CN102038126B - Health-care food for regulating blood fat and comprehensively antagonizing atherosclerosis and preparation method thereof - Google Patents
Health-care food for regulating blood fat and comprehensively antagonizing atherosclerosis and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to health-care foods for regulating blood fat and comprehensively antagonizing atherosclerosis, in particular to a health-care food for regulating blood fat and comprehensively antagonizing atherosclerosis with high safety performance, remarkable effect and stable and accordant quality control and a preparation method thereof. The health-care food is prepared from the following raw materials in parts by weight: 10 to 35 parts of functional monascus red powder, 1 to 10 parts of pueraria isoflavones powder, 1 to 8 parts of isoflavone powder, 1 to 8 parts of bamboo leaf flavone powder, 1 to 8 parts of resveratrol powder, 1 to 6 parts of hawthorn powder, 1 to 6 parts of rhizoma gastrodiae powder, 1 to 30 parts of black fungus powder, 0.1 to 2 parts of seahorse powder, 0.008 to 0.04 part of astaxanthin powder, 0.1 to 0.3 part of menthol powder, and 20 to 50 parts of resistant starch. The health-care food has the advantages of mild medicine property, delicious taste, and no toxicity, safety, fixed content of effective components, remarkable effect, controllable quality, stable action and long term edibility, and is all natural.
Description
Technical field
The invention belongs to and transfer the atherosclerotic health food of the comprehensive antagonism of blood fat, it is high to be specifically related to a kind of security performance, and effect significantly and the atherosclerotic health food of the comprehensive antagonism of accent blood fat of Quality Control stable and consistent and preparation method thereof.
Background technology
Along with the change of growth in the living standard and rhythm of life, (atherosclerosis, AS) property cardiovascular and cerebrovascular diseases M & M rises atherosclerotic year by year, has become harm humans healthy " No.1 killer ".Show that according to web material every year is died from the number of cardiovascular and cerebrovascular disease up to 1,500 ten thousand people in the whole world, surpassed 2.7 hundred million people China cardiovascular and cerebrovascular disease patient! Annual dead nearly 3,000,000 people, account for our annual total dead cause of disease of state 51%! Survivor 75% is disability in various degree, and 40% is heavy residual.Offer report in a separate paper, risk factors of cardiovascular diseases is a ubiquity and corresponding in the world.But countries in the world all are not enough to its treatment and control work.
AS is the vascular conditions of the slow development that causes of multiple factor multipath.At present; Atherosclerotic definite etiology unknown; The massive epidemiology data shows have the hazards of obvious statistics relation that high fat of blood, hypertension, smoking, diabetes and age, obesity, movable few are arranged with AS, and stress, postmenopausal women, heredity etc. can reach thousands of kinds.Its main pathological change comprises that the vascular endothelial cell 26S Proteasome Structure and Function is unusual, lipid soaks into, formation, platelet adhesion reaction gathering, smooth muscle cell and the fibroblast proliferation of foam cells, macrophage inflammatory soak into, the damage of the expression of the immunity factor, oxygen radical, local thrombus formation, VSMC (VSMC) calcium overload etc.Wherein endothelial cell structure, dysfunction and smooth muscle cell hyperplasia are that it is the most important.
At present, it is three kinds that the measure that medicine is prevented and treated atherosclerotic is divided into, first kind: Western medicine has hemangiectasis respectively, regulates blood fat, suppresses multiple medicines such as blood platelet, thrombus and anti-freezing, in treatment, obtains certain effect respectively.Treat but mostly Western medicine is single chemical composition, single approach, single target spot, it is big to take side effect for a long time in a large number.Second kind: the traditional Chinese medical science adopts traditional prescription to carry out whole diagnosis and treatment based on an overall analysis of the illness and the patient's condition, also obtains certain curative effect.But traditional prescription active ingredient is difficult for quantizing, and how the mechanism of action is not confirmed by scientific experiment, is difficult for getting into the international market.The third: transfer blood fat to be used for atherosclerotic health food merely, effect is simple relatively, is difficult to the atherosclerotic that comprehensive antagonism is caused by numerous factors.
Summary of the invention
The objective of the invention is to overcome the shortcoming of prior art and provide a kind of security performance high, have no side effect, with low cost, chemical composition is clear, effect is significantly and the atherosclerotic health food of the comprehensive antagonism of accent blood fat of Quality Control stable and consistent and preparation method thereof.
The objective of the invention is to realize like this: formulated according to parts by weight: functional red koji powder 10-35 part, pueraria flavone powder 1-10 part, isoflavones powder 1-8 part, bamboo-leaves flavones powder 1-8 part, resveratrol powder 1-8 part, hawthorn powder 1-6 part, Rhizoma Gastrodiae powder 1-6 part, black fungus powder 1-30 part, hippocampus powder 0.1-2 part, astaxanthin powder 0.008-0.04 part, menthol powder 0.1-0.3 part and resistant starch 20-50 part by following raw material.
A kind of preparation method who transfers the comprehensive antagonism atherosclerotic of blood fat health food comprises the steps:
One, with functional red koji powder 10-35 part, pueraria flavone powder 1-10 part, isoflavones powder 1-8 part, bamboo-leaves flavones powder 1-8 part, resveratrol powder 1-8 part, hawthorn powder 1-6 part, Rhizoma Gastrodiae powder 1-6 part, black fungus powder 1-30 part, hippocampus powder 0.1-2 part, astaxanthin powder 0.008-0.04 part; Menthol powder 0.1-0.3 part and resistant starch 20-50 part stir, and fully mix;
Two, with the mixture packing in the step 1, sealing.
Three, the mixture behind the sealed packaging in the step 2 is carried out the 7kGy60Co radiation sterilization, is up to the standards, finished product.
In the described step 2 after the packing every bag be 10g-10kg.
Functional red koji powder, pueraria flavone powder, isoflavones powder, bamboo-leaves flavones powder, resveratrol powder, hawthorn powder, Rhizoma Gastrodiae powder, black fungus powder, hippocampus powder, astaxanthin powder among the present invention, the pharmacology of menthol powder and resistant starch and effect.
1, functional red yeast rice: the red colouring agent for food, also used as a Chinese medicine flavor is sweet, warm, returns liver, spleen, large intestine channel.Function cures mainly: promoting blood circulation and removing blood stasis, and reinforcing spleen to promote digestion.Its functional red yeast rice contains natural Mo Nakelin class or Lovastatin class material, is the metabolite of under the Strict aseptic process conditions, being cultivated generation by bacterial classifications such as purplish red aspergillus, forms with alcohol extract is refining.70% cholesterol is by synthetic in the body in the human body.Functional red yeast rice has efficient special inhibitory action to the synthetic rate-limiting enzyme of cholesterol in vivo, can effectively block the synthetic of body inner cholesterol, has remarkable effect for reducing blood fat.Can obviously reduce serum triglyceride (TG), cholesterol (TC), low-density lipoprotein (LDL-C); Increasing high density lipoprotein (HDL-C); The protection vascular endothelial cell; Suppress lipid and deposit, increase the erythrodegeneration index, reduce platelet aggregation and adhesion, reduction whole blood viscosity and hypotensive activity preferably, play the effect of control AS property cardiovascular and cerebrovascular disease at liver.
2, kudzu root flavone (Radix Puerariae): the main active ingredient that is the Chinese medicine root of kudzu vine.Root of kudzu vine flavor is sweet, hot, cool, and property is flat, returns taste two warps.Function cures mainly: clearing heat and detoxicating, relieve the effect of alcohol, the lose weight defaecation, hemangiectasis, toxin expelling of inducing sweat is anticancer etc.The root of kudzu vine contains 20%～25% starch, contains abundant essential amino acid, also contains the mineral matter and the trace element of more than 10 kind of needed by human such as iron, calcium, phosphorus, zinc, copper, selenium, and selenium is up to 12.5pg/100g.The kudzu root flavone compounds is referred to as " phytoestrogen ", can bring into play multiple effect to antagonism AS with the protection treating cardiac and cerebral vascular diseases: 1. vasodilator smooth muscle, and hypotensive, blood supply is organized in improvement, the ischemia injuries such as heart and brain kidney due to the anti-AS; 2. reducing blood lipid reduces (TG), (TC) and low-density lipoprotein, increasing high density lipoprotein.3. anticoagulation suppresses haemocyte and platelet aggregation, reduces blood viscosity, improves blood flow state, suppresses thrombosis.4. reducing hyperglycaemia.5. improve the activity of superoxide dismutase (SOD), reduce MDA (MDA), remove free radical, suppress the old and feeble retrogression pathological changes due to the MDA; 6. suppress osteoclast, promote effects such as osteoblastic proliferation and differentiation, suppress calcium overload.7. improve the ability of learning and memory of rat, improve the activity of cholinacetyltranslase (ChAT) in the brain, the memory acquisition disturbance due to the antagonism hyoscine, protective wire plastochondria and neuron improve memory and neural regulatory function, anti-dementia.8. suppress the catalytic activity of junket ammonia enzyme significantly, suppress melanic generation and formation, beautifying face and moistering lotion is arranged, function in delaying senility.
3, (soybean isoflavone, IS): IS also is called as " phytoestrogen " to isoflavones, has to be equivalent to 1,/10 ten thousand estradiol activity, has multiple pharmacological effect and health care.Can effectively reduce blood lipid level, suppress atherosclerotic plaque and form, the protection cardiovascular and cerebrovascular.Epidemiology survey finds that the bean product of ingesting for a long time can stop atherosclerotic, effectively prevents the heart, cranial vascular disease.Can improve in addition the immunity of body, anticancer, anti-ageing, prevention of osteoporosis disease, improve multiple effect such as Woman climacteric obstacle.IS has similar pharmacological action with kudzuvine root isoflavone.
4, bamboo-leaves flavones (Organic Bamboo Leaf Flavonoids): the main health-care components that is the leaf of bamboo.Leaf of bamboo flavor is sweet, light, cold, the thoughts of returning home, lung, stomach warp.Function cures mainly: clearing heat and detoxicating, the diuresis of promoting the production of body fluid.The function factor of bamboo-leaves flavones is flavone glycoside (Ebl), is main with carbon glycosides flavones, and the characteristics of carbon glycosides flavones: Stability Analysis of Structures is difficult for being degraded; Can be deep into lesions position, directly bring into play curative effect; Hydrophily strengthens, and helps the exploitation of drug and food, cosmetics etc.Main effect: 1. bamboo-leaves flavones can significantly strengthen the heart power that contracts, and improves myocardial ischemia, expansion capillary, mediation microcirculation, compares with compound Danshen Root and to have a clear superiority in.2. substantial reduction in triglycerides (TG), cholesterol (TC), low-density lipoprotein (LDL-C), increasing high density lipoprotein (HDL-C).3. the resistive to hydrogen peroxide lipid peroxidation of inducing, anti-human body LDL-c peroxidation, the vigor of rising glutathione peroxidase (GSH-px) and superoxide dismutase (SOD) reduces blood viscosity, the protection cardiovascular and cerebrovascular.4. improve sleep, activation brain, promote memory, function is exempted from service in enhancing, antifatigue, anti-ageing, beautify skin, antibiotic, antiviral, protect effects such as liver, anticancer, deodorizing flavouring.5. the structure of bamboo-leaves flavones is similar with the hemoglobin of human body, and human beings'health longevity is had great significance.6. experiment proof bamboo extractive can effectively suppress growth of microorganism, extends shelf life, and be desirable natural Hangzhoupro oxidant.
5, (resveratrol, Res): Res is a polyphenols to resveratrol, is a kind of phytoalexin of vitis spp generation.The effect of research proof Res: 1. regulate blood fat; 2. suppress platelet aggregation, promote fibrinolysis, anti-thrombosis function; 3. protect blood vessel endothelium and smooth muscle cell, and suppress its propagation; 4. anti-leucocyte effect; 5. antagonism endothelin-1 (endothelinl, ET-1) effect; 6. the function of anti-LDL oxidation; 7. the transcript and expression that suppresses MMPs plays the effect of stabilize plaque; 8. estrogenic activity, GIA, immunoregulation effect etc.
6, hawthorn: the main functional component of hawthorn is a hawthorn fruit total flavone.Hawthorn flavor acid, sweet, tepor is returned liver, the spleen channel.Function cures mainly: reinforcing spleen to promote digestion, promoting blood circulation and removing blood stasis.Modern pharmacology research shows that hawthorn fruit total flavone has: 1. have increase myocardial contractive power, increase heart throughput rate, reducing heart rate, vasodilator, the effect that brings high blood pressure down, improve microcirculation, improve the CBF of ishemic part, anti-heart and brain renal ischaemia property damaging action; 2. reduce TG, TC, LDL-C; Rising HDL-C improves lipid-metabolism, reduces serum and liver MDA (MDA) content; Increase the content of red blood cell and liver superoxide dismutase (SOD); Also increase the activity of whole blood glutathione reductase, stop the lipid of artery, cardiac muscle and liver calm, experimental atherosclerosis is had therapeutic action; 3. oxygen lack resistant function; 4. improve blood platelet, erythrocyte surface electric charge, increase the repulsive force between the cell, improve haemodynamics, platelet aggregation-against and antithrombotic; 5. reduce blood sugar.6. gentleness, slow and lasting diuresis are arranged, less to the electrolyte influence, can promote the drainage of body harmful substance.Many-sided atherosclerotic generation of intervention and development.Clinically be usually used in treating hyperlipemia, also be used for coronary heart disease and hypertensive supplemental treatment.Its tart flavour can also play the effect of seasoning for the present invention.
7, rhizoma Gastrodiae: it is sweet to distinguish the flavor of, and property is flat, and is nontoxic.Anti-epileptic is arranged, and resisting throbs with fear faints antirheumatic; Calmness, antispastic, analgesia, qi-restoratives, the effect of suppressing hyperactive liver for calming endogenous wind.Diseases such as dizzy, extremity numbness are usually used in having a headache.Modern study, rhizoma Gastrodiae are rich in Gastrodin (be main active ingredient, its content is about 0.025%), Vanillin, protein, amino acid, trace element.Pharmacological action: 1. improve sleep.Gastrodin unit can act on the maincenter benzodiazepine receptors, and performance is stable, calmness, hypnosis, of flaccid muscles and anticonvulsant action.2. improve memory.Rhizoma Gastrodiae TA 0.1-0.5/kg can improve the memory dysfunction due to 30% ethanol.3. rhizoma Gastrodiae extract and Gastrodine can reduce coronary artery and cerebral vascular resistance, and slight and lasting hypotensive activity is arranged, and myocardial ischemia is had protective effect.4. delay senility, improve mouse aging SOD vigor.5. gastrodia elata polysaccharide has immunocompetence.
8, black fungus: the flat flavor of property is sweet, goes into stomach, large intestine two warps.Be that a kind of flavour is delicious, the abundant edible mushroom of nutrient.Nutrient is worth and contains abundant protein, iron, calcium, vitamin, crude fibre, and wherein protein content and meat are suitable, and iron is higher 10 times than meat, and calcium is 20 times of meat, and vitamin B2 is more than 10 times of vegetables.Dietary function: useful gas is kept fit, nourshing kidney nourishing the stomach, the effect such as invigorate blood circulation of enriching blood.Modern medicine investigation proof: 1. black fungus contains a kind of composition that suppresses platelet aggregation, and the effect of anticoagulant, antithrombotic, reduction blood viscosity is arranged, and its antiplatelet aggregative activity and low-dosage aspirin are suitable, but the Prevention of Cardiovascular onste.2. reducing blood lipid impels the drainage of enteron aisle fat food, increases the absorption of fat in the food, avoids very thin and antiobesity action thereby play.3. the original stronger suction-operated of contained natural plant gum, vegetable soda promote the secretion of alimentary canal, the various bodies of gland of the urinary tract, and cellulose can promote gastrointestinal peristalsis, and acting in conjunction can smooth enteron aisle, the catalysis calculus, and the intestines toxin expelling is washed in clearing stomach, avoids constipation.4. contained mannosan, wood sugar and dietary fiber have certain help to reducing the blood sugar for human body fluctuation and regulating insulin secretion.
9, hippocampus (Hippocampus).It is sweet warm in nature to distinguish the flavor of.Have improve the health, tonifying kidney and strengthening yang, stimulate the circulation of the blood and cause the muscles and joints to relax, medicinal function such as anti-inflammatory analgetic, tranquilizing and allaying excitement.Main component: 1. steroid class material.Courage steroid-5 alkene-3 β is arranged, 7 salmefamols, courage steroid-4 alkene-3-ketone and courage steroid-3,6-diketone etc.Has hormonal properties.2. other.Contain protein 67.90%～73.56%, the total amino acid content 59.65%～65.82% after the hydrolysis.Contain 13 kinds of aliphatic acid, unsaturated fatty acids account accounts for 65.18%～76.22% of TFA amount, and wherein DHA (DHA) accounts for 3.25%～8.6%, is one of main matter of prostatic fluid and sperm.Physiological function: 1. antithrombotic.Can obviously suppress the formation of rat experiment property arteria carotis thrombus and rat brain thrombus.2. gonadotropic Effect: the ethanol extract of hippocampus can bring out and prolong the estrus of female mice, and the weight of uterus and ovary is increased, and the weight of male mouse prostate, seminal vesicle, levator ani is obviously increased, and shows as androgen-like action.3. delay senility.Water or alcohol extract can increase SOD content in the mouse blood, reduce the content of lipid peroxide (LPO) in the Mouse Liver, suppress the activity of MAO-B in the mouse brain, strengthen mouse memory, improve Hemorheology and microcirculation.4. antifatigue etc.The generation of lactic acid and urea nitrogen when EEH both can reduce motion, the removing of lactic acid and urea nitrogen after promoting again to move can also obviously prolong mouse to anoxic and cold tolerance time.
10, astaxanthin (astaxanthin): be natural algae source astaxanthin extract, the highest level product that type Hu Luosu is synthetic is the human up to now the strongest anti-oxidant of nature of finding, is described as " super VE ".Mainly be used in the cosmetics of super quality, field of health care food.Natural algae source astaxanthin extract is classified as new food resource by health ministry [defending No. the 0011st, the new examination of food word (2007)].Anti-AS of astaxanthin and the cardiovascular effect that mainly contains 3 aspects of protection: 1. have remarkable rising HDL and the function of falling LDL in vivo, prevent the oxidation of LDL, but the atherosis generation of prevention of arterial; 2. superpower non-oxidizability is 550 times of vitamin E, 200 times of lycopene, 150 times of anthocyanidin OPC, 60 times of Co-Q10.17 times of grape pip; 10 times of carotenoid such as beta carotene, luteole, lutein and canthaxanthin; Be called as " super anti-oxidant "; Can significantly weaken active oxygen (ROS) and matrix metalloproteinase (NMP) destruction, guarantee the eubolism of blood vessel endothelium, dermis of skin blood vessel endothelium, dermis of skin collagen, elastin; 3. can pass through blood-brain barrier, protection brain, eyes and nerve center are avoided damage.Can also be used for toning of the present invention.
11, menthol powder: be one of main functional component of peppermint.Mint flavored is hot, cool, returns lung, Liver Channel.Function cures mainly: clearly good to eat, clearing away heart-fire makes eye bright, sweating and heat resolving, soothing the liver promoting the circulation of qi.In some food, cake, candy, drinks, beverage, add peppermint, have the pleasant cool smell of tangible fragrance, can promote digestion, improve a poor appetite.Pharmacological action has antipruritic, the expelling phlegm and arresting coughing of analgesia, cholagogic, sterilization, antivirus action.Also can be the effect that the present invention plays seasoning.
12. resistant starch (resistant starch): be can not be in small intestine, but in people's intestines and stomach colon, can play a kind of starch structure of fermentation reaction with volatile fatty acid by enzymolysis.Anti-AS of resistant starch and the cardiovascular effect that mainly contains 4 aspects of protection: the amount increase of cholesterol and triglyceride in the excreta behind the 1. edible resistant starch, reduced the total cholesterol level in serum and the liver significantly.Increase HDL and low-density, the shared ratio of VLDL, reduce evidence of coronary heart diseases.2. regulate blood sugar.Resistant starch can be resisted the decomposition of enzyme, and it is slow to discharge glucose in vivo, has lower insulin response, can control blood glucose balance, reduces hunger, special suitable for patients with diabetes mellitus; 3. resistant starch has the function of soluble edible fibre, can increase feces volume after the food, reduces constipation, and the defecation of exerting oneself when avoiding constipation increases the weight of the heart burden and blood pressure raises, and reduces the danger of colon cancer; 4. antiobesity action.Resistant starch increases lipid on the one hand to be drained, and reduces calorie intake; Resistant starch indigestion in small intestine absorbs on the other hand, can not increase heat to human body, and full abdomen effect is comparatively lasting, and then can receive the effect of the weight reducing of going on a diet.
Indication of the present invention: 1, suitable high fat of blood, AS patient's dietotherapy; 2, the preventative dietotherapy of suitable high fat of blood, AS Susceptible population.Use the present invention to prevent high fat of blood, AS to take 60-240mg every day, high fat of blood and the dietotherapy of AS early stage patient are with obeying 240-600mg every day, and serious high fat of blood and AS middle and advanced stage patient dietotherapy are with obeying 600-1800mg every day.
Be suitable for points for attention of the present invention: 1, children and the anti-AS Chinese medicinal food of young woman's inedibility the present invention preparation.2, preventative edible general flavone is controlled in the 500mg every day, and 60-240mg is comparatively suitable; 3, high fat of blood and AS edible for patients general flavone are controlled in the 2000mg every day, and 800-1200mg is comparatively moderate, its objective is ancillary drug treatment AS, observe the dietotherapy dosage of the anti-AS health food of the present invention preparation under the guidance the doctor and can adjust; 4, the present invention contains auricularia auriculajudae, and hemorrhagic disease and chronic diarrhea person inedibility is arranged.
The present invention sees table 1 to the influence of high fat diet rat blood serum T-CHOL (TC), triglycerides (TG), HDL (HDL-C), low-density lipoprotein (LDL-C).
The influence of table 1 TC of the present invention, TG, HDL-C, LDL-C
Annotate: A normal group, B model group, the good low dose group of C heart arteries and veins, the good middle dose groups of D heart arteries and veins, the good high dose group of E heart arteries and veins; Compare * P＜0.05 with model group; With compared with normal, ▼ P＜0.05.
The present invention sees table 2 to the influence of high fat diet rat blood serum MDA and SOD.
Table 2 the present invention is to the influence of rat blood serum MDA and SOD
| Group | Number of rats | MDA | SOD |
| Group | Number | (nmol/l) | (NU/mg?prot) |
| Normal group | 10 | 9.77±2.85 | 251.78±17.12 |
| Model group | 8 | 15.02±8.60** | 199.26±21.03▼ |
| The good low dose group of heart arteries and veins | 9 | 3.64±2.38** | 298.36±19.18▼ |
| Dose groups during heart arteries and veins is good | 10 | 2.45±1.77** | 357.52±10.98▼ |
| The good high dose of heart arteries and veins | 9 | 3.11±1.36** | 401.39±14.36▼ |
Annotate: A normal group, B model group, the good low dose group of C heart arteries and veins, the good middle dose groups of D heart arteries and veins, the good high dose group of E heart arteries and veins; Compare * P＜0.05, * * P＜0.01 with model group; With compared with normal, ▼ P＜0.05.
The present invention observes the tectology of high fat diet rat LCC clamp place vascular wall
The result shows: normal rat vascular wall clear layer, and inner membrance is smooth complete, and endothelial cell connects closely, and nothing comes off, no lipid striped or fiber plate, the gap is less under the inner membrance, and smooth muscle is arranged very neat; The model group endothelial cell damage comes off, lipidosis, smooth muscle arrangement disorder; The good low dose group of heart arteries and veins local lipidosis is arranged but in the vascular wall rete more complete; Middle dose groups endangium has certain cell proliferation but does not have lipidosis; The good effect of heart arteries and veins of high dose is best, less the coming off of low relatively, the middle dose groups of endothelial cell, and inner membrance is more smooth, and smooth muscle is arranged more regular.
The present invention is to the transmission electron microscope observing of high fat diet rat LCC clamp place vascular wall
The result shows: the visible endothelial cell morphology of normal group inner membrance is normal, smooth complete, and endothelial cell connects closely; SES is narrow and small; See organelles such as endoplasmic reticulum that content does not wait and mitochondria in the cell space, interior elastic plate thickness is evenly clear more, and middle film is seen the smooth muscle marshalling; It is thus clear that collagen microfibrils and elastic fibers do not see that fat drips deposition.The model group endotheliocytic swelling, volume increases, and profile is irregular; Prominent to the chamber face or come off, connect obviously between endothelial cell and enlarge, in see a plurality of cavitys; The nucleus electron density strengthens (downright bad), and interior elastic plate obviously thickens, out-of-shape; The part fracture, smooth muscle cell sees that to inner membrance migration down a large amount of fat drip.The good low dose group endothelial cell of heart arteries and veins strips off, and interior elastic plate thickens, smooth muscle cell proliferation, and visible part fat drips.The dose groups endothelial cell morphology was complete basically during heart arteries and veins was good, and part comes off, and SES increases, the elastic plate irregular arrangement, and visible a small amount of fat drips in endothelial cell and the smooth muscle cell kytoplasm.The good high dose group endothelial cell morphology of heart arteries and veins is normal basically, and part is prominent to the chamber face, and endothelial cell connects to be owed closely, and SES is big, and nuclear pericyte device increases, and elastic plate is more clear, and irregular arrangement is rare or lose fat and drip.
The present invention has advantage:
1, the present invention is according to mainly according to four key links of AS morbidity---ischemia injuries such as the heart that hyperlipidemia → lipid peroxidation → thrombosis → thrombus causes, brain, kidney; The component that the ischemia injury effect that selected hyperlipidemia disease, anti peroxidation of lipid, antithrombotic form and antithrombotic causes in edible Chinese medicine is outstanding is created the health food of a kind of multicomponent, multipath, the comprehensive antagonism AS of many target spots.
2, the present invention had both drawn that Western medicine active drug composition is confirmed, the mechanism of action is clear and definite, and action pathway, action target spot can be by the scientific superiorities of experiment confirm; Brought into play the advantage of whole sight of the traditional Chinese medical science and Chinese medicine compound prescription multicomponent, multipath, the slow antagonism AS of many target spots again, the Chinese medicine and health food of research and development " come from Chinese medicine, be higher than tradition " anti-AS.
3, the extract of the main active ingredient of the selected edible pure natural Chinese herbal medicine of the present invention; Its property of medicine is gentle, good to eat, nontoxic or intimate nontoxic; The antagonism of dietotherapy for a long time AS does not receive the restriction of individual cold and heat and asthenia and sthenia again, is the health food of a kind of very desirable antagonism AS.
4, the present invention adopts the Chinese medicine and health food of the comprehensive antagonism AS that the main effective component extracts of Chinese medicine processes; Avoided Chinese medicine influenced by the place of production, season etc. and made the active constituent content factors of instability; Effective content is confirmed; Experiment can repeated authentication with clinical effectiveness, for laying a good foundation the entering international market.
5, the invention belongs to a kind of Chinese medicine and health food of transferring blood fat, the comprehensive antagonism AS of anti peroxidation of lipid of technical field of traditional Chinese medicines, its target is to come from Chinese medicine, be higher than tradition, and the generation of prevention high fat of blood and AS delays the development of AS or impels AS to disappear.AS is the common great public welfare project of paying close attention in field, the world.This invention meets national policy, belongs to the traditional Chinese medicine construction project category that country helps.Point out in China's " traditional Chinese medicine development Eleventh Five-Year Plan ", " government to the public health investment in special items in, increase traditional Chinese medical science special subsidies funds; When formulating great health development plan, fully pay attention to the demand of traditional Chinese medicine development, increase traditional Chinese medicine construction project share; In major scientific and technological program, arrange more traditional Chinese medicine project.”
6, the present invention caters to the needs in international environment and market.21 century will be the epoch of natural drug.Along with people's is to the high praise and the naturopathic rise of natural products, and the world perhaps " prevents and treatment " all to have very high expectation to natural drug " maintaining healthy ".Have no side effect safely,, action temperature and, have the effect multifarious natural medicinal formulations will be to the optimal medicine of the particularly old many organ diseases patient of chronic disease.Strict in states such as America and Europes to the control of prescription medicine; And it is relatively easy to the import of the drug health food of non-prescribed medicine and non-obvious treatment motivation; And wherein the most competitive be Chinese medicine preparation; Especially the America and Europe numerous patients AS and vulnerable crowd are arranged, expectation is benefited in traditional Chinese medicine prevention AS property disease.Believe that the present invention transfers blood fat, the comprehensive antagonism AS of anti peroxidation of lipid health food in a single day to drop into product; Have very vast market; Can especially to safeguarding the health of high fat of blood, AS patient and Susceptible population, very important effect and immeasurable value be arranged to safeguarding human beings'health.
In a word; Chinese medicine and health food of the present invention has that the property of medicine is gentle, good to eat, pure natural is nontoxic, safety, active constituent content are confirmed, effect significantly, can Quality Control; Effect stable with the advantage that can eat for a long time, both met the CHINESE INDUSTRIES policy, cater to the needs of environment and market both at home and abroad again.
The specific embodiment
The present invention is formulated according to parts by weight by following raw material: functional red koji powder 10-35 part, pueraria flavone powder 1-10 part, isoflavones powder 1-8 part, bamboo-leaves flavones powder 1-8 part, resveratrol powder 1-8 part, hawthorn powder 1-6 part, Rhizoma Gastrodiae powder 1-6 part, black fungus powder 1-30 part, hippocampus powder 0.1-2 part, astaxanthin powder 0.008-0.04 part, menthol powder 0.1-0.3 part and resistant starch 20-50 part.
A kind of preparation method who transfers the comprehensive antagonism atherosclerotic of blood fat health food comprises the steps:
One, with functional red koji powder 10-35 part, pueraria flavone powder 1-10 part, isoflavones powder 1-8 part, bamboo-leaves flavones powder 1-8 part, resveratrol powder 1-8 part, hawthorn powder 1-6 part, Rhizoma Gastrodiae powder 1-6 part, black fungus powder 1-30 part, hippocampus powder 0.1-2 part, astaxanthin powder 0.008-0.04 part; Menthol powder 0.1-0.3 part and resistant starch 20-50 part stir, and fully mix;
Two, with the mixture packing in the step 1, sealing.
Three, the mixture behind the sealed packaging in the step 2 is carried out the 7kGy60Co radiation sterilization, is up to the standards, finished product.
In the described step 2 after the packing every bag be 10g-10kg.
Provide several concrete allocation plan of the present invention below:
Embodiment 1
37.208kg the weight that the present invention includes each raw material be respectively: functional red koji powder 10kg, pueraria flavone powder 1kg, isoflavones powder 1kg, bamboo-leaves flavones powder 1kg, resveratrol powder 1kg, hawthorn powder 1kg, Rhizoma Gastrodiae powder 1kg, black fungus powder 1kg, hippocampus powder 0.1kg, astaxanthin powder 0.008kg, menthol powder 0.1kg and resistant starch 20kg.
One, with functional red koji powder 10kg, pueraria flavone powder 1kg, isoflavones powder 1kg, bamboo-leaves flavones powder 1kg, resveratrol powder 1kg, hawthorn powder 1kg, Rhizoma Gastrodiae powder 1kg, black fungus powder 1kg, hippocampus powder 0.1kg, astaxanthin powder 0.008kg; Menthol powder 0.1kg and resistant starch 20kg stir, and fully mix;
Two, with the mixture packing in the step 1, sealing.
Three, the mixture behind the sealed packaging in the step 2 is carried out the 7kGy60Co radiation sterilization, is up to the standards, finished product.
In the described step 2 after the packing every bag be 10g.
Embodiment 2
163.34kg the weight that the present invention includes each raw material be respectively: functional red koji powder 35kg, pueraria flavone powder 10kg, isoflavones powder 8kg, bamboo-leaves flavones powder 8kg, resveratrol powder 8kg, hawthorn powder 6kg, Rhizoma Gastrodiae powder 6kg, black fungus powder 30kg, hippocampus powder 2kg, astaxanthin powder 0.04kg, menthol powder 0.3kg and resistant starch 50kg.
One, with functional red koji powder 35kg, pueraria flavone powder 10kg, isoflavones powder 8kg, bamboo-leaves flavones powder 8kg, resveratrol powder 8kg, hawthorn powder 6kg, Rhizoma Gastrodiae powder 6kg, black fungus powder 30kg, hippocampus powder 2kg, astaxanthin powder 0.04kg; Menthol powder 0.3kg and resistant starch 50kg stir, and fully mix;
Two, with the mixture packing in the step 1, sealing.
Three, the mixture behind the sealed packaging in the step 2 is carried out the 7kGy60Co radiation sterilization, is up to the standards, finished product.
In the described step 2 after the packing every bag be 5.005kg.
Embodiment 3
100.274kg the weight that the present invention includes each raw material be respectively: functional red koji powder 22.5kg, pueraria flavone powder 5.5kg, isoflavones powder 4.5kg, bamboo-leaves flavones powder 4.5kg, resveratrol powder 4.5kg, hawthorn powder 3.5kg, Rhizoma Gastrodiae powder 3.5kg, black fungus powder 15.5kg, hippocampus powder 1.05kg, astaxanthin powder 0.024kg, menthol powder 0.2kg and resistant starch 35kg.
One, with functional red koji powder 22.5kg, pueraria flavone powder 5.5kg, isoflavones powder 4.5kg, bamboo-leaves flavones powder 4.5kg, resveratrol powder 4.5kg, hawthorn powder 3.5kg, Rhizoma Gastrodiae powder 3.5kg, black fungus powder 15.5kg, hippocampus powder 1.05kg, astaxanthin powder 0.024kg; Menthol powder 0.2kg and resistant starch 35kg stir, and fully mix;
Two, with the mixture packing in the step 1, sealing.
Three, the mixture behind the sealed packaging in the step 2 is carried out the 7kGy60Co radiation sterilization, is up to the standards, finished product.
In the described step 2 after the packing every bag be 10kg.
The present invention is not limited to the foregoing description, can also do any adjustment according to the ratio range of claim; The present invention not only can be made as Powdered taking, and becomes capsule but also can make, oral liquid and biscuit etc.
Case 1: still so-and-so, the woman, 69 years old, hypertension, dizzy nearly 20 years were suffered from the rural area, take depressor always.Suddenly fell in a swoon in one day, mind is fuzzy, and the back one side limbs of waking up are not obedient, and hospital resolutely refuses; Child adds the present invention for her, and affected limb recovers normal after two months, after adhere to taking, the decompression dose deducts 1/2; Take care of oneself, can also be in ground in do some light work, spirit fine.
Case 2: suffered from coronary heart disease and diabetes 15 years in 73 years old this year of Lao Song, 2003 in Henan large hospital done twice coronary artery balloon expandable continuously and performed the operation with support, but postoperative angina pectoris still has outbreak at every turn, every day 1～3 time, feels run-down.Come to seek advice from after learning the effective message of the present invention, begin to take this anti-AS Chinese medicine and health food, angina pectoris outbreak in the 3rd day alleviates; One week back angina pectoris stops outbreak, weak alleviating after January, and patient basically can normal life after three months; Adhere to afterwards taking always; The medicine of treatment coronary heart disease reduces gradually, existing takes once in a while, does not occur pectoralgia, symptom uncomfortable in chest again.
Case 3: Liu so-and-so, the man, 49 years old, chest pain, weakness of limbs appear suddenly because of it is cold, confirm that through electrocardiogram inspection the heart front and rear wall all has ischemic, do the cardiovascular radiography, the slight hemadostewnosis in visible many places, treatment does not operate.Drug therapy continues two months poor effect, the painful still outbreak repeatedly in the pit of the stomach.Take one week of the present invention, symptom is eased, and no longer takes; Stopped for 3 weeks and come again, heavily obey the present invention, make symptom be eased gradually, disappear, after adhere to taking always, dosage reduces, the chest is painful, weak does not recommit; Can normally go to work at present.
Case 4: Dong so-and-so; The man, 51 years old, hypertension was for many years; The IU22 of U.S. PHilips company produces CDFI imager high frequency ultrasound (12MHz linear array probe); Record bilateral common carotid arteries near the big oval patch of a soya bean is arranged under the crotch endangium, the criminal's of soaking ductus arteriosus wall reaches 30%, and is very uneasy.Adhere to taking the present invention, patch dwindles nearly 1/2 after 1 year.
Claims (3)
1. transfer the atherosclerotic health food of the comprehensive antagonism of blood fat for one kind; It is characterized in that: formulated according to parts by weight: functional red koji powder 10-35 part, pueraria flavone powder 1-10 part, isoflavones powder 1-8 part, bamboo-leaves flavones powder 1-8 part, resveratrol powder 1-8 part, hawthorn powder 1-6 part, Rhizoma Gastrodiae powder 1-6 part, black fungus powder 1-30 part, hippocampus powder 0.1-2 part, astaxanthin powder 0.008-0.04 part, menthol powder 0.1-0.3 part and resistant starch 20-50 part by following raw material.
2. a preparation method who transfers the comprehensive antagonism atherosclerotic of blood fat health food is characterized in that: comprise the steps:
One, with functional red koji powder 10-35 part, pueraria flavone powder 1-10 part, isoflavones powder 1-8 part, bamboo-leaves flavones powder 1-8 part, resveratrol powder 1-8 part, hawthorn powder 1-6 part, Rhizoma Gastrodiae powder 1-6 part, black fungus powder 1-30 part, hippocampus powder 0.1-2 part, astaxanthin powder 0.008-0.04 part; Menthol powder 0.1-0.3 part and resistant starch 20-50 part stir, and fully mix;
Two, with the mixture packing in the step 1, sealing;
Three, the mixture behind the sealed packaging in the step 2 is carried out 7kGy
60The Co radiation sterilization is up to the standards, finished product.
3. the preparation method of the comprehensive antagonism atherosclerotic of accent blood fat according to claim 2 health food is characterized in that: in the described step 2 after the packing every bag for 10g-10kg.
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| CN103598579A (en) * | 2013-11-08 | 2014-02-26 | 苏州冉新生物技术有限公司 | Health-care food containing soy isoflavone |
| CN103656301B (en) * | 2013-12-17 | 2016-05-04 | 新乡医学院 | The good formula of heart and brain is in the application of preparing in hepatic |
| CN104107424B (en) * | 2014-07-31 | 2015-07-15 | 杜志政 | Qi cultivating thrombolytic medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN104187619A (en) * | 2014-08-04 | 2014-12-10 | 东莞市天益生物工程有限公司 | Functional red kojic rice healthy food and preparation method thereof |
| CN104644901A (en) * | 2015-02-02 | 2015-05-27 | 万光瑞 | Chinese medicinal preparation for long-term prevention and treatment of cardiovascular and cerebrovascular diseases at remission stage and preparation method of Chinese medicinal preparation |
| GB201602626D0 (en) * | 2016-02-15 | 2016-03-30 | Alchemy Foodtech Pte Ltd And Goh Zhi M V | Glycemic reducing composition |
| CN106262803A (en) * | 2016-07-14 | 2017-01-04 | 新乡医学院 | Compositions that a kind of strong anti-oxidation prevention of arterial is atherosis and application thereof |
| CN108617957A (en) * | 2018-05-10 | 2018-10-09 | 丽睿客信息科技（北京）有限公司 | Nutraceutical with fat-reducing effect |
| CN108968062A (en) * | 2018-08-13 | 2018-12-11 | 万光瑞 | A kind of Adjust-blood lipid anti peroxidation of lipid composition and the preparation method and application thereof |
| CN112316124A (en) * | 2020-12-04 | 2021-02-05 | 浙江蓝美生物技术有限公司 | Blueberry powder compound solid preparation capable of protecting and improving heart health and preparation method and application thereof |
| CN115006455A (en) * | 2022-05-19 | 2022-09-06 | 新乡医学院 | Application of traditional Chinese medicine compound Xinmaijia in preparation of medicines for treating or preventing atherosclerosis diseases |
| CN117204565A (en) * | 2023-09-13 | 2023-12-12 | 深圳康普生物药业有限公司 | Medicinal and edible composition for reducing blood fat and blood pressure and preparation method thereof |
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| CN1593643A (en) * | 2004-07-05 | 2005-03-16 | 中山大学 | Medicinal composition for preventing and treating cardiovascular heart disease and its preparation |
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