CN1136874C - Composite medicine for treating hyperlipemia - Google Patents

Abstract

The invention relates to a pharmaceutical composition for treating hyperlipidemia, which is made of the following raw materials, Nitraria japonica, seabuckthorn, yellow thorn, wolfberry, cassia seed and hawthorn according to the conventional preparation process; the invention has comprehensive nutritional components and outstanding blood lipid-lowering function , can significantly improve the immune function of the body, and is suitable for patients with hyperlipidemia, hypertension, atherosclerosis, hyperglycemia and low immune function.

Description

Pharmaceutical composition for treating hyperlipidemia

The invention relates to a medicine for treating hyperlipidemia processed by natural plants.

Nitraria, Lycium barbarum and Hippophae rhamnoides are dominant economic plants on the Qinghai-Tibet Plateau, especially in the Qaidam area. They are highly adaptable, resistant to wind and cold, sandstorms, drought, low oxygen, saline-alkali water, and windproof and sand-fixing, water and soil conservation, and soil improvement. , to rebuild the "pioneer" tree species of afforestation in the beautiful mountains and rivers of Northwest China. The emphasis on ecological benefits in the western development has rejuvenated economic plant resources such as Nitraria and seabuckthorn, which have become a cross-century research and development hotspot in the health care product industry.

Resources such as Nitraria thorn, wolfberry and seabuckthorn are traditional medicinal materials of local Mongolian, Tibetan and other ethnic minorities. They are widely used in the treatment of various diseases and have broad-spectrum nutritional and health effects. Based on this, hyperlipidemia caused by nutritional imbalance is a very common disease in clinical practice, which can be secondary to obesity, hypertension, coronary heart disease, fatty liver, diabetes and low HDL blood, etc. Diseases, whose incidence is increasing day by day, seriously threaten people's health.

At present, the "three thorns" (white thorn, sea buckthorn and yellow thorn) products are relatively popular, with few specialty products, high production costs, and no specific health care functions and relatively fixed consumer groups, thus limiting the market scope.

Hyperlipidemia is a very common clinical disease at present. It can be secondary to obesity, hypertension, coronary heart disease, fatty liver, diabetes and low HDL blood lipids. Its incidence is increasing and it seriously threatens people's health. . In clinical medicine, drug therapy is mainly used.

The purpose of the present invention is to provide a kind of nutritional composition comprehensive, outstanding function of lowering blood fat, can significantly improve the immune function of the body, suitable for the treatment of hyperlipidemia in patients with hyperlipidemia, hypertension, atherosclerosis, hyperglycemia and low immune function. A pharmaceutical composition for the disease.

The purpose of the present invention can be achieved through the following measures:

A pharmaceutical composition for treating hyperlipidemia is made of the following raw materials in percentage by weight according to a conventional preparation process: 10-68% of Nitraria japonica, 10-68% of seabuckthorn, 10-68% of japonica japonica, 10-68% of wolfberry 68%, Cassia 1-60%, Hawthorn 1-60%.

Compared with the prior art, the present invention has the following advantages:

1. The present invention is rich in nutrients such as protein, amino acid, vitamin, mineral constants and trace elements, among which bioflavonoids, saponins and other chemical components are lipid-lowering health care ingredients, which can be suitable for hyperlipidemia, hypertension, atherosclerosis It is a characteristic health food for patients with sclerosis, hyperglycemia and low immune function.

2. The present invention has been proved by experiments to significantly reduce Tch and TG of hyperlipidemia mice; significantly reduce Tch, TG and LDL-C of hyperlipidemia rats, and present a dose-effect relationship; the present invention can significantly increase HDL/Tch And the value of HDL/LDL, that is, it is beneficial to remove cholesterol from the blood vessel wall and relieve the health care function of atherosclerosis.

3. The present invention can enhance the delayed-type hypersensitivity of normal and immunocompromised mice, and can improve the cellular immune function of mice; at the same time, it can increase the hemolysin level of normal and immunocompromised mice, which can improve the humoral immune function of mice role.

4. No mouse LD ₅₀ has been detected in the acute toxicity test of the present invention; the maximum tolerated dose of mice is greater than 60 g/kg, which is equivalent to 3 kg per day for adults, and is a non-toxic substance.

The present invention will also be described in further detail in conjunction with embodiment:

Example 1:

A pharmaceutical composition for treating hyperlipidemia is made from the following raw materials in percentage by weight according to a conventional preparation process: 20% Nitraria japonica, 20% Hippophae rhamnoides, 20% yellow thorn, 20% wolfberry, 10% cassia seed, hawthorn 10%.

Example 2:

A pharmaceutical composition for treating hyperlipidemia is made of the following raw materials in percentage by weight according to a conventional preparation process: 60% Nitraria japonica, 10% Hippophae rhamnoides, 10% yellow thorn, 10% wolfberry, 5% cassia seed, hawthorn 5%.

Example 3:

A pharmaceutical composition for treating hyperlipidemia is made from the following raw materials in percentage by weight according to a conventional preparation process: 10% Nitraria japonica, 60% Hippophae rhamnoides 60%, 10% yellow thorn, 10% wolfberry, 2% cassia seed, hawthorn 8%.

Example 4:

A pharmaceutical composition for treating hyperlipidemia is made from the following raw materials in percentage by weight according to the conventional preparation process: 10% Nitraria japonica, 10% Hippophae rhamnoides, 60% yellow thorn, 10% wolfberry, 8% cassia seed, hawthorn 2%.

Example 5:

A pharmaceutical composition for treating hyperlipidemia is made from the following raw materials in percentage by weight according to the conventional preparation process: 15% Nitraria japonica, 10% Hippophae rhamnoides 10%, 15% yellow thorn, 10% wolfberry, 1% cassia seed, hawthorn 49%.

Embodiment 6:

A pharmaceutical composition for treating hyperlipidemia is made from the following raw materials in percentage by weight according to a conventional preparation process: 40% Nitraria japonica, 10% Hippophae rhamnoides 10%, 10% yellow thorn, 10% wolfberry, 29% cassia seed, hawthorn 1%.

The curative effect observation result of the present invention is as follows:

1. Consumer selection principles and test methods

1. If the consumer suffers from a disease, the type of disease should be relatively simple and the complications should be few.

2. The age and sex of the eaters should have a certain proportion.

3. All testers should eat continuously according to the dose and frequency of consumption without interruption.

4. Observation period: the whole process is 6-7 weeks. Edible dosage: 4 capsules made of the compatibility of the present invention at a time, taken three times a day.

2. Case selection basis

1. Diagnostic indicators

A. Serum total cholesterol (Tch), triglyceride (TG), high-density lipoprotein (HDL-C).

B. Liver function, kidney function, etc.

2. Case selection

All patients who meet the above diagnostic criteria.

3. Curative effect standard

A. Significant effect: After treatment, the symptoms basically disappeared, and the serum total cholesterol (Tch) dropped to ≤5.0mmol/L.

B. Effective: After treatment, the symptoms are obviously improved, and the serum total cholesterol (Tch) is reduced to ≤6.0mmol/L).

C. Ineffective: After more than two months of treatment, the decline in serum total cholesterol (Tch) has not reached the effective standard.

4. Observation method

Patients with hyperlipidemia took the capsule of the present invention for 6 weeks, and regularly checked serum total cholesterol (Tch), triglyceride (TG), high-density lipoprotein (HDL-C), liver function, kidney function, etc. Ask about symptoms, record.

5. Results and Evaluation

A. Test results

The present invention has been clinically verified by Qinghai Red Cross Hospital and Qinghai Provincial Cardiovascular Hospital in 25 cases, including 14 males and 11 females, aged between 30-74 years old, with an average age of 47.7 years old. According to the statistics of clinical curative effect, the average effective rate is 92.9%.

B. Statistics on curative effect of clinical symptoms

(1) Improvement of serum total cholesterol (Tch) and triglyceride (TG) symptoms: It has a significant effect on reducing serum total cholesterol (Tch) and triglyceride (TG), with the effective rates being 85.7% and 75% respectively.

(2) It has a certain improvement effect on the increase of high-density lipoprotein (HDL-C), and the effective rate is 55%.

C. Efficacy evaluation

1. The present invention significantly improves serum total cholesterol (Tch), triglyceride (TG), high-density lipoprotein (HDL-C), etc. in patients with hyperlipidemia, and is more effective than taking a certain lipid-lowering drug alone , non-toxic and side effects, safe and reliable.

2. In the absence of abundant medicines for the treatment of hyperlipidemia, especially the lack of natural Chinese Tibetan medicine plants under high altitude, drought and anoxic environment, the present invention is a safe and reliable natural medicine preparation with promising prospects.

Curative effect typical case of the present invention:

Li ××, male, cadre, 32 years old. The patient was diagnosed with hyperlipidemia a few months ago, and felt dizzy, palpitation and dreaminess.

Check serum total cholesterol (Tch7.60mmol/L), triglyceride (TG1.92mmol/L), high-density lipoprotein (HDL-C1.60mmol/L). Diagnosis of hyperlipidemia. Strictly control diet after admission, take 4 capsules/time of the preparation of the present invention, every day 3 times. After 2 weeks, the symptoms were significantly relieved, and after 4 weeks, the serum total cholesterol basically dropped to normal. After being discharged from the hospital, symptoms such as dizziness, palpitation and dreaminess basically disappeared, my sleep improved greatly, and my spirit improved. Still take 9 hypoglycemic capsules of the present invention every day, take in 3 times.

Zhang ××, female, 50 years old, a cadre.

Physical examination revealed hyperlipidemia, dizziness, palpitation, fatigue, poor spirits, and frequent pains. Admission investigation: serum total cholesterol (Tch8.58mmol/L), triglyceride (TG1.07mmol/L), high-density lipoprotein (HDL-C1.06mmol/L), liver and kidney function were normal.

Treatment: under the premise of diet and exercise therapy, take 3 capsules of the present invention. Three times a day, after two weeks, the symptoms were relieved, and after four weeks, the above symptoms disappeared completely, the spirit took a turn for the better, and the diet and sleep were normal.

Serum total cholesterol (Tch5.25mmol/L), triglyceride (TG1.18mmol/L), high-density lipoprotein (HDL-C1.34mmol/L), liver and kidney function were normal again.

Claims (1)

1, a kind of pharmaceutical composition for the treatment of hyperlipidemia, it is characterized in that said composition be with following raw materials in percentage by weight routinely preparation process make medicament:

The yellow thorn of Cortex Acanthopanacis Radicis 10-68% Fructus Hippophae 10-68% 10-68%

Fructus Lycii 10-68% Semen Cassiae 1-60% Fructus Crataegi 1-60%.