MX360465B - Composiciones de nucleasas terapeuticas y metodos. - Google Patents

Composiciones de nucleasas terapeuticas y metodos.

Info

Publication number
MX360465B
MX360465B MX2014013439A MX2014013439A MX360465B MX 360465 B MX360465 B MX 360465B MX 2014013439 A MX2014013439 A MX 2014013439A MX 2014013439 A MX2014013439 A MX 2014013439A MX 360465 B MX360465 B MX 360465B
Authority
MX
Mexico
Prior art keywords
methods
therapeutic nuclease
nuclease compositions
compositions
therapeutic
Prior art date
Application number
MX2014013439A
Other languages
English (en)
Inventor
A Ledbetter Jeffrey
Elkon Keith
Hayden-Ledbetter Marthe
Sun Xizhang
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of MX360465B publication Critical patent/MX360465B/es

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Biotechnology (AREA)
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  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)

Abstract

La presente invención se refiere a un polipéptido que comprende RNasa acoplada operativamente con o sin un primer dominio conector a un dominio FC, y DNasa acoplada operativamente con o sin un segundo domino conector al dominio Fc, en donde el dominio Fc es un dominio Fc mutante de inmunoglobulina humana con enlace reducido a receptores Fcy en células humanas.
MX2014013439A 2009-11-02 2010-11-02 Composiciones de nucleasas terapeuticas y metodos. MX360465B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25745809P 2009-11-02 2009-11-02
US37075210P 2010-08-04 2010-08-04
PCT/US2010/055131 WO2011053982A2 (en) 2009-11-02 2010-11-02 Therapeutic nuclease compositions and methods

Publications (1)

Publication Number Publication Date
MX360465B true MX360465B (es) 2018-11-01

Family

ID=43923071

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2012005062A MX341084B (es) 2009-11-02 2010-11-02 Composiciones de nucleasas terapéuticas y métodos.
MX2014013439A MX360465B (es) 2009-11-02 2010-11-02 Composiciones de nucleasas terapeuticas y metodos.
MX2018013333A MX2018013333A (es) 2009-11-02 2012-04-30 Composiciones de nucleasas terapeuticas y metodos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2012005062A MX341084B (es) 2009-11-02 2010-11-02 Composiciones de nucleasas terapéuticas y métodos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018013333A MX2018013333A (es) 2009-11-02 2012-04-30 Composiciones de nucleasas terapeuticas y metodos.

Country Status (24)

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US (9) US20130089546A1 (es)
EP (3) EP3460056B1 (es)
JP (6) JP6199033B2 (es)
KR (5) KR102624939B1 (es)
CN (3) CN102770533B (es)
AU (4) AU2010313103B2 (es)
BR (1) BR112012010202A2 (es)
CA (2) CA3091939A1 (es)
CY (3) CY1119166T1 (es)
DK (3) DK2496691T3 (es)
ES (2) ES2702053T3 (es)
HR (2) HRP20170757T1 (es)
HU (2) HUE041426T2 (es)
IL (4) IL297588A (es)
LT (3) LT3202898T (es)
MX (3) MX341084B (es)
NZ (1) NZ774435A (es)
PL (2) PL3202898T3 (es)
PT (2) PT2496691T (es)
RS (1) RS55989B1 (es)
SG (3) SG10201912573YA (es)
SI (3) SI3460056T1 (es)
WO (1) WO2011053982A2 (es)
ZA (3) ZA201705246B (es)

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ES2702053T3 (es) 2019-02-27
MX341084B (es) 2016-08-05

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