CN103431377A - Foodstuff capable of reducing blood pressure and preventing complications - Google Patents

Abstract

The invention discloses a foodstuff capable of reducing blood pressure and preventing complications, and belongs to high-end health food. The foodstuff is a new product researched and developed based on the raw materials comprising Tibetan plateau none-polluted natural high-quality medicinal and edible plant mononucleotide, gamma-aminobutyric acid, genseng extract, lyciumruthenicum extract, nitrariatangutorum extract, sea-buckthorn extract, polygonatum rhizome extract, cinnamomum cassia extract, balsam pear extract, curcumin, tea polyphenol, common fenugreek seed extract, flaxseed extract and chromium. The product has functions of tonifying kidney, benefiting the essence, reinforcing qi, nourishing blood, nourishing yin, protecting liver, strengthening spleen and stomach, invigorating the circulation of blood, and the like; and the product has the efficacies of reducing blood sugar, preventing and controlling various diabetes complications, reducing blood fat, reducing blood pressure, preventing and controlling arteriosclerosis and cardio cerebrovascular diseases, enhancing immunity, resisting inflammation, resisting oxidation, improving constipation, delaying aging, and the like. The manufacture of the product comprises: mixing the raw materials, stirring, filling capsules, sealing, examining, and packaging to form formal products.

Description

Hypoglycemic anti-complication

One, technical field: the invention belongs to high-end health food, especially with the natural pollution-free high-quality medicine food dual purpose plant mononucleotide in Qinghai-Tibet Platean, the raw materials such as GABA, ginseng, black matrimony vine, white thorn, sea-buckthorn, sealwort, Chinese cassia tree, balsam pear, curcumin, Tea Polyphenols, faenum graecum, linseed, chromium, the health food of taking modern advanced technologies to process.

Two, background technology: this is invented with mononucleotide, the health food that the raw materials such as GABA, ginseng, black matrimony vine, white thorn, sea-buckthorn, sealwort, Chinese cassia tree, balsam pear, curcumin, Tea Polyphenols, faenum graecum, linseed, chromium are made.This product has tonifying kidney and benefiting sperm, nourishing qi and blood, liver is protected in enriching yin, and strengthening the spleen and stomach is invigorated blood circulation etc., be adapted to hypoglycemic, prevent and treat the various complication of diabetes, reducing blood lipid, hypotensive, prevent and treat artery sclerosis and cardiovascular and cerebrovascular disease, strengthen immunity, anti-inflammatory, anti-oxidant, improve constipation, the effect such as delay senility.Also not this product appearance in the market, this product of innovation research and development can be a kind of new product to diabetes and diabetic complication patient is provided, and this product is hard shell capsules or tablet, belongs to pure natural, have no side effect, taking convenience, successful.

Three, summary of the invention: diabetes are a kind of with the decline of carrying out property of p-cell function, and it is the chronic progressive disease of feature that blood sugar continues to raise.Interaction result due to factors such as gene genetic, nutrition and environment, cause the endocrine metabolism imbalance, cause a series of metabolic disorders such as protein, fat, power and water Xie Zhi, make the absolute and relative hyposecretion of insulin, and target tissue reduces insulin sensitivity, insulin resistance appears.Along with the development of the state of an illness, multiple chronic complicating diseases be can occur, and multisystem and many organ injuries caused, have a strong impact on people's physical and mental health, bring the financial burden of load-bearing to family and society.According to the national authority department statistics, show, there are more than 93,000 10,000 type chaff urine patients, pre-diabetes 1.5 hundred million in China at present; Have every year more than 400 ten thousand people to die from diabetes, more than 100 ten thousand people are because of the diabetic complication amputation; And the diabetes number is still with annual 3% speed increase.Therefore, the innovation research and development prevent and treat the new product of diabetes and complication, have important change significance of times.

Four, composition of raw materials: 15 kilograms of mononucleotides, 50 kilograms of GABAs, 20 kilograms of ginseng extracts, 50 kilograms of black wolfberry fruit extracts, to sting 20 milligrams of 40 kilograms of extracts, 40 kilograms of hippophae rhamnoides, 50 kilograms of Rhizoma Polygonati extracts, 30 kilograms of cinnamomum cassia extracts, 30 kilograms of Bitter Melon P.Es, 40 kilograms of curcumins, 50 kilograms of Tea Polyphenols, 50 kilograms of fenugreek extracts, 50 kilograms of extractive of flax seed, chromium in vain be raw material.

Five, technical scheme:

(1) mononucleotide (Nucleotide) mononucleotide is generic purine base or a pyrimidine base; The compound that ribose or deoxyribose and tricresyl phosphate kind material form.Mononucleotide is the basic composition unit of ribonucleic acid and DNA, is the precursor substance of nucleic acid in body.Mononucleotide is along with nucleic acid is distributed in the core and kytoplasm of each organ pipe of organism, tissue, cell, and participates in the basic vital movement such as biological heredity, growth, growth as the constituent of nucleic acid.Mononucleotide can belong to some simple compou nd synthesis in vivo, as asparatate, glycine, glutamine, one carbon unit and CO ²deng.The mononucleotide compound has important physiologic function, and they have participated in nearly all biochemical reaction process in organism.At human body, easily be absorbed, can stimulate circulation, improve the brain function, improve memory, control myopia, regulate immunologic function, enhance metabolism, antifatigue, radioresistance, the effect such as build up health, delay senility.

Physiological function: 1, improve immunologic function: mononucleotide can improve body's immunity, according to the study, fill with and feed appropriate mononucleotide to mouse, can obviously improve Phagocytosis By The Peritoneal Macrophages In Mice, can increase specific antibody and central immune organ thymus index.Mononucleotide can also make the spleen index of mouse, spleen lymphocyte proliferation ability improve.To the effect that also is significantly improved of body immunity function.Separately studies have found that, mononucleotide can improve immunity of organisms, builds up one's resistance to disease.Improve quantity and the leukocytic phagocytic rate of leucocyte, killer cell and neutrophil cell.Can recover immune system growth and immunologic function after supplementing nucleotide nutrient.

2, protection liver: use mononucleotide to be conducive to hypoproteinosis and the hepar damnification that causes, the symptoms such as body and cerebral function decline.Mononucleotide recovers to have important effect to liver function.Research shows, mononucleotide is to the protection liver cell, promotes that DNA is synthetic and liver cell is repaired and protein is synthetic all to have obvious curative effect, also has the effect of obvious anti-hepatic fibrosis, to improving chronic hepatitis and the cirrhosis protein metabolism also has certain curative effect.Abroad scientist finds under study for action, and by after the hepatotomy of rat 70%, suitable supplementary schedule nucleotides can obviously strengthen the rat liver power of regeneration; Can make the liver function recovery of mouse very fast to cirrhosis mouse supplementary schedule nucleotides; Clinical research finds, supplementary schedule nucleotides can make the various transference cures of children's icterepatitis or go down, and therefore, mononucleotide has and protects significantly the liver hepatoprotective effect.

3, prevent and treat diabetes: mononucleotide can promote the effect of pancreatic cell regeneration, and collaborative antioxidant reduces the p Apoptosis, activate impaired p cell to guarantee insulin synthesis, effectively improve chaff urine patient polydipsia, insomnia, many foods, hidrosis, the symptom such as weak.Harvard University's life scientist research is found, mononucleotide can effectively disturb Multidrug resistance, thereby improve the sensitiveness of disease to medicine, diabetes are given to mononucleotide in inoperative medicine to 321 diabetics in various degree, allowing them take, the result demonstration, the patient alleviates drug resistance, and after 3 weeks, blood sugar, glucose in urine tend to normal, 3 months glucostasis patient 299 people, efficient up to 94%.Cytology research is found, mononucleotide can activate the carbohydate metabolism of p cell, make the glutinous polysaccharide of transmission of information be distributed in uniformly the inside and outside top layer of cell membrane, the regulating and expressing function that is gene improves, cell can react for the medicine of suitable consumption, thereby the effect of medicine is obviously strengthened.

4, prevent and treat cardiovascular and cerebrovascular diseases: mononucleotide can make the blood vessel end send expansion.Increase coronary blood flow, improve the myocardial metabolism ability.The HDL-C that increase is useful to human body, reduce LDL-C and in the vascular wall oxide deposition, thereby prevent artery sclerosis, angina pectoris, miocardial infarction, cerebral thrombus etc.In addition, mononucleotide also can increase CBF in brain, reduces the cerebrovascular and blocks, and effectively improves the symptoms such as apoplexy sequelae, cerebral arteriovenous malformation.

In addition, mononucleotide also is improved PFT, effects such as improving eye fatigue and dysacousis, increase muscle power, eliminate muscular fatigue, antiallergy, delay senility, be anticancer.

(2) GABA: 2, prevent and treat diabetes: GABA can promote pancreas islet p cytothesis, avoids the basis damage.The research discovery, the GABA of beta Cell of islet secretion can prevent and reverse the experimental rats type 1 diabetes.It is reported domestic research, GABA can not only promote the regeneration of beta Cell of islet, and can also stop the infringement of immune system to pancreas islet p cell.Clinically, the treatment that the type 1 diabetes patient relies on insulin sustains life, but insulinize is helpless to the treatment type 1 diabetes of beta Cell of islet regeneration.The researcher studies discovery to multiple diabetic mice, by giving the injected in mice GABA, not only can effectively prevent the generation of diabetes, can also prevent and treat diabetes.Researcher's discovery of California, USA university, Gabanergic effectively improves sugar tolerance and raises and eliminate insulin resistance.Its effect is main by suppressing the glutamic acid hydrochlorate acceptor in human body, and the body inflammatory immune response caused from suppressing the latter, reach the effect that prevents and treats diabetes.

In addition, GABA p also have lose weight, antianxiety, increase muscle strength, the effect of sleep quality improved.

(3) ginseng extract (Radis Ginseng) is the dry root of Araliaceae ginseng.Property put down, distinguish the flavor of sweet, micro-hardship, return spleen, lung, the heart channel of Hang-Shaoyin.Have strengthen the body resistance to consolidate the constitution, reinforce vital energy, supplementing blood and promoting the production of body fluid, effects such as increasing intelligence reinforces the spleen to benefit the lung, calms the nerves.For deficiency of vital energy and blood, neurasthenia, the cold weak pulse of limb, deficiency syndrome of the lung food less, the effects such as the deficiency syndrome of the lung breathes with cough, interior heat is quenched one's thirst, prolonged illness weak, palpitation with fear insomnia, impotence palace are cold, in heart failure, cardiogenic shock.

Chemical composition: the compositions such as ginseng saponin, panoxadiol, triol, polysaccharide, protein, sterol, adenosine, choline, enzyme, polypeptide, amino acid, monose oligosaccharides, alkaloid, organic acid, multivitamin, volatile oil and ester.

Pharmacological action: 1, regulate immunologic function.A zoopery discovery, the important component panaxoside in ginseng can strengthen the normal mouse humoral immune function, the reinforced partly non-specific immune function.The researcher has measured mouse spleen lymphocyte and has transformed and NK (NK) activity in testing in vitro.In the experiment, give the mouse stomach panaxoside after 37 days in vivo, measure the mouse carbon granule and clean up the indexs such as speed, immune organ weight, serum hemolysin content or antibody-producting cell number.Result shows, panaxoside is external to be had no significant effect the T lymphopoiesis, but can strengthen NK cytophagy activity.Ginsenoside Rg3 can increase rat blood serum hemolysin content and antibody-producting cell number, but mouse immune organ weight and carbon granule are cleaned up to speed, has no significant effect.

Result of study also shows that panaxoside can obviously increase mice serum hemolysin content and antibody-producting cell quantity, shows that it can obviously strengthen the mouse humoral immune function.

2, anti-oxidant: panaxoside can significantly suppress the lipid peroxidation in mouse brain, hepatic tissue, the activity of hepatocuprein and peroxidase in the raising cell, and make " somatoblast does not transfer somatoblast to " in old and feeble cell, the somatoblast division cycle is shortened.

3, hypotensive: ginseng has the hypertensive effect of control.According to external, ginseng treatment hypertension has obtained good effect.Results of animal shows, so ginseng only has the hypertensive effect of obvious treatment, its mechanism to be, ginseng can make the useful hypotensive material of cells of vascular wall secretion; It two is that saponin component in ginseng can suppress the active material in blood vessel, thereby produces hypotensive effect.Evidence is arranged, and ginseng can make blood pressure rise to normal range (NR), illustrates that ginseng has the double-bang firecracker regulating action to blood pressure.

4, protection liver: the anxious rising of giving birth to the SGOT of hepatitis that panaxoside brings out D-galactosamine has inhibitory action; Liver and vascular wall connective tissue to the chronic hepatitis of Carbon Tetrachloride Induced present propagation or suppress tendency, and the activity of its anti-hepatitis surpasses glycyrrhizic acid.

5, reducing blood lipid, anti arteriosclerosis: panaxoside can promote the lipid-metabolism of intact animal, and cholesterol is reduced.Zoopery shows, panaxoside can make the blood fat of Hyperlipidemia Rabbits reduce, cholesterol/phosphatide ratio reduces, and in liver, fat is invaded profit and atherosclerosis obviously improves, and Ginseng Root Powder has preventive and therapeutic action to the hypertensive cerebral retinal arteriosclerosis of rabbit.

6, hypoglycemic: the panaxan has significant effect of lowering blood sugar.Not only normal mouse is had to obvious hypoglycemic activity, the hyperglycaemia mouse due to alloxan is also had to good hypoglycemic activity.To find up to now the most effective blood sugar reducing component in ginseng.Ginseng can also be to antiadrenergic drug, the effect of corticotropin and hyperglycemic factor, and strengthen insulin to glycometabolic impact.Blood sugar reducing component in ginseng is a lot, and the panaxan all has obvious reducing effect to experimental hyperglycemia mouse and rabbit hyperglycaemia, and the panaxan also has blood sugar reducing function to the experimental hyperglycemia rat, and can prevent and treat the decomposition of adrenal gland to hepatic glycogen.Folium panacis japonici cum caule's saponin can obviously improve serum insulin, reduces blood sugar.According to external, Japanology personnel discovery, ginseng has the effect of hypoglycemic and hinders the active function of digestive ferment α-glucosidase.The results of animal demonstration, ginseng extract has the effect of the alpha-gluconase activity enzymatic activity that suppresses the effect of decomposition sugar, the effect that also has steady postprandial plasma glucose level to rise.Therefore prove that it has hypoglycemic effect.In the human trial result, also find, ginseng extract has the blood glucose value of reduction and improves the good result of insulin resistance, and liver is had no side effect.

7, anti-angiocardiopathy: ginseng has certain effect to hypertension, cardiac muscular dystrophy, coronary sclerosis, angina pectoris etc.Ginseng has dilating effect to animal coronary artery, the cerebrovascular, ocular angiogenesis.The total saponin of intravenous injection ginseng can reduce dog hind leg blood vessel and cerebral vascular resistance.

8, antifatigue: ginseng is administration in various degree, all can strengthen the mobility of necton under different water temperatures, extends swimming time, has antifatigue effect.Also obviously the acute weight loading of prolong rats is forced swimming time.

In addition, ginseng also have increase intelligence, prevent and treat cardiovascular and cerebrovascular disease, strengthen hematopoiesis, antiulcer, anti-stress, radioresistance, anti-anoxic, anti-sudden change, antibiotic, delay senility, the effect such as antitumor.

(4) black wolfberry fruit extract: (Lyciam barbarnm extraat), black matrimony vine is to be grown in Qinghai-Tibet green ecological environment, pure natural treasure medicine food dual purpose plant is deceived the matrimony vine dry fruit.Black matrimony vine is the high-end invigorant of a kind of ecosystem of rare preciousness.Black matrimony vine is the matrimony vine of solanaceae plant ripening fruits.Property is put down, and distinguishes the flavor of sweet.Return liver, kidney channel.Effect with nourishing liver and kidney, benefiting shrewd head, moistening lung.For consumptive disease essence lose, soreness of waist and knee joint, dizzy tinnitus, interior heat are quenched one's thirst, the deficiency of blood is sallow, improve eyesight, blurred vision is not clear etc.Modern medicine study thinks, black matrimony vine has the immunity of enhancing, antifatigue, hypotensive, reducing blood lipid, hypoglycemic, protection liver, fat-reducing, the function such as anti-ageing, anticancer.

Chemical composition: black matrimony vine is containing trace elements such as the multivitamin such as polysaccharide, amino acid, betaine, carrotene, Cobastab, vitamin C, nicotinic acid and manganese, chromium, zinc, copper, magnesium, calcium, germanium, cobalts.And also have abundant natural procyanidins, wherein procyanidin content is the several times of blueberry content, is the wild plant of finding that up to now procyanidin content is the highest.

Pharmacological action: 1, strengthen immunity: mouse gavaging water extract or intramuscular injection alcohol extract all can significantly strengthen the phagocytic activity of its reticuloendothelial system to india ink.Water extract or LBP-X all can promote lysozyme activity in Phagocytosis By The Peritoneal Macrophages In Mice and serum.Give normal or Aged Mice gavages or the abdomen LBP-X, can significantly strengthen peritoneal macrophage c ₃the acceptor number of b and Fc and vigor, can make the Aged Mice suppressor T lymphocyte regulate the level that antibody function returns to adult mice.Black LBP-X sterling has more significant immune response effect than crude product, every immune indexes (comprise immune organ quality, the macrophage phagocytic effect of nospecific immunity, the serum hemolysin of specific humoral immunity, moving back hair style allergy, lymphocyte transformation rate, E rosette formation etc. in specific cellular immunity) all has significant difference.

2, protection liver, AFL: black wolfberry fruit extract has certain effect to protection liver and AFL tool.Modern medicine study is found, in black matrimony vine, contains a kind of active ingredient one betaine, and it is very effective to the treatment liver diseases.Experiment shows, betaine has the fat of inhibition to deposit in liver cell, promotes the effect of liver cell regeneration.In addition, the middle betaine of black matrimony vine can prevent that in liver, excess fat is stored, and the effect of anti-fatty liver is arranged, and it is reported, feeds water extract or betaine feed to ccl through rat for a long time ₄the hepatic lesion caused has protective effect, can obviously reduce the variation of lipid in transaminase and liver, can suppress lipidosis and promotion liver cell new life in liver, and to hepatic lipid peroxidation, damage has significant protective effect.

3, reducing blood lipid, prevent and treat artery sclerosis: black wolfberry fruit extract animal and clinical trial all have good effect for reducing blood fat.Polysaccharide has obvious effect to the blood fat of high fat of blood rabbit, can obviously reduce the content of serum cholesterol and triacylglycerol.Black matrimony vine also can reduce the rat serum cholesterol, and obviously suppresses to fill with the rabbit anteserum cholesterol rising of feeding cholesterol and lard, also has the effect of anti arteriosclerosis.

4, hypotensive and protection cardiovascular and cerebrovascular: the oxidation hardening gradually of the elastomer in blood vessel is to cause hypertensive main cause.The black contained OPC of matrimony vine, can reduce blood pressure by improving blood vessel elasticity.Experiment showed, that black wolfberry fruit extract can reduce the Blood Cholesterol level, on the minimizing vascular wall, cholesterol deposition and inhibition angiotonase activity reduce blood pressure.Research is separately arranged, add black wolfberry fruit extract, chromium, zinc composition in rat feed, and the experimental group blood pressure is starkly lower than control group, its mechanism is the formation that black wolfberry fruit extract has reduced free radical, improves the sensitiveness of insulin.

5, anti-oxidant: black matrimony vine has good antioxidation.Black matrimony vine contains abundant OPC, can suppress the lipid peroxidation free radical nucleus formation in blood plasma, can block lipid peroxidation again.Exempting from oxidative damage in protection DNA, protein and membrane structure plays an important role; superoxide dismutase activity in known human body crystalline lens, cornea and vitreum is low; the elderly's blood plasma and tissue; this is that a kind of support mechanism weakens; may be the elderly's plasma lipid peroxide increased content and easily suffer from one of major reason of the diseases such as cataract; OPC in black matrimony vine, have powerful antioxidation, can reverse this process.According to another report, the OPC in black matrimony vine, due to the hydroxyl that electronics is arranged in molecular structure (phenolic group) part, be by good hydrogen or the donor of neutron, and very strong oxidation resistance is arranged.Be about in vivo 50 times of vitamin E, be ascorbic 20 times.According to the test report of the French Academy, think OPC be found the most up to now, one of the clear agent of the most effective free radical, active especially in vivo, be that other antioxidants are incomparable.

6, hypoglycemic: the control secondary diabetes: black wolfberry fruit extract has the significant hypoglycemic function with preventing and treating diabetes.Research shows, black LBP-X shows on the impact of the blood sugar of normal mouse and sugar tolerance and to the protective effect that alloxan causes the hyperglycaemia mouse, and fill with and feed a certain amount of black LBP-X to normal mouse respectively, its result obviously reduces blood sugar.Sugar tolerance is tested and is shown, a certain amount of black LBP-X can obviously resist normal mouse and give the blood sugar rising that a certain amount of glucose causes.Obviously, black LBP-X all has hypoglycemic activity to normal and diabetes model animal in research.According to another research, black matrimony vine can effectively be controlled postprandial blood sugar, obviously reduces Postprandial peak glucose, thereby forms the demand of glycemic peaks phase insulin, alleviates the load of insulin cell excreting insulin, thereby reaches the effect of protection insulin cell.Long-term taking can also reduce the effect of fasting blood-glucose.Experiment shows, no matter to the normal person, or can reduce Postprandial peak glucose after the impaired glucose tolerance person is taken and reduce level of postprandial blood sugar, prevents secondary diabetes.Also have report, results of animal shows, deceives the matrimony vine OPC and contributes to reduce diabetic's blood sugar.Can make animal pancreatic cell insulin output increase by 50%.Univ Michigan-Ann Arbor USA section studies person chart and shows, edible fruits contains OPC with other and becomes branch to produce great impact to human body and insulin level.

7, prevention and treatment of DR: DRP is the retinal microvascular pathology, it shows as, diabetes blood glucose's fluctuation causes the respective change such as blood pressure, blood vessel to meeting, cause the chain reactions such as optical fundus blood vessel is hemorrhage, has influence on amphiblestroid function.Research shows, the anthocyanidin in black matrimony vine has powerful anti-oxidation efficacy, and the effect of protection diabetic retinal tissue in rat oxidative damage is arranged.Clinical studies show, black matrimony vine anthocyanidin can reduce LPO content in the diabetic retina patients serum, rising Vit C contents and SOD activity, the effect with significant prevention and treatment of DR.According to NIH, studies confirm that, the eye disease that the OPC in black matrimony vine causes treatment diabetes and hypertension is effective, especially contributes to prevent and treat the ocular angiogenesis infringement that diabetes and hypertension etc. cause and causes retinal damage.In addition, black matrimony vine anthocyanidin has certain effect to eye diseases such as the macular degeneration of age-dependent, cataract.

(5) sting in vain extract (Nitraria tangutorum Bobr), white thorn is to be grown in Qinghai-Tibet height above sea level wild medicine food dual purpose plant berry of nitraria tangutorum bobr in the Caidamu Basin more than 3000 meters.White thorn is zygophyllaceae plant drying ripening fruits.Return that liver, large intestine channel, property are flat, sweet-puckery flavor.Tonifying liver improving eyesight, interior heat are quenched one's thirst, blurred vision is not clear, have the blood fat of adjusting, hypotensive, hypoglycemic, regulate immunologic function, antifatigue, anti-anoxic, the eyesight of improving, anti-oxidant, eliminate free radical, cold-resistant heat-resisting, the effect such as delay senility.

Chemical composition: white thorn is containing polysaccharide, amino acid, flavones, alkaloid; Unrighted acid, terpene, steroid, anthocyanin, spend the trace elements such as glucoside, pectin, carrotene, carotenoid, VitAVitE, vitamin C, Cobastab, vitamin K in vain.

Pharmacological action: 1, reducing blood lipid: sting in vain extract and can significantly reduce T-CHOL and lipid peroxide contents, triglycerides in serum, by the activity that suppresses HMC-COA reductase in liver, be suppressed the synthetic of endogenous cholesterol; Thereby cholesterol, triglycerides, low-density lipoprotein and increasing high density lipoprotein cholesterol in reduction blood plasma; Suppress the formation of atherosclerotic plaque; The protection vascular endothelial cell, suppress the deposition of lipid in liver, and the severe cholesterolemia is also had to good curative effect.

2, hypoglycemic: stinging in vain extract all has reducing effect to the blood sugar of the diabetic mice of normal mouse blood sugar and model induced by alloxan.And can obviously resist the blood sugar that adrenal gland and glucose causes and raise.White thorn water decoction is filled with to feed to rat and can obviously be reduced the hyperglycaemia that alloxan causes, to normal mouse, adrenal gland hyperglycaemia mouse and alloxan diabetes mouse, can produce obvious hypoglycemic activity.According to another research, sting in vain polysaccharide and can effectively control postprandial blood sugar.Human experimentation shows can reduce glycemic peaks after no matter the normal person still being taken the impaired glucose tolerance person.The impaired glucose tolerance person takes white thorn polysaccharide can control level of postprandial blood sugar.Prevent secondary diabetes.Further research, white perverse polysaccharide can suppress hepatic glycogen decomposition, muscle glycogen glycolysis, suppresses gluconeogenesis, falls hypoglycemic purpose thereby reach, and can prevent and treat the generation of diabetic vascular complications.

3, anti-oxidant: as to sting in vain water decoction and can obviously reduce the content of lipid peroxide in mice plasma, liver and brain to mouse gavaging, improve the activity of superoxide dismutase in the liver brain, and the cerebrovascular contraction that the inhibition free radical of concentration dependent is brought out, suppress the generation of vascular wall MDA, improve periphery T cell α-naphthylacetate positive rate, strengthen the ability of removing free radical.

4, strengthen immunologic function: sting in vain polysaccharide and there is obvious complement activity and promote Proliferation of lymphocytes.White thorn polysaccharide can make the quantity of macrophage increase, and cell volume increases, and phagocytic function strengthens.White thorn can also be resisted the inhibitory action of a large amount of hydrocortisones to Turnover of Mouse Peritoneal Macrophages in addition, promotes thymocyte E garland to form.The cavy that phagocytic rate is descended has the function that promotes that complement recovers.

5, resist myocardial ischemia: sting in vain extract to rabbit vein and lumbar injection, pituitrin is caused to the variation of Rabbit Myocardium ischemic cardiac electrograph and improve significantly.This may with its coronary artery dilating, increase CF, reduce MCO, improve myocardium anti-anoxia ability relevant.

6, antifatigue: sting in vain extract and can obviously extend mouse frozen water swimming time, the hypodermic injection alcohol extract energy significant prolongation mice burden swimming time, have significantly and resist and grab excellent fatigue effect.There is good antifatigue effect.

(6) hippophae rhamnoides (Seahuckehorn), sea-buckthorn is to give birth at Qinghai-Tibet height above sea level a kind of wild plant-fructus hippophae more than 3000 meters.Due to the special Geographical natural environment and climate condition in Qinghai-Tibet Platean, high and cold anoxic, sunshine-duration is long, day and night temperature is large, breed and treat that to have a special bioactive substance content abundant, be the top grade of other various places sea-buckthorns, live in Qinghai-Tibet Tibetan and look sea-buckthorn for " angle fruit ", extremely strong medical value is arranged.At Tibetan medicine's monumental work Four-Volume Medical Code and " Qinghai-Tibet medicine history ", discussion is arranged.The fruit that sea-buckthorn is Elaeangnaceae plant sea-buckthorn.Warm in nature, sour-puckery flavor.Effect with expelling phlegm and arresting coughing, relieving dyspepsia, promoting blood circulation to remove blood stasis.For indigestion, cough ant phlegm, hemostasis amenorrhoea etc.

Modern medicine study thinks, sea-buckthorn has the immunity of enhancing, regains one's strength, eliminates fatigue, strong spirit, patient myocardial ischemia anoxic, hypotensive, reducing blood lipid, hypoglycemic, prevent and treat artery sclerosis, cerebral thrombus, anti-oxidant, anti-ageing, anti-asthenopia, anticancer prevention and pharmacological action preferably arranged.

Chemical composition: sea-buckthorn is containing 20 several amino acids, unrighted acid, alkaloid, flavones, monosaccharide, polysaccharide, quebrachitol, superoxide dismutase, sterols, triterpenes, anthocyanidin, 12 kinds of organic acids, vitamin C, E, A, B ₁, B ₂, folic acid, carrotene, calcium, 32 kinds of more than 200 kind of bioactivators useful to human body such as trace element.Be described as " treasure-house of vitamin " by the expert of China and foreign countries.

Pharmacological action: 1, improve immunity: Hippophae Rhamnoides L. juice and Seabuckthorn Oil can increase the weight of immune organ, improve the serum half and hold blood value antibody titer and antigenic stimulus antibody titer again.Promote macrophage phagocytic function.The similar Hippophae Rhamnoides L. juice of the effect of Hippophate flavone and Seabuckthorn Oil, and can make the Mouse Blood antibody horizontal of immunologic hypofunction raise.

2, protection liver: Seabuckthorm Seed Oil can alleviate the mouse liver injury that carbon tetrachloride causes; rising to hepatic injury mouse MDA (MAD) due to carbon tetrachloride and serum glutamic pyruvic transminase (SGPT) has obvious inhibitory action; and can suppress the MDA of liver due to paracetamol and increase, resist impaired liver glutathione (GSH).In addition, sea buckthorn juice can be protected ccl ₄hepatic injury due to paracetamol.

3, antiallergy: the total seabuckthorn flavone lumbar injection can suppress the passive cutaneous anaphylaxis of mouse, and its anti-allergic effects link may be in the reaction that improves target organ and cell, also unlike competition receptor in target cell such as chlorpheniramine medicines and play a role.May be relevant with factors such as the combination that suppresses antigen or medium releases.

4, anti-oxidant: studies show that, Hippophate flavone has obvious removing ability to active oxygen.The sea-buckthorn water decoction annotates to the mouse abdomen or rats gavaged can obviously reduce the LPO raising SOD activity such as cardiac muscle, and also the free radical because of substance in vivo peroxidating generation capable of blocking, have significant antioxidation activity.It is reported, the compositions such as the carrotene in sea-buckthorn, vitamin C, vitamin E are to the hydrogen peroxide (H in lymphocyte ₂o ₂) caused DNA damage has protective effect.After the fracture of mouse lymphocyte DNA chain, in cell is cultivated, add carrotene, vitamin C, vitamin E, after cultivating, the fracture chain connects again.Hippophae rhamnoides, as efficient antioxidant, suppresses the caused chromosome aberration of oxidative stress and occurs, improves the damaged dna clearance rate, to the inhibitory action that is formed with of the damage of genetic materials such as chromosome aberration DNA and micronucleus.

5, reducing blood lipid, prevent artery sclerosis: research shows, hippophae rhamnoides can significantly reduce cholesterol and the triglyceride levels in serum and liver, especially more obvious to reduce triglycerides.Can reduce the deposition of cholesterol in vascular wall, anti-curing hyperlipemia and atherosclerotic.The zoopery demonstration, Seabuckthorn Oil and total seabuckthorn flavone can make the T-CHOL in blood fat disease rat blood serum, and the total cholesterol level in triglyceride level decline and hepatic tissue descends, and serum middle-high density lipoprotein content is raise, and blood fat is obviously descended.

6, hypotensive: contain abundant flavones and vitamin C in fructus hippophae, the research discovery, in Aged Patients With Essential Hypertension, the Vit C contents soprano in blood, its blood pressure is minimum.It is confirmed that, vitamin C can improve blood vessel elasticity, hemangiectasis and protection arteries endothelial cell and avoid the effects such as the interior harmful substance infringement of body.Therefore there is hypotensive activity.

7, hypoglycemic and control diabetic complication: study and think both at home and abroad, plant flavone has good hypoglycemic activity.Domestic research discovery, in sea-buckthorn, flavonoid substance contributes to overcome in body " resistin ", thereby makes the too high patient of blood sugar recover the euglycemia value.Studies show that, be widely grown in Qinghai-Tibet wild sea-buckthorn, contain abundant Flavonoid substances, there is the effect of significant anti-" resistin ".Through experiment, confirm, after experimenter's diabetes B is edible, it is normal that blood glucose value recovers.Hippophate flavone is a kind of natural plants Hypoglycemics, has good blood sugar reducing function, and it can stop the formation of AGEP, therefore, generation and the treatment that prevents chronic diabetic complications is had certain effect.Fructus Hippophae polysaccharide also has good effect to diabetes B.For sea buckthorn juice, diabetes B animal hypoglycemic activity is studied to discovery according to Peking University.Sea buckthorn juice can improve artificial diabetes blood sugar and insulin level.The db/mm mouse be take as contrast in seminar, and the db/db mouse is the model contrast, and the positive contrast of db/db mouse that melbine (biguanides) is intervened is intervened with sea buckthorn juice and the sea buckthorn juice that is rich in the quebrachitol of various dose.Found that, sea buckthorn juice can significantly reduce diabetes B model db/db mouse body weight, alleviate obesity, and can significantly improve more diabetes B is eaten, drunk more, the symptom of diuresis; To drink the symptom effect remarkable more to improving diabetes B for the sea buckthorn juice of the quebrachitol that contains low dosage.Sea buckthorn juice may improve heart, kidney, spleen, complication that pancreas is relevant.Experiment is also found containing the sea buckthorn juice of the quebrachitol of low dosage the most obvious to fasting blood-glucose improvement effect, and effect is better than melbine.The sea buckthorn juice of the quebrachitol that contains low dosage can significantly promote the secretion of diabetes B mouse islets element, improves serum insulin level; Contain low, middle dosage quebrachitol sea buckthorn juice and more can significantly improve serum insulin level than melbine, significantly improve the hyperglycaemia symptom.Researcher's confirmation, sea buckthorn fruit can improve diabetes B, and quebrachitol is the important activity composition that improves blood sugar in sea buckthorn juice, prevents and treats diabetes.

In addition, sea-buckthorn also there is delaying senility, promote hematopoiesis, protection stomach lining, beautifying face and moistering lotion, antithrombotic, the effect such as antitumor.

(7), Rhizoma Polygonati extract (Rhizoma Polygonati), the dry rhizome that the Qinghai sealwort is the liliaceous plant sealwort, property is put down, distinguishes the flavor of sweet.Return spleen, lung, kidney channel.Effect with boosting qi and nourishing yin, tonifying spleen moistening lung, kidney-nourishing.For weakness of the spleen and the stomach, damage of kidney-essence, asthenia of essence and blood, fatigue and asthenia, dry food less, deficiency syndrome of the lung cough caused by dryness, interior heat quenches one's thirst etc., modern medicine study is thought, sealwort has reducing blood lipid, anti arteriosclerosis, strengthens coronary blood flow, the effect such as hypotensive, hypoglycemic.

Chemical composition: sealwort is containing polysaccharide, steroid saponin, flavonoids, amino acid, alkaloid, sweet mellow wine, anthraquinone analog compound etc.

Pharmacological action: 1, strengthen immunologic function: Rhizoma Polygonati extract can improve body's immunity, promotes the synthetic of DNA, RNA or protein.Lymphocyte transformation to the patient of immunocompromised has facilitation.Can make mouse thymus weight significantly increase, can improve the humoral immunity level of animal spleen T TCS and external source thymus-dependent antigen, strengthen cellular immune function.The thick polysaccharide of mouse gavaging can obviously increase the Thymus and spleen quality, obviously strengthens the phagocytic activity of reticuloendothelial system to india ink.Give the thick polysaccharide of mouse gavaging of immunocompromised, can obviously increase spleen weight.

2, protection liver: Siberian solomonseal rhizome polysaccharide can obviously reduce CCl ₄mda content in the poisoning mice hepatic tissue, have liver-protective function.

3, reducing blood lipid, antiatherosclerosis: sealwort can make the serum total cholesterol (CT) of hyperlipemia rat, serum triglyceride (TG) reduce.The experimental atherosclerosis degree is alleviated.Gavage the sealwort decoction to Experimental Hyperlipemia Rabbits, can obviously reduce triacylglycerol beta lipoprotein cholesterol (TC), alleviate aorta wall patch and crown artery sclerosis.

4, hypoglycemic: Rhizoma Polygonati extract has obvious hypoglycemic activity to alloxan mouse hyperglycaemia pathology model.The blood sugar rising mouse that the sealwort methanolic extract brings out normal and streptozotocin all has hypoglycemic activity, and can obviously to the caused blood sugar of antiadrenergic drug, raise.Its hypoglycemic activity is relevant with the function that suppresses glycogen glycolysis system.According to another report, Rhizoma Polygonati extract has the effect of hypoglycemic hemoglobin.Sealwort has the effect of boosting qi and nourishing yin, moistening lung kidney-nourishing.Contained Siberian solomonseal rhizome polysaccharide can suppress the albumen non-glycosylation process under hyperglycemia state, thereby cause AGEP to generate, reduces, and to reduce glycosylated hemoglobin, also can prevent diabetic microvascular complication.Suitable especially diabetes microvascular complication (diabetic nephropathy, DRP) is taken.

5, coronary artery dilating, resist myocardial ischemia: the sealwort methanolic extract can obviously strengthen the convergent force of toad heart and rat atrial, also can increase the dog CF.Infusion can increase the extrasomatic rabbit heart CF.To intravenous rabbit injection sealwort solution, the effect of antagonism Neurohypophysin induced Acute myocardial ischemia is arranged.

6, antifatigue: but sealwort decoction significant prolongation mouse swimming time improves the mouse mobility.This effect is relevant with its reduction creatine acid enzyme.

In addition, sealwort in addition anti-oxidant, delay senility, the effect such as hypotensive, anti-inflammatory, antipathogen.

(8) cinnamomum cassia extract (Dinnamon) is the dry bark of canella Chinese cassia tree.Hot in nature, acrid-sweet flavor, return liver kidney, heart the spleen channel.Have mend that fire is supporing yang, the effect of eliminating cold to stop pain, activating blood to promote menstruation.Cold for deficiency of yang aversion to cold and cold limbs, impotence, palace, suffer from a deficiency of the kidney do to breathe heavily, the effects such as waist knee crymodynia, hot eyes pharyngalgia, cold of insufficiency type vomiting and diarrhoea, palpitaition, weakness due to chronic disease.

Chemical composition: containing volatile oil, diterpene-kind compound, flavanols, polymer, p-sitosterol, choline, former catechu alkali, vanillic acid, syringic acid, D-Glucose etc.

Pharmacological action: 1, regulate immunity: cinnamomum cassia extract has certain inhibitory action to specific immunity and non-thing opposite sex immunologic function, can alleviate the growing animal spleen weight, suppresses the reticuloendothelial system phagocytic function, reduces haemolytic index, suppresses the formation of antibody.In addition, cinnaman has the effect that strengthens the reticuloendothelial system function, is no matter lumbar injection or gavages and can both improve the huge ability of biting carbon granules of mouse.

2, hypotensive, hemangiectasis: Chinese cassia tree decoction and cinnamic acid can make peripheral vascular expansion, blood pressure drops.Decoction, cinnamic acid, cumarin can increase blood vessel flow, antithrombotic.Decoction has the contracting blood vessel function of pair antiprostaglandin, can also reduce blood pressure and the urine aldosterone of adrenal regeneration hypertension rat model and discharge, and significantly increases corpus straitum and hypothalamic enkephalin content, improves the hypertensive cerebral infringement of aortic tunica intima.It is reported, the Chinese cassia tree water decoction can make anaesthetized dog blood pressure obviously reduce, and peripheral vascular resistance descends, and the intra arterial injection administration can make peripheral vascular resistance obviously descend, and shows that Chinese cassia tree has the peripheral vascular effect of direct expansion.Can increase the CBF of heart and brain vitals.

3, hypoglycemic: traditional Chinese traditional medicine cinnamon is used to the treatment of " diabetes " for a long time.Therefore, cinnamomum cassia extract has certain prevention effect to diabetes B.According to domestic, the scientific research personnel carries out a randomized double-blind clinical trial and finds, after the patient takes the cinnamomum cassia extract of low dosage or high dose in three months continuously, fasting blood-glucose and glycosylated hemoglobin level are all significantly lower than control group.In addition, take the low dosage cinnamomum cassia extract and can significantly reduce patients serum's triglyceride levels.This experiment has pointed out cinnamomum cassia extract to can be used as an effective auxiliary treatment means for the intervention of diabetes B patient clinical.All find according to English, U.S. and domestic research, take the effect that Chinese cassia tree has hypoglycemic.Report and confirm through the double blinding clinical trial, take a certain amount of Chinese cassia tree every day, the effect of hypoglycemic is just arranged.The researcher is slightly overweight to 58 body weight, suffer from the diabetes B adult and carry out the tracking test of 12 weeks by a definite date, after 12 weeks, the person of participating in the experiment of edible Chinese cassia tree, its fasting blood-glucose constitutional index and systolic pressure, diastolic pressure, before experiment, all descend to some extent, glycosylated hemoglobin in its body, blood sugar and blood pressure index also have obvious reduction.The American Studies person suffers from diabetes B, the age volunteer's experimental result in 40-65 year by 60 and shows, the level of volunteer's blood sugar, triglyceride, T-CHOL, low-density lipoprotein all descends to some extent.

4, anti-inflammatory: give the mouse gavaging cinnamomum cassia extract, can suppress abdominal cavity capillary permeability due to the auricular concha swelling of diformazan due to stupid and acetic acid and increase, water extract can also suppress the rat paw edema that carrageenan causes.

In addition, Chinese cassia tree also there is antalgic and sedative, antiulcer, anti-freezing, resist myocardial ischemia, antibiotic, relieving asthma, antiendotoxin, radioresistance, antitumor, regulate the effects such as endocrine, desinsection, regulate body temperature.

(9) Bitter Melon P.E (Baisam Pear) is the fruit of cucurbitaceous plant balsam pear.Bitter cold in nature, return liver, spleen, the heart, stomach warp.Have except heat symptoms caused by an exopathgen, separate tired, spleen benefiting and stimulating the appetite, the improving eyesight that clears away heart-fire, removing toxic substances, beneficial gas yang invigorating functions.For pyreticosis polydipsia, dysentery, cute conjunctivitis swell and ache, the swollen erysipelas of carbuncle etc.

Chemical composition: the compositions such as protein, balsam pear peptide, carrotene, sterol, quinine, Charantin, amino acid.

Physical action: 1, regulate immunologic function: Bitter Gourd Juice and balsam pear extract all have obvious humidification to leukocytes phagocytic ability in the content of normal mice serum coagulation antibody titre, serum lysozyme, blood.Results of in vitro studies shows, the non-cytotoxicity effect of α-Charantin and B Charantin can suppress the mitogenic response that mouse boosting cell produces due to the existence of concanavalin A phytolectin and lipopolysaccharides significantly, and inhibitory action and dosage are proportionate.Charantin can significantly suppress delayed hypersensitivity, and the antibody that can suppress to be caused by sheep red blood cell (SRBC) forms and by the macrophage migration of dredging base acetate and inducing.

2, hypoglycemic: scientific research is found, the similar insulin of chemical composition structure in Bitter Melon P.E.An external and zoopery demonstration, the similar function of Bitter Melon P.E and animal insulin, be called as glucokinin.Therefore, Bitter Melon P.E has hypoglycemic activity.It is reported, Water extracts from momordica charantia has hypoglycemic activity to experimental alloxan diabetes rats; Can postpone the cataractous generation of diabetes with secondary or can alleviate nerve or other symptoms before hypoglycemia occurs.The mechanism of its hypoglycemic is to stimulate p emiocytosis insulin.Separately studies have reported that, bitter gourd polypeptide P2 has significant hypoglycemic activity to normal mouse and diabetic mice.The results show, bitter melon polysaccharide can reduce the blood sugar of normal mouse and alloxan diabetes model mice, and diabetes B is had to certain function of reducing blood sugar.Normal insulin is comprised of 51 amino acid, and bitter gourd polypeptide has with pancreas islet and have similar composition.

In addition, the Charantin that balsam pear contains and Charantin can promote that appetite, spleen benefiting and stimulating the appetite, contained alkaloids substance quinine have diuresis, invigorate blood circulation, the effect of anti-inflammatory antipyretic, the improving eyesight that clears away heart-fire.Bitter Melon P.E also has significant antitumaous effect.

(10) curcumin (Curcumin), curcumin is a kind of chemical composition of extracting from the rhizome of some natural plants of Zingiber, Araeceae; Being the very rare pigment with diketone of plant kingdom, is dione compounds, has many BA effects.Medical research shows, curcumin has reducing blood lipid, antitumor, anti-oxidant, inflammation-inhibiting reaction, cholagogic, resisting rheumatoid disease effect.

Physiological function: 1, active anticancer: it is reported, research is found, curcumin and derivative thereof can suppress by 1, abnormal glandular hyperplasia before the mouse junction cancer that 2 one dimethylhydrazines (DMH) bring out becomes, lumbar injection (IP) DMH, after three weeks, oral (PO) tetrahydro curcumin 15-12 week, found that, it is abnormal before canceration that the glandular hyperplasia quality/the mouse quality is (46.6 ± 17.7) %, and control group (not giving tetrahydro curcumin) is that this ratio is (63.3 ± 19.4) %, the hyperplasia of abnormal body of gland before this explanation curcumin and derivative tetrahydro curcumin thereof can stop mouse junction cancer to become.Above result of study finds out, the anticarcinogenic effect of curcumin is that some link of resisting various carcinogenic factors or inhibition tumor cell development by the protection normal cell works.According to another U.S.'s report, curcumin can effectively suppress the skin cancer cell growth.The researcher uses various dose and different number of times curcumin to test three batches of melanoma, and result shows, curcumin can make the easier self-destruction of melanoma skin cancer cell.The researcher also finds, curcumin contributes to prevent that breast cancer tumour is diffused into lung, also can suppress two kinds and can make the never dead protein of tumour cell.According to another Japan Report, curcumin has the effect of inhibition of cell proliferation.The researcher is put into two kinds by curcumin and it is believed that in the relevant enzyme of cancer cell hyperplasia, at the temperature of 37 ℃, they is reacted, the result confirmation, and the cancer therapy drug that the curcumin ratio is used now is the activity of inhibitory enzyme better.Its effect of the active anticancer of curcumin is the anti-oxidation efficacy performance.Because cancer is main, by producing a large amount of oxygen radicals in human body, cause, and curcumin has certain absorption Free Radical as a class polyphenol, so the free radical produced by removing human body demonstrates and has certain antitumaous effect.

2, anti-oxidant: curcumin has very strong antioxidation, can remove harmful free radical in body, to the clearance rate of OH free radical, can reach 69%.Curcumin can improve the activity of multiple antioxidase in the liver tissues of rats homogenate, can make SOD, catalase, and the activity of glutathione peroxidase improves respectively approximately 20%, the strongest in the oxidation resistance that has compared various curcumins and α-Vitamin E.Through test, curcumin has been organized obvious antioxidation to rat chest, the heart, liver, kidney, dirty etc., lipid peroxide (LPO) content is reduced, thereby delay failure.

3, anti-inflammatory, antibacterial: be to bring out multiple chronic disease inducement in inflammation.Someone finds that by research curcumin has stronger antiinflammatory action, and its effect is very similar to the NSAIDs antiinflammatory action.Subsequently, enter the II clinical trial phase as effective nonsteroidal anti-inflammatory drug, 18 rheumatic arthritis and patients with osteoarthritis are done to short-term, double blinding, cross matching, demonstrate gratifying result, research is arranged again, mode by gavage gives formaldehyde and brings out arthritic rat curcumin and curcumin sodium, and its inhibiting rate is 45-50% as a result.Also have research to show, curcumin suppresses appearance enzyme body and the arachidonic metabolism of rat abdominal cavity macrophage secretion, and lumbar injection (IP) curcumin 1h, can obviously suppress arachidonic metabolism, reduces PGE ₂(PGE ₂) release reach 45%, interleukin B ₄be 61%, interleukin C ₄be 34%, simultaneously to clostridiopetidase A, the secretion inhibiting rate of elastoser and hyaluronidase is respectively 57%, 61% and 66%, shows that the turmeric Huang plays antiinflammatory action to the evolution of inflammation-inhibiting reaction.

4, reducing blood lipid: curcumin can significantly reduce serum and liver cholesterol and triglyceride levels, especially more obvious with the triglycerides effect.Research experiment thinks, curcumin may be by suppressing the synthetic of cholesterol, playing the effect that reduces high fat of blood.

5, antiviral: curcumin has antiviral physiologically active.Find that in to curcumin research it has inhibitory action to human immunodeficiency virus (HIV), main by suppressing HIV LTR (LTR) activity, the relevant enzyme (reverse transcriptase, protease and HIVI integrase) that suppresses virus replication reaches the impact on cell factor, and the albumen that further suppresses the HIVI integrase copies.There is research to point out, a kind of material that Tat is secreted by the HIVI infection cell, and Tat can activate HIVI-LTR conversely, and curcumin can suppress this interaction between Tat and HIVI-LTR, and inhibiting rate reaches 70-80%.

6, protection liver: the damage due to turmeric have antagonism carbon tetrachloride and galactosamine when rat primary metabolism cell is cultivated, the toxicity of the Rat Primary Hepatocytes that carbon tetrachloride carbon and galactosamine are caused also has antagonism.Curcumin can also make the millet straw, the glutamic-pyruvic transaminase value that raise reduce respectively, gives in advance curcumin and can alleviate rat to hepatic injury due to acetamido phenol.External report, the current research discovery, the curcumin in curry has protective effect to liver.The rat control experiment that the researcher will suffer from chronic hepatitis shows, the mouse of feeding curry after several weeks hepatitis symptom alleviate.Control group is without significant change.Therefore, curcumin has obvious hepatoprotective effect.Further research, curcumin is protected hepatocellular effect in addition, and the treatment hepatopathy is had to certain effect.

7, prevent and treat diabetes, hypoglycemic: according to foreign study, curcumin can be prevented and treated diabetes, can make the diabetes high-risk patient avoid ill.The researcher finds, take a certain amount of 9 months curcumin time every day, can stop pre-diabetes to develop into diabetes, pre-diabetes refers in the patient who suffers from hyperglycemia and hypoglycemia and has impaired glucose metabolism, although do not reach the diagnostic criteria of diabetes B, may develop into diabetes fully.Previous experiment finds, curcumin can help cell resistance inflammation, anti-oxidant and inflammation and oxidation can cause a series of disease.The researcher is taken curcumin capsule and placebo to 240 adults that suffer from pre-diabetes by random experiments, after 9 months, in the patient that 116 are taken placebo, there are 19 people to develop into diabetes B, and take in 119 people of curcumin, do not have 1 to develop into diabetes B.Researcher's discovery, curcumin can strengthen the function of insulin β cell, and this cell discharges the insulin of regulating blood sugar just.The researcher says, is that the anti-inflammatory effect of curcumin has protected pancreatic beta cell to avoid infringement.

8, improve lipid-metabolism: curcumin can reduce the concentration of p-alpha lipoprotein.Research thinks, curcumin can, by suppressing the synthetic of cholesterol, play the effect for the treatment of high fat of blood.The obese patient is mostly with hyperlipemia, and long-term high fat of blood can cause atherosclerotic, causes early ageing or heart disease.To the treatment of obesity, except going on a diet, reducing body fat is main purpose.The experiment demonstration, curcumin has the effect that reduces cholesterol and triglycerides, especially obvious to reduce triglycerides, body weight is approached normal.Its mechanism may be that the effect of triglycerides in curcumin reduction blood fat or liver is remarkable.Can be used for the treatment of obesity and IV type high fat of blood, and can prevent fatty liver.

(11) Tea Polyphenols (EGCG) is a kind of chemical analysis extracted from tealeaves.Account for 25 in tealeaves---35%.Tea Polyphenols comprises catechin, the compound general name of phenolic acid and depside, flavonols and Pigments.Its chemical constitution, with a plurality of activity hydroxies, has many health-care efficacies to human body.Fat-reducing, reducing blood lipid, hypotensive, hypoglycemic, strengthen immunity, antibiotic and sterilizing, anticancer, antiviral, beautifying face and moistering lotion, protect the liver, anti-oxidant, the function such as delay senility.

Chemical analysis: the Tea Polyphenols main component is catechin.(C), L-Epicatechin gallate (EGC), Epigallo-catechin gallate (EGCG) (EGCG) etc.

Physiological function: 1, fat-reducing: (1), promotion fat oxidation and metabolism: Tea Polyphenols can promote the oxidation Decomposition of aliphatic acid, reduce the accumulation of fat at belly, the activity that can also suppress the liver fat synzyme, thereby reduce the synthetic and Liver fatty deposition of fat, can also stop the absorption of fat at enteron aisle, promote fat to discharge from ight soil simultaneously.The absorption that reduces carbohydrate is converted into fat and the obesity that causes.

(2), suppress the activity of carbohydrase: Tea Polyphenols can suppress invertase, the sweet enzyme of glucose, α---diastatic activity, and the absorption that reduces carbohydrate is converted into fat and the obesity that causes.The scientific research confirmation, carbohydrate can form fat by enzyme and biological chemistry action in vivo.Therefore, the activity that Tea Polyphenols can suppress lipase plays antiobesity action.

(3) activity that, suppresses lipase: Tea Polyphenols can suppress lipase, thereby reduces the accumulation that the food digestion rate reduces body fat.Tea Polyphenols also can directly act on the differentiation of adipocyte, and can induce mature cell to adjust and die.Further research, Tea Polyphenols can directly suppress gastric lipase and pancreatic lipase modulation of appetite.The researcher also finds that Tea Polyphenols suppresses the fat absorption in food, and acceleration fat ejects the performance antiobesity action in body.

(4), regulate leptin secretion: leptin is that it enters blood by a kind of polypeptide hormone of adipocyte secretion, and circulate rear and hypothalamic leptin receptors bind, come the consumption of modulation of appetite and energy to control body weight by hypothalamus.Leptin can directly suppress the secretion of insulin, reduces Fatty synthesis, reduces depot fat.Domestic experiment confirmation, Tea Polyphenols has obvious antiobesity action to obese rat, and the IC of rat, fat have obvious reduction, prove that Tea Polyphenols has obvious fat-reducing effect.According to external, Germany scientist confirms by zoopery, and tea polyphenolic compounds can reduce mouse body fat content, thereby plays antiobesity action.The researcher thinks, Tea Polyphenols is to reach fat-reducing by reducing fat in the absorption of enteron aisle and strengthening fatty oxidation.The Japan scientist studies discovery, and Tea Polyphenols can suppress neutral fat in blood effectively to be increased, and stops the absorption of fat in enteron aisle, thereby fat is excreted.In clinical trial, the fat content after the feed of picked-up Tea Polyphenols in blood reduces by 20%.Separately, report, thease can obviously lower visceral adipose in this research, and the experimenter takes Tea Polyphenols in continuous 90 days, in the situation that do not change diet and body movement activity, and the slight body weight of super severe one, in waistline and abdomen, fatty area all significantly reduces.The researcher explains, the effect that Tea Polyphenols can the exciting human self-energy consumes, and the fat of abdominal viscera excites responsively especially to this, therefore, Tea Polyphenols can obviously dwindle overweight people's belly and waistline.

2, hypotensive, research thinks, one of function of human kidney is secretion " Angiotensin II " that blood pressure is increased and is " bradykinin " of Blood pressure drop balance with the maintenance blood pressure.When the enzymatic activity that promotes two class materials conversions, cross when strong, Angiotensin II increases, and blood pressure just rises, and Tea Polyphenols has the effect of stronger inhibition converting Enzyme activity, draws and can play the effect that reduces and keep blood pressure stabilization.Report is separately arranged, and Tea Polyphenols can improve the permeability of blood vessel, can effectively increase cardiac muscle and vessel wall elasticity, effectively reduces blood pressure.

3, reducing blood lipid suppresses atherosclerotic: Tea Polyphenols has important effect to Human Lipid Metabolism.Can obviously suppress the rising of cholesterol in blood plasma and liver, there is the effect that promotes that lipid excretes from ight soil, therefore, there is the artery sclerosis of preventing.Experiment confirms, Tea Polyphenols can make in serum T-CHOL and triglycerides descend approximately 19%, but the ratio of high density lipoprotein increasing and low-density lipoprotein, before and after experiment, ratio differs 36.1%, the mechanism of its Tea Polyphenols reducing blood lipid is by suppressing the absorption of the exogenous cholesterol of enteron aisle, accelerates the metabolism of cholesterol and promotes excretion.Reduce the absorption of exogenous triglycerides by the activity that suppresses pancreatic lipase.

4, hypoglycemic: diabetes are by insufficient insulin and blood sugar too high and the glycolipid fat and the protein metabolism disorder that cause.Tea Polyphenols has regulating action to the metabolism obstacles of blood glucose of human body, can reduce blood sugar level, thereby can effectively prevent and treat diabetes.According to another relevant report, Tea Polyphenols suppresses the absorbability of human body to glucose.Its mechanism of action mainly reduces blood-sugar content by the absorption that stops glucose and the two kinds of modes of hydrolysis that reduce carbohydrate.It is monose and not by intestinal absorption that the enzymes such as α---amylase can make starch or carbohydrate degradation.Therefore, the activity that suppresses this fermentoid can make the generation of monose descend, thereby reduces blood sugar concentration.

5, beautifying face and moistering lotion: young beautiful, beautiful skin is everyone dream, but due to environmental factor, solar radiation, the factor such as aging, and people's skin will the blackening chap, follows the string, and what have also can produce foxiness, and freckles etc. affect people's beauty.The scientific research confirmation, Tea Polyphenols can effectively play the effects of beautification and nourishing face such as protection skin, freckle removing and whitening, elimination acne.

6, remove free radical, delay senility: Tea Polyphenols can effectively be removed too much free radical in human body, Cell protection membrane structure, reducing human aging.Experiment shows, the emulative and combined with radical of Tea Polyphenols energy, and the chain reaction of termination free radical, thus prevent and alleviate the damage of excessive free radicals to human body, reach the effect except disease and health.Because the structure of tea multienzyme is enriched phenolic hydroxy group, the phenolic group structure has higher stability,

Therefore, Tea Polyphenols has obvious removing free radical and delaying senility function.

7, anti-oxidant: a large amount of experiments show, Tea Polyphenols has very strong antioxidation and physiologically active and removes the effect of free radical, and it can stop the reaction of disconnected fat oxidation, removes organized enzyme, reaches oxidation resistant effect.It is reported, Japanese scholars research is existing, and Tea Polyphenols is a kind of strong polyphenoils, and the halmatogenesis of cell is had to very strong inhibitory action.

8, strengthen immunologic function: experiment showed, that Tea Polyphenols has multiple effect to body's immunity.It is mainly manifested in by lowering cell per-compound content or regulating immunity by removing the excessive free radical generated in immune response pathway; And Tea Polyphenols has the double action of endogenous antioxidant and exogenous antioxidant concurrently; therefore the resultant effect of mutual coordinative role is arranged; it has the Promote immunity of stimulation raising effect (as the decline of delaying human body thymus gland to the body of immunologic hypofunction; the protection lymphocyte is impaired; promote the activity of thymocytes proliferation; stimulate antibody activity variation etc.), and normal body's immunity is had to certain mediation protective effect, the epidemic prevention allergy.Aspect the raising immunologic function, very important effect is being arranged.

9, defaecation: studies have shown that, Tea Polyphenols selectively acts on gut flora, to the harmful bacteria inhibitory action, as suppressed staphylococcus, proteus, beneficial bacterium being had to activation, lactic acid coccus, Bacillus acidi lactici and Bifidobacterium etc., thus effectively promote health.In addition, Tea Polyphenols can also strengthen enteron aisle and shrink and wriggling function, accelerates gastric emptying, and harmful substance in body is excreted in time, reaches the purpose of defaecation.The mechanism of Tea Polyphenols defaecation is mainly contraction and the creeping effect that can increase large intestine.

(12) fenugreek extract (Semen Trigonellae) is the ripe dry seed of legume faenum graecum.Warm in nature, bitter, return kidney channel, there is warming kidney to invigorate yang, the effect such as eliminating cold to stop pain.For cold, the cold and pain in the lower abdomen of kidney void, the disturbance of lower legs due to pathogenic cold and dampness etc.The effects such as that modern pharmacological research has is hypoglycemic, reducing blood lipid, fat-reducing, protection are cardiovascular, antitumor, protection kidney, diuresis, anti-inflammatory.

Chemical composition: alkaloid, choline, the diosgenins etc. such as the polysaccharide that faenum graecum is representative containing galactomannans, protein, carpaine, trigonelline, flavonoids, phytosterol, dietary fiber, aliphatic acid, vitamin and mineral matter and other components.

Pharmacological action: 1, hypoglycemic: fenugreek extract all has reducing effect to the blood glucose value of healthy and diabetes rat and blood cholesterol and lipid.The different leucin of 4-hydroxyl has the effect that stimulates excreting insulin, and the blood glucose value of the diabetes rat of model induced by alloxan is descended.And the plant soluble dietary fibers such as galactomannans can delay the absorption of glucose in food, be conducive to alleviate the burden of insulin p cell, and can improve the sensitiveness of body to insulin.Improve the hypoglycemic effect of insulin, therefore can significantly reduce blood sugar.

2, reducing blood lipid: faenum graecum can suppress, delay, stop the absorption of human body to cholesterol, triglycerides, promotes cholesterol metabolic and bile excretion, can prevent and improve coronary heart disease symptom, and can prevent gall stone.

3, fat-reducing: with the disposable mouse of feeding of fenugreek extract (with the high lipid food containing tallow 40%), neutral fat in blood (triglycerides) amount has obvious decline.Another in the feeding experiment of 20 days, fenugreek extract is added in high lipid food (containing tallow 40%) by 0.3% and 1% amount, the body weight of mouse can significantly decrease, but still higher than low fat (containing tallow 5%).Also have in mice viscera (around uterus) fat and liver content of triglyceride relatively in, with 4 weeks mouse ratios of the raising that is all high fat diet, fenugreek extract all has obvious inhibitory action.

4, protection kidney: fenugreek extract can reduce renal failure rat blood serum urea nitrogen and creatinine level, improves renal function, the protection nephron.Also can reduce the content of trace of albumin in the renal failure rat urine, the visible Pathological of tectology inspection improves and obviously alleviates.

5, protect cardiovascular: carpaine can make rabbits blood pressure descend, and makes isolated frog heart, the rabbit heart stop at diastole, makes rabbit kidney, small intestine and crown vasodilation, but frog hind leg vessel retraction.

6, antifatigue: after having the people once to use the fenugreek extract per os to mouse 1-5 week, by himself body weight, increase by 10% weight loading, carry out Loaned swimming test, result shows, when giving 150mg/kg days, can obviously extend the effect of swimming time.

(13) extractive of flax seed (Flax seed): have another name called flax.Dry mature seed for flax family (Linaceae) plant flax.Property is put down, distinguishes the flavor of sweet.Have and moisturize, the effect of dispeling the wind, a large amount of studies show that, the chronic disease that linseed is anti-treated constipation, reduced cholesterol levels, control blood sugar, reducing blood lipid, control cause because of inflammation, as heart disease, apoplexy, diabetes and complication, the effects such as obesity, senile dementia, arthritis, cancer.

Chemical composition: linseed is rich in omega-fatty acid, dietary fiber, lignan, protein, choline, mineral matter, vitamin and trace element.

Pharmacological action: 1, reducing blood lipid and prevent and treat artery sclerosis: in linseed, gamma-Linolenic acid has total courage of reducing in serum level because of alcohol and triglycerides, and its effect is stronger than other linoleic acid.The experiment demonstration, gamma-Linolenic acid can reduce the content of low-density lipoprotein courage alcohol, the increasing high density lipoprotein cholesterol.Further research, extractive of flax seed can promote the excretion of class cholesterol and cholic acid in ight soil, prevents the absorption of body inner cholesterol, avoids cholesterol deposition to cause atherosclerotic in the arteries inwall, to preventing and treating cardiovascular and cerebrovascular diseases, has great importance.Report is separately arranged, and the gamma-Linolenic acid in linseed can be converted into the dimerization gamma-Linolenic acid in human body, then changes into eicosenoic acid, and can synthesis of prostaglandins.It can reduce Blood Cholesterol, suppresses platelet aggregation, and has hemangiectasis, makes blood circulation unimpeded, can effectively prevent and treat artery sclerosis.

2, hypoglycemic and control diabetic complication: much research is found, gamma-Linolenic acid in linseed can significantly reduce diabetic and hyperglycemic patients fasting blood-glucose, its hypoglycemic mechanism is the gamma-Linolenic acid precursor substance of synthesis of prostaglandins in vivo, PGE1 and PGE2 are the constituents of hormone, there is ILA, and can strengthen the physiological effect of insulin, if shortage can cause the endocrine metabolism dysfunction.Research is discovery also, and gamma-Linolenic acid can promote insulin β emiocytosis insulin, reduces the opposing of target cell to insulin, improves the sensitiveness of insulin receptor on cell membrane, plays the effect of control and stabilizing blood sugar.Gamma-Linolenic acid also can be regulated lipid metabolism, suppresses diabetic complication, reduces the probability of creatine, ketoacidosis.Report is separately arranged, and linseed contains abundant lignan, is a kind of plant polyphenol.Find according to the study, the intervention of linseed lignan can significantly improve diabetes B patient's blood sugar and insulin resistance and control the C reactive protein level, the research discovery, the linseed intervention can significantly reduce T-CHOL and low-density lipoprotein cholesterol level in blood.After this, the researcher clinical with the linseed lignan to the diabetes B patient carried out random, the double blinding of 3 months by a definite date, cross-over design, placebo the intervention study result show, in control group, compare, the lignan intervention group has significantly been improved different blood glucose levels, show as remarkable reduction chaff urine patient's glycosylated hemoglobin level, also suppressed the rising of c reactive protein simultaneously.

3, anti-inflammatory: ω-6 and ω-3 are that aliphatic acid belongs to essential fatty acid together, are parts that forms cell membrane, aspect cellular metabolism, play an important role.They can convert hormonal substance to, as eicosanoid, omega-fatty acid metabolism generate the eicosanoid with antiinflammation.Cellular activity will cause inflammation, and chronic inflammation also finally develops into inflammatory disease, as heart disease, diabetes, apoplexy, atherosclerotic and arthritis.And omega-fatty acid has antiinflammation.It is reported, Canadian scholar's research discovery, the gamma-Linolenic acid in linseed has very strong antiinflammatory action.The experiment demonstration, gamma-Linolenic acid can change the dimerization gamma-Linolenic acid at human body into through further metabolism, and then generates the material of the Eicosanoids of anti-inflammatory.Dimerization gamma-Linolenic acid and other metabolite also can affect heterogeneic expression.And these genes play an important role in immunity and Apoptosis.

4, improve constipation: studies show that, contain abundant dietary fiber in linseed, can promote intestines peristalsis, and very strong water absorbing capacity is arranged, make ight soil keep certain volume, shorten the intestines Dissolve things inside by the time of enteron aisle, remove constipation.

(14) chromium picolinate (Chromiun Picolinate), chromium is one of body trace element, and its active component is trivalent chromium, and chromium can not synthesize at human body self, closely related with health.Chromium mainly is distributed in bone, skin, fat, adrenal gland, brain and muscle.Chromium at human body as glucose tolerance at son (GTF) composition, the effect of performance insulin, promote the utilization of body to glucose.Through studies confirm that both at home and abroad, there is fat-reducing, prevent and treat diabetes, reducing blood lipid, hypotensive, prevent and treat artery sclerosis, anticancer, protect cardiovascular, the function such as delay senility.

Physiological function: 1, hypoglycemic: chromium is the composition of GTF, makes the confactor of insulin, thus to increase the sensitiveness of surrounding tissue to insulin, impel glycosyloxy to decompose and accelerate, to reduce blood sugar.Chromium can pass through GTF (GTF) affects glycometabolism, and GTF is synthetic in liver, and the multiple thing consisted of trivalent chromium and amino acid (cysteine, glutamic acid, glycine) participates in forming.Chromium is that insulin is essential in human body performance best-of-breed functionality institute, also can promote sugar to turn to glycogen at transit cell.Chromium is as a confactor of insulin, can strengthen the stability of insulin, keep insulin level in blood, by insulin and reacting cells set to acceptor, promote the effect of insulin or improve the sensitiveness of tissue to insulin, scarce chromium can make the quick property reduction of tissue to insulin.

2, prevent and treat diabetes: diabetes are by the glycosuria metabolic disorder, and body chromium discharge rate is increased, and also exist chromium is changed into to the ability reduction of active chromium and utilizes ability poor, and therefore, chromium can be prevented and treated diabetes.

It is reported, the researcher is to 833 diabetes patients benefit chromium of 10 months by a definite date, clinical observation shows, 90% patient's fasting blood-glucose and postprandial blood sugar improvement are only just arranged after 1 month, and maintained the normal level state in 10 months, the symptom such as the patient more than 85% has improved frequent micturition, mouth is drunk and tired always.According to another relevant report, the California, USA university research shows, chromium is the part of GTF, for regulating glycometabolism, maintains normal sugar tolerance in body and plays an important role.Chromium, also as phosphorus mutase in glucose metabolism, plays the effect of activation insulin.

3, lowering blood-fat and reducing weight: chromium can promote decomposition and the excretion of cholesterol, thereby reduces cholesterol and content of triglyceride in blood.The zoopery discovery, scarce chromium can cause disorders of lipid metabolism, and serum cholesterol raises, and causes atherosclerotic.As give enough chromium agent, and can improve the lipodogramme in blood, reduce the effect of blood cholesterol and low-density lipoprotein.According to United States Medicine research, find, chromium contributes to fat-reducing.The chromium element plays an important role to the glucose of stablizing in blood, also contributes to reduce appetite, controls body weight.Report is separately arranged, and the chromium element is effective to reducing neutral fat, can also appetite control, eliminate hunger.

4, anti-angiocardiopathy: study and show, chromium can affect lipid-metabolism, reduces cholesterol and content of triglyceride in blood, anti-angiocardiopathy.Research finds, human body lack chromium the most outstanding show as coronary sclerosis, coronary sclerosis can make hemadostewnosis, blocks, causes myocardium iron blood, anoxic and the heart disease that causes (coronary heart disease).Human body lacks chromium also can be caused cholesterol to increase coronary atherosclerosis to increase the weight of, cause fat metabolism incomplete, thereby increases heart disease and blood vessel morbidity chance, to suffering from the coronary disease patient, the recurrence that increases the weight of angina pectoris, miocardial infarction can be arranged.According to external, North America cardiovascular death number accounts for 50% of total death toll, becomes the disease that North America people are fearful.The content of finding chromium in chemical examination suffers from arteriosclerosis patient's blood is starkly lower than the normal person, and almost can not chemically examine the chromium element at arteriosclerosis dead volume sustainer.

5, strengthen immunity: it is reported, to domestic animal injection chromium, can make serum immune globulin increase, influential to specific immune function.Also studies show that, give and supplement chromium in the stress situation livestock for the immunity effect of improving in feed, therefore confirm that chromium is on immunoreactive impact.

In sum, this product has tonifying kidney and benefiting sperm, nourishing qi and blood, and liver is protected in enriching yin, strengthening the spleen and stomach, invigorate blood circulation etc., be adapted to hypoglycemicly, prevent and treat the various complication of diabetes, reducing blood lipid, hypotensive, prevent and treat artery sclerosis and cardiovascular and cerebrovascular disease, strengthen immunity, anti-inflammatory, anti-oxidant, improve constipation, the effect such as delay senility.

Six, manufacture craft:

1, raw material mixes: the raw material in formula is mixed by physical characteristic.

2, stir: mixed raw material is sent into to mixer and stir.

3, capsule-filling: the raw material stirred is sent into to filling machine, raw material is filled in capsule.

4, capsule sealing: by the capsule of populated raw material, by national standard, seal mouth.

5, test package: will seal the capsule of mouth, and be up to the standards, packing becomes formal product.

The raw material mixed processes is the process by component design, all raw materials mix.The raw material agitating procedure is the process that mixed raw material is stirred.The capsule-filling operation is that the raw material will stirred is filled in the process in capsule.The capsule sealing process is by the process of the capsule of populated raw material sealing.The test package operation is that the capsule of populated raw material is up to the standards, and packing becomes the process of formal product.

Seven, quality standard:

1, physical and chemical index:

2, adaptation population: be adapted to each age group diabetic and diabetic complication patient.

3, instructions of taking: every day 3 times, each serving consumption 1.5-2.0 gram.

Embodiment: get 15 kilograms of mononucleotides, 50 kilograms of GABAs, 20 kilograms of ginseng extracts, 50 kilograms of black wolfberry fruit extracts, to sting 20 milligrams of 40 kilograms of extracts, 40 kilograms of hippophae rhamnoides, 50 kilograms of Rhizoma Polygonati extracts, 30 kilograms of cinnamomum cassia extracts, 30 kilograms of Bitter Melon P.Es, 40 kilograms of curcumins, 50 kilograms of Tea Polyphenols, 50 kilograms of fenugreek extracts, 50 kilograms of extractive of flax seed, chromium in vain be the raw material mixing, stir, sending into filling machine is filled in raw material in capsule, the capsule sealing, be up to the standards, packing becomes formal product.

Claims (1)

1. hypoglycemic anti-complication manufacture craft, it is characterized by: 15 kilograms of mononucleotides, 50 kilograms of GABAs, 20 kilograms of ginseng extracts, 50 kilograms of black wolfberry fruit extracts, 40 kilograms of white thorn extracts, 40 kilograms of hippophae rhamnoides, 50 kilograms of Rhizoma Polygonati extracts, 30 kilograms of cinnamomum cassia extracts, 30 kilograms of Bitter Melon P.Es, 40 kilograms of curcumins, 50 kilograms of Tea Polyphenols, 50 kilograms of fenugreek extracts, 50 kilograms of extractive of flax seed, 20 milligrams of chromium are raw material, through above raw material is mixed, stir, sending into filling machine is filled in raw material in capsule, the capsule sealing, be up to the standards, packing becomes formal product.