CN113347993A - 突变牛痘病毒及其用途 - Google Patents

突变牛痘病毒及其用途 Download PDF

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CN113347993A
CN113347993A CN201980084497.0A CN201980084497A CN113347993A CN 113347993 A CN113347993 A CN 113347993A CN 201980084497 A CN201980084497 A CN 201980084497A CN 113347993 A CN113347993 A CN 113347993A
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vaccinia virus
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amino acid
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宋晓彤
M·维斯科夫斯卡
M·L·戈麦斯梅达利亚
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Isao Clarks Therapy Co ltd
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CN201980084497.0A 2018-10-22 2019-10-21 突变牛痘病毒及其用途 Pending CN113347993A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862749102P 2018-10-22 2018-10-22
US62/749,102 2018-10-22
US201962912344P 2019-10-08 2019-10-08
US62/912,344 2019-10-08
PCT/US2019/057134 WO2020086423A1 (en) 2018-10-22 2019-10-21 Mutant vaccinia viruses and use thereof

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EP (1) EP3870217A4 (https=)
JP (1) JP2022508942A (https=)
KR (1) KR20210108944A (https=)
CN (1) CN113347993A (https=)
AU (1) AU2019367965A1 (https=)
CA (1) CA3117378A1 (https=)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114369587A (zh) * 2021-12-25 2022-04-19 苏州瀚源新酶生物科技有限公司 牛痘病毒加帽酶突变体、重组载体、重组工程菌及其应用
CN116179654A (zh) * 2022-12-30 2023-05-30 军事科学院军事医学研究院环境医学与作业医学研究所 一种检测水中镉离子的滚环扩增检测体系及其应用
CN116990507A (zh) * 2023-06-29 2023-11-03 深圳市新产业生物医学工程股份有限公司 一种用于猴痘病毒感染的早期筛查的方法

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020232247A1 (en) 2019-05-14 2020-11-19 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
IL298999A (en) 2020-06-11 2023-02-01 Provention Bio Inc Methods and compositions for the prevention of type 1 diabetes
CN116615442A (zh) * 2020-09-08 2023-08-18 优特力克斯有限公司 程序性细胞死亡1多肽变体
WO2022147480A1 (en) 2020-12-30 2022-07-07 Ansun Biopharma, Inc. Oncolytic virus encoding sialidase and multispecific immune cell engager
US20240067936A1 (en) * 2021-02-26 2024-02-29 Sillajen, Inc. Oncolytic virus and uses thereof
JP2024520444A (ja) 2021-05-24 2024-05-24 プロヴェンション・バイオ・インコーポレイテッド 1型糖尿病を治療するための方法
CN113322280A (zh) * 2021-06-18 2021-08-31 苏州工业园区唯可达生物科技有限公司 一种可以逃逸体内存在的既有抗痘苗病毒中和抗体的重组痘苗病毒载体
CN113481241A (zh) * 2021-06-18 2021-10-08 苏州工业园区唯可达生物科技有限公司 一种敲除h3l基因的重组痘苗病毒载体
CN113322279A (zh) * 2021-06-18 2021-08-31 苏州工业园区唯可达生物科技有限公司 一种敲除d8l基因的重组痘苗病毒载体
CN113481240A (zh) * 2021-06-18 2021-10-08 苏州工业园区唯可达生物科技有限公司 一种敲除l1r基因的重组痘苗病毒载体
CN114058645A (zh) * 2021-06-22 2022-02-18 苏州工业园区唯可达生物科技有限公司 一种可以逃逸体内存在的既有抗痘苗病毒中和抗体的重组痘苗病毒载体
CN114058643A (zh) * 2021-06-22 2022-02-18 苏州工业园区唯可达生物科技有限公司 一种可以逃逸体内存在的既有抗痘苗病毒中和抗体的重组痘苗病毒载体
CN114058644A (zh) * 2021-06-22 2022-02-18 苏州工业园区唯可达生物科技有限公司 一种可以逃逸体内存在的既有抗痘苗病毒中和抗体的重组痘苗病毒载体
GB2614309A (en) 2021-12-24 2023-07-05 Stratosvir Ltd Improved vaccinia virus vectors
KR20240003051A (ko) * 2022-06-29 2024-01-08 신라젠(주) Cd55 및 cd59를 동시 발현하는 항암 바이러스
WO2025184411A1 (en) 2024-02-27 2025-09-04 Calidi Biotherapeutics (Nevada), Inc. Serum-resistant eev viruses and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030165477A1 (en) * 2000-04-14 2003-09-04 Jean-Marc Balloul Poxvirus with targeted infection specificity
US7393533B1 (en) * 2004-11-08 2008-07-01 La Jolla Institute For Allergy And Immunology H3L envelope protein immunization methods and H3L envelope passive protection methods
WO2009026456A2 (en) * 2007-08-21 2009-02-26 University Of Massachusetts Poxvirus methods and compositions
CN102573902A (zh) * 2009-11-05 2012-07-11 分子医学和免疫学中心 用于基于亚单位的痘病毒疫苗的包含痘病毒衍生肽和针对抗原呈递细胞的抗体的免疫偶联物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US165477A (en) * 1875-07-13 Improvement in smelting-furnaces
JP4344805B2 (ja) * 2000-07-07 2009-10-14 独立行政法人科学技術振興機構 遺伝子組換えワクシニアウイルスワクチン
JP4802401B2 (ja) * 2000-11-07 2011-10-26 トランスジェン・ソシエテ・アノニム 標的化感染特異性を有するポックスウイルス
US7645456B2 (en) * 2001-04-23 2010-01-12 Sanofi Pasteur Biologics Co. Vaccinia virus strains
US7521195B1 (en) * 2005-07-21 2009-04-21 Celera Corporation Lung disease targets and uses thereof
WO2009048769A2 (en) * 2007-10-10 2009-04-16 Kirin Pharma Kabushiki Kaisha Vaccinia virus h3l and b5r specific monoclonal antibodies and methods of making and using same
FI20115914L (fi) * 2011-09-16 2013-03-17 Oncos Therapeutics Ltd Muunnettu onkolyyttinen virus
WO2013112986A1 (en) * 2012-01-27 2013-08-01 Gliknik Inc. Fusion proteins comprising igg2 hinge domains
CA3029106A1 (en) * 2016-06-28 2018-01-04 Universitat Ulm Complement inhibitors and uses thereof
IL264893B (en) * 2016-08-19 2022-08-01 Sementis Ltd Vaccines for viruses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030165477A1 (en) * 2000-04-14 2003-09-04 Jean-Marc Balloul Poxvirus with targeted infection specificity
US7393533B1 (en) * 2004-11-08 2008-07-01 La Jolla Institute For Allergy And Immunology H3L envelope protein immunization methods and H3L envelope passive protection methods
WO2009026456A2 (en) * 2007-08-21 2009-02-26 University Of Massachusetts Poxvirus methods and compositions
CN102573902A (zh) * 2009-11-05 2012-07-11 分子医学和免疫学中心 用于基于亚单位的痘病毒疫苗的包含痘病毒衍生肽和针对抗原呈递细胞的抗体的免疫偶联物

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114369587A (zh) * 2021-12-25 2022-04-19 苏州瀚源新酶生物科技有限公司 牛痘病毒加帽酶突变体、重组载体、重组工程菌及其应用
CN114369587B (zh) * 2021-12-25 2024-03-15 苏州瀚源新酶生物科技有限公司 牛痘病毒加帽酶突变体、重组载体、重组工程菌及其应用
CN116179654A (zh) * 2022-12-30 2023-05-30 军事科学院军事医学研究院环境医学与作业医学研究所 一种检测水中镉离子的滚环扩增检测体系及其应用
CN116179654B (zh) * 2022-12-30 2023-09-15 军事科学院军事医学研究院环境医学与作业医学研究所 一种检测水中镉离子的滚环扩增检测体系及其应用
CN116990507A (zh) * 2023-06-29 2023-11-03 深圳市新产业生物医学工程股份有限公司 一种用于猴痘病毒感染的早期筛查的方法

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JP2022508942A (ja) 2022-01-19
IL282509A (en) 2021-06-30
WO2020086423A1 (en) 2020-04-30
US20210388388A1 (en) 2021-12-16
EP3870217A1 (en) 2021-09-01
AU2019367965A1 (en) 2021-06-03
KR20210108944A (ko) 2021-09-03
MX2021004403A (es) 2021-10-22

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