CN113365988A - Shp2抑制剂及其应用 - Google Patents

Shp2抑制剂及其应用 Download PDF

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CN113365988A
CN113365988A CN202080008742.2A CN202080008742A CN113365988A CN 113365988 A CN113365988 A CN 113365988A CN 202080008742 A CN202080008742 A CN 202080008742A CN 113365988 A CN113365988 A CN 113365988A
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amino
compound
dihydrospiro
indene
thio
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CN113365988B (zh
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吴颢
吴文茂
陈忠研
李玲
林远望
吴云飞
朱林强
袁丁
王丰
张展
冯东杰
赵新涛
余军
束庆玉
程见洪
韩晗
郭晶
兰宏
王家炳
丁列明
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Betta Pharmaceuticals Co Ltd
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Betta Pharmaceuticals Co Ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

提供一种作为含Src同源区2蛋白质酪氨酸磷酸酶2(SHP2)抑制剂应用的化合物(如式Ⅰ所示)，及其药物组合物、制备方法，以及其在治疗SHP2介导的疾病中的用途。所述化合物通过参与调节细胞增殖、凋亡、迁移、新生血管生成等多个过程而发挥作用。

Description

PCT国内申请，说明书已公开。

Claims (52)

  1. PCT国内申请，权利要求书已公开。
CN202080008742.2A 2019-01-31 2020-01-17 Shp2抑制剂及其应用 Active CN113365988B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2019/074141 2019-01-31
CN2019074141 2019-01-31
CN201910834019 2019-09-04
CN2019108340199 2019-09-04
PCT/CN2020/072774 WO2020156243A1 (zh) 2019-01-31 2020-01-17 Shp2抑制剂及其应用

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CN113365988A true CN113365988A (zh) 2021-09-07
CN113365988B CN113365988B (zh) 2023-10-03

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TW (1) TW202043212A (zh)
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CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
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WO2022241975A1 (en) * 2021-05-20 2022-11-24 Etern Biopharma (Shanghai) Co., Ltd. Methods for treating cancers associated with egfr mutation
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CN115521305A (zh) * 2022-09-20 2022-12-27 中国药科大学 Shp2&nampt双靶向化合物及其药物组合物和用途
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WO2020156243A1 (zh) 2020-08-06
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