RU2333764C1 - Medicine for treatment and prevention of thyroid gland diseases - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention concerns chemical pharmaceutical industry, particularly production of herbal-originating medicines applied in endocrinology. The medicine for prevention and treatment of thyroid gland diseases includes roots and rhizomes of cinquefoil (Potentila alba L.), herb of bur beggar-ticks (Bidens tripartite L.) and roots of common licorice (Glycyrhiza glabra L.). The medicine can be made in the form of water infusion, ethanolic extraction and dry extracts, as well as capsules with 500.0 mg of dry components.

EFFECT: obtaining a medicine facilitating resorption of small palpable node abnormalities in thyroid gland, normalisation of pressure, tachycardia, body weight stabilisation and improvement of hormone hemogram.

3 cl, 4 ex

Description

The invention relates to the pharmaceutical industry, in particular to herbal products for the prevention and treatment of thyroid diseases.

The known pharmacological preparations traditionally used to treat thyroid diseases are thyroid hormone preparations (thyroidin, triiodothyronine) (1,3), antithyroid drugs (mercazolyl) (1,3), and preparations containing iodine (2,3).

However, they have a number of adverse side effects on the body. Thyroidin and triiodothyronine are contraindicated in thyrotoxicosis, diabetes mellitus, coronary heart disease;

merkazolil can cause the development of leukopenia and granulocytopenia, is contraindicated in pregnancy and the presence of nodes in the gland; iodine preparations are contraindicated in pregnancy, kidney disease, allergic diseases, thyroid neoplasms. The disadvantages of surgical removal of the thyroid gland are:

lifelong hormone replacement therapy, the development of a state of hypothyroidism, high risks of damage to the parathyroid gland during the operation.

Known collection for the restoration of thyroid function, containing rice, celandine roots, plantain and thuja with the following mass ratios of components: 3: 0.8: 1: 2.

This collection can be applied in the form of water infusion, tablets and capsules (RF patent No. 2129005).

A disadvantage of the known collection is:

1. a narrow spectrum of therapeutic activity, 2. multicomponent composition, in which some components are active, while others are taken as the basis, 3. the complexity of preparing the collection.

The objective of the present invention is to provide a herbal remedy that effectively removes the effects of thyrotoxicosis, does not show side effects and, in addition, leads the thyroid gland to an euthyroid state.

This problem is solved as follows.

A tool is proposed for the prevention and treatment of diseases of the thyroid gland, the roots and rhizomes of the white cinquefoil (Potentilla alba L.), grass of a series of trifid (Bidens tripartita L.) and licorice roots (Glycyrrhiza glabra L.) with the following components in parts:

Cinquefoil white Potentilla alba L. - 3

Three-part succession Bidens tripartita L. - 2

Licorice Glycyrrhiza glabra L. - 1

The tool can be made in the form of water infusion, alcohol extraction and dry extracts, and, in addition, the tool can be made in the form of capsules containing dry extracts in an amount of 500.0 mg.

The tool is prepared by grinding the roots and rhizomes of the white cinquefoil, the roots of licorice and grass of a succession to a particle size of 1-2 mm.

The components are mixed in the ratios indicated above to a homogeneous state.

The final product is the sum of biologically active substances in the form of an amorphous brown powder.

In the process of research it was found that the use of collection in the form of infusion, alcohol extraction and a mixture of dry extracts in different doses causes an improvement in conditions of the thyroid gland.

According to the claimed invention, for the use of capsule collection, one capsule contains 500.0 mg of the final product in the form of a dry concentrate. It is recommended to use capsules of 1-2 pcs, 2-3 times a day before meals.

Since 2005, the invention has been tested on 32 volunteers with thyroid disease. All treatment was advisory. With the consent to treatment, various therapeutic regimens were selected that were optimal for a particular patient. In order to avoid uncontrolled effects and ensure the reliability of treatment effectiveness, the cancellation of any chemotherapy was recommended.

Gender and age groups. There are 28 women, men 4. Up to 20 years - 4 people, from 21 to 30 years - 4, from 31 to 40 - 7, from 41 to 50 - 9, from 51 to 65 - 8.

According to the results of the examination by an endocrinologist, 3 patients were diagnosed with hypothyroidism (primary), 12 hyperthyroidism (Bazedov-Graves disease, toxic nodular goiter), 8 eutheroid goiter (nodular and multinodular), 9 autoimmune thyroiditis (Hashimoto's thyroiditis).

In 4 people, the disease was diagnosed for the first time, the duration of the disease up to a year was noted in 13, more than a year - in 15 patients.

Many patients had pronounced clinical symptoms characteristic of these endocrinopathies.

When selecting a course and treatment regimen, the presence of concomitant diseases was taken into account.

It was found that alcohol tincture and dry collection extract possess the greatest breadth and therapeutic activity, but in some cases, due to known shortcomings, it was decided to abandon the use of alcohol tincture.

The results of the studies showed that the use of the dry extract of the collection effectively and reliably removed the phenomenon of thyrotoxicosis, did not cause adverse reactions and led the thyroid gland to an euthyroid state.

All patients subsequently, in order to prevent relapse, periodically conducted a second course of treatment. Relapse of the disease was not observed in patients, in connection with which it was concluded that the agent for the prevention of thyroid disease was highly effective.

To achieve the maximum therapeutic effect (especially with hypothyroidism and euthyroid goiter), a special diet was recommended for patients, which consisted of eating foods rich in organic iodine: sea kale (kelp), sea fish (cod, hake), squid, shrimp, persimmon, walnuts etc.

The invention is illustrated by the following examples:

Example No. 1

Patient N., born in 1957

At the beginning of treatment: FT ₃ 4.45; FT ₄ 15.33; TSH 5.37; Etc. 8.41; Knot D 4 mm; L.d. 8.67; Knot D 11 mm; V _sum 17.08; Per. 4.0

After the first course of treatment: FT ₃ 5.1; FT4 16.4; TSH 3.19; Etc. 8.5; L.d. 6.3; Node 0.9 · 0.7 cm; V _sum 14.8; Per. 5.0.

During the first course of treatment, the patient took a collection in the form of a dry extract of 2-3 capsules per day for 3 months. At the moment, the patient is undergoing a second course of treatment.

Example No. 2

Patient Yu., 1981

Diagnosis: Graves disease, moderate thyrotoxicosis.

At the beginning of treatment: FT ₃ 18.8; FT ₄ 3.6; TSH 0.23; Etc. 5.0 * 1.7 * 2.4; L.d. 4.5 · 1.8 · 2.1; V _sum -; Per.-.

After the first course of treatment: FT ₃ 6.9; FT ₄ 14.2; TSH 3.84; Ultrasound was not performed.

After the first course of treatment (took a collection in the form of alcohol extraction of 2-3 tablespoons per day), the patient was transferred to combination therapy. At the moment, after establishing a stable state of euthyroidism, as a prophylaxis, it receives a maintenance dosage.

Example No. 3

Patient D., born in 1970

Diagnosis: primary hypothyroidism. Sick for more than 2 years.

At the start of treatment: FT ₃ 5.1; FT ₄ 12.0; TSH 8.6; Anti-Tg 2033; Anti-TPO 515; Etc. 6.0 * 1.7 * 1.4; L.d. 5.3 · 1.6 · 1.3; V _sum 12.1; Per. 0.3.

After the first course of treatment: FT ₃ 4.9; FT ₄ 14.0; TSH 5.2; Anti-Tg 356; Anti-TPO 98; Ultrasound was not performed.

After the second course of treatment: FT ₃ 4.8; FT ₄ 13.7; TSH 4.1; Anti-Tg 46.4; Anti-TPO 36.5; Etc. 5.2 · 1.9 · 1.1; L.d. 5.1 * 1.7 * 1.2; V _sum 10.2; Per. 0.3.

During the first course of treatment, the patient took a collection in the form of a dry extract of 2-3 capsules per day for 2 months.

During the second course of treatment, the patient took a collection in the form of a dry extract of 1 capsule per day for 3 months.

At the moment, after establishing a stable state of euthyroidism, as a prophylaxis, it receives a maintenance dosage.

Example No. 4

Patient L., born 1988

Diagnosis: nodular microfollicular goiter with hemorrhage. It was aimed at thyroidectomy, which was abandoned. Sick for more than 3 years.

At the start of treatment: FT ₃ 4.85; FT ₄ 0.54; TSH 0.784; Etc. 6.2 V _green 24.5 · 11 · 16; L.d. 3.5; V _sum 9.7; Per. 2.4.

After the first course of treatment: FT ₃ 6,2; FT ₄ 13.6; TSH 0.894; Etc. 7.2 Node 23 · 10 · 16; L.d. 3.2; V _sum 10.4; Per. 3.0.

After the second course of treatment: FT ₃ 4.8; FT ₄ 12.8; TSH 0.610; Etc. 5.1 Node 20 · 10 · 15; L.d. 2.3; V _sum 7.4; Per. 3.0.

After the third course of treatment: FT ₃ 4.6; FT ₄ 12.3; TSH 0.978; Etc. 5.5 Knot 17 · 9 · 13; L.d. 2.4; V _sum 7.9; Per. 2.9.

All three courses of treatment had a duration of 3 months each. During the first course of treatment, the patient took a collection in the form of a dry extract of 6 capsules per day, then 3 capsules per day.

Currently undergoing 4 courses of treatment.

Studies have shown that the drug has a positive therapeutic effect in the treatment of thyroid diseases. As a result of the treatment, all patients noted a subjective improvement in well-being. Their irritability decreased, their sleep improved, their hand tremors disappeared. Objectively, it was found that after 1-2 courses of treatment the thyroid gland decreased in size, small nodular formations resolved, the hormonal blood picture, tachycardia normalized, blood pressure normalized, and stabilization of body weight was observed in patients.

Information sources

1. Mashkovsky M.D. Medicines In two parts. Part I. - 12th ed., Revised. and add. - M .: Medicine, 1998, p. 544-548.

2. Mashkovsky M.D. Medicines In two parts. Part II. - 12th ed., Revised. and add. - M .: Medicine, 1998, p.129-133.

3. Kukes V.G. Clinical Pharmacology: Uch. - 2nd ed., Revised. and add. - M: GEOTAR MEDICINE, 1999, pp. 404-406.

Claims (3)

1. An agent for the prevention and treatment of thyroid diseases based on plant materials, characterized in that it contains the roots and rhizomes of the white cinquefoil (Potentila alba L.), grass of the tripartite series (Bidens tripartite L.) and licorice roots (Glycyrhiza glabra b.) In the following components, including: roots and rhizomes of a white cinquefoil (Potentila alba L.) 3 grass of a series of tripartite (Bidens tripartite L.) 2 licorice roots (Glycyrhiza glabra L.) one. 2. The tool according to claim 1 can be made in the form of water infusion, alcohol extraction and dry extracts. 3. The tool according to claim 2 is made in the form of capsules containing dry extracts in an amount of 500.0 mg.