DE60041331D1 - Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz - Google Patents

Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz

Info

Publication number
DE60041331D1
DE60041331D1 DE60041331T DE60041331T DE60041331D1 DE 60041331 D1 DE60041331 D1 DE 60041331D1 DE 60041331 T DE60041331 T DE 60041331T DE 60041331 T DE60041331 T DE 60041331T DE 60041331 D1 DE60041331 D1 DE 60041331D1
Authority
DE
Germany
Prior art keywords
injector
liquid chromatography
columns
pumping
detector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60041331T
Other languages
English (en)
Inventor
Thomas N Corso
Pelt Colleen K Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advion Inc
Original Assignee
Advion Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advion Biosystems Inc filed Critical Advion Biosystems Inc
Application granted granted Critical
Publication of DE60041331D1 publication Critical patent/DE60041331D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00452—Means for the recovery of reactants or products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B01J2219/00587—High throughput processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/202—Injection using a sampling valve rotary valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/628—Multiplexing, i.e. several columns sharing a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
DE60041331T 1999-04-23 2000-04-20 Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz Expired - Fee Related DE60041331D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13076199P 1999-04-23 1999-04-23
PCT/US2000/008741 WO2000064557A1 (en) 1999-04-23 2000-04-20 High-throughput parallel liquid chromatography system

Publications (1)

Publication Number Publication Date
DE60041331D1 true DE60041331D1 (de) 2009-02-26

Family

ID=22446202

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60041331T Expired - Fee Related DE60041331D1 (de) 1999-04-23 2000-04-20 Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz

Country Status (7)

Country Link
US (1) US6318157B1 (de)
EP (1) EP1194200B1 (de)
AT (1) ATE419911T1 (de)
AU (1) AU4450900A (de)
DE (1) DE60041331D1 (de)
DK (1) DK1194200T3 (de)
WO (1) WO2000064557A1 (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632404B1 (en) * 2000-08-02 2003-10-14 Symyx Technologies, Inc. Automatically actuated parallel sample injector valve
US6501073B1 (en) * 2000-10-04 2002-12-31 Thermo Finnigan Llc Mass spectrometer with a plurality of ionization probes
US6743356B1 (en) * 2000-10-27 2004-06-01 Johnson & Johnson High throughput high performance chromatography system
US6635173B2 (en) * 2000-12-28 2003-10-21 Cohesive Technologies, Inc. Multi column chromatography system
WO2002055188A2 (en) * 2001-01-10 2002-07-18 Memorial Sloan-Kettering Cancer Center System and process for microfluidics-based automated chemistry
US6755074B2 (en) * 2001-02-27 2004-06-29 Isco, Inc. Liquid chromatographic method and system
US6904784B2 (en) * 2001-02-27 2005-06-14 Teledyne Isco, Inc. Liquid chromatographic method and system
US8414774B2 (en) * 2001-04-25 2013-04-09 Agilent Technologies, Inc. Systems and methods for high-throughput screening of fluidic samples
US6812030B2 (en) * 2001-04-25 2004-11-02 Biotrove, Inc. System and method for high throughput sample preparation and analysis using column chromatography
US7588725B2 (en) * 2001-04-25 2009-09-15 Biotrove, Inc. High throughput autosampler
US20050123970A1 (en) * 2001-04-25 2005-06-09 Can Ozbal High throughput autosampler
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
US6808685B2 (en) * 2001-09-17 2004-10-26 Uop Llc Apparatus and method for generating a plurality of isolated effluents
AU2002325755A1 (en) * 2001-09-18 2003-04-01 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
JP3870367B2 (ja) * 2001-11-19 2007-01-17 ▲たけ▼徳 谷村 調製クロマトグラフィ装置およびそれを用いた分離・精製方法
US20050079526A1 (en) * 2002-02-20 2005-04-14 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing refolding and aggregation of biological molecules
US20040072356A1 (en) * 2002-02-20 2004-04-15 Guillermo Senisterra Methods and apparatuses for characterizing stability of biological molecules
WO2003087834A2 (en) * 2002-04-08 2003-10-23 Affinium Pharmaceuticals, Inc. High throughput analysis of recombinant proteins in multi-well plates
US6749749B2 (en) * 2002-06-26 2004-06-15 Isco, Inc. Separation system, components of a separation system and methods of making and using them
US7473367B2 (en) 2002-06-26 2009-01-06 Dionex Corporation Monolithic column
US20040121445A1 (en) * 2002-07-31 2004-06-24 Fabien Marino Cell cultures
US7214320B1 (en) 2002-08-08 2007-05-08 Nanostream, Inc. Systems and methods for high throughput sample analysis
US6812458B2 (en) * 2002-08-08 2004-11-02 Nanostream, Inc. Systems and methods for high-throughput microfluidic sample analysis
WO2004040295A1 (en) * 2002-10-31 2004-05-13 Nanostream, Inc. Parallel detection chromatography systems
US6936167B2 (en) * 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
US20060076482A1 (en) * 2002-12-13 2006-04-13 Hobbs Steven E High throughput systems and methods for parallel sample analysis
US6987263B2 (en) * 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
JP4018975B2 (ja) * 2002-12-16 2007-12-05 野村化学株式会社 逆相液体クロマトグラフィー
US20040129676A1 (en) * 2003-01-07 2004-07-08 Tan Roy H. Apparatus for transfer of an array of liquids and methods for manufacturing same
SE0301639D0 (sv) * 2003-06-06 2003-06-06 Biacore Ab Method and apparatus for characterization of intercations
US7373255B2 (en) * 2003-06-06 2008-05-13 Biacore Ab Method and system for determination of molecular interaction parameters
EP1631829B1 (de) * 2003-06-06 2016-04-13 GE Healthcare Bio-Sciences AB Verfahren und vorrichtung zur charakterisierung von wechselwirkungen
US8196896B2 (en) * 2004-03-05 2012-06-12 Waters Technologies Corporation Combination flow through injection and isolation valve for high pressure fluids
US20060156792A1 (en) * 2004-10-12 2006-07-20 Yongdong Wang Multi-dimensional liquid chromatography separation system and method
WO2007001984A2 (en) * 2005-06-21 2007-01-04 Waters Investments Limited Apparatus and methods for performing steps of a multi-step process in parallel
US7462280B2 (en) * 2005-07-22 2008-12-09 Agilent Technologies, Inc. Liquid chromatography chip with flexible interface
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US8920645B2 (en) * 2005-12-07 2014-12-30 Tarpon Biosystems Inc. Disposable chromatography valves and system
US8257586B2 (en) * 2007-07-04 2012-09-04 Agilent Technologies, Inc. Two-valve arrangement for liquid chromatography
JP5433580B2 (ja) * 2007-11-02 2014-03-05 バイオシアス ライフ サイエンシーズ， インコーポレイテッド 試料注入システム
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
WO2011112892A1 (en) * 2010-03-12 2011-09-15 Purecircle Usa Inc. High-purity steviol glycosides
WO2011159644A1 (en) * 2010-06-16 2011-12-22 Waters Technologies Corporation Valve for high pressure analytical system
US11690391B2 (en) 2011-02-17 2023-07-04 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9771434B2 (en) 2011-06-23 2017-09-26 Purecircle Sdn Bhd Products from stevia rebaudiana
CH706929A1 (de) * 2012-09-11 2014-03-14 Werner Doebelin Ultra-Hochdruck-Spritzenpumpensystem für den Gradienten Betrieb im Bereich der HPLC.
US10952458B2 (en) 2013-06-07 2021-03-23 Purecircle Usa Inc Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
DK3003058T4 (da) 2013-06-07 2023-07-24 Purecircle Usa Inc Stevia-ekstrakt indeholdende udvalgte steviolglycosider som aroma-, salt- og sødmeprofilmodifikator
JP2017508960A (ja) * 2014-02-11 2017-03-30 ビュヒ ラボーアテヒニク アクチエンゲゼルシャフトＢｕｅｃｈｉ Ｌａｂｏｒｔｅｃｈｎｉｋ ＡＧ マルチプルカラムクロマトグラフィシステムおよび使用方法
CN105980847B (zh) * 2014-02-14 2018-12-04 通用电气健康护理生物科学股份公司 自动多步纯化系统
GB2527803B (en) * 2014-07-02 2018-02-07 Microsaic Systems Plc A method and system for monitoring biomolecule separations by mass spectrometry
WO2016025738A1 (en) * 2014-08-13 2016-02-18 Sensiq Technologies, Inc. Method and apparatus for rapid sequential flow injection
CN107072237B (zh) 2014-09-02 2021-12-14 谱赛科有限责任公司 甜菊提取物
BR122020008481B1 (pt) 2015-10-26 2022-10-18 Purecircle Usa Inc Composição de glicosídeo de esteviol contendo rebaudiosídeo q glicosilado e rebaudiosídeo r glicosilado e método para melhorar o perfil de doçura de um adoçante de estévia
WO2017106577A1 (en) 2015-12-15 2017-06-22 Purecircle Usa Inc. Steviol glycoside compositions
KR102658086B1 (ko) * 2015-12-18 2024-04-16 에프. 호프만-라 로슈 아게 자동화된 임상 진단 시스템 및 방법
EP3559657A1 (de) * 2016-12-23 2019-10-30 Roche Diagnostics GmbH Verfahren zur identifizierung eines reagens während eines verfahrens in einem analysesystem
WO2018115243A1 (en) * 2016-12-23 2018-06-28 Roche Diagnostics Gmbh Method for tracking a sample identity during a process in an analysis system
JP6790963B2 (ja) * 2017-03-30 2020-11-25 株式会社島津製作所 液体クロマトグラフ
US11415563B2 (en) * 2017-04-13 2022-08-16 Shimadzu Corporation Method for analyzing sample by liquid chromatograph mass spectrometry
US11079360B2 (en) * 2017-10-04 2021-08-03 Waters Technologies Corporation Systems and methods for chromatographic analysis
WO2020084334A1 (en) * 2018-10-26 2020-04-30 Agilent Technologies, Inc. Injector serving multiple sample separation apparatuses
CN209559837U (zh) * 2019-01-14 2019-10-29 中国科学院南海海洋研究所 一种lc/ms和ms自动切换高通量连续进样装置
US20220050088A1 (en) * 2019-02-26 2022-02-17 Hitachi High-Tech Corporation Liquid Chromatograph Analyzer and Method of Controlling the Same
GB201902743D0 (en) * 2019-02-28 2019-04-17 Ge Healthcare Bio Sciences Ab Improvements in and relating to optimizing the operation of a chromatography system
WO2023211943A2 (en) * 2022-04-25 2023-11-02 Fluid Management Systems, Inc. Programmable semi-automatic and automatic single or multi-task liquid extraction and purification system

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2972246A (en) * 1958-05-19 1961-02-21 Phillips Petroleum Co Chromatographic analyzer
DE1598205B1 (de) * 1964-04-13 1971-05-19 Ceskoslovenska Akademie Ved Einrichtung zur chromatographie von aminosaeuren und derglei chen enthaltenden gemischen
SE326056B (de) 1966-01-07 1970-07-13 Ceskoslovenska Akademie Ved
US3676649A (en) * 1970-05-08 1972-07-11 Phillips Petroleum Co Signal analysis and recording
US3841059A (en) * 1972-09-25 1974-10-15 W Mccabe Compressed and thermostated air regulated gas liquid chromatography oven with simultaneously operated multiple chromatography columns
US3926559A (en) * 1973-08-06 1975-12-16 Dow Chemical Co Method and apparatus for quantitative chromatographic analysis of cationic species
FR2279104A1 (fr) * 1974-07-18 1976-02-13 Aquitaine Petrole Procede d'analyse par chromatographie en phase liquide
US3923460A (en) 1974-11-12 1975-12-02 Dow Chemical Co Dual ion chromatograph using parallel columns for ionic analysis
US4271697A (en) 1979-10-17 1981-06-09 Phillips Petroleum Company Chromatographic analysis
US4364263A (en) 1980-09-15 1982-12-21 Burroughs Wellcome Co. High pressure liquid chromatographic system
JPS57139661A (en) * 1981-02-23 1982-08-28 Gasukuro Kogyo Kk Gas analyzer
US4446105A (en) 1982-10-29 1984-05-01 The United States Of America As Represented By The United States Department Of Energy System for analyzing coal liquefaction products
US4577492A (en) 1983-05-12 1986-03-25 Phillips Petroleum Company Analytical method and apparatus
JPS60115854A (ja) * 1983-11-28 1985-06-22 Shimadzu Corp 多項目分析用液体クロマトグラフ
JPS60219554A (ja) * 1984-04-16 1985-11-02 Yokogawa Hokushin Electric Corp 多量成分中の微量成分を測定する方法およびその装置
JPH0723887B2 (ja) 1985-09-13 1995-03-15 株式会社島津製作所 ホツプ由来の苦味成分の分析法及び装置
US4699718A (en) 1986-01-21 1987-10-13 Millipore Corporation Ion chromatography method and apparatus
US4859342A (en) 1986-10-14 1989-08-22 Suntory Limited Process for industrially separating biopolymers
US5135718A (en) * 1987-03-02 1992-08-04 Tosoh Corporation Apparatus for simultaneously analyzing vanillylmandelic acid, homovanillic acid and creatinine
JPH01126544A (ja) * 1987-11-11 1989-05-18 Hitachi Ltd 生化学分析方法及び装置
CA1336474C (en) 1989-04-20 1995-08-01 Martin Blake Hocking Hydrogen peroxide recovery from coloured aqueous solutions
US5091092A (en) * 1989-05-03 1992-02-25 Analytical Bio-Chemistry Laboratories, Inc. Single-loop chromatography system and method
US5071547A (en) * 1990-03-23 1991-12-10 Separations Technology, Inc. Column chromatographic column apparatus with switching capability
US5205845A (en) * 1990-09-28 1993-04-27 The Regents Of The University Of Michigan Mechanical gas chromatography injection valves and column multiplexing techniques
EP0533909B1 (de) 1991-03-28 1997-01-08 Perseptive Biosystems, Inc. Produktinformation in chromatographischem effluenten durch differenzbildung
US5419208A (en) 1993-01-29 1995-05-30 Upchurch Scientific, Inc. Multiport selection valve
US5630943A (en) 1995-11-30 1997-05-20 Merck Patent Gesellschaft Mit Beschrankter Haftung Discontinuous countercurrent chromatographic process and apparatus
US5983703A (en) * 1996-09-09 1999-11-16 Perkin-Elmer (Canada) Ltd. Analytical engine for gas chromatograph
US6175409B1 (en) * 1999-04-02 2001-01-16 Symyx Technologies, Inc. Flow-injection analysis and variable-flow light-scattering methods and apparatus for characterizing polymers

Also Published As

Publication number Publication date
EP1194200A4 (de) 2004-04-07
EP1194200B1 (de) 2009-01-07
ATE419911T1 (de) 2009-01-15
EP1194200A1 (de) 2002-04-10
AU4450900A (en) 2000-11-10
WO2000064557A1 (en) 2000-11-02
DK1194200T3 (da) 2009-05-04
US6318157B1 (en) 2001-11-20

Similar Documents

Publication Publication Date Title
DE60041331D1 (de) Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz
Venkatramani et al. An automated orthogonal two-dimensional liquid chromatograph
DK1371984T3 (da) Chromatografisk assay-anordning og fremgangsmåde til detektion af tilstedeværelsen af en analyt i en helblodpröve
DK1297338T3 (da) Mikroopstillinger til udförelse af proteomikanalyser
WO2003052142A3 (en) Analysis and detection of multiple target sequences using circular probes
AU2001239178A1 (en) Device and method for detecting organic molecules in a test substance
ATE277348T1 (de) Parallel- gaschromatograph mit mikrosensormatrix
NZ501838A (en) Retentate chromatography and protein chip arrays with applications in biology and medicine
DK1869475T3 (da) In vitro metode til samtidig detektering og identifikation af antibiotika i forskellige klasser og et tilsvarende diagnosekit
Xu et al. High-throughput mass-directed parallel purification incorporating a multiplexed single quadrupole mass spectrometer
DE69210687T2 (de) Probensammel- und Einlasssystem für Gaschromatographen
DE69638008D1 (de) Chromatograph für die Flüssigkeitschromatographie
WO2005048126A3 (en) High throughput autosampler
Fahrner et al. Real-time control of antibody loading during protein A affinity chromatography using an on-line assay
ITFI910005A0 (it) Provetta per analisi biologiche munita di dispositivo di controllo, di efficienza e di posizione, per letture fotometriche.
Zhang et al. A novel automated online SPE-coupled CE system for the analysis of sulfonamide antibiotics in wastewater
Tempels et al. On-line coupling of size exclusion chromatography and capillary electrophoresis via solid-phase extraction and a Tee-split interface
DK1360491T3 (da) Biokemisk fremgangsmåde og apparat til detektion af proteinegenskaber
DK1360329T3 (da) Biokemisk fremgangsmåde og apparat til detektion af genetiske egenskaber
DE3781793T2 (de) Chromatographischer duennschicht-flammionisationsdetektor fuer die mengenmaessige analyse von chromatographisch getrennten substanzen.
Jagota et al. Determination of trace levels of hydrazine in the penultimate intermediate of a novel anti-infective agent
DE69618904D1 (de) Probenanalyse
Ku et al. Determination of aminitrozole, metronidazole, ornidazole and tinidazole adulterated in traditional Chinese medicine by high performance liquid chromatography
DE59811247D1 (de) Nachweis von adenosin in kleinen proben
McAtee et al. Isolation of monoclonal antibody charge variants by displacement chromatography

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee