RU2351354C1 - Medication for treatment and prevention of thyroid gland diseases - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to chemical-pharmaceutical industry, namely to creation of herbal preparations for treatment and prevention of thyroid gland diseases. Herbal preparation for treatment and prevention of thyroid gland diseases represents mixture, consisting of white cinquefoil, liquorice, Herba Bidentis and thallus of sugar wrack with the following component ratio -20:5:8:7 respectively, it contains roots and rhizomes of white cinquefoil, or land part of white cinquefoil, or their mixture and can be made in form of crushed herbal powder, water-alcohol tinctures, liquid or dry extracts.

EFFECT: preparation has wide spectrum of therapeutic influence, it is used for treatment and prevention of thyroid gland diseases, including hypothyroidism, hyperthyroidism (Graves' disease, toxic nodular goiter), euthyroid goiter, autoimmune thyroiditis.

3 cl

Description

The invention relates to the chemical and pharmaceutical industry, namely to the creation of herbal products for the treatment and prevention of thyroid diseases.

The known pharmacological preparations traditionally used to treat thyroid diseases are thyroid hormone preparations (thyroidin, triiodothyronine) (1,3), antithyroid drugs (mercazolyl) (1,3), and preparations containing iodine (2,3). However, they all have a number of negative side effects on the body. Thyroidin and triiodothyronine are contraindicated in thyrotoxicosis, diabetes mellitus, coronary heart disease; merkazolil can cause the development of leukopenia and granulocytopenia, is contraindicated in pregnancy and the presence of nodes in the gland; iodine preparations are contraindicated in pregnancy, kidney disease, allergic diseases, thyroid neoplasms.

The disadvantages of surgical removal of the thyroid gland are: lifelong hormone replacement therapy, the development of hypothyroidism, high risks of damage to the parathyroid gland during surgery.

The problem to which the invention is directed, is to create a safe herbal remedy that does not have negative side effects. The inventive tool has a wide range of actions and is aimed at the treatment and prevention of the following diseases: hypothyroidism, hyperthyroidism (Bazedov-Graves disease, nodular toxic goiter), euthyroid goiter, autoimmune thyroiditis.

The problem was solved by creating a collection consisting of white cinquefoil, licorice root, grass of a series of tripartite and thallus sugary kelp, with the following ratio of components - 20: 5: 8: 7, respectively. In preparing the collection, the roots and rhizomes of the white cinquefoil or the terrestrial part of the white cinquefoil, or a mixture thereof were used. The collection was made in the form of crushed vegetable powder, water-alcohol tinctures, liquid and dry extracts.

The collection is prepared as follows.

The roots and rhizomes of the cinquefoil and licorice root are crushed to a particle size of 1-2 mm. The grass of the succession and thallus of kelp is crushed into powder with a particle size of 1-2 mm. The components are mixed in the proportions indicated in the claims to a homogeneous state. The final product is the sum of biologically active substances in the form of an amorphous brown powder. The yield of the final product is 90-95% of the amount of feedstock.

Instead of sugar kelp, the use of other seaweed is allowed.

In the process of research it was found that the use of collection in the form of infusion, alcohol extraction and a mixture of dry extracts in different doses causes an improvement in the condition of the thyroid gland diseases. Infusions and decoctions are made according to classic pharmaceutical prescriptions. For the preparation of water-alcohol tinctures, liquid, thick and dry extracts, 40% ethyl alcohol is used.

Dry extracts are obtained according to the technology known in the pharmaceutical industry — countercurrent extraction followed by drying on a spray dryer.

According to the claimed invention, for use in capsule form, one capsule contains 400.0 mg of the final product as a mixture of dry extracts. It is recommended to use capsules of 1-2 pcs. 2-3 times a day before meals for 40 days.

When using the product in the form of an alcohol-based tincture, the course of treatment is 40 days. To do this, tincture should be taken 1 tablespoon 2-3 times a day before meals.

The inventive tool as a water-alcohol tincture was tested on 12 patients suffering from diseases of the thyroid gland (hypothyroidism, hyperthyroidism, euthyroid goiter, autoimmune thyroiditis) of varying severity. In all patients, after a two-month course of administration, the weakening of clinical symptoms or their complete elimination, improvement of the hormonal picture of the blood, and improvement of general well-being were noted.

Case History Examples

Patient N., born in 1957

Diagnosis: multinodular euthyroid goiter. Sick for more than 4 years.

At the beginning of treatment FT3 4.45
FT4 15.33
TSH 5.37 Etc. 8.41 Knot D 4 mm
L.d. 8.67 Knot D 11 mm
Vsum 17.08
Per. 4.0 After the first course of treatment FT ₃ 5.1
FT ₄ 16.4
TSH 3.19 Etc. 8.5
L.d. 6.3 Knot 0.9 × 0.7 cm
V _sum 14.8
Per. 5,0

At the moment, the patient is undergoing a second course of treatment.

Patient Yu., 1981

Diagnosis: Graves disease, moderate thyrotoxicosis

At the beginning of treatment FT ₃ 18.8
FT ₄ 3.6
TSH 0.23 Etc. 5.0 × 1.7 × 2.4
L.d. 4.5 × 1.8 × 2.1
V _sum -
Per.- After the first course of treatment FT ₃ 6.9
FT ₄ 14.2
TSH 3.84 No ultrasound scan

After the first course of treatment, the patient was transferred to combination therapy. At the moment, after establishing a stable state of euthyroidism, he receives a maintenance dosage as a prophylaxis.

In 16 patients with thyroid disorders, the agent was tested in the form of a mixture of dry extracts of cinquefoil, licorice, a series of tripartite and sugary kelp. Improving well-being, normalizing the hormonal balance of the blood, the disappearance of clinical symptoms was observed after the first month of using the drug.

Case History Examples

Patient D., born in 1970

Diagnosis: primary hypothyroidism. Sick for more than 2 years.

At the beginning of treatment FT ₃ 5.1
FT ₄ 12.0
TSH 8.6
Anti-Tg 2033
Anti-TPO 515 Etc. 6.0 × 1.7 × 1.4
L.d. 5.3 × 1.6 × 1.3
V _sum 12.1
Per. 0.3 After the first course of treatment FT ₃ 4.9
FT ₄ 14.0
TSH 5.2
Anti-Tg 356
Anti-TPO 98 No ultrasound scan After the second course of treatment FT ₃ 4.8
FT ₄ 13.7
TSH 4.1
Anti-Tg 46.4
Anti-TPO 36.5 Etc. 5.2 × 1.9 × 1.1
L.d. 5.1 × 1.7 × 1.2
V _sum 10.2
Per. 0.3

At the moment, after establishing a stable state of euthyroidism, he receives a maintenance dosage as a prophylaxis.

Patient L., born 1988

Diagnosis: nodular microfollicular goiter with hemorrhage. It was aimed at thyroidectomy, which was abandoned. Sick for more than 3 years.

At the beginning of treatment FT3 4.85
FT4 0.54
TSH 0.784 Etc. 6.2 Node 24.5 × 11 × 16
L.d. 3,5
V _sum 9.7
Per. 2,4 After the first course of treatment FT3 6.2
FT4 13.6
TSH 0.894 Etc. 7.2 Node 23 × 10 × 16
L.d. 3.2
V _sum 10.4
Per. 3.0 After the second course of treatment FT3 4.8
FT4 12.8
TSH 0.610 Etc. 5.1 Node 20 × 10 × 15
L.d. 2,3
V _sum 7.4
Per. 3.0 After the third course of treatment FT3 4.6
FT4 12.3
TSH 0.978 Etc. 5.5 Node 17 × 9 × 13
L.d. 2,4
V _sum 7.9
Per. 2.9

Currently undergoing 4 courses of treatment.

In the course of clinical trials, it was proved that the developed tool has a positive therapeutic effect in the treatment of thyroid diseases. As a result of the treatment, all patients noted a subjective improvement in well-being. Their irritability decreased, their sleep improved, their hand tremors disappeared. Objectively, it was found that after 1-2 courses of treatment the thyroid gland decreased in size, small nodular formations resolved, the hormonal blood picture, tachycardia normalized, blood pressure normalized, and stabilization of body weight was observed in patients.

Thus, cinquefoil in combination with plant components such as licorice, a series of tripartite and sugary kelp can be used as an effective tool for the treatment and prevention of thyroid diseases.

The combination of the components of the collection in these ratios creates synergy due to the biochemical characteristics of each of the plants. Studies show that the presence of a white sum of phenolic compounds in the cinquefoil returns the thyroid gland to an eutheroid state. Licorice due to glycyrrhizic acids restores the hormonal imbalance of the body. Polyphenolic compounds (flavonoids and flavonoid glycosides, tannins), contained in a three-part sequence, have immunomodulating activity and allow to achieve the maximum therapeutic effect with nodular goiter and autoimmune thyroiditis. Due to the presence of a wide range of macro- and microelements of kelp, saccharine normalizes biochemical processes in the thyroid gland.

Information sources

1. Mashkovsky M.D. Medicines In two parts. Part I. - 12th ed., Revised. and add. - M .: Medicine, 1998, p. 544-548.

2. Mashkovsky M.D. Medicines In two parts. Part II. - 12th ed., Revised. and add. - M .: Medicine, 1998, p.129-133.

3. Kukes V.G. Clinical Pharmacology: Uch. - 2nd ed., Revised. and add. - M: GEOTAR MEDICINE, 1999, pp. 404-406.

Claims (3)

1. An agent for the treatment and prevention of thyroid diseases, which is a collection consisting of white cinquefoil, licorice roots, three-part grass and thallus sugary thalli, with the following ratio of components - 20: 5: 8: 7, respectively. 2. The tool according to claim 1 contains the roots and rhizomes of a white cinquefoil or the terrestrial part of a white cinquefoil, or a mixture thereof. 3. The tool according to claim 1 or 2 is made in the form of crushed vegetable powder, water-alcohol tinctures, liquid and dry extracts.