幽门螺杆菌感染患者。
2、治疗方法
取实施例1制备得到的治疗幽门螺杆菌感染的颗粒剂5g,用50mL开水冲服,每天3次,服药3个月-1年,服药期间忌辛辣食物。
3、临床症状
13C尿素酶呼气试验阳性,且具有下列至少一种症状:腹胀、反酸、嗳气、恶心、烧心、胸痛、呕血、食欲减退、黑便、食后上腹部饱胀、食后上腹部不适、食后上腹部疼痛、上消化道少量出血等。
4、治疗标准
显效:持续缓解3个月以上,胃镜检查病变消失,胃粘膜HP转阴。
有效:胃镜检查炎症病变减轻,HP检测转阴或呈弱阳性。
无效:症状体征缓解不明显或短期内复发,胃镜所见病变无明显改善,HP检测持续阳性。
5、临床结果
58例患者中,显效42例(72.4%),有效8例(13.8%),无效8例(13.8%),总有效率为86.2%。
6、典型病例
病例1:颜某,女,36岁,患有幽门螺杆菌感染。服用本发明实施例1制备得到的治疗幽门螺杆菌感染的颗粒剂5g,用50mL开水冲服,每天3次,饭后服用,服药6个月。复查结果显示,幽门螺杆菌为阴性。3个月后随访,幽门螺杆菌为阴性。
病例2:胡某,女,48岁,患有幽门螺杆菌感染。服用本发明实施例1制备得到的治疗幽门螺杆菌感染的颗粒剂5g,用50mL开水冲服,每天3次,饭后服用,服药1年。复查结果显示,幽门螺杆菌为阴性。3个月后随访,幽门螺杆菌为阴性。
病例3:梁某,男,52岁,患有幽门螺杆菌感染。服用本发明实施例1制备得到的治疗幽门螺杆菌感染的颗粒剂5g,用50mL开水冲服,每天3次,饭后服用,服药1年。复查结果显示,幽门螺杆菌为阴性。3个月后随访,幽门螺杆菌为阴性。
以上所述仅为本发明的较佳实施例,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (8)
1.一种治疗幽门螺杆菌感染的中药组合物,其特征在于,由如下重量份数的原料制成:黄连10-14份、黄芩14-16份、蒲公英18-22份、黄芪14-16份、三七10-14份、炒白术14-16份、法半夏10-14份、紫花地丁14-16份、金荞麦14-16份、茯苓18-22份、白花蛇舌草10-14份、柴胡18-22份、厚朴8-12份、陈皮14-16份和炙甘草8-12份。
2.根据权利要求1所述的治疗幽门螺杆菌感染的中药组合物,其特征在于,由如下重量份数的原料制成:黄连10份、黄芩16份、蒲公英18份、黄芪16份、三七10份、炒白术16份、法半夏10份、紫花地丁16份、金荞麦14份、茯苓22份、白花蛇舌草10份、柴胡22份、厚朴8份、陈皮16份和炙甘草8份。
3.根据权利要求1所述的治疗幽门螺杆菌感染的中药组合物,其特征在于,由如下重量份数的原料制成:黄连12份、黄芩15份、蒲公英20份、黄芪15份、三七12份、炒白术15份、法半夏12份、紫花地丁15份、金荞麦15份、茯苓20份、白花蛇舌草12份、柴胡20份、厚朴10份、陈皮15份和炙甘草10份。
4.根据权利要求1所述的治疗幽门螺杆菌感染的中药组合物,其特征在于,由如下重量份数的原料制成:黄连14份、黄芩14份、蒲公英22份、黄芪14份、三七14份、炒白术14份、法半夏14份、紫花地丁14份、金荞麦16份、茯苓18份、白花蛇舌草14份、柴胡18份、厚朴12份、陈皮14份和炙甘草12份。
5.一种治疗幽门螺杆菌感染的中药组合物的制备方法,其特征在于,包括如下步骤:
分别称取如下重量份数的原料:熟地黄14-16份、海螵蛸18-22份、沙参7-11份、麦冬14-16份、山茱萸8-10份、白芍14-16份、党参7-11份、白术10-14份、火麻仁28-32份、柏子仁18-22份、酸枣仁14-16份、玉竹8-10份、炙甘草4-8份、三七7-11份、龟板8-12份和知母4-6份,分别粉碎过筛后,再混合均匀,即得所述治疗幽门螺杆菌感染的中药组合物。
6.权利要求1-4任一项所述的治疗幽门螺杆菌感染的中药组合物单独或作为活性组分在制备治疗幽门螺杆菌感染的药物中的应用。
7.一种治疗幽门螺杆菌感染的药物,其特征在于,取权利要求1-4任一项所述的治疗幽门螺杆菌感染的中药组合物,加入一种或多种药学上可接受的辅料,按常规工艺制成水丸剂、颗粒剂、片剂或胶囊剂。
8.根据权利要求7所述的治疗幽门螺杆菌感染的药物,其特征在于,所述辅料包括淀粉、微晶纤维素、可可豆脂、卡波姆、苯甲酸钠、泊洛沙姆和苯扎溴铵中的任意一种或多种。
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