CN113528485B - 治疗性核酸酶组合物和方法 - Google Patents

治疗性核酸酶组合物和方法 Download PDF

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CN113528485B
CN113528485B CN202110852975.7A CN202110852975A CN113528485B CN 113528485 B CN113528485 B CN 113528485B CN 202110852975 A CN202110852975 A CN 202110852975A CN 113528485 B CN113528485 B CN 113528485B
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polypeptide
certain embodiments
hybrid nuclease
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CN113528485A (zh
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J·A·莱德贝特
M·海登-莱德贝特
K·艾肯
孙锡章
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University of Washington
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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CN202110852975.7A 2009-11-02 2010-11-02 治疗性核酸酶组合物和方法 Active CN113528485B (zh)

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Application Number Priority Date Filing Date Title
US25745809P 2009-11-02 2009-11-02
US61/257,458 2009-11-02
US37075210P 2010-08-04 2010-08-04
US61/370,752 2010-08-04
PCT/US2010/055131 WO2011053982A2 (en) 2009-11-02 2010-11-02 Therapeutic nuclease compositions and methods
CN201080060471.1A CN102770533B (zh) 2009-11-02 2010-11-02 治疗性核酸酶组合物和方法

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CN113528485B true CN113528485B (zh) 2025-06-27

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CN201610979041.9A Active CN106399276B (zh) 2009-11-02 2010-11-02 治疗性核酸酶组合物和方法
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CN201080060471.1A Active CN102770533B (zh) 2009-11-02 2010-11-02 治疗性核酸酶组合物和方法

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JP (7) JP6199033B2 (enExample)
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