CN113454450B - 液相色谱分析装置及其控制方法 - Google Patents

液相色谱分析装置及其控制方法 Download PDF

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Publication number
CN113454450B
CN113454450B CN202080015451.6A CN202080015451A CN113454450B CN 113454450 B CN113454450 B CN 113454450B CN 202080015451 A CN202080015451 A CN 202080015451A CN 113454450 B CN113454450 B CN 113454450B
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China
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flow path
liquid
pressure
liquid feeding
mobile phase
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Chinese (zh)
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CN113454450A (zh
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秋枝大介
野上真
伊藤伸也
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Hitachi High Tech Corp
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Hitachi High Technologies Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/328—Control of physical parameters of the fluid carrier of pressure or speed valves, e.g. check valves of pumps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/382—Flow patterns flow switching in a single column
    • G01N2030/385—Flow patterns flow switching in a single column by switching valves

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Sampling And Sample Adjustment (AREA)
CN202080015451.6A 2019-02-26 2020-02-26 液相色谱分析装置及其控制方法 Active CN113454450B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019032872 2019-02-26
JP2019-032872 2019-02-26
PCT/JP2020/007598 WO2020175510A1 (ja) 2019-02-26 2020-02-26 液体クロマトグラフ分析装置、及びその制御方法

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CN113454450A CN113454450A (zh) 2021-09-28
CN113454450B true CN113454450B (zh) 2024-12-03

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CN202080015451.6A Active CN113454450B (zh) 2019-02-26 2020-02-26 液相色谱分析装置及其控制方法

Country Status (5)

Country Link
US (1) US12298283B2 (https=)
EP (1) EP3933399B1 (https=)
JP (1) JP7351897B2 (https=)
CN (1) CN113454450B (https=)
WO (1) WO2020175510A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7444036B2 (ja) * 2020-12-01 2024-03-06 株式会社島津製作所 モニタリングシステム
US20240192180A1 (en) * 2021-04-14 2024-06-13 Hitachi High-Tech Corporation Automatic analyzer including hplc and control method for the same
JPWO2024080246A1 (https=) * 2022-10-14 2024-04-18
CN120019274A (zh) * 2022-10-31 2025-05-16 株式会社日立高新技术 液相色谱仪的控制方法以及液相色谱仪

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018207295A1 (ja) * 2017-05-10 2018-11-15 株式会社島津製作所 送液装置及びその送液装置を備えた液体クロマトグラフ

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2972246A (en) * 1958-05-19 1961-02-21 Phillips Petroleum Co Chromatographic analyzer
US3892531A (en) * 1973-07-05 1975-07-01 Beckman Instruments Inc Apparatus for sequencing peptides and proteins
US4059009A (en) * 1976-09-10 1977-11-22 Micromeritics Instrument Corporation Liquid chromatography system
JP2504356B2 (ja) * 1992-04-09 1996-06-05 株式会社島津製作所 示差屈折計
EP0723152A2 (en) * 1995-01-23 1996-07-24 Hewlett-Packard Company Method and apparatus for detector ignition
JP3603506B2 (ja) * 1996-11-01 2004-12-22 株式会社島津製作所 液体クロマトグラフのオートインジェクタ
ATE419911T1 (de) * 1999-04-23 2009-01-15 Advion Biosystems Inc Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz
JP4451067B2 (ja) * 2001-03-02 2010-04-14 ウォーターズ・インヴェストメンツ・リミテッド 流体漏れの有無を決定する方法及び装置
US6805799B2 (en) * 2002-12-21 2004-10-19 Qi-Feng Ma Simulated moving bed chromatographic focusing
GB2434003B (en) * 2004-03-05 2008-09-24 Waters Investments Ltd Pressure monitor optimization of fluid path utilization
JP2005257609A (ja) 2004-03-15 2005-09-22 Shimadzu Corp 液体クロマトグラフ装置
US7460958B2 (en) * 2004-10-07 2008-12-02 E.I. Du Pont De Nemours And Company Computer-implemented system and method for analyzing mixtures of gases
EP1589336A1 (en) 2005-02-04 2005-10-26 Agilent Technologies, Inc. Leakage checking and calibration of a liquid delivery system
JP5028109B2 (ja) * 2007-02-28 2012-09-19 株式会社日立ハイテクノロジーズ 液体クロマトグラフ装置
EP2244091B8 (en) * 2009-04-21 2016-02-24 Agilent Technologies, Inc. Leak detection upstream of a mixing point
WO2010139359A1 (en) 2009-06-03 2010-12-09 Agilent Technologies, Inc. Sample injector with metering device balancing pressure differences in an intermediate valve state
JP5249908B2 (ja) * 2009-11-06 2013-07-31 株式会社日立ハイテクノロジーズ 液体クロマトグラフ装置
US9417219B2 (en) 2009-11-16 2016-08-16 Agilent Technologies, Inc. Sample separation device with valve
JP2012047655A (ja) * 2010-08-30 2012-03-08 Hitachi Ltd 液体クロマトグラフ装置及び分析方法
US10054569B2 (en) * 2010-10-29 2018-08-21 Thermo Finnigan Llc Method and system for liquid chromatography fluidic monitoring
EP2632561B1 (en) 2010-10-29 2017-09-20 Thermo Finnigan LLC Method and system for liquid chromatograph with compressibility and viscosity monitoring to identify fluids
US9228982B2 (en) * 2011-09-16 2016-01-05 Agilent Technologies, Inc. Single injection valve for HPLC combining sample introduction, wash cycles and diagnosis
DE102011087935B4 (de) * 2011-12-07 2020-01-02 Agilent Technologies Inc. Spülventil für Hochdruckpumpe im Niedrigflussbetrieb
WO2013086281A1 (en) * 2011-12-09 2013-06-13 Waters Technologies Corporation Select valve for liquid chromatography systems
JP5270771B2 (ja) * 2012-02-03 2013-08-21 株式会社日立ハイテクノロジーズ 液体クロマトグラフ装置及び試料導入装置
JP2015052533A (ja) * 2013-09-06 2015-03-19 株式会社日立製作所 クロマトグラフィー装置およびクロマトグラフィー方法
WO2015189927A1 (ja) * 2014-06-11 2015-12-17 株式会社島津製作所 液体試料導入装置
DE102016121512A1 (de) 2016-11-10 2018-05-17 Dionex Softron Gmbh System, Verfahren und Verwendung der Flüssigkeitschromatografie

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018207295A1 (ja) * 2017-05-10 2018-11-15 株式会社島津製作所 送液装置及びその送液装置を備えた液体クロマトグラフ

Also Published As

Publication number Publication date
JPWO2020175510A1 (https=) 2020-09-03
WO2020175510A1 (ja) 2020-09-03
EP3933399A1 (en) 2022-01-05
EP3933399B1 (en) 2024-11-20
CN113454450A (zh) 2021-09-28
JP7351897B2 (ja) 2023-09-27
US12298283B2 (en) 2025-05-13
EP3933399A4 (en) 2022-11-16
US20220050088A1 (en) 2022-02-17

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