JP2005325025A - Diabetes-preventing/treating composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a diabetes-preventing/treating agent capable of lowering blood glucose and hemoglobin A1c (HbA1c) levels in the blood simply and safely. <P>SOLUTION: This composition comprising a galenical components containing Commiphora mukul, Glycyrrhiza glabra, Momordica charantia, Gymunema sylvestre, Boerhavia diffusa, Tinospora cordifolia, Phyllanthus emblica, Curcuma longa and Azardichta indica, and a mineral component shows a small load to internal organs and a high safety, has an activity to lower the blood glucose and HbA1c levels of diabetes patients and exhibits excellent preventing and treating effects on diabetes. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a composition for preventing and treating diabetes, which is a composition comprising herbs and mineral components, and which can be expected to reduce blood sugar levels and blood hemoglobin levels.

  Diabetes is a metabolic disease in which blood sugar level rises as a result of a decrease in glucose utilization rate in blood due to insufficient amount of insulin that helps to take glucose in blood into cells, or insufficient action. Insulin-dependent type 1 diabetes and non-insulin-dependent type 2 diabetes. Furthermore, type 2 diabetes is classified into those with impaired insulin secretion, those with impaired insulin action (insulin resistance), and those with both disorders.

  Type 1 diabetes often develops relatively rapidly, mainly in infants and younger than 15 years of age, and was once called “young diabetes”. In this type of diabetes, pancreatic β-cells are destroyed due to viral infection, autoimmunity, etc., resulting in a decrease in insulin secretion ability. As a result, it is difficult to use glucose in the body. It develops.

  Type 2 diabetes often develops after adulthood and occurs when insulin secretion is reduced or insulin's blood glucose lowering action is weakened. In addition to genetic predisposition, excessive intake of energy It develops due to lifestyle factors such as dietary lifestyle, nutritional deficiencies, lack of exercise, smoking, and stress.

  For the treatment of diabetes, it is necessary to lower the hemoglobin A1c (HbA1c) value as well as lower the blood glucose level.

  This hemoglobin A1c (HbA1c) value is not affected by physiological factors compared to blood glucose level and urine glucose level, and accurately reflects the average blood glucose level of the past 1-3 months. It can be a more important guideline as a standard.

  Treatment methods for diabetes include exercise therapy, food therapy, and pharmacotherapy. Depending on the type of diabetes, pharmacotherapy includes insulin preparations, sulfonylureas that are oral hypoglycemic agents, and biguanides. Agents, thiazolidine derivatives, α-glucosidase inhibitors, phenylalanine derivatives and the like are used.

  In addition, it is known that some herbal medicines have an action to lower blood sugar and have an excellent effect on diabetes, and these materials are superior by using a combination of multiple materials. It is known that it can be effective. For example, the following Patent Document 1 discloses a therapeutic drug for diabetes mainly composed of plant human beech, plant Mexican sunflower, plant kidney chicken, or plant clove.

  Patent Document 2 below describes 15 kinds of herbal ingredients, namely carrots, yellow reams, sadako, water husks, large yellows, acquaintances, red ginsengs, ginsengs, ground bones, tiger canes, bellflowers, kibana. An anti-diabetic composition comprising plant herbal medicines such as ogi, kudzu root, strawberry mulberry, and mulberry peel, vitamins B1 and B6, and inorganic substances such as zinc, manganese, chromium and germanium are disclosed.

  Patent Document 3 below discloses a therapeutic agent for diabetes containing a mixture of herbal medicines and / or extract extracts composed of mah, licorice and gypsum as active ingredients.

Further, Patent Document 4 below discloses a composition for preventing and treating diabetes comprising a mineral component, brewer's yeast chromium, mulberry leaf extract, and gymnema extract.
JP 08-127538 A JP 2002-226389 JP2003-81860 JP 2002-332236 A

  Drugs used in the treatment of conventional diabetes require careful caution in their use, and if the dose or timing of administration is wrong, there are side effects such as hypoglycemia, gastrointestinal disorders, liver disorders, and skin disorders. It may appear, especially when it is administered for a long time.

  Moreover, although improvement can be expected by daily intake of foods that are effective in preventing and treating diabetes, there is a problem that the effect is difficult to be exhibited unless they are taken in large amounts.

  For the treatment of diabetes, it is necessary to lower the hemoglobin A1c (HbA1c) value as well as lower the blood glucose level. However, it is known that it is very difficult to reduce the hemoglobin A1c (HbA1c) value.

  Accordingly, an object of the present invention is to provide a diabetes preventive / therapeutic composition capable of easily and safely lowering blood glucose level and hemoglobin A1c (HbA1c) level by daily intake. is there.

  In order to achieve the above-mentioned purpose, as a result of various studies, by using a combination of a herbal medicine component consisting of guggle, licorice, bitter gourd, gymnema, benicassumi, gudachi, amla, turmeric, and neem and a mineral component, It has been found that an excellent effect is exerted on the decrease and the decrease in the hemoglobin A1c (HbA1c) value.

  That is, the diabetes preventive / therapeutic composition of the present invention is characterized by containing a herbal medicine component consisting of goggle, licorice, bitter gourd, gymnema, Benicumi, gudachi, amla, turmeric and neem, and a mineral component.

  A combination of herbal medicines obtained from guggul, licorice, bitter gourd, gymnema, benicusumi, gudachi, amla, turmeric, and neem has a large decrease in blood glucose level and a decrease in hemoglobin A1c (HbA1c) level, thus preventing diabetes. In addition, it shows an effect on the treatment, and further, by adding a mineral component to the herbal component, the synergistic action of the herbal component and the mineral component prevents the diabetes without causing a burden on the organ, and It can have a better effect on treatment.

  Moreover, it is preferable that the mineral component contained in the diabetes preventive / therapeutic composition of the present invention is at least one selected from beer yeast and koji calcium.

  Further, the composition for preventing and treating diabetes according to the present invention includes Indian asparagus, pepper, tulsi, fenugreek, ashvaganda, brami, bernoki, citrus, kikon, seitakamirobaran, koganegishigishi, emberia, kubeba, ginger, indaga It is preferable that at least one herbal ingredient selected from the group consisting of pepper is further included. By further adding the herbal medicine component, a more effective action can be brought about for the prevention and treatment of diabetes.

  And it is preferable to contain the at least 1 sort (s) of excipient | filler chosen from the group which consists of gum arabic, corn starch, corn starch paste, and lactose. According to this, since the diabetes prevention and treatment composition of this invention can be used with the form as a tablet, it can be set as the form which can be ingested easily.

  The present invention is a composition comprising a herbal medicine component consisting of guggul, licorice, bittern, gymnema, benicumi, gudachi, amla, turmeric, and neem and a mineral component as an active ingredient, and has a reduced blood glucose level, hemoglobin A1c (HbA1c ) Brings a lowering effect and exerts an excellent effect on diabetes. In addition, the diabetes prevention and treatment composition of the present invention is a product obtained from all natural products, there is no worry about side effects such as chemicals, and there is no burden on the organ, and in daily life. It can be taken easily.

  The diabetes preventive / therapeutic composition of the present invention comprises a crude drug component and a mineral component.

  The herbal medicine contained in the composition for preventing and treating diabetes according to the present invention is composed of nine kinds of herbal medicines such as guggul, licorice, bitter gourd, gymnema, benicassumi, gudachi, amla, turmeric, and neem, more preferably Indian. It contains 15 kinds of herbal medicines such as asparagus, pepper, tulsi, fenugreek, ashvaganda, brami, bernoki, citrus, kikon, seitakamirobaran, koganegishighi, emberia, kubeba, ginger, indaga pepper.

  A combination of components obtained from nine kinds of herbal medicines such as guggul, licorice, bitter gourd, gymnema, bencus mi, gudachi, amla, turmeric, and neem is excellent in blood glucose level lowering and hemoglobin A1c (HbA1c) level lowering actions. In addition, 15 kinds of herbal ingredients such as Indian Asparagus, Pepper, Tulsi, Fenugreek, Ashvaganda, Brahmi, Bernolki, Citrus, Kyukon, Seitaka Milobaran, Scarabidae, Emberia, Kubeba, Ginger, Indian Naga Pepper are added. As a result, it is possible to provide a more excellent effect on diabetes prevention and treatment.

  In the herbal medicine used in the present invention, a goggle (Commiphora mukul) is a plant of the family Orchidaceae. The resin contains guggnolactone, and has such effects as increased white blood cell count, improved carbohydrate metabolism by thyroid activation, and antibacterial action.

  Licorice (Glycyrrhiza glabra) is a leguminous plant whose roots contain flavonoids such as glycyrrhizin, and have effects such as anti-inflammatory action, liver function activation, and antioxidant action in the body.

  The bitter gourd (Momordica charantia) is a plant of the Cucurbitaceae family, and its fruit contains a polypeptide similar to bovine insulin and has effects such as hypoglycemic action.

  Gymnema (Gymnema sylvestre) is a plant of the genus Gaimidae, and its leaves contain gymnemic acid, which suppresses the absorption of saccharides in the body and acts to suppress an increase in blood sugar. It also has the function of promoting insulin secretion in the body.

  Boenhasumi (Boerhavia diffusa) is a plant belonging to the family Oroleubanidae, whose roots contain dihydro, isofrenoxanthine, etc., and have effects such as diuretic effect and sweating effect.

  Gudachi (Tinospora cordifolia) is a plant of the lobster family Raffodiaceae, whose stem contains berberine, and has effects such as insulin secretion promotion and blood sugar effect action.

  Amla (Phyllanthus emblica) is a plant of the Euphorbiaceae family, and its fruits contain vitamin C and polyphenols, and have effects such as antioxidant in the body.

  Turmeric (Curcuma longa) is a ginger family plant that has curcumin as the main component in its roots and stems, and has excellent antioxidant activity in the body, lowering blood glucose, strengthening liver function and bile secretion It has a function to promote.

  Neem (Azardichta indica) is a plant belonging to the family Sendanidae, and its leaves contain triterpenes and have anti-inflammatory and antibacterial effects.

  Asparagus (Asparagus recemosus) is a plant belonging to the lily family, and its roots contain aspartic acid and have effects such as analgesic action, diuretic effect, and nourishing tonic effect.

  Pepper (Piper nigrum) is a plant belonging to the family Pepperaceae, which actually contains piperine, and has effects such as digestion promotion and metabolism promotion.

  Tulsi (Ocimum tenuiflorum) is a plant of the family Lamiaceae, and the ethanol extract of its leaves has effects such as hypoglycemic action, antibacterial action, and sedative action.

  Trigonella foenum is a leguminous plant whose seed contains galactan and trigonelline and has effects such as hypoglycemic action and liver function activation.

  Ashwagandha (Withania somnifera) is a solanaceous plant whose roots contain vitanoids and have benefits such as nourishing tonic.

  Brami (Centella asiatica) is a plant belonging to the celery family and has effects such as nerve adjustment, constitution improvement and diuretic action.

  Bernoulli (Aegle marmelos) is a plant of the citrus family, and its fruit has effects such as gastrointestinal activation.

  Citrus (Citrus aurantinum) is a plant of the citrus family, and its fruits have antibacterial, antioxidant, and fat burning effects.

  Kyrkon (Berberis aristata) is a barberry family plant whose root contains berberine and contributes to the improvement of liver function.

  A black-tailed beetle (Terminalia belerica) is a plant belonging to the family Cypridaceae, and its fruits have effects such as nutritional tonic and intestinal regulation.

  Rumex maritimus is a plant of the family Tadeidae, whose root contains ansoraquinone and has an action to promote defecation.

  Embelia ribes is a plant belonging to the family Aceraceae, and its fruit contains emberin, piperine, etc., and has effects such as fat burning.

  Cuperba (Piper chaba) is a plant belonging to the family Pepperaceae, which actually contains piperine, and has effects such as digestion promotion and metabolism promotion.

  Ginger (Zingiber officiale) is a plant belonging to the family Ginger, and its root contains gingerol, gingerol, etc., and has a sweating action and a digestion promoting action.

  Indian persimmon (Piper chaba) is a plant belonging to the family Pepperaceae, and actually contains piperine and chabicin, and has effects such as digestion promotion and metabolism promotion.

  As the mineral component contained in the diabetes prevention / treatment composition of the present invention, those containing calcium, magnesium, sodium, potassium, iron, copper, zinc, selenium, manganese, iodine, phosphorus and the like in a balanced manner can be used. In particular, it is particularly preferable to use brewer's yeast and koji calcium as mineral component materials.

  Beer yeast is a material that contains nutrients such as amino acids, vitamin B, dietary fiber, nucleic acids, glutathione, calcium, iron, potassium, magnesium, phosphorus, zinc, etc., improving digestion, increasing appetite, activating the gastrointestinal tract, iron content It helps to promote absorption. The brewer's yeast used in the present invention is preferably used as a dry powder.

  Moreover, salmon calcium is a natural material rich in minerals such as calcium, magnesium, iron, zinc, manganese, copper, potassium, cobalt, molybdenum and nickel, and calcium obtained from salmon calcium is particularly excellent in absorption efficiency.

  The diabetes preventive / therapeutic composition of the present invention is preferably a tablet, powder, granule, solution, capsule or the like formed into a form that can be administered orally with an excipient, and more preferably a tablet.

  Excipients that can be used in the diabetes prevention / treatment composition of the present invention include gum arabic, corn starch, corn starch paste, lactose, dextrin, kaolin, fructose, carmellose, xylitol, light anhydrous silicic acid, crystalline cellulose, D- Sorbitol, sucrose, refined sucrose, potato starch, hydroxypropylcellulose, povidone, D-mannitol, calcium hydrogen phosphate, pregelatinized starch, crospovidone, hydroxypropyl starch, etc. can be used, but gum arabic, corn starch, corn starch paste And an excipient composed of four types of lactose.

  Next, the preferable manufacturing method of the diabetes prevention and treatment composition of this invention is demonstrated.

  Guggul, licorice, bittern, Gymnema, Benicasumi, Gudachi, Amla, Turmeric, Neem, Indian Asparagus, Pepper, Tulsi, Fenugreek, Ashvaganda, Brami, Bernoki, which can be used in the diabetes preventive / treating composition of the present invention Each herbal component of citrus, kikon, stag beetle, scallop, emberia, kubeba, ginger, and indaga pepper is obtained by concentrating and drying an extract obtained by water extraction of each herb and using it as a powder.

  Mixing the above herbal medicine component (powder body), mineral component consisting of brewer's yeast and koji calcium, and excipients consisting of gum arabic, corn starch, corn starch paste and lactose, and formulating into tablets etc. by conventional methods Thus, the diabetes prevention / treatment composition of the present invention can be obtained.

  The herbal components used in the present invention are 2 to 15 parts by weight of goggle, 2 to 15 parts by weight of licorice, 2 to 15 parts by weight of bitter gourd, 2 to 10 parts by weight of gymnema, It is preferably a composition containing 2 to 10 parts by mass, 2 to 10 parts by mass of gudachi, 2 to 10 parts by mass of Amla, 2 to 10 parts by mass of turmeric, and 2 to 10 parts by mass of neem.

  In addition, the diabetes preventive / therapeutic composition of the present invention includes 37 to 89 parts by mass of a herbal medicine component, 3 to 15 parts by mass of a mineral component, and 8 to 36 parts by mass of an excipient with respect to 100 parts by mass of the composition. Preferably, the composition is

  A composition comprising a herbal medicine component, a mineral component, and an excipient within the above-mentioned ratio can bring a more effective action against a decrease in blood glucose level and a decrease in hemoglobin A1c (HbA1c) level, and is superior to diabetes. Can exert the effect.

  In the administration of the diabetes prevention / treatment composition of the present invention, the daily intake of one adult is preferably 1,800 to 10,800 mg, more preferably 3,600 to 4,500 mg. . The number of administration is preferably divided into 2 to 3 times per day and taken at intervals of 6 to 12 hours.

  When the intake amount is 1,800 (mg / person / day) or less, the action effect on blood glucose lowering and hemoglobin A1c (HbA1c) value reduction is poor, and it is more than 10,800 (mg / person / day). Symptoms such as loose stool may occur, but there is no particular problem with safety even if the number is more than the above.

  Since the diabetes prevention / treatment composition of the present invention is composed of all natural materials, it does not cause side effects such as hypoglycemia, and is effective as a pharmaceutical, health food, etc. for diabetes prevention / treatment. Can be used.

[Production example]
Guggul, Daylily, Bitter melon, Gymnema, Benicasumi, Gudachi, Amla, Turmeric, Neem, Indian Asparagus, Pepper, Tulsi, Fenugreek, Ashvaganda, Brami, Bernoki, Citrus, Kyukon, Seta Milobaran, Koganegishigishi, Emberia, Kubaba A total of 24 kinds of herbal medicines, ginger and Indian pepper were used as herbal ingredients.

  The roots, stems and leaves of the herbal medicine are washed, dried, crushed and crushed to an appropriate size, then packed into a cotton bag, water is added to the tank and heated for a long time to extract the herbal extract. did. The solid extract obtained by concentrating and drying the obtained herbal extract was pulverized into a powder form, whereby a dry powder body in which the herbal components were concentrated was obtained. The above dry powder bodies of each herbal medicine, beer yeast, koji calcium, gum arabic, corn starch, corn starch paste, and lactose were mixed in the ratios shown in Table 1.

In order to facilitate mixing with the above mixture, a necessary amount of water is added and mixed. After sterilizing the mixed material, tableting is performed, and the tablet is dried and tableted. Hereinafter, simply referred to as a composition).

Test example 1
Tests were performed using male Swiss albino rats. Standard pellet food (Bagarol, Saitsuruga food) and water were ingested in a timely manner, and no other than water was ingested 16 hours before the start of the experiment. Twenty rats were divided into 4 groups (n = 6), and rats in group A were blank and received no treatment. In rats B to D, 120 mg / kg body weight of alloxan (Sigma Chemical) was administered to induce slowly progressive type 2 diabetes (including slowly progressive type 1 diabetes) with impaired insulin secretion. Was triggered. Blood was collected 72 hours after alloxan administration, and the blood glucose level was measured by the GOD / POD method.

Then, the following test substances were given to each group of mice.
Group A: normal rats (appropriate administration of pellet food and water only)
Group B: Diabetic rats (only pellet food and water were administered as appropriate)
Group C: Diabetic rats (100 mg / kg body weight of pellet diet and water and 30% aqueous solution of the above composition)
Group D: Diabetic rat (500 mg / kg body weight of pellet food and water and 30% aqueous solution of the above composition)

  Then, blood of rats of each of the A to D groups was collected 2, 4, 6, and 8 hours after administration of the test substance, and the blood glucose level was measured by the GOD / POD method. The measurement results are shown in Table 2.

  By administration of alloxan, the blood glucose level of rats increased from an average of 75 mg / dl to about 250 to 260 mg / dl. However, a decrease in blood glucose level could be confirmed in the rats of Group C and Group D administered with the above composition. The blood glucose level after 8 hours was about 9% lower in the group C rats and about 15% lower in the group D rats. Since the change of blood glucose level was not observed in the rats of Group A and Group B that were not administered with the above composition, the composition of the present invention has an action of lowering blood glucose level in a short period of time.

Test example 2
The test substance was administered from the alloxan administration to the 15th day to the rats of the A to D groups treated in the same manner as in Test Example 1.

  Before alloxan administration (initial value), after 3 days, 6 days, and thereafter every 3 days until 15th day, a vote was taken from the tail vein of each rat, and blood glucose level was measured by GOD / POD method. Table 3 shows the measurement results.

  By continuous administration of the above composition, blood glucose levels of alloxan diabetes-induced rats could be significantly reduced. In Group C, the blood glucose level dropped by about 32% on the 15th day. In addition, the blood glucose level of 45% could be lowered in the rats of Group D. From this result, the blood glucose level of diabetic rats can be lowered by continuous administration of the composition of the present invention. It can also be seen that the effect depends on the concentration.

Test example 3
The body weights of rats A to D that had been treated in the same manner as in Test Example 2 were measured on the third day (initial value) and 15th day of alloxan administration. Further, blood was collected from the tail vein on the 15th day (final day) after administration of alloxan, and 1) the total white blood cell count and 2) the white blood cell fraction (Leishman staining) were examined. Thereafter, rats were sacrificed and blood was collected by cardiac puncture. 3) Liver function tests (glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP)), 4) Kidney function tests (blood urea nitrogen, creatinine). went. The measurement results are shown in Tables 4 and 5.

  As can be seen from Table 4, the weight of the rats in Group B was reduced by about 16%, but almost no change in body weight was observed in the rats of Groups C and D to which the composition of the present invention was administered. Therefore, it can be seen that the composition of the present invention has a function of suppressing weight loss caused by alloxan administration (diabetes induction). In addition, administration of alloxan (inducing diabetes) reduces the total white blood cell count compared to normal rats (Group A), but it can be seen that continued administration of the composition of the present invention can suppress the decrease in white blood cells. .

  From Table 5, GPT value and ALP value were increased by alloxan administration (diabetes induction), and abnormal liver function was observed. However, it can be seen that these values can be kept relatively low in Group C and Group D to which the composition of the present invention is administered, and that the effect is great depending on the dose. As for renal function, blood urea level and creatinine level increased by alloxan administration (diabetes induction), indicating a decrease in renal function. However, in Group C and Group D administered with the composition of the present invention, the increase in these values can be suppressed to a low value, and it can be seen that the effect is large depending on the dose.

  Therefore, from the results of Test Examples 1 to 3, administration of the composition of the present invention can bring about a significant decrease in blood glucose level and improve liver and kidney dysfunction caused by diabetes. Can be effective for diabetes prevention and treatment.

Test example 4
(Example of a 59-year-old man)
One month after taking the above composition 12 tablets (3600 mg) a day, the fasting blood glucose level was 270-280 mg / dl, but it was reduced to 150-160 mg / dl, and the hemoglobin HbA1c value was 9. What was 0 dropped to 8.0. Thereafter, the dose was continued, and after 6 months, the blood glucose level dropped to 120-130 mg / dl, and the hemoglobin HbA1c level also dropped to 5.8. During this time, no side effects such as phytotoxicity were observed.

  The diabetes preventive / therapeutic composition of the present invention can lower blood glucose level and hemoglobin A1c (HbA1c) level by daily intake to diabetic patients or people who may have diabetes. It can be used as pharmaceuticals, health foods, etc. for the prevention and treatment of diabetes.

Claims (4)

  A diabetic prevention / treatment composition comprising a herbal medicine component including a goggle, a licorice, a bitter gourd, a gymnema, a benecusmi, a gudachi, an amla, a turmeric, and a neem, and a mineral component.   The diabetes preventive / therapeutic composition according to claim 1, wherein the mineral component is at least one selected from beer yeast and koji calcium.   In addition, at least one selected from the group consisting of Indian asparagus, pepper, tulsi, fenugreek, ashvaganda, brami, bernoki, citrus, kikon, seitakamirobaran, koganegishighi, emberia, kubeba, ginger, indaga pepper The composition for preventing or treating diabetes according to claim 1 or 2, comprising a crude drug component. The diabetes preventive / therapeutic composition according to any one of claims 1 to 3, comprising at least one excipient selected from the group consisting of gum arabic, corn starch, corn starch paste, and lactose.