CN113454069A - 1，2，4-三嗪-3，5-二酮类化合物及其制备方法和应用 - Google Patents
1，2，4-三嗪-3，5-二酮类化合物及其制备方法和应用 Download PDFInfo
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- CN113454069A CN113454069A CN202080005958.3A CN202080005958A CN113454069A CN 113454069 A CN113454069 A CN 113454069A CN 202080005958 A CN202080005958 A CN 202080005958A CN 113454069 A CN113454069 A CN 113454069A
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- triazine
- dichloro
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
本发明提供了一种1，2，4‑三嗪‑3，5‑二酮类化合物及其制备方法和应用，本发明提供的具有式(I)所示结构的，2，4‑三嗪‑3，5‑二酮类化合物对THRβ具有选择性激动作用，其活性、选择性和代谢稳定性相对于已公开化合物存在显著优势，能够作为甲状腺激素受体相关疾病的治疗和/或预防药物来发挥作用，甲状腺激素受体相关疾病包括但不限于肥胖、糖尿病、高胆固醇血症、高脂血症、高甘油三酯血症、肝脏脂肪病变、非酒精性脂肪肝、非酒精性脂肪性肝炎、家族性高胆固醇血症、血脂异常、动脉粥样硬化症、甲状腺功能减退症、甲状腺癌。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019111774827 | 2019-11-26 | ||
| CN201911177482 | 2019-11-26 | ||
| PCT/CN2020/131367 WO2021104288A1 (zh) | 2019-11-26 | 2020-11-25 | 1，2，4-三嗪-3，5-二酮类化合物及其制备方法和应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113454069A true CN113454069A (zh) | 2021-09-28 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080005958.3A Pending CN113454069A (zh) | 2019-11-26 | 2020-11-25 | 1，2，4-三嗪-3，5-二酮类化合物及其制备方法和应用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230089582A1 (zh) |
| EP (1) | EP4083024A4 (zh) |
| JP (1) | JP2023503154A (zh) |
| CN (1) | CN113454069A (zh) |
| CA (1) | CA3158379A1 (zh) |
| TW (1) | TWI763147B (zh) |
| WO (1) | WO2021104288A1 (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022184177A1 (zh) * | 2021-03-04 | 2022-09-09 | 甫康（上海）健康科技有限责任公司 | 一种芳香化合物、其制备方法及其应用 |
| CN115073429A (zh) * | 2021-03-15 | 2022-09-20 | 昆药集团股份有限公司 | 一种1，2，4-三嗪-3，5-二酮类化合物的盐型、晶型及其制备方法 |
| CN115583920A (zh) * | 2022-08-31 | 2023-01-10 | 浙江大学 | 一种四嗪类化合物及其制备方法和应用 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202342457A (zh) * | 2022-02-07 | 2023-11-01 | 大陸商四川海思科製藥有限公司 | 一種嗒𠯤酮衍生物製備方法及其中間物 |
Citations (7)
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| CN115583920A (zh) * | 2022-08-31 | 2023-01-10 | 浙江大学 | 一种四嗪类化合物及其制备方法和应用 |
| CN115583920B (zh) * | 2022-08-31 | 2024-02-20 | 浙江大学 | 一种四嗪类化合物及其制备方法和应用 |
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| CA3158379A1 (en) | 2021-06-03 |
| TW202120498A (zh) | 2021-06-01 |
| US20230089582A1 (en) | 2023-03-23 |
| JP2023503154A (ja) | 2023-01-26 |
| EP4083024A1 (en) | 2022-11-02 |
| TWI763147B (zh) | 2022-05-01 |
| WO2021104288A1 (zh) | 2021-06-03 |
| EP4083024A4 (en) | 2023-11-01 |
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