CN113260862A - 采用颗粒聚集或解聚的均相测定 - Google Patents

采用颗粒聚集或解聚的均相测定 Download PDF

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Publication number
CN113260862A
CN113260862A CN201980066465.8A CN201980066465A CN113260862A CN 113260862 A CN113260862 A CN 113260862A CN 201980066465 A CN201980066465 A CN 201980066465A CN 113260862 A CN113260862 A CN 113260862A
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particles
sample
plates
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analyte
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Chinese (zh)
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斯蒂芬·Y·周
丁惟
李骥
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Shanghai Yisheng Biotechnology Co ltd
Yewei Co ltd
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Essenlix Corp
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0227—Investigating particle size or size distribution by optical means using imaging; using holography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/045—Connecting closures to device or container whereby the whole cover is slidable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0042—Investigating dispersion of solids
    • G01N2015/0053—Investigating dispersion of solids in liquids, e.g. trouble
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0092—Monitoring flocculation or agglomeration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N2015/025—Methods for single or grouped particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/03—Electro-optical investigation of a plurality of particles, the analyser being characterised by the optical arrangement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
CN201980066465.8A 2018-08-16 2019-08-16 采用颗粒聚集或解聚的均相测定 Pending CN113260862A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862719062P 2018-08-16 2018-08-16
US62/719,062 2018-08-16
PCT/US2019/046949 WO2020037289A1 (en) 2018-08-16 2019-08-16 Homogeneous assay with particle aggregation or de-aggregation

Publications (1)

Publication Number Publication Date
CN113260862A true CN113260862A (zh) 2021-08-13

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Country Status (4)

Country Link
US (1) US11709162B2 (https=)
JP (1) JP2021536563A (https=)
CN (1) CN113260862A (https=)
WO (1) WO2020037289A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114184800A (zh) * 2020-09-15 2022-03-15 深圳迈瑞生物医疗电子股份有限公司 样本分析方法及样本分析装置

Families Citing this family (5)

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US20220074845A1 (en) * 2019-01-03 2022-03-10 Pixcell Medical Technologies Ltd. Systems and methods for analyzing a fluid sample
US20220276235A1 (en) * 2019-07-18 2022-09-01 Essenlix Corporation Imaging based homogeneous assay
EP4132708A4 (en) * 2020-04-09 2024-04-03 Ilytica LLC Assays with induced aggregation for enhanced sensitivity
WO2022168434A1 (ja) * 2021-02-05 2022-08-11 株式会社堀場製作所 粒子分析装置、粒子分析方法、及び、粒子分析装置用プログラム
CN115219570B (zh) * 2022-07-18 2024-03-26 山东大学 一种基于纳米粒子间电荷转移实现双发射电化学发光的方法

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WO1987003690A1 (en) * 1985-12-10 1987-06-18 Murex Corporation Particle-bound binding component immunoassay
CN1176698A (zh) * 1995-02-03 1998-03-18 英国生物电池国际有限公司 分析设备与方法
CN1178580A (zh) * 1996-02-05 1998-04-08 达德国际有限公司 均相溶胶－溶胶测定
WO2002023154A2 (en) * 2000-09-13 2002-03-21 Biometric Imaging, Inc. Aggregation-based assays
US20030215810A1 (en) * 2002-05-10 2003-11-20 Yi Lu Simple catalytic DNA biosensors for ions based on color changes
CN101389960A (zh) * 2005-12-21 2009-03-18 梅索斯卡莱科技公司 具有分析试剂的分析模块及其制备和使用方法
CN103917870A (zh) * 2011-11-16 2014-07-09 贝克顿·迪金森公司 用于检测样品中的分析物的方法和系统
CN104169707A (zh) * 2012-02-02 2014-11-26 奥里巴Abx股份有限公司 用于从生物样品进行血液学和生物化学测量的装置和方法
CN105246682A (zh) * 2013-03-15 2016-01-13 普林斯顿大学理事会 用于化学和生物感测的复合纳米颗粒结构
CN105247366A (zh) * 2013-01-31 2016-01-13 普瑞威尔公司 测试设备
WO2017048871A1 (en) * 2015-09-14 2017-03-23 Essenlix Corp. Device and system for analyzing a sample, particularly blood, as well as methods of using the same
US20180202903A1 (en) * 2015-08-10 2018-07-19 Essenlix Corporation Bio/chemical assay devices and methods for simplified steps, small samples, accelerated speed, and ease-of-use

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CN103917870A (zh) * 2011-11-16 2014-07-09 贝克顿·迪金森公司 用于检测样品中的分析物的方法和系统
CN104169707A (zh) * 2012-02-02 2014-11-26 奥里巴Abx股份有限公司 用于从生物样品进行血液学和生物化学测量的装置和方法
CN105247366A (zh) * 2013-01-31 2016-01-13 普瑞威尔公司 测试设备
CN105246682A (zh) * 2013-03-15 2016-01-13 普林斯顿大学理事会 用于化学和生物感测的复合纳米颗粒结构
US20180202903A1 (en) * 2015-08-10 2018-07-19 Essenlix Corporation Bio/chemical assay devices and methods for simplified steps, small samples, accelerated speed, and ease-of-use
WO2017048871A1 (en) * 2015-09-14 2017-03-23 Essenlix Corp. Device and system for analyzing a sample, particularly blood, as well as methods of using the same

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Publication number Priority date Publication date Assignee Title
CN114184800A (zh) * 2020-09-15 2022-03-15 深圳迈瑞生物医疗电子股份有限公司 样本分析方法及样本分析装置

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US11709162B2 (en) 2023-07-25
WO2020037289A1 (en) 2020-02-20
US20210255177A1 (en) 2021-08-19
JP2021536563A (ja) 2021-12-27

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