CN104306554B - A kind of food, health products or pharmaceutical composition for treating gastric ulcer - Google Patents
A kind of food, health products or pharmaceutical composition for treating gastric ulcer Download PDFInfo
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- CN104306554B CN104306554B CN201410542518.8A CN201410542518A CN104306554B CN 104306554 B CN104306554 B CN 104306554B CN 201410542518 A CN201410542518 A CN 201410542518A CN 104306554 B CN104306554 B CN 104306554B
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The present invention provides a kind of food, health products or pharmaceutical composition for treating gastric ulcer, raw material is grouped as by the group of following weight proportion：60~75 parts of Seabuckthorm Seed Oil, 10~15 parts of Boxthorn Seed Oil, 15~20 parts of oil of Nitraria seeds.The present composition has played synergistic function after each material matching use, can effectively treat gastric ulcer, and each materials safety is nontoxic, and without other side effects, a kind of new selection is provided for clinical application.
Description
Technical field
The present invention relates to a kind of food, health products or pharmaceutical composition for treating gastric ulcer.
Background technology
Canker is a kind of common chronic systemic disease, is divided into gastric ulcer and duodenal ulcer, is most common
Mucous membrane to the intestines and stomach illness, is called and does peptic ulcer.It is because previously thinking that stomach is burst why it is referred to as peptic ulcer
Ulcer and duodenal ulcer are since hydrochloric acid in gastric juice and pepsin are formed by mucous membrane autodigestion.In fact, hydrochloric acid in gastric juice and stomach egg
One of the main reason for white enzyme is ulcer formation, also other reasons can form canker.Treatment gastric ulcer is main at present
By drug therapy, mainly treated from following several respects：1, it is treated using antiacid class drug.Antiacid class drug includes mainly
Antiacid, anticholinergic agents, H2RA class drugs, proton pump inhibitor (proton pump inhibitor, PPI).2, it uses
Mucosa protective agent is treated.Mucosa protective agent includes mainly simple mucosa protective agent or mucous membrane protection and fungicide.3, resist
HP is treated.Include mainly proton pump inhibitor Omeprazole+antibiotic.4, gastro-kinetic agent.If any abdominal distension, the diseases such as nausea and vomiting
Shape, which adds, uses medicine for stomach dynamic.It is had the disadvantage that using said medicine treatment：After i.e. said medicine is cut out, stomach trouble recurrence rate is very
It is high；And these drugs have prodigious side effect while treatment.
Sea-buckthorn Hippophae rhamnodes L. systems Elaeangnaceae hippophae plant contains a variety of lifes beneficial to human body
Active substances have effects that relieving cough and reducing sputum, relieving dyspepsia, promoting blood circulation to remove blood stasis.China is that the medical history of sea-buckthorn is earliest in the world
Country, the Tang Dynasty before 1300《Month king medicine is precious》、《Four doctor's allusion quotations》And the Qing Dynasty《Jingzhubencao》Deng describing sand
The medical usage of spine.Sea-buckthorn also is used as treating the common drug of a variety of diseases in the ethno-medicines such as Tibetan medicine, Mongolian medicine.China is husky
Most abundant one of the country of spine resource, existing Seabuckthorn Forest account for 90% or more of world's sea-buckthorn gross area ten thousand mu about more than 1800.1977
Year, sea-buckthorn was included in by the Ministry of Public Health for the first time《Chinese Pharmacopoeia》, and it is medicinal and edible varieties to announce sea-buckthorn in succession：(1) contain it is abundant not
Saturated fatty acid, liposoluble vitamin can reduce rapidly cholesterol and triglyceride concentration in blood, prevent Atherosclerosis
Change, reduce blood viscosity, to be effectively improved cardiovascular and cerebrovascular function, adjusts blood pressure, reducing blood lipid, prevent cardiac arrhythmia, reduce
The total fat of blood plasma and low-density lipoprotein are with obvious effects；(2) contain that there are many anti-inflammatory, antiulcer composition and lipoids to close object, to gastric ulcer,
Acute gastric mucosal injury, chronic diarrhea, ulcerative colitis caused by duodenal ulcer, gastritis, chemotherapy have significant auxiliary
Therapeutic effect.(3) phospholipids compounds such as the lecithin contained are a kind of higher compositions of bioactivity, can promote cell generation
It thanks, improves liver function, anti-fatty liver, anti-hepatic sclerosis.(4) Seabuckthorm Seed Oil contains the weak acid property for maintaining skin, to fungi, mould
Play inhibiting effect, moreover it is possible to promote repair of damaged tissues, improve epidermis microcirculation, prevent moisture from dissipating, prevent foreign matter from invading.It is husky
A variety of antioxidants and immunomodulator are rich in spine oil, the mutual cooperation of these ingredients can effectively improve body immunity, to
Have the function that delay body aging.(5) brain tonic and intelligence development, promotion upgrowth and development of children effect are notable.Containing abundant in seed oil
Unsaturated fatty acid, protein isoreactivity substance, intellectual development and physical growth to children have good facilitation.It is long
Phase, which takes the energy and muscle power vigorous to the intellectual level, respond and the holding that improve children, good effect.For
The a series of research and development of chemical such as sea-buckthorn dry fruit, sea-buckthorn fresh fruit, Leaves of Hippophae L, seabuckthorn seeds have been carried out very much,
Relate generally to health food, drink or drug etc..
The Seabuckthorm Seed Oil extracted from seabuckthorn seeds is rich in multiple biological activities composition, wherein the malic acid contained, oxalic acid etc.
Organic acid and flavones, vitamin C, vitamin E, unsaturated fatty acid, sterol isoreactivity ingredient.China research worker couple
Seabuckthorm Seed Oil has carried out a large amount of work, is widely studied from active ingredient, pharmacological toxicology, clinic, it was demonstrated that Seabuckthorm Seed Oil
Contain the active ingredients such as unsaturated fatty acid, vitamins, sterol, Coumarins, triterpene alkenes；It is demonstrate,proved through toxicity and pharmacological research
Real Seabuckthorm Seed Oil has no toxic side effect, and has anti-gastric-ulcer, antitumor, reducing blood lipid, blood pressure lowering and other effects, Seabuckthorm Seed Oil is both can medicine
With edible vegetable oil again.China Patent No. is " 200610163278.5 ", and patent name is that " strengthen immunity glues stomach
Membrane damage has health food of defencive function and preparation method thereof " a kind of health food is disclosed, which includes husky
Spine seed oil and propolis etc. strengthen immunity and can have assistant protection function to gastric mucosa damage.China Patent No. is
" 201110387158.5 ", patent name are that " protection stomach lining, nourishing the stomach, the composition and preparation method thereof for protecting stomach " discloses one
Kind composition, the composition include Seabuckthorm Seed Oil and oil of ginger, have the function of protecting stomach lining, nourishing the stomach and shield stomach.
The present invention wishes to study a kind of new compositions of the treatment gastric ulcer based on Seabuckthorm Seed Oil.
Invention content
The purpose of the present invention is to provide a kind of food, health products or pharmaceutical composition for treating gastric ulcer.The present invention's
Another object is to provide the preparation method of the composition and purposes.
After the present invention is the study found that Seabuckthorm Seed Oil and Boxthorn Seed Oil, oil of Nitraria seeds are used in combination, under Isodose,
The drug activity for the treatment of gastric ulcer is significantly better than one-component, shows that present composition compatibility is precise and appropriate, has played synergy
Effect, therefore, the present invention provides a kind of food, health products or pharmaceutical composition for treating gastric ulcer, and raw material is by following weight
The group of proportioning is grouped as：
60~75 parts of Seabuckthorm Seed Oil, 10~15 parts of Boxthorn Seed Oil, 15~20 parts of oil of Nitraria seeds.
Further, raw material is grouped as by the group of following weight proportion：
60 parts of Seabuckthorm Seed Oil, 12 parts of Boxthorn Seed Oil, 16 parts of oil of Nitraria seeds.
The seed of matrimony vine seed, that is, matrimony vine contains the abundant and comprehensive bioactive substance for breeding life development and growth.
And Boxthorn Seed Oil, using modernization abstraction technique extraction, has been effectively kept a variety of of matrimony vine exactly using matrimony vine seed as raw material
Functional component is such as：Linoleic acid, gamma-Linolenic acid, VE, beta carotene, alkaloid etc. health products, wherein unsaturated fatty acid is total
Content is up to 80% or more.Beta carotene, vitamin E, Organic Selenium, kryptoxanthin equal size are high.Boxthorn Seed Oil can reduce human body blood
Cholesterol level is starched, blood fat and atherosclerosis are prevented；Have to hypertension, the coronary heart disease caused by hyperlipidemia significant slow
Solution acts on；Skin metabolism is directly participated in, oxygen radical is eliminated, delay skin aging reinforces skin hydration function, makes skin
Soft and high resilience, there is apparent whitening effect；In addition, edible Boxthorn Seed Oil can also eliminate moth patch in human skin,
Melanin enables skin more glossy, can inhibit the regeneration of whelk, acne, dark sore, can alleviate physical fatigue, be effectively improved and sleep
Sleep and other effects.Research shows that beta carotene has protection stomach lining effect, can be used for treating gastric ulcer and atrophic gastritis.Matrimony vine
Contain a large amount of beta carotene in seed oil, but its effect in terms of protection gastrointestinal mucosa, treatment gastric ulcer is there is not yet document report
Road.
White thorn is that the perennial fallen leaves drought life of Ji Li sections or super non-irrigated raw Typical Desert shrub, growth are thin, high-strength in oxygen
In degree radiation, the king-sized Qinghai-Tibet adverse circumstances of the temperature difference, so with high resist oxygen lack, anti-radiation active substances.Fruit
Contain the abundant neutraceutical active ingredients such as abundant vitamin, amino acid, polysaccharide in reality.Especially amino acid, in sherbet
Content in dry powder is up to 10% or so, and is free amino acid, is easily absorbed and utilized by the body.White bur seed contains grease
Main component be unsaturated fatty acid, content is up to 97%, and only linoleic content just accounts for nearly 70%, higher than deep sea fish oil
20% or so, there is high nutritive and medicinal value.Through proving every clinical trial of animal：Oil of Nitraria seeds has notable
Resist oxygen lack, antifatigue effect.The nutritional ingredients such as linoleic acid, lecithin, multivitamin contained by white thorn oil, have adjusting machine
Body is metabolized, resist oxygen lack, antifatigue, has apparent preventive and therapeutic action to hyperlipidemia, atherosclerosis etc..Berry of nitraria tangutorum bobr
In the B group vitamins that contain, have the effect of enhancing human immunological competence, and oil of Nitraria seeds treats stomach in protection gastrointestinal mucosa
Effect in terms of ulcer is there is not yet document report.
The present invention controls gastric ulcer studies have shown that by after Seabuckthorm Seed Oil and Boxthorn Seed Oil, oil of Nitraria seeds collocation use
Treatment effect, which is far above, is applied alone Seabuckthorm Seed Oil, or even is also substantially better than Seabuckthorm Seed Oil and propolis, Seabuckthorm Seed Oil and oil of ginger combination group,
Illustrate that compatibility of the present invention is precise and appropriate, each component has played synergistic function.
Wherein, Seabuckthorm Seed Oil is prepared by the following method：Seabuckthorn seeds are crushed, supercritical carbon dioxide extracting is placed in and sets
In standby, extracting pressure is 25~45MPa, and extraction temperature is 40~55 DEG C, CO2Flow is 20~35L/h, and separating pressure is set as
8~12MPa, separation temperature are set as 45~60 DEG C, and extraction time is 0.5~2.0 hour to get Seabuckthorm Seed Oil.
Wherein, Boxthorn Seed Oil is prepared by the following method：After matrimony vine seed drying and crushing, it is placed in supercritical carbon dioxide extraction
In taking equipment, extracting pressure is 25~45MPa, and extraction temperature is 40~55 DEG C, CO2Flow is 20~35L/h, and separating pressure is set
It is set to 8~12MPa, separation temperature is set as 45~60 DEG C, and extraction time is 0.5~2.0 hour to get Boxthorn Seed Oil.
Wherein, oil of Nitraria seeds is prepared by the following method：It is placed on supercritical extract after dry white thorn seed is crushed
CO is used in device2It is extracted, extracting pressure is 15~45MPa, and extraction temperature is 40~55 DEG C, CO2Flow is 20~35L/h,
Separating pressure is set as 8~12MPa, and separation temperature is set as 45~60 DEG C, and extraction time is 0.5~2.0 hour to get white thorn
Seed oil.
Wherein, the composition is the oral preparation being prepared after being mixed by bulk pharmaceutical chemicals.
Further, the oral preparation is soft capsule.
Other than soft capsule, conventional formulation means can also be used, above-mentioned composition is prepared into other oral preparations,
The clinical dosage form needed of tablet, granule, powder, pill is prepared after such as including.
Further, the soft capsule is prepared by the component of following weight proportion：
60~75 parts of Seabuckthorm Seed Oil, 10~15 parts of Boxthorn Seed Oil, 15~20 parts of oil of Nitraria seeds, 2~5 parts of glycerine and gelatin 5
~15 parts.
Preferably, the soft capsule is prepared by the component of following weight proportion：
60 parts of Seabuckthorm Seed Oil, 12 parts of Boxthorn Seed Oil, 16 parts of oil of Nitraria seeds, 4 parts of glycerine, 8 parts of gelatin
The present invention also provides the preparation methods of above-mentioned food, health products or pharmaceutical composition, it includes that following operation walks
Suddenly：
(1) each component is taken according to the ratio；
(2) it takes each component outside gelatin to be uniformly mixed, gelatin is heated to mixing species are added after melting, suppresses flexible glue
Capsule to get.
The present invention also provides above-mentioned food, health products or pharmaceutical compositions in food, the health care for preparing treatment gastric ulcer
Purposes in product or drug.
The present composition has played synergistic function after each material matching use, can effectively treat stomach and burst
Ulcer, and each materials safety is nontoxic, and without other side effects, a kind of new selection is provided for clinical application.
Specific implementation mode
Embodiment 1：The preparation of Seabuckthorm Seed Oil soft capsule
With charging spoon by raw material according to weight percent：60 grams of Seabuckthorm Seed Oil, 12 grams of Boxthorn Seed Oil, 16 grams of oil of Nitraria seeds
It is stirred evenly for 4 grams with glycerine；The content being stirred pours into container, adds 50 DEG C~60 DEG C of 8 grams of gelatin solution, pressure
0.5g/ soft capsules are made, up to soft capsule of the invention after shady and cool, drying.
Embodiment 2：The preparation of Seabuckthorm Seed Oil soft capsule
With charging spoon by raw material according to weight percent：65 grams of Seabuckthorm Seed Oil, 10 grams of Boxthorn Seed Oil, 15 grams of oil of Nitraria seeds
It is stirred evenly for 3 grams with glycerine；The content being stirred pours into container, adds 50 DEG C~60 DEG C of 7 grams of gelatin solution, pressure
0.5g/ soft capsules are made, up to soft capsule of the invention after shady and cool, drying.
The commercially available marketable material of Seabuckthorm Seed Oil, Boxthorn Seed Oil and oil of Nitraria seeds, also can be used existing method in the present invention
It prepares.The Homemade method used in the above embodiment of the present invention is as follows：
Seabuckthorn seeds, matrimony vine seed are taken respectively or pierces seed in vain, using carbon dioxide supercritical extraction technology extraction seed oil, extract item
Part is as follows：Extracting pressure 45MPa, extraction temperature are 50 DEG C, CO2Flow is 35L/h, and separating pressure is set as 10MPa, separation temperature
Degree is set as 45 DEG C, and extraction time is 1.5 hours.
Beneficial effects of the present invention are proved below by way of specific experiment.
Test example 1：1 soft gel products urgency toxicity test of the embodiment of the present invention
Given the test agent：0.5g/ soft capsules made from the embodiment of the present invention 1.
Animal subject：Kunming kind healthy mice 20,20~25g of weight, half male and half female.
Experimental method：20 mouse are divided into 2 groups, every group 10；1st group of 1 soft capsule of feeding embodiment, the 2nd group of feeding
2 soft capsule of embodiment；Early daily, evening each feeding 10mg (oily accumulated dose), is spaced 8 hours；Continuous feeding 7 days.Using identical
Dosage.After administration, the general symptom of mouse, activity condition are observed, spirit observes and records mouse poisoning symptom；After 7 days
The whole mouse of dissection are put to death, whether there is or not lesions for observation main organs.
Experimental result：Two groups of experiment mices 100% are survived, and do not occur apparent toxic reaction；Mice organs after dissection
Without lesion.
Conclusion：Danger of the product without poisoning of the present invention.
Test example 2：1 soft gel products of the embodiment of the present invention treat gastric ulcer effect experiment
Animal subject：Kunming kind healthy mice, 20~25g of weight, half male and half female.
Experimental method：Using acetic acid inducing mouse gastric ulcer damage model, healthy Kun Ming mice 40, male and female are each
Half.4 groups are randomly divided into, every group 10, animal divides cage group rearing under identical conditions.First group be sham-operation group, second group be mould
Type group, third group are supercritical extract pure Seabuckthorm Seed Oil soft capsule treatment group (Seabuckthorm Seed Oil is identical as raw material of the present invention), the 4th
Group is 1 capsule for treating group of the embodiment of the present invention.Third group and the 4th group are in operation consent difference gastric infusion three days, every morning one
Secondary, dosage is 20mg (oily accumulated dose), first group and second group of gavage water supply.For 24 hours in operation consent fasting, 10% chloraldurate
Intraperitoneal injection of anesthesia, the longitudinally slit stomach wall about 2cm under xiphoid-process, exposure body of stomach, and lean on antrum side in paries anterior gastricus body sinus intersection
Serosal surface, the 3mm filter paper impregnated with 50% acetic acid overlay 50s, and then for 24 hours, 10% chloraldurate abdominal cavity is noted for operation consent fasting
Anesthesia is penetrated, the longitudinally slit stomach wall about 2cm under xiphoid-process, exposure body of stomach, and antrum side serosal surface is leaned in paries anterior gastricus body sinus intersection,
The 3mm filter paper impregnated with 50% acetic acid overlays 50s, then by stomach receptosome, puts back to original position, layer-by-layer suture.After operation
Three groups and the 4th group of difference gastric infusion 15 days, every morning is primary, first group and second group of gavage water supply.Last time gavage
Stomach is taken out in dissection in 1 hour afterwards, is fixed with 10% formaldehyde and splits stomach along greater curvature after ten minutes, open and flat on glass, measures
Ulcer spot longest diameter and most short diameter, using longest diameter and most short diameter average value is as ulcer index.Each group uses phase
Same dosage.
Experimental result：Ulcer index the results are shown in Table 1.Data analysing method：Data are indicated with average value.
Table 1：1 sample of the embodiment of the present invention and the individually influence with Seabuckthorm Seed Oil to acetic acid induced mice ulcer index
Conclusion：The ulcer index of the 1st group (sham-operation group) is 0.12 ± 0.12；The ulcer index of the 2nd group (model group) is
10.40±0.63；The ulcer index of the 3rd group (independent Seabuckthorn Oil) is 5.87 ± 0.59；4th group (1 product of the present embodiment) bursts
Ulcer index is 2.23 ± 0.42.Pass through the comparison of above-mentioned ulcer index, it can be deduced that：Third group is burst with certain treatment stomach
Ulcer effect, and 1 product of the embodiment of the present invention has effects that stronger protection stomach Transmucosal Membrane Treatment gastric ulcer, illustrates its composition
Components compatibility is precise and appropriate, has played synergistic function.
Test example 3：1 soft gel products of the embodiment of the present invention treat the clinical trial effect of gastric ulcer
Gastric Ulcer standard：Upper abdomen secret anguish, dull pain burn sample pain, alleviate after taking alkaline drug, such pain tool
Have rhythmicity, mostly occur in postprandial 1 hour, gradually alleviate after 1~2 hour, generally there is also sour regurgitation, belch, it is heartburn,
The indigestion symptoms such as Abdeminal pain, Nausea and vomiting；The visible niche of upper digestive tract radiography；Endoscopy, can in stomach see circle or
It is oval, bottom is smooth, neat in edge ulcer, ulcer surface is that greyish white or brown tongue film covers, edge swelling, and color and luster is ruddy, light
It is sliding and soft (i.e. gastric ulcer activity time).Accept 30 for medical treatment altogether, endoscopy is confirmed as gastric ulcer.
Criterion of cure：Upper abdomen pain disappears, endoscopy, it is seen that ulcer colourless tongue has disappeared, and becomes red hyperemia
Scar, it is seen that pleat concentrates (i.e. cicatricial phase).
Effective standard：Upper abdomen pain disappears or alleviates, and endoscopy, tongue film is thinning, and ulcer reduces, around it is visible viscous
The blush of film epithelium regeneration；Or stain ulcer face almost disappears, and has few thin tongue (i.e. healing stage) thereon.
Therapy：1 product soft capsule of Example is taken for 2 times, 2 tablets each time per bu.
Therapeutic effect：It continuously takes medicine, treats 20~30 days by therapy, cure 30, account for the 100% of total case.
Model case 1
Hair certain, man, 52 years old because work it is more busy, diet is irregular and often stays up late.Find that upper abdomen has after the meal afterwards
Pain, and with indigestion symptoms such as glutted, Nausea and vomitings, have a meal after without happiness, weight loss.Through gastrocopy, confirm
For gastric ulcer.
After taking medicine 7 days by 3 method of test example, this disappearance of epigastric pain sensillary base, feeling of repletion, belch phenomenon are alleviated, after 15 days, meal
Amount has restored suitable with normal epoch, and after 25 days, through gastrocopy, stomach ulcer face has been healed, and feels that appetite, stomach are felt
Well, weight is gone up, and constitution is also enhanced.
4 present composition of test example is compared with the drug activity of existing product
The preparation method of contrast groups A drugs is as follows：
Using soft capsule technology of preparing, Seabuckthorm Seed Oil is wrapped up, be pressed into 0.5g/ soft capsules to get to pair
Than a group A medicinal soft capsules.
The preparation method of contrast groups B drugs is as follows：
Ginger to be shredded, is placed in supercritical carbon dioxide extraction equipment, extracting pressure 45MPa, extraction temperature is 50 DEG C,
CO2 flows are 35L/h, and separating pressure is set as 10MPa, and separation temperature is set as 45 DEG C, and extraction time is 1.5 hours.It obtains
Oil of ginger.Obtained oil of ginger is stood and is filtered, by weight Seabuckthorm Seed Oil: oil of ginger=60: 40, it is uniformly mixed, use is soft
Capsule technology of preparing, Seabuckthorm Seed Oil and oil of ginger are wrapped up, and are pressed into 0.5g/ soft capsules to get to contrast groups B medicines
Composition soft capsule.
The preparation method of contrast groups C drugs is as follows：
After commercially available propolis is crushed, 70% ethyl alcohol of 6~10 times of weight is added, at 60~80 DEG C, extraction 1~3 time, often
Secondary 1~2 hour, filtering was to get filtrate after merging extracting solution.It is 1.30~1.33 that filtrate decompression, which is concentrated in vacuo to relative density,
Thick paste, it is thick paste is dry, be ground into 120 mesh fine powders, obtain propolis extract dry powder.By propolis extract dry powder and Seabuckthorm Seed Oil
By weight Seabuckthorm Seed Oil: propolis extract dry powder=60: 40, it uniformly mixes, using soft capsule technology of preparing, by Seabuckthorm Seed Oil
It is wrapped up with propolis extract dry powder, is pressed into 0.5g/ soft capsules to get to contrast groups C medicinal soft capsules.
Gastric Ulcer standard：Upper abdomen secret anguish, dull pain burn sample pain, alleviate after taking alkaline drug, such pain tool
Have rhythmicity, mostly occur in postprandial 1 hour, gradually alleviate after 1~2 hour, generally there is also sour regurgitation, belch, it is heartburn,
The indigestion symptoms such as Abdeminal pain, Nausea and vomiting；The visible niche of upper digestive tract radiography；Endoscopy, can in stomach see circle or
It is oval, bottom is smooth, neat in edge ulcer, ulcer surface is that greyish white or brown tongue film covers, edge swelling, and color and luster is ruddy, light
It is sliding and soft (i.e. gastric ulcer activity time).
Criterion of cure：Upper abdomen pain disappears, endoscopy, it is seen that ulcer colourless tongue has disappeared, and becomes red hyperemia
Scar, it is seen that pleat concentrates (i.e. cicatricial phase).
Effective standard：Upper abdomen pain disappears or alleviates, and endoscopy, tongue film is thinning, and ulcer reduces, around it is visible viscous
The blush of film epithelium regeneration；Or ulcer surface almost disappears, and has few thin tongue (i.e. healing stage) thereon.
Test method：Choose 120 has the patient of stomach ulcer to carry out clinical test after diagnosing.By sex ratio 1: 1, put down
Four groups are divided into, every group of 30 people.First group is taken contrast groups A medicinal soft capsules；Second group is taken contrast groups B medicinal soft capsules；
Third group takes contrast groups C medicinal soft capsules；4th group is taken 1 soft gel products of embodiment.By 3 method of test example medication 15
It, uses identical medication dose.Experimental result is shown in Table 2.
Conclusion：The experimental results showed that individually take Seabuckthorm Seed Oil has certain curative effect to treatment gastric ulcer, but it is used alone
The effect of Seabuckthorm Seed Oil is to treatment gastric ulcer is relatively limited, it is too late with other active ingredients with the use of the effect of capable of playing,
Such as arrange in pairs or groups with propolis, oil of ginger.But from analysis of experimental data it can be found that 1 product of the embodiment of the present invention has best treatment
The effect of gastric ulcer, cure rate are up to 90.0%.That is the collocation use of Seabuckthorm Seed Oil, Boxthorn Seed Oil and oil of Nitraria seeds is far above
The effect and curative effect that Seabuckthorm Seed Oil and propolis, oil of ginger collocation can play in terms for the treatment of stomach ulcer, illustrate its composition
Components compatibility is precise and appropriate, and each component has played synergistic function, and each materials safety is nontoxic, without other side effects, for clinic
Medication provides a kind of new selection.
Claims (10)
1. a kind of health products or pharmaceutical composition for treating gastric ulcer, it is characterised in that：Its raw material by following weight proportion group
It is grouped as：
60~75 parts of Seabuckthorm Seed Oil, 10~15 parts of Boxthorn Seed Oil, 15~20 parts of oil of Nitraria seeds.
2. health products according to claim 1 or pharmaceutical composition, it is characterised in that：Its raw material is by following weight proportion
Group is grouped as：
60 parts of Seabuckthorm Seed Oil, 12 parts of Boxthorn Seed Oil, 16 parts of oil of Nitraria seeds.
3. health products according to claim 1 or 2 or pharmaceutical composition, it is characterised in that：Seabuckthorm Seed Oil is by the following method
It is prepared：Seabuckthorn seeds are crushed, are placed in supercritical carbon dioxide extraction equipment, extracting pressure is 25~45MPa, extraction temperature
Degree is 40~55 DEG C, CO2Flow is 20~35L/h, and separating pressure is set as 8~12MPa, and separation temperature is set as 45~60
DEG C, extraction time is 0.5~2.0 hour to get Seabuckthorm Seed Oil.
4. health products according to claim 1 or 2 or pharmaceutical composition, it is characterised in that：Boxthorn Seed Oil is by the following method
It is prepared：It after matrimony vine seed drying and crushing, is placed in supercritical carbon dioxide extraction equipment, extracting pressure is 25~45MPa, extraction
It is 40~55 DEG C to take temperature, CO2Flow is 20~35L/h, and separating pressure is set as 8~12MPa, separation temperature is set as 45~
60 DEG C, extraction time is 0.5~2.0 hour to get Boxthorn Seed Oil.
5. health products according to claim 1 or 2 or pharmaceutical composition, it is characterised in that：Oil of Nitraria seeds is by the following method
It is prepared：It is placed in supercritical extraction unit after dry white thorn seed is crushed and uses CO2It is extracted, extracting pressure 15
~45MPa, extraction temperature are 40~55 DEG C, CO2Flow is 20~35L/h, and separating pressure is set as 8~12MPa, separation temperature
It is set as 45~60 DEG C, extraction time is 0.5~2.0 hour to get oil of Nitraria seeds.
6. health products according to claim 1 or 2 or pharmaceutical composition, it is characterised in that：The composition is by raw material
The oral preparation being prepared after medicine mixing.
7. health products according to claim 6 or pharmaceutical composition, it is characterised in that：The oral preparation is soft capsule
Agent.
8. health products according to claim 7 or pharmaceutical composition, it is characterised in that：The soft capsule is by following weight
The component of proportioning is prepared：
60~75 parts of Seabuckthorm Seed Oil, 10~15 parts of Boxthorn Seed Oil, 15~20 parts of oil of Nitraria seeds, 2~5 parts of glycerine and gelatin 5~15
Part.
9. the preparation method of health products or pharmaceutical composition described in claim 8, it is characterised in that：It includes that following operation walks
Suddenly：
（1）Each component is taken according to the ratio；
（2）It takes each component outside gelatin to be uniformly mixed, gelatin is heated to mixing species are added after melting, suppresses soft capsule, i.e.,
.
10. health products or pharmaceutical composition described in claim 1 ~ 8 any one are in the health products or medicine for preparing treatment gastric ulcer
Purposes in product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410542518.8A CN104306554B (en) | 2014-09-29 | 2014-09-29 | A kind of food, health products or pharmaceutical composition for treating gastric ulcer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410542518.8A CN104306554B (en) | 2014-09-29 | 2014-09-29 | A kind of food, health products or pharmaceutical composition for treating gastric ulcer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104306554A CN104306554A (en) | 2015-01-28 |
| CN104306554B true CN104306554B (en) | 2018-07-27 |
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| CN201410542518.8A Active CN104306554B (en) | 2014-09-29 | 2014-09-29 | A kind of food, health products or pharmaceutical composition for treating gastric ulcer |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108432885A (en) * | 2018-01-24 | 2018-08-24 | 中国科学院西北高原生物研究所 | A kind of composition containing hippophae rhamnoides fruit oil |
| CN108142587A (en) * | 2018-01-24 | 2018-06-12 | 青海大学 | A kind of composition containing Seabuckthorm Seed Oil |
| CN112251286B (en) * | 2020-11-17 | 2021-05-28 | 江苏鸿祺生物科技有限公司 | Sea-buckthorn seed oil and extraction process thereof |
| CN115462528A (en) * | 2022-08-31 | 2022-12-13 | 中南大学湘雅三医院 | Natural food composition and its application |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089301A (en) * | 1993-04-24 | 1994-07-13 | 商业部西安油脂科学研究所 | The preparation method of Seabuckthorm Seed Oil |
| CN100998406A (en) * | 2006-12-18 | 2007-07-18 | 东北虎药业股份有限公司 | Health-care food with functions of improving immunocompetence and protecting damaged gastric mucosa and its preparing method |
| CN102397524A (en) * | 2011-11-29 | 2012-04-04 | 宝健（中国）日用品有限公司 | Composition for protecting gastric mucosa, nourishing stomach and protecting stomach and preparation method thereof |
| CN103211761A (en) * | 2013-04-07 | 2013-07-24 | 史小军 | Seabuckthorn seed oil oral emulsion with gastric mucosa protective effect and preparation method and use thereof |
| CN103431377A (en) * | 2013-07-17 | 2013-12-11 | 苟春虎 | Foodstuff capable of reducing blood pressure and preventing complications |
-
2014
- 2014-09-29 CN CN201410542518.8A patent/CN104306554B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089301A (en) * | 1993-04-24 | 1994-07-13 | 商业部西安油脂科学研究所 | The preparation method of Seabuckthorm Seed Oil |
| CN100998406A (en) * | 2006-12-18 | 2007-07-18 | 东北虎药业股份有限公司 | Health-care food with functions of improving immunocompetence and protecting damaged gastric mucosa and its preparing method |
| CN102397524A (en) * | 2011-11-29 | 2012-04-04 | 宝健（中国）日用品有限公司 | Composition for protecting gastric mucosa, nourishing stomach and protecting stomach and preparation method thereof |
| CN103211761A (en) * | 2013-04-07 | 2013-07-24 | 史小军 | Seabuckthorn seed oil oral emulsion with gastric mucosa protective effect and preparation method and use thereof |
| CN103431377A (en) * | 2013-07-17 | 2013-12-11 | 苟春虎 | Foodstuff capable of reducing blood pressure and preventing complications |
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| CN104306554A (en) | 2015-01-28 |
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