ATE419911T1 - Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz - Google Patents

Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz

Info

Publication number
ATE419911T1
ATE419911T1 AT00925886T AT00925886T ATE419911T1 AT E419911 T1 ATE419911 T1 AT E419911T1 AT 00925886 T AT00925886 T AT 00925886T AT 00925886 T AT00925886 T AT 00925886T AT E419911 T1 ATE419911 T1 AT E419911T1
Authority
AT
Austria
Prior art keywords
injector
liquid chromatography
columns
pumping
throughput
Prior art date
Application number
AT00925886T
Other languages
English (en)
Inventor
Thomas Corso
Pelt Colleen K Van
Original Assignee
Advion Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advion Biosystems Inc filed Critical Advion Biosystems Inc
Application granted granted Critical
Publication of ATE419911T1 publication Critical patent/ATE419911T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00452—Means for the recovery of reactants or products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B01J2219/00587—High throughput processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/202—Injection using a sampling valve rotary valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/628—Multiplexing, i.e. several columns sharing a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AT00925886T 1999-04-23 2000-04-20 Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz ATE419911T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13076199P 1999-04-23 1999-04-23

Publications (1)

Publication Number Publication Date
ATE419911T1 true ATE419911T1 (de) 2009-01-15

Family

ID=22446202

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00925886T ATE419911T1 (de) 1999-04-23 2000-04-20 Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz

Country Status (7)

Country Link
US (1) US6318157B1 (de)
EP (1) EP1194200B1 (de)
AT (1) ATE419911T1 (de)
AU (1) AU4450900A (de)
DE (1) DE60041331D1 (de)
DK (1) DK1194200T3 (de)
WO (1) WO2000064557A1 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632404B1 (en) * 2000-08-02 2003-10-14 Symyx Technologies, Inc. Automatically actuated parallel sample injector valve
US6501073B1 (en) * 2000-10-04 2002-12-31 Thermo Finnigan Llc Mass spectrometer with a plurality of ionization probes
US6743356B1 (en) * 2000-10-27 2004-06-01 Johnson & Johnson High throughput high performance chromatography system
US6635173B2 (en) * 2000-12-28 2003-10-21 Cohesive Technologies, Inc. Multi column chromatography system
AU2002241818A1 (en) * 2001-01-10 2002-07-24 Memorial Sloan-Kettering Cancer Center System and process for microfluidics-based automated chemistry
US6904784B2 (en) 2001-02-27 2005-06-14 Teledyne Isco, Inc. Liquid chromatographic method and system
US6755074B2 (en) 2001-02-27 2004-06-29 Isco, Inc. Liquid chromatographic method and system
US20050123970A1 (en) * 2001-04-25 2005-06-09 Can Ozbal High throughput autosampler
US7588725B2 (en) * 2001-04-25 2009-09-15 Biotrove, Inc. High throughput autosampler
US8414774B2 (en) * 2001-04-25 2013-04-09 Agilent Technologies, Inc. Systems and methods for high-throughput screening of fluidic samples
US6812030B2 (en) * 2001-04-25 2004-11-02 Biotrove, Inc. System and method for high throughput sample preparation and analysis using column chromatography
WO2009059286A1 (en) * 2007-11-02 2009-05-07 Biotrove, Inc. Devices and methods for coupling mass spectrometry devices with chromatography systems
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
US6808685B2 (en) * 2001-09-17 2004-10-26 Uop Llc Apparatus and method for generating a plurality of isolated effluents
WO2003025156A2 (en) * 2001-09-18 2003-03-27 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
JP3870367B2 (ja) * 2001-11-19 2007-01-17 ▲たけ▼徳 谷村 調製クロマトグラフィ装置およびそれを用いた分離・精製方法
US20050079526A1 (en) * 2002-02-20 2005-04-14 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing refolding and aggregation of biological molecules
CA2477021A1 (en) * 2002-02-20 2003-08-28 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing stability of biological molecules
WO2003087834A2 (en) * 2002-04-08 2003-10-23 Affinium Pharmaceuticals, Inc. High throughput analysis of recombinant proteins in multi-well plates
US6749749B2 (en) * 2002-06-26 2004-06-15 Isco, Inc. Separation system, components of a separation system and methods of making and using them
US7473367B2 (en) * 2002-06-26 2009-01-06 Dionex Corporation Monolithic column
US20040121445A1 (en) * 2002-07-31 2004-06-24 Fabien Marino Cell cultures
US7214320B1 (en) 2002-08-08 2007-05-08 Nanostream, Inc. Systems and methods for high throughput sample analysis
WO2004015411A1 (en) * 2002-08-08 2004-02-19 Nanostream, Inc. Systems and methods for high-throughput microfluidic sample analysis
AU2003287449A1 (en) * 2002-10-31 2004-05-25 Nanostream, Inc. Parallel detection chromatography systems
US6936167B2 (en) * 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
US6987263B2 (en) * 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
US20060076482A1 (en) * 2002-12-13 2006-04-13 Hobbs Steven E High throughput systems and methods for parallel sample analysis
JP4018975B2 (ja) * 2002-12-16 2007-12-05 野村化学株式会社 逆相液体クロマトグラフィー
US20040129676A1 (en) * 2003-01-07 2004-07-08 Tan Roy H. Apparatus for transfer of an array of liquids and methods for manufacturing same
US7373255B2 (en) * 2003-06-06 2008-05-13 Biacore Ab Method and system for determination of molecular interaction parameters
SE0301639D0 (sv) * 2003-06-06 2003-06-06 Biacore Ab Method and apparatus for characterization of intercations
EP1631829B1 (de) * 2003-06-06 2016-04-13 GE Healthcare Bio-Sciences AB Verfahren und vorrichtung zur charakterisierung von wechselwirkungen
US8196896B2 (en) * 2004-03-05 2012-06-12 Waters Technologies Corporation Combination flow through injection and isolation valve for high pressure fluids
US20060156792A1 (en) * 2004-10-12 2006-07-20 Yongdong Wang Multi-dimensional liquid chromatography separation system and method
US8802035B2 (en) * 2005-06-21 2014-08-12 Waters Technologies Corporation Apparatus and methods for performing steps of a multi-step process in parallel
US7462280B2 (en) * 2005-07-22 2008-12-09 Agilent Technologies, Inc. Liquid chromatography chip with flexible interface
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US8920645B2 (en) * 2005-12-07 2014-12-30 Tarpon Biosystems Inc. Disposable chromatography valves and system
EP2165191B1 (de) * 2007-07-04 2014-11-12 Agilent Technologies, Inc. Zwei-ventil-anordnung für die flüssigkeitschromatographie
EP4108668A1 (de) * 2010-03-12 2022-12-28 PureCircle USA Inc. Hochreine steviol-glycoside
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
EP2583008A4 (de) * 2010-06-16 2014-07-30 Waters Technologies Corp Ventil für ein hochdruckanalysesystem
US11690391B2 (en) 2011-02-17 2023-07-04 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9771434B2 (en) 2011-06-23 2017-09-26 Purecircle Sdn Bhd Products from stevia rebaudiana
CH706929A1 (de) * 2012-09-11 2014-03-14 Werner Doebelin Ultra-Hochdruck-Spritzenpumpensystem für den Gradienten Betrieb im Bereich der HPLC.
US10952458B2 (en) 2013-06-07 2021-03-23 Purecircle Usa Inc Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
CN105682467A (zh) 2013-06-07 2016-06-15 谱赛科美国股份有限公司 含有选择的甜叶菊醇糖苷作为香、咸和甜度特征修饰物的甜叶菊提取物
JP2017508960A (ja) * 2014-02-11 2017-03-30 ビュヒ ラボーアテヒニク アクチエンゲゼルシャフトＢｕｅｃｈｉ Ｌａｂｏｒｔｅｃｈｎｉｋ ＡＧ マルチプルカラムクロマトグラフィシステムおよび使用方法
EP3105580B1 (de) * 2014-02-14 2023-10-04 Cytiva Sweden AB Mehrstufiges automatisches reinigungssystem
GB2527803B (en) * 2014-07-02 2018-02-07 Microsaic Systems Plc A method and system for monitoring biomolecule separations by mass spectrometry
US10788507B2 (en) 2014-08-13 2020-09-29 Sartorius Bioanalytical Instruments, Inc. Method and apparatus for rapid sequential flow injection
BR112017004240B1 (pt) 2014-09-02 2022-04-05 The Coca-Cola Company Processo para preparar uma composição de glicosídeo de esteviol aquoso não tratado, extrato de stevia aquoso não tratado preparado pelo referido processo e alimento ou bebida
CN108495559A (zh) 2015-10-26 2018-09-04 谱赛科美国股份有限公司 甜菊醇糖苷组合物
CN108712864A (zh) 2015-12-15 2018-10-26 谱赛科美国股份有限公司 甜菊醇糖苷组合物
EP3391041B1 (de) * 2015-12-18 2019-10-16 H. Hoffnabb-La Roche Ag System und verfahren zur automatisierten klinischen diagnose
EP3559656A1 (de) * 2016-12-23 2019-10-30 Roche Diagnostics GmbH Verfahren zur verfolgung einer probenidentität während eines verfahrens in einem analysesystem
EP3559657A1 (de) * 2016-12-23 2019-10-30 Roche Diagnostics GmbH Verfahren zur identifizierung eines reagens während eines verfahrens in einem analysesystem
JP6790963B2 (ja) * 2017-03-30 2020-11-25 株式会社島津製作所 液体クロマトグラフ
US11415563B2 (en) * 2017-04-13 2022-08-16 Shimadzu Corporation Method for analyzing sample by liquid chromatograph mass spectrometry
EP3692364A1 (de) * 2017-10-04 2020-08-12 Waters Technologies Corporation Systeme und verfahren zur chromatografischen analyse
WO2020084334A1 (en) * 2018-10-26 2020-04-30 Agilent Technologies, Inc. Injector serving multiple sample separation apparatuses
CN209559837U (zh) * 2019-01-14 2019-10-29 中国科学院南海海洋研究所 一种lc/ms和ms自动切换高通量连续进样装置
EP3933399A4 (de) * 2019-02-26 2022-11-16 Hitachi High-Tech Corporation Flüssigkeitschromatografieanalysator und steuerverfahren dafür
GB201902743D0 (en) * 2019-02-28 2019-04-17 Ge Healthcare Bio Sciences Ab Improvements in and relating to optimizing the operation of a chromatography system
CN110152353B (zh) * 2019-06-18 2024-05-28 大连博迈科技发展有限公司 一种连续色谱装置及三七总皂苷生产方法
US20230341433A1 (en) * 2022-04-25 2023-10-26 Fluid Management Systems, Inc. Programmable semi-automatic and automatic single or multi-task liquid extraction and purification system

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2972246A (en) * 1958-05-19 1961-02-21 Phillips Petroleum Co Chromatographic analyzer
DE1598205B1 (de) * 1964-04-13 1971-05-19 Ceskoslovenska Akademie Ved Einrichtung zur chromatographie von aminosaeuren und derglei chen enthaltenden gemischen
SE326056B (de) 1966-01-07 1970-07-13 Ceskoslovenska Akademie Ved
US3676649A (en) * 1970-05-08 1972-07-11 Phillips Petroleum Co Signal analysis and recording
US3841059A (en) * 1972-09-25 1974-10-15 W Mccabe Compressed and thermostated air regulated gas liquid chromatography oven with simultaneously operated multiple chromatography columns
US3926559A (en) * 1973-08-06 1975-12-16 Dow Chemical Co Method and apparatus for quantitative chromatographic analysis of cationic species
FR2279104A1 (fr) * 1974-07-18 1976-02-13 Aquitaine Petrole Procede d'analyse par chromatographie en phase liquide
US3923460A (en) 1974-11-12 1975-12-02 Dow Chemical Co Dual ion chromatograph using parallel columns for ionic analysis
US4271697A (en) 1979-10-17 1981-06-09 Phillips Petroleum Company Chromatographic analysis
US4364263A (en) 1980-09-15 1982-12-21 Burroughs Wellcome Co. High pressure liquid chromatographic system
JPS57139661A (en) * 1981-02-23 1982-08-28 Gasukuro Kogyo Kk Gas analyzer
US4446105A (en) 1982-10-29 1984-05-01 The United States Of America As Represented By The United States Department Of Energy System for analyzing coal liquefaction products
US4577492A (en) 1983-05-12 1986-03-25 Phillips Petroleum Company Analytical method and apparatus
JPS60115854A (ja) * 1983-11-28 1985-06-22 Shimadzu Corp 多項目分析用液体クロマトグラフ
JPS60219554A (ja) * 1984-04-16 1985-11-02 Yokogawa Hokushin Electric Corp 多量成分中の微量成分を測定する方法およびその装置
JPH0723887B2 (ja) 1985-09-13 1995-03-15 株式会社島津製作所 ホツプ由来の苦味成分の分析法及び装置
US4699718A (en) 1986-01-21 1987-10-13 Millipore Corporation Ion chromatography method and apparatus
US4859342A (en) 1986-10-14 1989-08-22 Suntory Limited Process for industrially separating biopolymers
US5135718A (en) * 1987-03-02 1992-08-04 Tosoh Corporation Apparatus for simultaneously analyzing vanillylmandelic acid, homovanillic acid and creatinine
JPH01126544A (ja) * 1987-11-11 1989-05-18 Hitachi Ltd 生化学分析方法及び装置
CA1336474C (en) 1989-04-20 1995-08-01 Martin Blake Hocking Hydrogen peroxide recovery from coloured aqueous solutions
US5091092A (en) * 1989-05-03 1992-02-25 Analytical Bio-Chemistry Laboratories, Inc. Single-loop chromatography system and method
US5071547A (en) * 1990-03-23 1991-12-10 Separations Technology, Inc. Column chromatographic column apparatus with switching capability
US5205845A (en) * 1990-09-28 1993-04-27 The Regents Of The University Of Michigan Mechanical gas chromatography injection valves and column multiplexing techniques
JP3175941B2 (ja) 1991-03-28 2001-06-11 パーセプティブ バイオシステムズ インコーポレイテッド クロマトグラフ溶出液の減法に依るオンライン生成物確認方法及び装置
US5419208A (en) 1993-01-29 1995-05-30 Upchurch Scientific, Inc. Multiport selection valve
US5630943A (en) 1995-11-30 1997-05-20 Merck Patent Gesellschaft Mit Beschrankter Haftung Discontinuous countercurrent chromatographic process and apparatus
US5983703A (en) * 1996-09-09 1999-11-16 Perkin-Elmer (Canada) Ltd. Analytical engine for gas chromatograph
US6175409B1 (en) * 1999-04-02 2001-01-16 Symyx Technologies, Inc. Flow-injection analysis and variable-flow light-scattering methods and apparatus for characterizing polymers

Also Published As

Publication number Publication date
EP1194200B1 (de) 2009-01-07
WO2000064557A1 (en) 2000-11-02
DK1194200T3 (da) 2009-05-04
EP1194200A4 (de) 2004-04-07
EP1194200A1 (de) 2002-04-10
DE60041331D1 (de) 2009-02-26
US6318157B1 (en) 2001-11-20
AU4450900A (en) 2000-11-10

Similar Documents

Publication Publication Date Title
ATE419911T1 (de) Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz
AU2001239178A1 (en) Device and method for detecting organic molecules in a test substance
DK1371984T3 (da) Chromatografisk assay-anordning og fremgangsmåde til detektion af tilstedeværelsen af en analyt i en helblodpröve
CA2321376A1 (en) Parallel high-performance liquid chromatography with serial injection
DE69939479D1 (de) Modul und verfahren zur einführung einer probe in eine chromatographische kolonne
DK1297338T3 (da) Mikroopstillinger til udförelse af proteomikanalyser
DK0830591T3 (da) Fremgangsmåde og indretning til molekylær sekventering
ITRM920713A1 (it) Metodo di rivelazione multipunto per elettroforesi e cromatografia in capillari.
WO2003052140A3 (en) High throughput analysis and detection of multiple target sequences
NO996243L (no) Retentatkromatografi og proteinchipsrekker med anvendelse innen biologi og medisin
DK1869475T3 (da) In vitro metode til samtidig detektering og identifikation af antibiotika i forskellige klasser og et tilsvarende diagnosekit
BR9401570A (pt) Aparelhagem para detecção de microorganismos em amostras de espécime de fluido
Xu et al. High-throughput mass-directed parallel purification incorporating a multiplexed single quadrupole mass spectrometer
DE69210687D1 (de) Probensammel- und Einlasssystem für Gaschromatographen
DE69638008D1 (de) Chromatograph für die Flüssigkeitschromatographie
WO2005048126A3 (en) High throughput autosampler
Fahrner et al. Real-time control of antibody loading during protein A affinity chromatography using an on-line assay
ATE372510T1 (de) Mehrfachmodus-lesegerät
Zhang et al. A novel automated online SPE-coupled CE system for the analysis of sulfonamide antibiotics in wastewater
Tempels et al. On-line coupling of size exclusion chromatography and capillary electrophoresis via solid-phase extraction and a Tee-split interface
DK1360491T3 (da) Biokemisk fremgangsmåde og apparat til detektion af proteinegenskaber
Theodoridis et al. Automated sample treatment by flow techniques prior to liquid-phase separations
DK1360329T3 (da) Biokemisk fremgangsmåde og apparat til detektion af genetiske egenskaber
Jagota et al. Determination of trace levels of hydrazine in the penultimate intermediate of a novel anti-infective agent
DE3781793D1 (de) Chromatographischer duennschicht-flammionisationsdetektor fuer die mengenmaessige analyse von chromatographisch getrennten substanzen.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties