CN113244297A - Traditional Chinese medicine composition for treating swine infectious atrophic rhinitis and using method thereof - Google Patents
Traditional Chinese medicine composition for treating swine infectious atrophic rhinitis and using method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention belongs to the technical field of veterinary medicines, and provides a traditional Chinese medicine composition for treating infectious atrophic rhinitis of pigs and a using method thereof. The medicine is prepared from 110-130 parts of all-grass of herbaceous plants, 45-55 parts of cowlice, 36-44 parts of Chinese goldenrod herb, 36-44 parts of winter jasmine, 55-65 parts of camellia roots, 36-44 parts of elephantopus scaber and 36-44 parts of liquorice. The traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, relieving stuffy nose and inducing resuscitation, dispelling wind and eliminating dampness, and cooling blood and reducing swelling, has no toxic or side effect, and is suitable for treating the swine infectious atrophic rhinitis.
Description
Technical Field
The invention relates to the technical field of veterinary medicines, in particular to a traditional Chinese medicine composition for treating infectious atrophic rhinitis of pigs and a using method thereof.
Background
Infectious atrophic rhinitis of pig is also called chronic atrophic rhinitis or atrophic rhinitis, which is a chronic contact respiratory infectious disease of pig caused by toxigenic Pasteurella multocida (T + Pm) or/and Bordetella bronchiseptica (Bb). The syndrome diseases are characterized by rhinitis, nasal septum distortion, turbinate atrophy and growth retardation of sick pigs. Clinical diagnosis is characterized by sneezing, nasal obstruction, rhinorrhea, epistaxis, facial deformation or facial distortion and growth retardation, the disease usually occurs in 2-5-month-old pigs, and the disease almost occurs in developed areas of the pig industry in the world, and most of the areas in China occur. The disease is that the feed conversion rate of the pigs is reduced, the growth performance, the feed utilization rate and the body resistance of the pigs are reduced, and the pigs are susceptible to other diseases. Meanwhile, after the pig is infected by the pathogen, the normal structure and function of the respiratory tract are damaged, so that the resistance of the pig body is reduced, other pathogens are easily infected, respiratory system syndromes are caused, the death and culling rate of the pig is increased, and huge economic losses are caused to the intensive pig raising industry.
Early symptoms are mostly seen in 6-8 weeks old piglets, and are manifested as rhinitis, sneezing, nasal serous fluid, mucopurulent exudates, and difficulty in inhaling. Nosebleed can occur in individual pigs due to intense sneezing. The sick pigs often appear restless due to the irritation of the mucous membrane by rhinitis, and shake their head, arch, scratch or rub their nose until bleeding occurs. Blood stains are visible on the pen, the floor and the wall. Severe pigs may experience more bleeding in both nostrils, forming two blood lines. When breathing in, the nostril is opened to give out snore, and the serious patient breathes open. Due to the obstruction of nasolacrimal duct, tears increase, forming a meniscus-shaped moist area on the skin under the canthus of the eye, which sticks to a black mark called "tear spot" after being contaminated with dust.
After rhinitis, atrophy of turbinates and deformation of the nasal bridge and face often occur, which form characteristic symptoms. If the pathological injuries of the turbinates on two sides are the same, the nose bridge is shortened, and the skin right behind the nasal disc forms deeper wrinkles; if one side is severely atrophied, the nose is bent to that side. The atrophy of the turbinates and the abnormal development of the frontal sinuses can make the width of the two eyes smaller and the head contour deformed. The body temperature, spirit, appetite and feces of sick pigs are generally normal, but growth is stopped, and some pigs become cad pigs.
The smaller the week-old pig, the greater the likelihood of turbinate atrophy after infection and the more severe the presentation. The atrophic turbinates can be regenerated without repeated or mixed infection after infection. Rhinitis, which extends to the ethmoid plate, can spread to the brain and cause encephalitis. In addition, pneumonia often occurs in sick pigs, and it is possible that atrophy of the turbinates promotes the development of pneumonia, which in turn exacerbates the atrophy of the turbinates.
The disease is not seasonal, and can occur all the year round. Sick pigs and pigs with bacteria are main infection sources, and other animals with bacteria such as dogs, cats, livestock (poultry), rabbits, mice, foxes and people can carry bacteria to cause rhinitis, bronchopneumonia and the like, so that the pigs can also become infection sources. Mainly by droplet transmission, sick pigs and pigs with bacteria can infect piglets by contacting with respiratory tract. The disease is slow in spreading in the swinery and often sporadic or endemic. The pig breeding method can promote the occurrence of the pig breeding method through nutrient deficiency, mixed breeding of pigs of different ages in days, crowding, supercooling, overheating, air pollution, poor ventilation, long-term feeding of powder and other breeding methods, genetic factors and the like.
At present, no ideal treatment method and no specific medicine exist in western medicine for treating the swine infectious atrophic rhinitis. Commonly used drugs are broad spectrum antibiotics and sulfadiazine therapy. In fact, no matter which antibiotic drug is selected to control and treat the disease, the effect is temporary inhibition, but the drug with good curative effect can quickly inhibit or eliminate the symptoms of the disease, the symptoms can appear in swinery after the drug is stopped, and blind use of the antibiotic can inhibit or kill a plurality of nonpathogenic flora and destroy the constitutional structure of the flora, thus seriously affecting the digestive function of the organism and aggravating the disease; in addition, the long-term use of a large amount of antibiotics is easy to generate drug resistance. Chemical drugs, antibiotics and monomer drugs are abused greatly, so that various drug-induced diseases such as multi-drug resistance, receptor hypersensitivity and the like are generated, and the pollution of livestock and poultry products is caused, thereby endangering the health and safety of human food. The traditional Chinese medicine is derived from animals, plants and mineral substances, contains various biological effective components, most of the traditional Chinese medicines are prepared from natural plants, and have the advantages of abundant resources, easy acquisition, good effect, low price, small toxic and side effects, almost no residue, no drug resistance and no environmental pollution. Therefore, the selection of the traditional Chinese medicine preparation to replace chemical medicines and antibiotics is very important. The nontoxic Chinese herbal medicines can greatly improve the survival rate of the swinery, reduce the risk of fulminant infectious atrophic rhinitis of the swinery and accelerate the growth of piglets; the antiviral ability of the piglets is improved, the infection rate of the sick sows in the lactation period is reduced, the pure natural requirement of green food can be met, and considerable economic benefit can be obtained.
Disclosure of Invention
The invention aims to provide the traditional Chinese medicine composition for treating the swine infectious atrophic rhinitis, which has high cure rate and small toxic and side effects and is not easy to generate drug resistance.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a traditional Chinese medicine composition for treating swine infectious atrophic rhinitis, which comprises the following components in parts by mass:
110-130 parts of Chinese herbaceous flower, 45-55 parts of cowherb seed, 36-44 parts of Chinese goldthread, 36-44 parts of winter jasmine flower, 55-65 parts of camellia root, 36-44 parts of elephantopus scaber and 36-44 parts of liquorice.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 120 parts of hundred-flower grass, 50 parts of cow louse, 40 parts of Chinese silvergrass, 40 parts of winter jasmine flower, 60 parts of camellia root, 40 parts of elephantopus scaber and 40 parts of liquorice.
Preferably, the use method of the traditional Chinese medicine composition comprises the following steps: pulverizing the Chinese medicinal composition, and mixing with feed.
Preferably, the particle size and mesh number of the crushed traditional Chinese medicine composition are 50-70 meshes.
Preferably, the using amount of the traditional Chinese medicine composition is 1-3 g/kg according to the weight of the pig, and the traditional Chinese medicine composition is taken 1 time per day for 6-8 days continuously.
Preferably, the use method of the traditional Chinese medicine composition comprises the following steps: soaking the Chinese medicinal composition in hot water to obtain extractive solution.
Preferably, the temperature of the hot water is more than 95 ℃, the amount of the hot water is 2-4 times of the weight of the traditional Chinese medicine composition, and the soaking time is 11-12 hours.
Preferably, the dose of the obtained liquid medicine is 1-3 g/kg according to the weight of the pig, and the liquid medicine is continuously taken for 6-8 days 1 time per day.
The invention provides a traditional Chinese medicine composition for treating infectious atrophic rhinitis of pigs, which takes hundred flowers and plants as monarch drugs for clearing heat and detoxicating, cooling blood and detumescence, clearing liver and improving vision, and killing parasites and relieving pain. The cow louse can dispel rheumatism, dredge nasal orifices and kill parasites; herba Lysimachiae Fortunei has effects of dispelling pathogenic wind and inducing resuscitation; flos Jasmini sambac can dispel wind-cold and relieve stuffy nose; the three medicines are used as ministerial medicines. The root of camellia has the effects of clearing heat, eliminating dampness, purging fire, removing toxin and stopping bleeding; the elephantopus scaber, the root of rehmannia, the root, the herb of rehmannia, the root, the rehmannia root, the herb, the root, the rehmannia root, the herb, the root, the rehmannia root, the herb, the rehmannia root, the herb, the root, the herb, the root, the all used as an adjuvant, the herb, the root, the herb, the root, the herb, the root, the herb, the root, the herb, the root, the bark of rehmannia root, the. Licorice root, radix Glycyrrhizae, as a guiding drug, has the effects of tonifying the spleen and qi, relieving spasm and pain, and harmonizing the effects of the other drugs in the recipe. The Chinese medicinal composition is obtained by matching the raw materials. The traditional Chinese medicine composition has the functions of clearing away heat and toxic materials, relieving stuffy nose and inducing resuscitation, dispelling wind and eliminating dampness, and cooling blood and reducing swelling, has no toxic or side effect, and is suitable for treating the swine infectious atrophic rhinitis.
The compound medicine of the invention comprises:
all-grass of herbaceous plants: cold in nature and bitter in taste. It enters liver and lung meridians. Has the effects of clearing away heat and toxic materials, cooling blood, relieving swelling, removing liver fire, improving eyesight, killing parasites and relieving pain, and also has antibacterial and leptospira growth inhibiting effects, especially on Staphylococcus aureus, Salmonella typhi, Salmonella paratyphi A, Salmonella paratyphi B, Shigella dysenteriae and Shigella sonnei dysenteriae. The contained phenolic acid has the bacteriostatic action on influenza bacillus, streptococcus pneumoniae, streptococcus A, catacoccus, proteus and staphylococcus aureus.
Cow lice: warm in nature, pungent and bitter in flavor. It enters lung meridian. Has effects in dispelling pathogenic wind and dampness, relieving nasal obstruction, and killing parasite. Can be used for treating wind-cold headache, nasal discharge, rubella, pruritus, and arthralgia due to dampness. Pharmacological research shows that the louse has the functions of relieving cough, resisting bacteria, diminishing inflammation, resisting microbes, dilating blood vessel, strengthening blood vessel permeability, resisting thrombin, inhibiting cell immunity and humoral immunity.
Herba sedi: warm in nature and pungent in flavor. Enter lung and kidney meridians. Has effects in expelling pathogenic wind and inducing resuscitation. Can be used for treating nasosinusitis, toothache, phlegm retention, cough, and rheumatalgia.
Winter jasmine: warm in nature and pungent in flavor. It enters lung and stomach meridians. Has effects of dispelling pathogenic wind and cold, and relieving stuffy nose. Herbs with pungent and warm natured exterior-releasing herbs belong to the category of exterior-releasing herbs. Can be used for treating headache due to wind-cold evil, nasal obstruction, nasosinusitis, and thick nasal discharge. Research shows that the product has the pharmacological effects of anesthesia, antianaphylaxis, anti-inflammation, blood pressure reduction, uterine excitation, platelet aggregation resistance, microorganism resistance, pain relief and microcirculation improvement.
Camellia root: cold in nature and bitter in taste. It enters lung meridian, gallbladder meridian, spleen meridian, large intestine meridian, and small intestine meridian. Has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing toxic materials, and stopping bleeding. Herbs for clearing heat and drying dampness belong to the category of heat-clearing herbs. Has wide antibacterial spectrum, has effects of inhibiting Bacillus and coccus, treating influenza virus and dermatophyte, and has good curative effect on viral ophthalmopathy and upper respiratory infection. Animal experiment shows that the product has antiinflammatory, immunity promoting, tranquilizing and antipyretic effects; the extract has HIV-1 growth inhibiting effect. Has effects in resisting microorganism, resisting allergy, lowering blood pressure, promoting urination, reducing blood lipid, resisting platelet aggregation and anticoagulation, protecting liver, and protecting kidney injury; the low dose promotes the proliferation of immune cells, and the high dose inhibits; delaying the occurrence of cataract.
Herba elephantopi: cold in nature and bitter in taste. It enters liver meridian and gallbladder meridian. Has effects of clearing liver fire, removing dampness and heat, and invigorating stomach. Belongs to heat-clearing and fire-purging herbs classified under heat-clearing herbs. Can be used for treating conjunctival congestion, dizziness, deafness, ear swelling, hypochondriac pain, bitter taste, sore throat, epilepsy, convulsion, damp-heat, skin sore, eczema, pudendal swelling, pudendal pruritus, stranguria with urine, and anorexia. The pharmacological research has the pharmacological effects of protecting liver, benefiting gallbladder, invigorating stomach, resisting inflammation, enhancing immunity, resisting hyperthyroidism, resisting bacteria, relieving pain, calming the nerves and the like.
Licorice root: mild in nature and mild in taste. Enter heart, lung, spleen and stomach meridians. Has the effects of relieving spasm and pain, invigorating spleen and qi, and harmonizing the effects of the other medicines.
The traditional Chinese veterinary medicine considers that the infectious atrophic rhinitis of pigs is caused by that the lung qi is not diffused due to the external infection of six exogenous epidemic toxins or the heat pathogen suffocates the lung to block the lung orifice, the lung opens into the nose, the nose is the orifice outside the lung, the heat toxin is accumulated in the fumigating nasal passage, the body fluid hurts the flesh and the nose orifice is blocked. The traditional Chinese medicine generally adopts the methods of clearing away heat and toxic material, relieving stuffy nose and inducing resuscitation, eliminating dampness and reducing swelling, strengthening body resistance and eliminating evil and the like.
The medicine has strong antibacterial, anti-inflammatory and antiviral effects, has the effects of clearing heat and removing toxicity, relieving stuffy nose and inducing resuscitation, eliminating dampness and reducing swelling, has strong mucosa repair effect, and enhances the immunity. Has no residue, drug resistance and toxic and side effects, and is a specific medicine for treating the swine infectious atrophic rhinitis.
The invention has the advantages and beneficial effects that: 1. the traditional Chinese medicine composition adopts a veterinary therapy of traditional Chinese medicine, adopts pure traditional Chinese medicine components, adopts an oral traditional Chinese medicine mode, is quick in cure after being taken by pigs, has no side effect, and is beneficial to the growth of the pigs. 2. The traditional Chinese medicine compound of the invention has simple preparation, convenient use, low cost of raw materials, no toxic reaction after use, high cure rate and no residue, and is an ideal medicine for treating the swine infectious atrophic rhinitis.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating swine infectious atrophic rhinitis, which comprises the following components in parts by mass:
110-130 parts of Chinese herbaceous flower, 45-55 parts of cowherb seed, 36-44 parts of Chinese goldthread, 36-44 parts of winter jasmine flower, 55-65 parts of camellia root, 36-44 parts of elephantopus scaber and 36-44 parts of liquorice.
The content of the hundred flowers and plants in the invention is 110-130 parts, preferably 115-125 parts, and more preferably 120 parts.
The content of the cow lice in the feed additive is 45-55 parts, preferably 48-52 parts, and more preferably 50 parts.
The content of the chloranthus japonicus in the invention is 36-44 parts, preferably 38-42 parts, and more preferably 40 parts.
The content of the winter jasmine in the invention is 36-44 parts, preferably 38-42 parts, and more preferably 40 parts.
The content of the camellia root in the invention is 55-65 parts, preferably 58-62 parts, and more preferably 60 parts.
The content of the elephantopus scaber is 36-44 parts, preferably 38-42 parts, and more preferably 40 parts.
The content of licorice in the present invention is 36 to 44 parts, preferably 38 to 42 parts, and more preferably 40 parts.
The invention also provides a using method of the traditional Chinese medicine composition, which comprises the following steps: pulverizing the Chinese medicinal composition, and mixing with feed.
In the invention, the particle size and mesh number of the crushed traditional Chinese medicine composition are preferably 50-70 meshes, and more preferably 60 meshes;
the using amount of the traditional Chinese medicine composition is preferably 1-3 g/kg, and more preferably 2g/kg according to the weight of the pig;
the application method of the traditional Chinese medicine composition is preferably 1 time per day, and the traditional Chinese medicine composition is continuously taken for 6-8 days, more preferably 1 time per day and is continuously taken for 7 days.
The invention also provides another using method of the traditional Chinese medicine composition, which comprises the following steps: soaking the Chinese medicinal composition in hot water to obtain extractive solution.
In the using method of the traditional Chinese medicine composition, hot water is preferably above 95 ℃, and is further preferably 100 ℃;
in the using method of the traditional Chinese medicine composition, the amount of the hot water is preferably 2-4 times, and more preferably 3 times of the weight of the traditional Chinese medicine composition;
in the using method of the traditional Chinese medicine composition, the hot water soaking time is preferably 11-12 h, and more preferably 12 h;
the dosage of the obtained liquid medicine is preferably 1-3 g/kg according to the weight of the pig, and more preferably 2g/kg according to the weight of the pig;
the application method of the obtained liquid medicine is preferably 1 time per day, and the liquid medicine is continuously taken for 6-8 days, more preferably 1 time per day, and is continuously taken for 7 days.
The following examples are provided to describe the Chinese medicinal composition for treating swine infectious atrophic rhinitis in detail, but they should not be construed as limiting the scope of the present invention.
Example 1
The traditional Chinese medicine composition for treating the swine infectious atrophic rhinitis comprises the following medicines in parts by weight: 130 parts of Chinese flowering quince, 55 parts of pedicellus bovis seu Bubali, 44 parts of Chinese ephedra, 44 parts of winter jasmine flower, 65 parts of camellia root, 44 parts of elephantopus scaber and 44 parts of liquorice.
The specific administration method comprises the following steps: pulverizing the Chinese medicinal composition, and mixing with feed for use, wherein the particle size is 60 meshes, and the dosage is 2g/kg body weight per head, 1 time per day, and is continuously administered for 7 days.
Example 2
The traditional Chinese medicine composition for treating the swine infectious atrophic rhinitis comprises the following medicines in parts by weight: 120 parts of hundred-flower grass, 50 parts of pedicularis, 40 parts of Chinese silvergrass herb, 40 parts of winter jasmine flower, 60 parts of camellia root, 40 parts of elephantopus scaber and 40 parts of liquorice.
The specific administration method comprises the following steps: pulverizing the Chinese medicinal composition, and mixing with feed for use, wherein the particle size is 60 meshes, and the dosage is 2g/kg body weight per head, 1 time per day, and is continuously administered for 7 days.
Example 3
The traditional Chinese medicine composition for treating the swine infectious atrophic rhinitis comprises the following medicines in parts by weight: 110 parts of Chinese herbaceous flower, 45 parts of cow lice, 36 parts of Chinese ephedra herb, 36 parts of winter jasmine flower, 55 parts of camellia root, 36 parts of elephantopus scaber and 36 parts of liquorice.
The specific administration method comprises the following steps: pulverizing the Chinese medicinal composition, and mixing with feed for use, wherein the particle size is 60 meshes, and the dosage is 2g/kg body weight per head, 1 time per day, and is continuously administered for 7 days.
Example 4
The traditional Chinese medicine composition for treating the swine infectious atrophic rhinitis comprises the following medicines in parts by weight: 120 parts of hundred-flower grass, 50 parts of pedicularis, 40 parts of Chinese silvergrass herb, 40 parts of winter jasmine flower, 60 parts of camellia root, 40 parts of elephantopus scaber and 40 parts of liquorice.
The specific administration method comprises the following steps: pulverizing the Chinese medicinal composition, and mixing with feed for use, wherein the particle size is 60 meshes, and the dosage is 1g/kg body weight per head, 1 time per day, and is continuously administered for 7 days.
Example 5
The traditional Chinese medicine composition for treating the swine infectious atrophic rhinitis comprises the following medicines in parts by weight: 120 parts of hundred-flower grass, 50 parts of pedicularis, 40 parts of Chinese silvergrass herb, 40 parts of winter jasmine flower, 60 parts of camellia root, 40 parts of elephantopus scaber and 40 parts of liquorice.
The specific administration method comprises the following steps: pulverizing the Chinese medicinal composition, and mixing with feed for use, wherein the particle size is 60 meshes, the dose is 3g/kg body weight per head, and the administration is 1 time per day for 7 days.
Example 6
The traditional Chinese medicine composition for treating the swine infectious atrophic rhinitis comprises the following medicines in parts by weight: 120 parts of hundred-flower grass, 50 parts of pedicularis, 40 parts of Chinese silvergrass herb, 40 parts of winter jasmine flower, 60 parts of camellia root, 40 parts of elephantopus scaber and 40 parts of liquorice.
The specific administration method comprises the following steps: soaking the medicine in hot water of above 95 deg.C with water amount 3 times of the medicine weight, stirring, soaking for 12 hr to obtain medicinal liquid, adding 2g/kg medicinal liquid into each pig, and administering 1 time per day for 7 days.
Comparative example 1
The conventional medicine sulfadiazine and penicillin is adopted as the medicine for treating the swine infectious atrophic rhinitis, and the medicine is normally taken for 7 days according to the using method.
Clinical efficacy test
Different dose clinical treatment tests are carried out on the sick swinery for confirming the infectious atrophic rhinitis of pigs by adopting a random double-blind test method.
Three groups of high (example 5), medium (example 2) and low (example 4) were set and sulfadiazine + penicillin was selected as the positive drug control group (comparative example 1). The therapeutic effect of the traditional Chinese medicine composition on the swine infectious atrophic rhinitis is observed so as to discuss the feasibility of the application of the traditional Chinese medicine composition in livestock production.
80 pigs with natural onset confirmed by clinical diagnosis of Sichuan Mianyang-breed company are randomly divided into 4 groups, and each group has 20 pigs. Groups 1-3 were treated with the drugs described in example 4, example 2, example 5, respectively, of the present invention; group 4 is a sulfadiazine + penicillin positive drug control group; respectively isolating and feeding, and recording symptoms, cure, death and the like of the sick pigs in detail.
TABLE 1 experimental grouping for treating infectious atrophic rhinitis of pig
During clinical trials, i.e., before, during and 7d after drug administration, clinical symptoms (sneezing, nasal serous fluid, mucopurulent exudate, dyspnea, viscidity, purulent, bloody nasal fluid, lacrimation, etc.), activity, decreased appetite or increased appetite, increased body temperature, general symptoms such as mental, death and pathological anatomy, etc. were observed and recorded every day.
The experimental results are as follows: after 3 days of medicine feeding, the spirits of the pigs in the groups 1, 2, 3 and 4 are better than those before treatment, and the symptoms such as sneezing reduction, nasal serous fluid, mucopurulent exudate, dyspnea, viscidity, purulent, bloody nasal fluid, lacrimation and the like are relieved; after 5 days, the drugs 1, 2, 3, and 4 showed improvement in various degrees: the sick pig has no sneeze, nasal serous fluid, mucopurulent exudate, difficulty in inhaling, stickiness, purulent, bloody nasal fluid, lacrimation and other symptoms which are obviously relieved; after 7 days, the drug groups 1, 2, 3 and 4 had sneezing, nasal serous fluid, mucopurulent exudate, difficulty in breathing, stickiness, purulent, bloody nasal fluid, lacrimation and other symptoms disappeared, the spirit and appetite were improved (from the increase of the feeding amount), and the feces were normal.
TABLE 2 experimental results of treatment of infectious atrophic rhinitis in pigs
The test statistical result shows that 18 pigs in 20 sick pigs in the high-dose treatment group of the medicine are healed, 2 pigs have obviously relieved symptoms, the feed intake is lower than normal, and the cure rate is 90.0%; in 20 sick pigs in the medium-dose treatment group, 17 pigs are healed, 3 pigs are obviously lightened, the feed intake is lower than normal, and the cure rate is 85.0 percent; 16 of 20 sick pigs in the low-dose treatment group are cured, and the cure rate is 80.0 percent; in 20 pigs with sulfadiazine and penicillin (control group), 14 pigs were cured, 5 pigs were improved, and 1 pig was not effective, with a cure rate of 70.0%.
Experiments prove that the traditional Chinese medicine composition disclosed by the embodiment of the invention has a treatment effect on the swine infectious atrophic rhinitis and can relieve symptoms, and the traditional Chinese medicine composition disclosed by the embodiment 5, the embodiment 2 and the embodiment 4 has better effects than sulfadiazine and penicillin in the aspects of cure rate and the like. The traditional Chinese medicine composition disclosed by the invention can achieve the effects of treating diseases and improving the survival rate, and is both economic and remarkable in curative effect.
According to test results, the traditional Chinese medicine composition has the functions of clearing away heat and toxic materials, relieving stuffy nose and inducing resuscitation, dispelling wind and eliminating dampness, and cooling blood and reducing swelling. In the clinical test process, the medicine has no adverse reaction, has better treatment effect on the swine infectious atrophic rhinitis, and has better treatment effect than the sulfadiazine and penicillin group. According to the severity of the disease and the treatment cost, the clinical application is recommended to be 2g/kg body weight for each time, 1 time per day and 7 days continuously.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (8)
1. The traditional Chinese medicine composition for treating the swine infectious atrophic rhinitis is characterized by comprising the following components in parts by mass:
110-130 parts of Chinese herbaceous flower, 45-55 parts of cowherb seed, 36-44 parts of Chinese goldthread, 36-44 parts of winter jasmine flower, 55-65 parts of camellia root, 36-44 parts of elephantopus scaber and 36-44 parts of liquorice.
2. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 120 parts of hundred-flower grass, 50 parts of cow louse, 40 parts of Chinese silvergrass, 40 parts of winter jasmine flower, 60 parts of camellia root, 40 parts of elephantopus scaber and 40 parts of liquorice.
3. The method of using the Chinese medicinal composition of claim 1 or 2, comprising the steps of: pulverizing the Chinese medicinal composition, and mixing with feed.
4. The use method of the traditional Chinese medicine composition as claimed in claim 3, wherein the particle size after grinding is 50-70 mesh.
5. The use method of the traditional Chinese medicine composition as claimed in claim 4, wherein the use amount of the traditional Chinese medicine composition is 1-3 g/kg according to the weight of the pig, and the traditional Chinese medicine composition is taken 1 time per day for 6-8 days continuously.
6. The method of using the Chinese medicinal composition of claim 1 or 2, comprising the steps of: soaking the Chinese medicinal composition in hot water to obtain extractive solution.
7. The use method of the traditional Chinese medicine composition as claimed in claim 6, wherein the temperature of the hot water is above 95 ℃, the amount of the hot water is 2-4 times of the weight of the traditional Chinese medicine composition, and the soaking time is 11-12 h.
8. The use method of the traditional Chinese medicine composition as claimed in claim 7, wherein the administration amount of the obtained liquid medicine is 1-3 g/kg per weight of the pig, and the liquid medicine is taken 1 time per day for 6-8 days continuously.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083603A (en) * | 2014-07-25 | 2014-10-08 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine composition for preventing and treating swine infectious atrophic rhinitis and preparation method of traditional Chinese medicine composition |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083603A (en) * | 2014-07-25 | 2014-10-08 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine composition for preventing and treating swine infectious atrophic rhinitis and preparation method of traditional Chinese medicine composition |
Non-Patent Citations (2)
| Title |
|---|
| 徐家康: "猪萎缩性鼻炎危害与预防", 《兽医临床科学》 * |
| 陈学风等: "猪传染性萎缩性鼻炎的预防控制", 《猪业科学》 * |
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