AU2001239178A1 - Device and method for detecting organic molecules in a test substance - Google Patents

Device and method for detecting organic molecules in a test substance

Info

Publication number
AU2001239178A1
AU2001239178A1 AU2001239178A AU3917801A AU2001239178A1 AU 2001239178 A1 AU2001239178 A1 AU 2001239178A1 AU 2001239178 A AU2001239178 A AU 2001239178A AU 3917801 A AU3917801 A AU 3917801A AU 2001239178 A1 AU2001239178 A1 AU 2001239178A1
Authority
AU
Australia
Prior art keywords
test substance
organic molecules
detecting organic
detecting
polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001239178A
Inventor
Gerhard Hartwich
Harald Lossau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Friz Biochem Gesellschaft fuer Bioanalytik mbH
Original Assignee
Friz Biochem Gesellschaft fuer Bioanalytik mbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Friz Biochem Gesellschaft fuer Bioanalytik mbH filed Critical Friz Biochem Gesellschaft fuer Bioanalytik mbH
Publication of AU2001239178A1 publication Critical patent/AU2001239178A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B01J2219/00434—Liquid crystal masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/00439—Maskless processes using micromirror arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00729—Peptide nucleic acids [PNA]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00745—Inorganic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00745—Inorganic compounds
    • B01J2219/0075—Metal based compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/18—Libraries containing only inorganic compounds or inorganic materials
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

An apparatus for the detection of biomolecules and polymers in samples comprising: (a) an array of test samples (T1, T2 ...) each of which contains a specific molecule; (b) an illuminating system consisting of an array of separate light sources (B1, B2 ...) arranged so that each sample is illuminated by only one light source; and (c) a detection system for detecting which test samples interact with the molecule to be detected, is new. An independent claim is included for detecting biomolecules and polymers using the apparatus.
AU2001239178A 2000-03-17 2001-02-15 Device and method for detecting organic molecules in a test substance Abandoned AU2001239178A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10013254A DE10013254A1 (en) 2000-03-17 2000-03-17 New apparatus, useful for detecting biomolecules and polymers, comprises array of samples containing specific molecules with separate light sources and system for detecting which samples interact with molecule to be detected
DE10013254 2000-03-17
PCT/DE2001/000571 WO2001069210A1 (en) 2000-03-17 2001-02-15 Device and method for detecting organic molecules in a test substance

Publications (1)

Publication Number Publication Date
AU2001239178A1 true AU2001239178A1 (en) 2001-09-24

Family

ID=7635267

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001239178A Abandoned AU2001239178A1 (en) 2000-03-17 2001-02-15 Device and method for detecting organic molecules in a test substance

Country Status (8)

Country Link
US (1) US7045362B2 (en)
EP (1) EP1264167B1 (en)
JP (1) JP2003527598A (en)
CN (1) CN1416526A (en)
AT (1) ATE294383T1 (en)
AU (1) AU2001239178A1 (en)
DE (3) DE10013254A1 (en)
WO (1) WO2001069210A1 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10128449B4 (en) * 2001-06-12 2004-07-15 Robert Bosch Gmbh Device and method for testing a material
EP2461156B8 (en) * 2001-06-29 2020-10-28 Meso Scale Technologies, LLC. Apparatus for luminescence test measurements
DE10155142C2 (en) * 2001-11-12 2003-09-04 Friz Biochem Gmbh Dark-field imaging device for spatially resolved dark-field imaging of a flat sample
US6824275B2 (en) * 2001-12-31 2004-11-30 Texas Instruments Incorporated Folded projection lens
DE10236433A1 (en) * 2002-08-06 2004-02-19 Förderverein Institut für Medizintechnik Dresden e.V. Device for optically detecting liquid samples in droplet form formed discretely on planar substrate or in cavities of substrate comprises optical detector arranged in optical axis of light beam, and optical element
DE10254685A1 (en) * 2002-11-22 2004-06-03 Roche Diagnostics Gmbh Measuring device for the optical examination of a test element
WO2004065000A1 (en) * 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
JP4230430B2 (en) * 2003-09-25 2009-02-25 富士通株式会社 SUBJECT EVALUATION DEVICE AND SUBJECT EVALUATION METHOD
US20060211071A1 (en) * 2004-12-14 2006-09-21 Millennium Pharmaceuticals, Inc. Device for aggregating, imaging and analyzing thrombi and a method of use
US7612350B2 (en) * 2005-01-18 2009-11-03 Olympus Corporation Scanning microscope and specimen image obtaining method in which adjacent data obtaining points are not consecutively obtained
DE102005049715B3 (en) * 2005-10-18 2007-05-10 Carl Zeiss Jena Gmbh Digital image sensor illumination arrangement, has diffuser screen whose distance from light emitting surface, thickness and strewing angle are measured so that intensity bled-off curve of beam cuts with specific intensity value
EP1792563A1 (en) * 2005-12-02 2007-06-06 F.Hoffmann-La Roche Ag Analysis system comprising an OLED display element
DE102006027836B4 (en) 2006-06-16 2020-02-20 Carl Zeiss Microscopy Gmbh Microscope with auto focus device
JP2008102135A (en) * 2006-10-06 2008-05-01 Sharp Corp Microstructure, manufacturing method of the same, and dna assay method
US8232109B2 (en) * 2006-10-06 2012-07-31 Sharp Laboratories Of America, Inc. Micro-pixelated active-matrix fluid-assay performance
US8231831B2 (en) * 2006-10-06 2012-07-31 Sharp Laboratories Of America, Inc. Micro-pixelated fluid-assay structure
US8232108B2 (en) * 2006-10-06 2012-07-31 Sharp Laboratories Of America, Inc. Method of making micro-pixelated fluid-assay structure
US8236245B2 (en) * 2006-10-06 2012-08-07 Sharp Laboratories Of America, Inc. Micro-pixelated fluid-assay precursor structure
US8236571B2 (en) * 2006-10-06 2012-08-07 Sharp Laboratories Of America, Inc. Method of making micro-pixelated fluid-assay precursor structure
US8236244B2 (en) * 2006-10-06 2012-08-07 Sharp Laboratories Of America, Inc. Micro-pixelated fluid-assay structure with on-board addressable, pixel-specific functionalization
EP2037439A1 (en) * 2007-09-06 2009-03-18 F.Hoffmann-La Roche Ag Electronic protection measures for organic displays in small medical devices
DE102007062250A1 (en) * 2007-12-21 2009-06-25 Evotec Ag Chemical and biological samples e.g. cell, testing device, has set of detecting devices arranged on base element, where each detecting device is attached to individual or group of sample receiving areas
US8628940B2 (en) * 2008-09-24 2014-01-14 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
WO2009120374A2 (en) * 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Methods and compositions for nucleic acid sample preparation
AU2009229157B2 (en) 2008-03-28 2015-01-29 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
US8143030B2 (en) 2008-09-24 2012-03-27 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
US8725477B2 (en) 2008-04-10 2014-05-13 Schlumberger Technology Corporation Method to generate numerical pseudocores using borehole images, digital rock samples, and multi-point statistics
EP2263107A4 (en) 2008-04-10 2016-12-28 Services Petroliers Schlumberger Method for characterizing a geological formation traversed by a borehole
US8383369B2 (en) * 2008-09-24 2013-02-26 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
US8242462B2 (en) * 2009-01-23 2012-08-14 Lumencor, Inc. Lighting design of high quality biomedical devices
WO2010110096A1 (en) * 2009-03-26 2010-09-30 ユニバーサル・バイオ・リサーチ株式会社 Reaction optical measurement device and method for measurement therefor
US8311788B2 (en) * 2009-07-01 2012-11-13 Schlumberger Technology Corporation Method to quantify discrete pore shapes, volumes, and surface areas using confocal profilometry
US20110149294A1 (en) * 2009-12-18 2011-06-23 Electronics And Telecommunications Research Institute Integrated interferometric apparatus and bio detection sensor system using it
GB201019181D0 (en) * 2010-11-12 2010-12-29 Univ Leicester Improved optical arrangement
KR20130073354A (en) * 2011-12-23 2013-07-03 한국전자통신연구원 Biochip analysis device
US9435993B2 (en) 2013-03-24 2016-09-06 Bruker Nano, Inc. Three dimensional microscopy imaging
JP6239562B2 (en) * 2015-09-14 2017-11-29 株式会社東芝 LIGHTING DEVICE AND BIO INFORMATION MEASURING DEVICE INCLUDING THE SAME
EP3420535B1 (en) 2016-02-26 2022-09-07 University Of Southern California Optimized volumetric imaging with selective volume illumination and light field detection
EP3336523A1 (en) * 2016-12-14 2018-06-20 F. Hoffmann-La Roche AG Illumination techniques for samples

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE383064C (en) * 1923-10-09 Unger A G Geb A sausage filling machine consisting of a container which receives the sausage mass and a sausage filling machine which is displaceable in this and which pushes the sausage mass forward
US3013487A (en) * 1957-01-18 1961-12-19 Time Inc Apparatus for tension control
US3013467A (en) 1957-11-07 1961-12-19 Minsky Marvin Microscopy apparatus
US5500188A (en) * 1984-03-01 1996-03-19 Molecular Devices Corporation Device for photoresponsive detection and discrimination
DE3833064A1 (en) 1988-09-29 1990-04-05 Dynatech Ag Branch Denkendorf READING UNIT FOR A MICROTEST PLATE
JP2750605B2 (en) * 1989-05-17 1998-05-13 スズキ株式会社 Particle aggregation pattern determination method
US5736410A (en) * 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5631734A (en) * 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) * 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
CA2179364C (en) * 1995-06-27 1999-09-28 Klaus W. Berndt Method and apparatus for detecting microorganisms
DE19731078C2 (en) * 1997-05-28 2000-09-14 Micronas Intermetall Gmbh Measuring device
DE19736641A1 (en) * 1997-08-22 1999-03-11 Michael G Dr Weller Multicomponent analysis of fluids
US5985568A (en) * 1997-09-04 1999-11-16 Motorola, Inc. Method of photoelectro-manipulation of target molecules and apparatus therefor
JP3346727B2 (en) 1997-09-19 2002-11-18 日立ソフトウエアエンジニアリング株式会社 Biochip and biochip reader
US6185030B1 (en) 1998-03-20 2001-02-06 James W. Overbeck Wide field of view and high speed scanning microscopy
EP1405666B1 (en) * 1998-08-28 2007-03-21 febit biotech GmbH Substrate for methods to determine analytes and methods to manufacture such substrates
US5936730A (en) * 1998-09-08 1999-08-10 Motorola, Inc. Bio-molecule analyzer with detector array and filter device
US6203985B1 (en) 1998-09-08 2001-03-20 Motorola, Inc. Bio-molecule analyzer with photosensitive material and fabrication
DE19921940C2 (en) 1998-11-23 2003-02-06 Friz Biochem Gmbh Method for the electrochemical detection of nucleic acid oligomer hybrids
DE19901761A1 (en) 1999-01-18 1999-07-01 Gerhard Dr Hartwich Oligonucleotides tagged with photoinducible redox-active unit
DE19945398A1 (en) 1999-09-22 2001-04-05 Friz Biochem Gmbh Electrochemical detection of sequence specific nucleic acid oligomer hybridization events

Also Published As

Publication number Publication date
EP1264167B1 (en) 2005-04-27
ATE294383T1 (en) 2005-05-15
JP2003527598A (en) 2003-09-16
US7045362B2 (en) 2006-05-16
DE10013254A1 (en) 2001-10-04
WO2001069210A1 (en) 2001-09-20
DE10190978D2 (en) 2003-04-17
DE50106036D1 (en) 2005-06-02
CN1416526A (en) 2003-05-07
US20030035109A1 (en) 2003-02-20
EP1264167A1 (en) 2002-12-11

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