JP7351897B2 - 液体クロマトグラフ分析装置、及びその制御方法 - Google Patents

液体クロマトグラフ分析装置、及びその制御方法 Download PDF

Info

Publication number
JP7351897B2
JP7351897B2 JP2021502293A JP2021502293A JP7351897B2 JP 7351897 B2 JP7351897 B2 JP 7351897B2 JP 2021502293 A JP2021502293 A JP 2021502293A JP 2021502293 A JP2021502293 A JP 2021502293A JP 7351897 B2 JP7351897 B2 JP 7351897B2
Authority
JP
Japan
Prior art keywords
pressure
flow path
liquid
liquid feeding
channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021502293A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2020175510A1 (https=
JPWO2020175510A5 (https=
Inventor
大介 秋枝
真 野上
伸也 伊藤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi High Tech Corp
Original Assignee
Hitachi High Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi High Tech Corp filed Critical Hitachi High Tech Corp
Publication of JPWO2020175510A1 publication Critical patent/JPWO2020175510A1/ja
Publication of JPWO2020175510A5 publication Critical patent/JPWO2020175510A5/ja
Application granted granted Critical
Publication of JP7351897B2 publication Critical patent/JP7351897B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/328—Control of physical parameters of the fluid carrier of pressure or speed valves, e.g. check valves of pumps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/382—Flow patterns flow switching in a single column
    • G01N2030/385—Flow patterns flow switching in a single column by switching valves

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Sampling And Sample Adjustment (AREA)
JP2021502293A 2019-02-26 2020-02-26 液体クロマトグラフ分析装置、及びその制御方法 Active JP7351897B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019032872 2019-02-26
JP2019032872 2019-02-26
PCT/JP2020/007598 WO2020175510A1 (ja) 2019-02-26 2020-02-26 液体クロマトグラフ分析装置、及びその制御方法

Publications (3)

Publication Number Publication Date
JPWO2020175510A1 JPWO2020175510A1 (https=) 2020-09-03
JPWO2020175510A5 JPWO2020175510A5 (https=) 2022-06-28
JP7351897B2 true JP7351897B2 (ja) 2023-09-27

Family

ID=72239933

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021502293A Active JP7351897B2 (ja) 2019-02-26 2020-02-26 液体クロマトグラフ分析装置、及びその制御方法

Country Status (5)

Country Link
US (1) US12298283B2 (https=)
EP (1) EP3933399B1 (https=)
JP (1) JP7351897B2 (https=)
CN (1) CN113454450B (https=)
WO (1) WO2020175510A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7444036B2 (ja) * 2020-12-01 2024-03-06 株式会社島津製作所 モニタリングシステム
US20240192180A1 (en) * 2021-04-14 2024-06-13 Hitachi High-Tech Corporation Automatic analyzer including hplc and control method for the same
JPWO2024080246A1 (https=) * 2022-10-14 2024-04-18
CN120019274A (zh) * 2022-10-31 2025-05-16 株式会社日立高新技术 液相色谱仪的控制方法以及液相色谱仪

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002086437A1 (en) 2001-03-02 2002-10-31 Waters Investments Limited Methods and apparatus for determining the presence or absence of a fluid leak
JP2005257609A (ja) 2004-03-15 2005-09-22 Shimadzu Corp 液体クロマトグラフ装置
JP2007527014A (ja) 2004-03-05 2007-09-20 ウオーターズ・インベストメンツ・リミテツド 流体通路利用の圧力監視装置の最適化
JP2008209334A (ja) 2007-02-28 2008-09-11 Hitachi High-Technologies Corp 液体クロマトグラフィ装置
JP2011099764A (ja) 2009-11-06 2011-05-19 Hitachi High-Technologies Corp 液体クロマトグラフ装置
JP2015052533A (ja) 2013-09-06 2015-03-19 株式会社日立製作所 クロマトグラフィー装置およびクロマトグラフィー方法
WO2018207295A1 (ja) 2017-05-10 2018-11-15 株式会社島津製作所 送液装置及びその送液装置を備えた液体クロマトグラフ

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2972246A (en) * 1958-05-19 1961-02-21 Phillips Petroleum Co Chromatographic analyzer
US3892531A (en) * 1973-07-05 1975-07-01 Beckman Instruments Inc Apparatus for sequencing peptides and proteins
US4059009A (en) * 1976-09-10 1977-11-22 Micromeritics Instrument Corporation Liquid chromatography system
JP2504356B2 (ja) * 1992-04-09 1996-06-05 株式会社島津製作所 示差屈折計
EP0723152A2 (en) * 1995-01-23 1996-07-24 Hewlett-Packard Company Method and apparatus for detector ignition
JP3603506B2 (ja) * 1996-11-01 2004-12-22 株式会社島津製作所 液体クロマトグラフのオートインジェクタ
ATE419911T1 (de) * 1999-04-23 2009-01-15 Advion Biosystems Inc Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz
US6805799B2 (en) * 2002-12-21 2004-10-19 Qi-Feng Ma Simulated moving bed chromatographic focusing
US7460958B2 (en) * 2004-10-07 2008-12-02 E.I. Du Pont De Nemours And Company Computer-implemented system and method for analyzing mixtures of gases
EP1589336A1 (en) 2005-02-04 2005-10-26 Agilent Technologies, Inc. Leakage checking and calibration of a liquid delivery system
EP2244091B8 (en) * 2009-04-21 2016-02-24 Agilent Technologies, Inc. Leak detection upstream of a mixing point
WO2010139359A1 (en) 2009-06-03 2010-12-09 Agilent Technologies, Inc. Sample injector with metering device balancing pressure differences in an intermediate valve state
US9417219B2 (en) 2009-11-16 2016-08-16 Agilent Technologies, Inc. Sample separation device with valve
JP2012047655A (ja) * 2010-08-30 2012-03-08 Hitachi Ltd 液体クロマトグラフ装置及び分析方法
US10054569B2 (en) * 2010-10-29 2018-08-21 Thermo Finnigan Llc Method and system for liquid chromatography fluidic monitoring
EP2632561B1 (en) 2010-10-29 2017-09-20 Thermo Finnigan LLC Method and system for liquid chromatograph with compressibility and viscosity monitoring to identify fluids
US9228982B2 (en) * 2011-09-16 2016-01-05 Agilent Technologies, Inc. Single injection valve for HPLC combining sample introduction, wash cycles and diagnosis
DE102011087935B4 (de) * 2011-12-07 2020-01-02 Agilent Technologies Inc. Spülventil für Hochdruckpumpe im Niedrigflussbetrieb
WO2013086281A1 (en) * 2011-12-09 2013-06-13 Waters Technologies Corporation Select valve for liquid chromatography systems
JP5270771B2 (ja) * 2012-02-03 2013-08-21 株式会社日立ハイテクノロジーズ 液体クロマトグラフ装置及び試料導入装置
WO2015189927A1 (ja) * 2014-06-11 2015-12-17 株式会社島津製作所 液体試料導入装置
DE102016121512A1 (de) 2016-11-10 2018-05-17 Dionex Softron Gmbh System, Verfahren und Verwendung der Flüssigkeitschromatografie

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002086437A1 (en) 2001-03-02 2002-10-31 Waters Investments Limited Methods and apparatus for determining the presence or absence of a fluid leak
JP2007527014A (ja) 2004-03-05 2007-09-20 ウオーターズ・インベストメンツ・リミテツド 流体通路利用の圧力監視装置の最適化
JP2005257609A (ja) 2004-03-15 2005-09-22 Shimadzu Corp 液体クロマトグラフ装置
JP2008209334A (ja) 2007-02-28 2008-09-11 Hitachi High-Technologies Corp 液体クロマトグラフィ装置
JP2011099764A (ja) 2009-11-06 2011-05-19 Hitachi High-Technologies Corp 液体クロマトグラフ装置
JP2015052533A (ja) 2013-09-06 2015-03-19 株式会社日立製作所 クロマトグラフィー装置およびクロマトグラフィー方法
WO2018207295A1 (ja) 2017-05-10 2018-11-15 株式会社島津製作所 送液装置及びその送液装置を備えた液体クロマトグラフ

Also Published As

Publication number Publication date
JPWO2020175510A1 (https=) 2020-09-03
CN113454450B (zh) 2024-12-03
WO2020175510A1 (ja) 2020-09-03
EP3933399A1 (en) 2022-01-05
EP3933399B1 (en) 2024-11-20
CN113454450A (zh) 2021-09-28
US12298283B2 (en) 2025-05-13
EP3933399A4 (en) 2022-11-16
US20220050088A1 (en) 2022-02-17

Similar Documents

Publication Publication Date Title
JP7351897B2 (ja) 液体クロマトグラフ分析装置、及びその制御方法
JP5111476B2 (ja) 液体試料分析装置及び液体試料導入装置
JP6964065B2 (ja) 液体クロマトグラフ質量分析装置
CN109154291B (zh) 切换阀、二元泵以及具备该二元泵的液相色谱仪
EP2244091B1 (en) Leak detection upstream of a mixing point
US20180340916A1 (en) Methods for liquid chromatography fluidic monitoring
US10054569B2 (en) Method and system for liquid chromatography fluidic monitoring
US20150121996A1 (en) Automated Sample Injection Apparatus, Multiport Valve, and Methods of Making and Using The Same
US10954931B2 (en) Linear displacement pump with position sensing and related systems and methods
US9417219B2 (en) Sample separation device with valve
WO2013192036A1 (en) Linear displacement pump with position sensing and related systems and methods
JP6992882B2 (ja) オートサンプラ及び液体クロマトグラフ
US20140318224A1 (en) High-pressure constant flow rate pump and high-pressure constant flow rate liquid transfer method
US20200240960A1 (en) Methods for liquid chromatography fluidic monitoring
EP2703809B1 (en) Mobile phase preparation device for liquid chromatography
US20240360826A1 (en) Inspection method
EP3320335B1 (en) Microfluidic device
US20130091935A1 (en) Liquid chromatograph and pump unit for liquid chromatograph
CN117136301A (zh) 具有hplc的自动分析装置以及该自动分析装置的控制方法
JP2005257609A (ja) 液体クロマトグラフ装置
US20240230455A1 (en) Determining a restriction in a liquid network
EP4542033A1 (en) Liquid delivery abnormality diagnosis method and liquid chromatograph
US11940422B2 (en) Microfluidic device

Legal Events

Date Code Title Description
A529 Written submission of copy of amendment under article 34 pct

Free format text: JAPANESE INTERMEDIATE CODE: A5211

Effective date: 20210728

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220620

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220620

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230613

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230718

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230905

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230914

R150 Certificate of patent or registration of utility model

Ref document number: 7351897

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150