CN113603736A - 无热量甜味剂及合成方法 - Google Patents

无热量甜味剂及合成方法 Download PDF

Info

Publication number
CN113603736A
CN113603736A CN202110535948.7A CN202110535948A CN113603736A CN 113603736 A CN113603736 A CN 113603736A CN 202110535948 A CN202110535948 A CN 202110535948A CN 113603736 A CN113603736 A CN 113603736A
Authority
CN
China
Prior art keywords
rebaudioside
leu
glu
ala
reb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202110535948.7A
Other languages
English (en)
Chinese (zh)
Inventor
毛国红
X·于
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Conagen Inc
Original Assignee
Conagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conagen Inc filed Critical Conagen Inc
Publication of CN113603736A publication Critical patent/CN113603736A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01013—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Seasonings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Tea And Coffee (AREA)
  • Cosmetics (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Peptides Or Proteins (AREA)
CN202110535948.7A 2014-10-03 2015-10-02 无热量甜味剂及合成方法 Pending CN113603736A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462059498P 2014-10-03 2014-10-03
US62/059498 2014-10-03
US201462098929P 2014-12-31 2014-12-31
US62/098929 2014-12-31
CN201580053379.5A CN106795195B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580053379.5A Division CN106795195B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法

Publications (1)

Publication Number Publication Date
CN113603736A true CN113603736A (zh) 2021-11-05

Family

ID=55631622

Family Applications (7)

Application Number Title Priority Date Filing Date
CN202110535948.7A Pending CN113603736A (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法
CN201580053379.5A Active CN106795195B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法
CN202211009324.2A Active CN115918884B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法
CN201580051860.0A Active CN106714578B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法
CN201580052483.2A Active CN106795547B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法
CN201580052182.XA Active CN106715451B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法
CN202210685584.5A Active CN114908135B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法

Family Applications After (6)

Application Number Title Priority Date Filing Date
CN201580053379.5A Active CN106795195B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法
CN202211009324.2A Active CN115918884B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法
CN201580051860.0A Active CN106714578B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法
CN201580052483.2A Active CN106795547B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法
CN201580052182.XA Active CN106715451B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法
CN202210685584.5A Active CN114908135B (zh) 2014-10-03 2015-10-02 无热量甜味剂及合成方法

Country Status (14)

Country Link
US (22) US9850270B2 (enExample)
EP (4) EP3201212B1 (enExample)
JP (4) JP6883512B2 (enExample)
KR (4) KR102526446B1 (enExample)
CN (7) CN113603736A (enExample)
AU (4) AU2015327854B2 (enExample)
BR (3) BR112017006155A2 (enExample)
CA (4) CA2958434C (enExample)
DK (3) DK3201212T3 (enExample)
ES (3) ES2869823T3 (enExample)
HU (2) HUE053331T2 (enExample)
MX (4) MX368414B (enExample)
MY (4) MY183062A (enExample)
WO (4) WO2016054540A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114921434A (zh) * 2022-05-27 2022-08-19 中化健康产业发展有限公司 催化Reb A生产Reb M的重组糖基转移酶
CN115918884A (zh) * 2014-10-03 2023-04-07 康纳根有限公司 无热量甜味剂及合成方法

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014122227A2 (en) 2013-02-06 2014-08-14 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
US10264811B2 (en) 2014-05-19 2019-04-23 Epc Natural Products Co., Ltd. Stevia sweetener with improved solubility
JP6855376B2 (ja) 2014-12-17 2021-04-07 カーギル インコーポレイテッド 経口摂取又は経口使用のためのステビオールグリコシド化合物、組成物、及びステビオールグリコシド溶解度を増強するための方法
AU2016211124B2 (en) 2015-01-30 2022-04-14 Danstar Ferment Ag Production of steviol glycosides in recombinant hosts
CN107666834B (zh) 2015-04-03 2021-08-24 帝斯曼知识产权资产管理有限公司 甜菊醇糖苷
JP6793957B2 (ja) * 2015-04-14 2020-12-02 コナゲン インコーポレイテッド 改変された全細胞触媒を用いたノンカロリー甘味料の生成
US20190203244A1 (en) * 2015-08-20 2019-07-04 Pepsico, Inc. Preparation of rebaudioside m in a single reaction vessel
KR20180132696A (ko) 2016-04-13 2018-12-12 에볼바 에스아 재조합 숙주에서의 스테비올 글리코사이드의 생산
US11299723B2 (en) 2016-06-15 2022-04-12 Codexis, Inc. Engineered beta-glucosidases and glucosylation methods
SG11201811273RA (en) * 2016-06-17 2019-01-30 Cargill Inc Steviol glycoside compositions for oral ingestion or use
WO2018031955A2 (en) 2016-08-12 2018-02-15 Amyris, Inc. Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides
KR102540615B1 (ko) 2016-10-14 2023-06-08 코나겐 인크. 스테비올 글리코시드의 생합성 제조 및 이를 위한 방법
EP3530745A4 (en) 2016-10-21 2020-07-22 Pepsico, Inc. PROCESS FOR PREPARING REBAUDIOSIDE N USING AN ENZYMATIC PROCESS
JP6842800B2 (ja) * 2016-10-21 2021-03-17 ペプシコ・インク 酵素的方法を使用してレバウディオサイドｊを調製するための方法
WO2018093196A1 (ko) * 2016-11-17 2018-05-24 서울대학교산학협력단 변형 류코노스톡속 균주를 이용한 스테비오사이드 배당체의 합성 방법 및 이에 의하여 제조된 신규한 스테비오사이드 배당체
WO2018102725A1 (en) * 2016-12-01 2018-06-07 Arvinas, Inc. Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders
EP3878967A3 (en) 2017-02-03 2021-12-08 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
EP3614860B1 (en) * 2017-04-25 2025-07-02 The Coca-Cola Company Sweetness and taste improvement of steviol glycoside and mogroside sweeteners with dihydrochalcones
CN107164435B (zh) * 2017-05-27 2020-03-31 中国药科大学 一种莱鲍迪苷ka的制备方法
MY209836A (en) 2017-06-08 2025-08-07 Suntory Holdings Ltd Food or beverage with increased sweetness
EP3644758A4 (en) 2017-06-30 2021-03-31 Conagen Inc. Hydrolysis of steviol glycosides by beta-glucosidase
EP3765627A4 (en) * 2018-03-12 2021-10-13 Conagen Inc. BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDE REBAUDIOSIDE J AND REBAUDIOSIDE N
CN112135527B (zh) * 2018-05-08 2023-08-15 伊比西(北京)植物药物技术有限公司 具有改善风味的甜菊醇糖甙组合物
CN109021038B (zh) * 2018-06-11 2021-07-27 江西师范大学 一种甜菊糖苷的制备方法
CA3108268A1 (en) * 2018-07-30 2020-02-06 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
WO2019210607A1 (zh) * 2018-08-17 2019-11-07 邦泰生物工程(深圳)有限公司 一种稳定型烟酰胺核糖组合物及其制备方法
CN111073923A (zh) * 2018-10-22 2020-04-28 山东三元生物科技股份有限公司 一种莱鲍迪苷m的酶法制备方法
EP3877519B1 (en) 2018-11-09 2026-03-11 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
WO2020116664A1 (en) * 2018-12-07 2020-06-11 Suntory Holdings Limited Composition
MY206414A (en) * 2018-12-07 2024-12-16 Suntory Holdings Ltd Coffee beverage having improved quality of taste exhibited by sugar and sweetener
WO2020116637A1 (ja) * 2018-12-07 2020-06-11 サントリーホールディングス株式会社 糖および甘味料の呈する味質が改善したコーヒー飲料
MY203653A (en) * 2018-12-07 2024-07-11 Suntory Holdings Ltd Composition
WO2020123877A1 (en) * 2018-12-12 2020-06-18 Conagen Inc. Biosynthetic production of variant steviol glycosides
CN109750072B (zh) * 2019-01-31 2022-04-19 南京工业大学 一种酶法制备莱鲍迪苷e的方法
EP3799057A1 (en) 2019-09-25 2021-03-31 Koninklijke Philips N.V. Prediction tool for patient immune response to a therapy
EP4044823A4 (en) * 2019-10-16 2024-04-24 Sweegen, Inc. STEVIOL GLYCOSIDE FORMULATIONS FOR FOOD AND BEVERAGES
CN110734944B (zh) * 2019-11-11 2023-02-21 中化健康产业发展有限公司 一步法合成莱鲍迪苷m的方法
CN110846305B (zh) * 2019-11-11 2023-11-28 中化健康产业发展有限公司 一种固定化糖基转移酶催化莱鲍迪苷a生成莱鲍迪苷m的方法
CN110872586B (zh) * 2019-11-11 2024-01-30 天津大学 固定化葡萄糖基转移酶及制备方法及催化生产莱鲍迪苷d的方法
CN110846363B (zh) * 2019-11-11 2023-02-17 天津大学 一锅法生产莱鲍迪苷d的方法
CA3171399A1 (en) * 2020-03-13 2021-09-16 Stanley W. HERRMANN Rebaudioside m sweetener compositions
WO2021216504A1 (en) * 2020-04-20 2021-10-28 The Coca-Coca Company Beverages comprising siamenoside i with enhanced flavor
US20250320470A1 (en) * 2020-12-23 2025-10-16 Samyang Corporation Glycosyltransferase and steviol glucoside preparation method using same
JP7210626B2 (ja) * 2021-02-18 2023-01-23 ペプシコ・インク 酵素的方法を使用してレバウディオサイドｊを調製するための方法
KR102924285B1 (ko) * 2021-12-24 2026-02-09 주식회사 삼양사 당전이 효소 변이체 및 이를 이용한 스테비올 배당체의 제조방법
EP4496482A1 (en) 2022-03-23 2025-01-29 Sweegen, Inc. Sweetener comprising rebaudiose m and brazzein
DE202022103252U1 (de) 2022-06-09 2022-07-01 Wal Ankita Eine natürliche Süßstoffzusammensetzung als Süßungsmittel für Diabetes
CN116076694B (zh) * 2022-10-12 2024-06-28 四川盈嘉合生科技有限公司 一种甜菊糖苷甜味剂及其制备方法
CN121465226A (zh) * 2023-09-15 2026-02-06 郑州大学 呈味肽及其筛选
KR102876472B1 (ko) * 2023-12-26 2025-10-27 주식회사 삼양사 수크로우스 합성효소 변이체, udp-글루코실트랜스퍼라제 변이체 및 이들의 스테비올 배당체 생산 용도
KR102777875B1 (ko) * 2024-10-22 2025-03-13 대한민국 신규 페디오코커스 속 균주 및 그의 용도
CN119842657B (zh) * 2025-03-18 2025-05-27 青岛奔月生物技术有限公司 蔗糖合酶突变体及其应用
CN120813686A (zh) * 2025-05-07 2025-10-17 邦泰生物工程(深圳)有限公司 一种udp-葡萄糖基转移酶突变体及其制备莱鲍迪苷d的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102216313A (zh) * 2008-10-03 2011-10-12 守田化学工业株式会社 新的甜菊醇糖苷
US20110287164A1 (en) * 2010-05-21 2011-11-24 Purecircle Sdn Bhd High-Purity Rebaudioside C And Process For Purification Of The Same

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US17804A (en) * 1857-07-14 Improvement in locks
US4612942A (en) 1984-03-08 1986-09-23 Stevia Company, Inc. Flavor enhancing and modifying materials
JPH04149191A (ja) * 1990-10-09 1992-05-22 Nakano Vinegar Co Ltd ステビオサイド糖転移化合物及びその製造方法
US20090183270A1 (en) 2002-10-02 2009-07-16 Adams Thomas R Transgenic plants with enhanced agronomic traits
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
MX2009004344A (es) 2006-10-24 2009-05-05 Givaudan Sa Productos de consumo.
US20130071521A1 (en) 2007-03-14 2013-03-21 Pepsico, Inc. Rebaudioside d sweeteners and food products sweetened with rebaudioside d
US8277862B2 (en) * 2007-03-14 2012-10-02 Concentrate Manufacturing Company Of Ireland Beverage products having steviol glycosides and at least one acid
EP2575432B1 (en) * 2010-06-02 2019-08-14 Evolva, Inc. Recombinant production of steviol glycosides
WO2012075030A1 (en) * 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
AU2012294452C1 (en) * 2011-08-08 2017-11-30 Danstar Ferment Ag Recombinant production of steviol glycosides
EP3735841A1 (en) * 2011-12-19 2020-11-11 PureCircle SDN BHD Methods for purifying steviol glycosides and uses of the same
EP2826861B1 (en) 2012-03-16 2020-04-29 Suntory Holdings Limited Steviol glycosyltransferase and gene encoding same
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
MX352678B (es) * 2012-05-22 2017-12-04 Purecircle Sdn Bhd Glucosidos de esteviol de alta pureza.
US9611498B2 (en) * 2012-09-29 2017-04-04 Shanghai Institutes For Biological Sciences, Chinese Academy Of Sciences Method for producing stevioside compounds by microorganism
WO2014122227A2 (en) * 2013-02-06 2014-08-14 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
BR112015019160A2 (pt) 2013-02-11 2017-08-22 Dalgaard Mikkelsen Michael Produção de glicosídeos de esteviol em hospedeiros recombinantes
US9717267B2 (en) 2013-03-14 2017-08-01 The Coca-Cola Company Beverages containing rare sugars
EP2984077A4 (en) 2013-03-14 2017-03-15 Chromocell Corporation Compounds, compositions, and methods for modulating sweet taste
US10570164B2 (en) * 2013-03-15 2020-02-25 The Coca-Cola Company Steviol glycosides, their compositions and their purification
US20140342043A1 (en) 2013-05-14 2014-11-20 Pepsico, Inc. Rebaudioside Sweetener Compositions and Food Products Sweetened with Same
US20160183574A1 (en) 2013-06-19 2016-06-30 Phyto Tech Corp. Rebaudioside e and food products sweetened with rebaudioside e
BR112016000745B1 (pt) 2013-07-15 2021-01-05 Dsm Ip Assets B.V. processo para a preparação de rebaudiosídeo m
CN103397064B (zh) * 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
ES2709439T3 (es) 2013-11-01 2019-04-16 Conagen Inc Producción recombinante de glucósidos de esteviol
CN106471128A (zh) 2014-01-28 2017-03-01 百事可乐公司 一种酶法制备瑞鲍迪甙m的方法
US9522929B2 (en) * 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
US9907326B2 (en) * 2014-09-30 2018-03-06 Suntory Beverage & Food Limited Carbonated beverage, syrup used for preparing carbonated beverage, method for manufacturing carbonated beverage, and method for suppressing foaming in carbonated beverage
CN113603736A (zh) 2014-10-03 2021-11-05 康纳根有限公司 无热量甜味剂及合成方法
JP6793957B2 (ja) * 2015-04-14 2020-12-02 コナゲン インコーポレイテッド 改変された全細胞触媒を用いたノンカロリー甘味料の生成
SG11201811273RA (en) * 2016-06-17 2019-01-30 Cargill Inc Steviol glycoside compositions for oral ingestion or use
KR102540615B1 (ko) * 2016-10-14 2023-06-08 코나겐 인크. 스테비올 글리코시드의 생합성 제조 및 이를 위한 방법
WO2020123877A1 (en) * 2018-12-12 2020-06-18 Conagen Inc. Biosynthetic production of variant steviol glycosides
EP4044823A4 (en) * 2019-10-16 2024-04-24 Sweegen, Inc. STEVIOL GLYCOSIDE FORMULATIONS FOR FOOD AND BEVERAGES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102216313A (zh) * 2008-10-03 2011-10-12 守田化学工业株式会社 新的甜菊醇糖苷
US20110287164A1 (en) * 2010-05-21 2011-11-24 Purecircle Sdn Bhd High-Purity Rebaudioside C And Process For Purification Of The Same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
万会达，等: "甜菊糖的酶法改性及其生物活性研究进展", 中国食品添加剂, no. 5, 31 October 2011 (2011-10-31), pages 188 - 196 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115918884A (zh) * 2014-10-03 2023-04-07 康纳根有限公司 无热量甜味剂及合成方法
CN115918884B (zh) * 2014-10-03 2024-04-30 康纳根有限公司 无热量甜味剂及合成方法
CN114921434A (zh) * 2022-05-27 2022-08-19 中化健康产业发展有限公司 催化Reb A生产Reb M的重组糖基转移酶
CN114921434B (zh) * 2022-05-27 2024-02-20 中化健康产业发展有限公司 催化Reb A生产Reb M的重组糖基转移酶

Also Published As

Publication number Publication date
HUE045992T2 (hu) 2020-01-28
WO2016054534A1 (en) 2016-04-07
JP6774945B2 (ja) 2020-10-28
CN106714578A (zh) 2017-05-24
JP2017537606A (ja) 2017-12-21
DK3201351T3 (da) 2021-02-22
AU2015327858B2 (en) 2020-06-18
KR20170061680A (ko) 2017-06-05
BR112017006155A2 (pt) 2018-07-03
EP3201211A1 (en) 2017-08-09
MY183062A (en) 2021-02-10
US11884694B2 (en) 2024-01-30
MX367090B (es) 2019-08-05
US20230002435A1 (en) 2023-01-05
ES2741741T3 (es) 2020-02-12
AU2015327854B2 (en) 2019-09-12
CA2958105C (en) 2021-01-26
WO2016054544A1 (en) 2016-04-07
JP6883512B2 (ja) 2021-06-09
MY179680A (en) 2020-11-11
US20180258125A1 (en) 2018-09-13
CA2958434A1 (en) 2016-04-07
DK3201212T3 (en) 2018-11-26
BR112017006163B1 (pt) 2022-04-05
US20170218421A1 (en) 2017-08-03
JP2017531634A (ja) 2017-10-26
US10160781B2 (en) 2018-12-25
EP3201351A4 (en) 2018-03-28
KR102536036B1 (ko) 2023-05-23
US10800803B2 (en) 2020-10-13
ES2869823T3 (es) 2021-10-25
EP3201212A1 (en) 2017-08-09
AU2015327862B2 (en) 2020-05-07
KR102526446B1 (ko) 2023-04-27
CN106795195B (zh) 2021-11-12
CN106714578B (zh) 2020-07-28
US20160097072A1 (en) 2016-04-07
WO2016054548A1 (en) 2016-04-07
US10774103B2 (en) 2020-09-15
BR112017006163A2 (pt) 2018-07-31
US9850270B2 (en) 2017-12-26
CA2958437C (en) 2021-03-30
MY190567A (en) 2022-04-27
EP3201212B1 (en) 2018-09-19
ES2693371T3 (es) 2018-12-11
US20180258124A1 (en) 2018-09-13
US9643990B2 (en) 2017-05-09
US20160153018A1 (en) 2016-06-02
US20160097071A1 (en) 2016-04-07
US9783566B2 (en) 2017-10-10
MX2017004247A (es) 2017-05-19
US10059732B2 (en) 2018-08-28
JP2017529857A (ja) 2017-10-12
WO2016054540A1 (en) 2016-04-07
JP2017535251A (ja) 2017-11-30
CN106795547A (zh) 2017-05-31
AU2015327940A1 (en) 2017-03-16
US20180057521A1 (en) 2018-03-01
US20180057522A1 (en) 2018-03-01
US20170181452A1 (en) 2017-06-29
AU2015327858A1 (en) 2017-03-09
US20160326206A1 (en) 2016-11-10
US20220162248A1 (en) 2022-05-26
CN115918884A (zh) 2023-04-07
MX368414B (es) 2019-10-02
CN106715451B (zh) 2022-11-08
US20170218420A1 (en) 2017-08-03
BR112017006330A2 (pt) 2018-01-16
BR112017006139B1 (pt) 2022-04-05
EP3201211A4 (en) 2018-04-04
US10023604B2 (en) 2018-07-17
EP3201351A1 (en) 2017-08-09
US20200331952A1 (en) 2020-10-22
CN106715451A (zh) 2017-05-24
EP3201211B1 (en) 2021-09-29
US10597419B2 (en) 2020-03-24
US20200339621A1 (en) 2020-10-29
KR20170067738A (ko) 2017-06-16
BR112017006139A2 (pt) 2018-07-03
EP3200615A1 (en) 2017-08-09
AU2015327854A1 (en) 2017-03-09
US20180057520A1 (en) 2018-03-01
US10570163B2 (en) 2020-02-25
EP3200615B1 (en) 2019-05-29
US20180057519A1 (en) 2018-03-01
KR20170062461A (ko) 2017-06-07
CA2958093C (en) 2021-01-26
CA2958437A1 (en) 2016-04-07
JP6722177B2 (ja) 2020-07-15
JP6854238B2 (ja) 2021-04-14
CN114908135A (zh) 2022-08-16
CA2958093A1 (en) 2016-04-07
US11453692B2 (en) 2022-09-27
MY182725A (en) 2021-02-03
KR20170066371A (ko) 2017-06-14
US10450338B2 (en) 2019-10-22
US20160095338A1 (en) 2016-04-07
US10442831B2 (en) 2019-10-15
CN106795547B (zh) 2021-07-23
MX389979B (es) 2025-03-20
AU2015327940B2 (en) 2020-04-16
US20160097070A1 (en) 2016-04-07
CA2958105A1 (en) 2016-04-07
US10010099B2 (en) 2018-07-03
US20170362267A1 (en) 2017-12-21
US20180258126A1 (en) 2018-09-13
US10010101B2 (en) 2018-07-03
MX2017004246A (es) 2017-05-19
US9567619B2 (en) 2017-02-14
US20170196248A1 (en) 2017-07-13
MX2017004245A (es) 2017-05-19
DK3200615T3 (da) 2019-08-19
CN115918884B (zh) 2024-04-30
MX2017004248A (es) 2017-05-19
HUE053331T2 (hu) 2021-06-28
US10584143B2 (en) 2020-03-10
US9908913B2 (en) 2018-03-06
EP3201212A4 (en) 2017-11-22
EP3200615A4 (en) 2018-04-04
MX378831B (es) 2025-03-10
KR102521967B1 (ko) 2023-04-13
CA2958434C (en) 2021-01-19
KR102557670B1 (ko) 2023-07-20
CN114908135B (zh) 2024-10-18
US11186604B2 (en) 2021-11-30
CN106795195A (zh) 2017-05-31
EP3201351B1 (en) 2021-01-06
AU2015327862A1 (en) 2017-03-09

Similar Documents

Publication Publication Date Title
US11884694B2 (en) Non-caloric sweeteners and methods for synthesizing
US10941174B2 (en) Non-caloric sweetener
HK40063380A (en) Non-caloric sweeteners and methods for synthesizing
HK40093096A (zh) 无热量甜味剂及合成方法
HK40093096B (zh) 无热量甜味剂及合成方法
HK1237787A1 (en) Non-caloric sweeteners and methods for synthesizing
HK1237822A1 (en) Non-caloric sweeteners and methods for synthesizing
HK1236753A1 (en) Non-caloric sweeteners and methods for synthesizing
HK1236954B (en) Non-caloric sweeteners and methods for synthesizing
HK1236954A1 (en) Non-caloric sweeteners and methods for synthesizing
HK1237787B (zh) 无热量甜味剂及合成方法
HK1236753B (zh) 无热量甜味剂及合成方法
HK1237822B (zh) 无热量甜味剂及合成方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40063380

Country of ref document: HK