CN113365988A - Shp2抑制剂及其应用 - Google Patents

Shp2抑制剂及其应用 Download PDF

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CN113365988A
CN113365988A CN202080008742.2A CN202080008742A CN113365988A CN 113365988 A CN113365988 A CN 113365988A CN 202080008742 A CN202080008742 A CN 202080008742A CN 113365988 A CN113365988 A CN 113365988A
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amino
compound
dihydrospiro
indene
thio
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CN113365988B (zh
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吴颢
吴文茂
陈忠研
李玲
林远望
吴云飞
朱林强
袁丁
王丰
张展
冯东杰
赵新涛
余军
束庆玉
程见洪
韩晗
郭晶
兰宏
王家炳
丁列明
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Betta Pharmaceuticals Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

提供一种作为含Src同源区2蛋白质酪氨酸磷酸酶2(SHP2)抑制剂应用的化合物(如式Ⅰ所示),及其药物组合物、制备方法,以及其在治疗SHP2介导的疾病中的用途。所述化合物通过参与调节细胞增殖、凋亡、迁移、新生血管生成等多个过程而发挥作用。

Description

PCT国内申请,说明书已公开。

Claims (52)

  1. PCT国内申请,权利要求书已公开。
CN202080008742.2A 2019-01-31 2020-01-17 Shp2抑制剂及其应用 Active CN113365988B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2019/074141 2019-01-31
CN2019074141 2019-01-31
CN201910834019 2019-09-04
CN2019108340199 2019-09-04
PCT/CN2020/072774 WO2020156243A1 (zh) 2019-01-31 2020-01-17 Shp2抑制剂及其应用

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CN113365988A true CN113365988A (zh) 2021-09-07
CN113365988B CN113365988B (zh) 2023-10-03

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WO2022235866A1 (en) 2021-05-05 2022-11-10 Revolution Medicines, Inc. Covalent ras inhibitors and uses thereof
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WO2022241975A1 (en) * 2021-05-20 2022-11-24 Etern Biopharma (Shanghai) Co., Ltd. Methods for treating cancers associated with egfr mutation
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TW202317100A (zh) 2021-06-23 2023-05-01 瑞士商諾華公司 包含kras g12c抑制劑的藥物組合及其用於治療癌症之用途
MX2024002561A (es) 2021-09-01 2024-03-20 Novartis Ag Combinaciones farmaceuticas que comprenden un inhibidor de tead y usos de las mismas para el tratamiento de canceres.
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CN115521305A (zh) * 2022-09-20 2022-12-27 中国药科大学 Shp2&nampt双靶向化合物及其药物组合物和用途
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WO2020156243A1 (zh) 2020-08-06
TW202043212A (zh) 2020-12-01

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