CN113271962A - 利用靶向TGF-β抑制的三阴性乳腺癌的治疗 - Google Patents

利用靶向TGF-β抑制的三阴性乳腺癌的治疗 Download PDF

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CN113271962A
CN113271962A CN201980069495.4A CN201980069495A CN113271962A CN 113271962 A CN113271962 A CN 113271962A CN 201980069495 A CN201980069495 A CN 201980069495A CN 113271962 A CN113271962 A CN 113271962A
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hmga2
tgf
expression
seq
patient
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G·洛克
I·度赛特
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast
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    • C07K2319/00—Fusion polypeptide
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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CN201980069495.4A 2018-08-22 2019-08-22 利用靶向TGF-β抑制的三阴性乳腺癌的治疗 Pending CN113271962A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862721249P 2018-08-22 2018-08-22
US62/721,249 2018-08-22
PCT/US2019/047734 WO2020041607A1 (en) 2018-08-22 2019-08-22 Treatment of triple negative breast cancer with targeted tgf-b inhibition

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CN113271962A true CN113271962A (zh) 2021-08-17

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US (1) US20210196822A1 (https=)
EP (1) EP3840776A4 (https=)
JP (1) JP2021534195A (https=)
KR (1) KR20210046716A (https=)
CN (1) CN113271962A (https=)
AU (1) AU2019325593A1 (https=)
BR (1) BR112021003093A2 (https=)
CA (1) CA3110276A1 (https=)
IL (1) IL280958A (https=)
MX (1) MX2021002006A (https=)
SG (1) SG11202101663WA (https=)
WO (1) WO2020041607A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112640887A (zh) * 2020-12-25 2021-04-13 武汉睿健医药科技有限公司 一种神经干细胞冻存液及其应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230365653A1 (en) * 2020-07-24 2023-11-16 Mabwell (shanghai) Bioscience Co., Ltd. Tgf-beta rii mutant and fusion protein thereof
CN121319180A (zh) * 2020-07-28 2026-01-13 乐普生物科技股份有限公司 靶向PD-L1和TGF-β的双功能分子
KR20230020041A (ko) 2021-08-02 2023-02-10 숙명여자대학교산학협력단 miR-181a 억제제 및 커큐민을 유효성분으로 포함하는 삼중음성유방암 치료용 조성물
TW202330626A (zh) * 2021-09-30 2023-08-01 大陸商貝達藥業股份有限公司 雙特異性抗體及其應用
CN115671314A (zh) * 2022-11-16 2023-02-03 中南大学 一种抗血管生成靶向黑磷纳米片的制备方法及其应用

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WO2015118175A2 (en) * 2014-02-10 2015-08-13 Merck Patent Gmbh TARGETED TGFβ INHIBITION
WO2016145294A1 (en) * 2015-03-12 2016-09-15 The University Of Chicago Methods for determining prognosis for breast cancer patients
CN108431006A (zh) * 2015-10-13 2018-08-21 斯克利普斯研究院 酪蛋白激酶1δ在乳腺癌中的治疗靶向

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SG166768A1 (en) * 2003-12-23 2010-12-29 Rinat Neuroscience Corp Agonist anti-trkc antibodies and methods using same
WO2014205184A2 (en) * 2013-06-19 2014-12-24 University Of Miami Classification system, methods and kit for classifying. predicting and treating breast cancer

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2015118175A2 (en) * 2014-02-10 2015-08-13 Merck Patent Gmbh TARGETED TGFβ INHIBITION
WO2016145294A1 (en) * 2015-03-12 2016-09-15 The University Of Chicago Methods for determining prognosis for breast cancer patients
CN108431006A (zh) * 2015-10-13 2018-08-21 斯克利普斯研究院 酪蛋白激酶1δ在乳腺癌中的治疗靶向

Non-Patent Citations (2)

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Title
YAN LAN等: "Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β", SCI. TRANSL. MED., vol. 10, pages 1 - 15 *
李荣萍;张芳;韩猛;冯凯;张铁;: "PARP-1与HMGA2在三阴型老年局部晚期乳腺癌中的表达及对预后的影响", 山西医药杂志, no. 23, pages 2736 - 2739 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112640887A (zh) * 2020-12-25 2021-04-13 武汉睿健医药科技有限公司 一种神经干细胞冻存液及其应用

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MX2021002006A (es) 2021-04-28
BR112021003093A2 (pt) 2021-05-11
IL280958A (en) 2021-04-29
EP3840776A4 (en) 2022-09-28
KR20210046716A (ko) 2021-04-28
CA3110276A1 (en) 2020-02-27
EP3840776A1 (en) 2021-06-30
US20210196822A1 (en) 2021-07-01
SG11202101663WA (en) 2021-03-30
AU2019325593A1 (en) 2021-03-18
JP2021534195A (ja) 2021-12-09
WO2020041607A1 (en) 2020-02-27

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