CN113557236A - 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 - Google Patents

一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 Download PDF

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CN113557236A
CN113557236A CN202080018398.5A CN202080018398A CN113557236A CN 113557236 A CN113557236 A CN 113557236A CN 202080018398 A CN202080018398 A CN 202080018398A CN 113557236 A CN113557236 A CN 113557236A
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compound
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cancer
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CN113557236B (zh
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唐士兵
曾少高
米琦·丹尼尔·托特雷拉
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Guangzhou Institute of Biomedicine and Health of CAS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biomedical Technology (AREA)
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  • Molecular Biology (AREA)
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Abstract

一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物，所述调节剂具有如式I所示结构。双功能免疫调节剂包含同时阻断PD‑1/PD‑L1相互作用的苄苯醚类分子骨架和阻断TGF‑β信号通路的4‑(4‑吡唑)喹啉分子骨架，二者通过分子链片段相连接。因此，双功能免疫调节剂可同时阻断PD‑1/PD‑L1相互作用和TGF‑β信号通路。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202080018398.5A 2019-06-10 2020-06-05 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 Active CN113557236B (zh)

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CN201910497925 2019-06-10
CN2019104979254 2019-06-10
PCT/CN2020/094580 WO2020248908A1 (zh) 2019-06-10 2020-06-05 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物

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CN113307779B (zh) * 2021-05-25 2023-04-21 中国药科大学 杂环取代联苯类化合物、制备方法及用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1337950A (zh) * 1999-01-08 2002-02-27 日本烟草产业株式会社 2－氧代喹啉化合物及其药物用途
US20100254899A1 (en) * 2007-02-27 2010-10-07 The United States Of America, As Represented By The Secretary, Dept Of Health And Human Services Radiolabeled affibody molecules
CN105705489A (zh) * 2013-09-04 2016-06-22 百时美施贵宝公司 用作免疫调节剂的化合物
CN109305934A (zh) * 2018-08-07 2019-02-05 成都海博锐药业有限公司 苯醚类衍生物及可药用盐、医药上的用途
CN109824621A (zh) * 2019-03-28 2019-05-31 中国药科大学 噁二唑类和噻二唑类化合物及其制备方法和用途

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
DE60221392T2 (de) * 2001-05-24 2008-04-17 Eli Lilly And Co., Indianapolis Neue pyrrolderivate als pharmazeutische mittel
UA80571C2 (en) * 2002-11-22 2007-10-10 Lilly Co Eli Quinolinyl-pyrrolopyrazoles
US8871744B2 (en) * 2010-07-21 2014-10-28 B & G Partyers, LLC Compounds and methods for selectively targeting tumor-associated mucins
US9850225B2 (en) * 2014-04-14 2017-12-26 Bristol-Myers Squibb Company Compounds useful as immunomodulators
US10167334B2 (en) * 2015-04-03 2019-01-01 Xoma Technology Ltd. Treatment of cancer using anti-TGF-BETA and PD-1 antibodies
US10745382B2 (en) * 2015-10-15 2020-08-18 Bristol-Myers Squibb Company Compounds useful as immunomodulators

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1337950A (zh) * 1999-01-08 2002-02-27 日本烟草产业株式会社 2－氧代喹啉化合物及其药物用途
US20100254899A1 (en) * 2007-02-27 2010-10-07 The United States Of America, As Represented By The Secretary, Dept Of Health And Human Services Radiolabeled affibody molecules
CN105705489A (zh) * 2013-09-04 2016-06-22 百时美施贵宝公司 用作免疫调节剂的化合物
CN109305934A (zh) * 2018-08-07 2019-02-05 成都海博锐药业有限公司 苯醚类衍生物及可药用盐、医药上的用途
CN109824621A (zh) * 2019-03-28 2019-05-31 中国药科大学 噁二唑类和噻二唑类化合物及其制备方法和用途

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