CN1132581C - 含米尔塔扎平和一种或多种选择性5－羟色胺再摄取抑制剂的药物组合物 - Google Patents

含米尔塔扎平和一种或多种选择性5－羟色胺再摄取抑制剂的药物组合物 Download PDF

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Publication number
CN1132581C
CN1132581C CN97115549A CN97115549A CN1132581C CN 1132581 C CN1132581 C CN 1132581C CN 97115549 A CN97115549 A CN 97115549A CN 97115549 A CN97115549 A CN 97115549A CN 1132581 C CN1132581 C CN 1132581C
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CN
China
Prior art keywords
mirtazapine
selective serotonin
serotonin reuptake
pharmaceutically acceptable
fluoxetine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97115549A
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English (en)
Chinese (zh)
Other versions
CN1173330A (zh
Inventor
V·J·尼克尔森
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Organon NV
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Akzo Nobel NV
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Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of CN1173330A publication Critical patent/CN1173330A/zh
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Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN97115549A 1996-06-19 1997-06-19 含米尔塔扎平和一种或多种选择性5－羟色胺再摄取抑制剂的药物组合物 Expired - Fee Related CN1132581C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201703.4 1996-06-19
EP96201703 1996-06-19

Publications (2)

Publication Number Publication Date
CN1173330A CN1173330A (zh) 1998-02-18
CN1132581C true CN1132581C (zh) 2003-12-31

Family

ID=8224094

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97115549A Expired - Fee Related CN1132581C (zh) 1996-06-19 1997-06-19 含米尔塔扎平和一种或多种选择性5－羟色胺再摄取抑制剂的药物组合物

Country Status (24)

Country Link
US (1) US5977099A (enExample)
JP (2) JP4925074B2 (enExample)
KR (1) KR100481254B1 (enExample)
CN (1) CN1132581C (enExample)
AR (1) AR007609A1 (enExample)
AT (1) ATE213159T1 (enExample)
AU (1) AU727851B2 (enExample)
BR (1) BR9703624A (enExample)
CA (1) CA2208199C (enExample)
CZ (1) CZ290691B6 (enExample)
DE (1) DE69710390T2 (enExample)
DK (1) DK0813873T3 (enExample)
ES (1) ES2172744T3 (enExample)
HU (1) HU225534B1 (enExample)
ID (1) ID17051A (enExample)
IL (1) IL121076A (enExample)
NO (1) NO313177B1 (enExample)
NZ (1) NZ328113A (enExample)
PL (1) PL188520B1 (enExample)
PT (1) PT813873E (enExample)
RU (1) RU2181287C2 (enExample)
SG (1) SG60073A1 (enExample)
TR (1) TR199700522A2 (enExample)
ZA (1) ZA975335B (enExample)

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US6575147B2 (en) * 1999-02-25 2003-06-10 Go-Tec Internal combustion system adapted for use of a dual fuel composition including acetylene
US6545149B2 (en) 1999-04-19 2003-04-08 Teva Pharmaceutical Industries Ltd. Synthesis and crystallization of piperazine ring-containing compounds
EP1178805A4 (en) * 1999-04-19 2004-11-24 Teva Pharma NOVEL SYNTHESIS AND CRYSTALLIZATION OF PIPERAZINE-CONTAINING COMPOUNDS
US6759437B2 (en) * 1999-10-04 2004-07-06 Martin C. Hinz Comprehensive pharmacologic therapy for treatment of obesity including cysteine
US6403657B1 (en) * 1999-10-04 2002-06-11 Martin C. Hinz Comprehensive pharmacologic therapy for treatment of obesity
TWI256309B (en) * 1999-10-13 2006-06-11 Akzo Nobel Nv New formulation of mirtazapine
HUP0204050A3 (en) * 2000-01-19 2004-09-28 Akzo Nobel Nv Drug combination for the treatment of depression and related disorders comprising mirtazapine and gepirone
EP1656937A1 (en) * 2000-02-11 2006-05-17 Akzo Nobel N.V. The use of mirtazapine for the treatment of sleep disorders
WO2002036113A1 (en) * 2000-11-01 2002-05-10 Respiratorius Ab Composition comprising: serotonin receptor antagonists (5ht-2, 5ht-3) and agonist (5ht-4)
US20030105082A1 (en) * 2001-12-03 2003-06-05 Murphy Greer Marechal Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
DE60224078T2 (de) * 2001-02-12 2008-12-04 N.V. Organon Verwendung von Mirtazapin zur Verbesserung der Behandlung von Menschen mit starken Depressionen, welche Träger des Gens für Apolipoprotein E4 sind.
US6399310B1 (en) 2001-02-12 2002-06-04 Akzo Nobel N.V. Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
US20090311795A1 (en) * 2002-03-21 2009-12-17 Hinz Martin C Bilateral control of functions traditionally regulated by only serotonin or only dopamine
CA2479218A1 (en) * 2002-03-21 2003-10-02 Martin C. Hinz Serotonin and catecholamine system segment optimization technology
US20070293571A1 (en) * 2006-06-08 2007-12-20 Hinz Martin C Adminstration of dopa precursors with sources of dopa to effectuate optimal catecholamine neurotransmitter outcomes
AU2003274608A1 (en) * 2002-11-07 2004-06-07 Sunil Sadanand Nadkarni Process for preparation of polymorphic form of sertraline hydrochloride
AR042806A1 (es) 2002-12-27 2005-07-06 Otsuka Pharma Co Ltd Combinacion de derivados de carboestirilo e inhibidores de la reabsorcion de serotonina para el tratamiento de trastornos del animo
AU2003295235B2 (en) * 2002-12-27 2008-06-19 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders
BRPI0407619A (pt) * 2003-02-21 2006-03-01 Martin C Hinz tecnologia de otimização de segmento de sistema serotonina e catecolamina
TW200502222A (en) * 2003-04-02 2005-01-16 Novartis Ag Use of 10-hydroxy-10,11-dihydrocarbamazepine derivatives for the treatment of affective disorders
ES2639579T3 (es) 2003-04-29 2017-10-27 Orexigen Therapeutics, Inc. Composiciones para afectar la pérdida de peso que comprende un antagonista opioide y bupropión
US20050234093A1 (en) * 2003-06-25 2005-10-20 H. Lundbeck A/S Treatment of depression and other affective disorders
US7838029B1 (en) 2003-07-31 2010-11-23 Watson Laboratories, Inc. Mirtazapine solid dosage forms
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
ES2426915T3 (es) 2003-09-10 2013-10-25 Brentwood Equities Ltd. Diastereoisómeros de 4-ariloxi-3-hidroxipiperidinas
US7713959B2 (en) * 2004-01-13 2010-05-11 Duke University Compositions of an anticonvulsant and mirtazapine to prevent weight gain
TW200538100A (en) * 2004-04-21 2005-12-01 Akzo Nobel Nv Mirtazapine salts
US20060039866A1 (en) * 2004-08-20 2006-02-23 Cypress Bioscience, Inc. Method for treating sleep-related breathing disorders
RU2283097C2 (ru) * 2004-11-16 2006-09-10 Эльвира Ивановна Белобородова Способ лечения бронхиальной астмы, сочетанной с эрозивно-язвенными поражениями гастродуоденальной зоны
US20060122127A1 (en) * 2004-11-17 2006-06-08 Cypress Bioscience, Inc. Methods for reducing the side effects associated with mirtzapine treatment
EP2292269A3 (en) * 2004-11-19 2011-08-10 N.V. Organon Drug combination comprising a selective serotonin reuptake inhibitor and a glucocorticoid receptor antagonist for the treatment of depression
JP5180092B2 (ja) 2005-11-22 2013-04-10 オレキシジェン・セラピューティクス・インコーポレーテッド インスリン感受性を増すための組成物および方法
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
AR063959A1 (es) 2006-11-09 2009-03-04 Orexigen Therapeutics Inc Formulaciones farmaceuticas en capas
CN101573103A (zh) 2006-11-09 2009-11-04 奥雷西根治疗公司 用于施用重量减轻药物的单位剂量包装和方法
EP2167096A4 (en) * 2007-06-13 2010-07-14 Cypress Bioscience Inc IMPROVING TOLERANCE TO MIRTAZAPINE AND A SECOND ACTIVE INGREDIENT BY THE COMBINED USE OF THEM
CN101332193B (zh) * 2007-06-29 2012-12-12 杭州民生药业有限公司 一种马来酸氟伏沙明药物组合物的制备方法
US20110144145A1 (en) 2008-05-30 2011-06-16 Orexigen Therapeutics, Inc. Methods for treating visceral fat conditions
US8768578B2 (en) 2009-06-09 2014-07-01 Sumitomo Heavy Industries, Ltd. Hybrid excavator and method of controlling hybrid excavator
KR101414012B1 (ko) * 2009-11-13 2014-07-01 주식회사 녹십자 아릴피페라진-함유 퓨린 유도체 및 그의 용도
KR20120124423A (ko) 2010-01-11 2012-11-13 오렉시젠 세러퓨틱스 인크. 주우울증 환자들에 있어서 체중 감량 치료를 제공하는 방법
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RU2475235C2 (ru) * 2011-03-15 2013-02-20 Общество с ограниченной ответственностью "ЭР ЭНД ДИ ФАРМА" Фармацевтическая композиция для профилактики и лечения депрессивных состояний
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Also Published As

Publication number Publication date
CZ187097A3 (cs) 1998-01-14
AU2612997A (en) 1998-01-08
BR9703624A (pt) 1998-09-01
ATE213159T1 (de) 2002-02-15
NO313177B1 (no) 2002-08-26
JP4925074B2 (ja) 2012-04-25
NZ328113A (en) 1999-09-29
TR199700522A3 (tr) 1998-01-21
CZ290691B6 (cs) 2002-09-11
HU9701068D0 (en) 1997-08-28
MX9704579A (es) 1998-07-31
US5977099A (en) 1999-11-02
ZA975335B (en) 1998-01-26
PL188520B1 (pl) 2005-02-28
ES2172744T3 (es) 2002-10-01
TR199700522A2 (xx) 1998-01-21
RU2181287C2 (ru) 2002-04-20
AU727851B2 (en) 2001-01-04
HU225534B1 (en) 2007-02-28
IL121076A0 (en) 1997-11-20
NO972816D0 (no) 1997-06-18
HK1006081A1 (en) 1999-02-12
HUP9701068A2 (hu) 1998-08-28
CA2208199C (en) 2006-10-24
PT813873E (pt) 2002-06-28
AR007609A1 (es) 1999-11-10
DE69710390D1 (de) 2002-03-21
PL320628A1 (en) 1997-12-22
IL121076A (en) 2000-10-31
CN1173330A (zh) 1998-02-18
JP2009137970A (ja) 2009-06-25
HUP9701068A3 (en) 2000-07-28
JPH1067663A (ja) 1998-03-10
KR980000447A (ko) 1998-03-30
NO972816L (no) 1997-12-22
DE69710390T2 (de) 2002-08-14
CA2208199A1 (en) 1997-12-19
KR100481254B1 (ko) 2005-09-12
DK0813873T3 (da) 2002-05-27
ID17051A (id) 1997-12-04
SG60073A1 (en) 1999-02-22

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