CN108159342B - Traditional Chinese medicine composition for treating pneumonia of livestock and poultry and preparation method - Google Patents
Traditional Chinese medicine composition for treating pneumonia of livestock and poultry and preparation method Download PDFInfo
- Publication number
- CN108159342B CN108159342B CN201810246704.5A CN201810246704A CN108159342B CN 108159342 B CN108159342 B CN 108159342B CN 201810246704 A CN201810246704 A CN 201810246704A CN 108159342 B CN108159342 B CN 108159342B
- Authority
- CN
- China
- Prior art keywords
- parts
- pneumonia
- livestock
- traditional chinese
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for treating pneumonia of livestock and poultry, which is prepared from the following raw material medicines in proportion: pinellia ternate, almond, mangnolia officinalis, scutellaria baicalensis, oriental wormwood, ephedra, coix seed and fructus amomi; the invention is a pure Chinese medicinal preparation, the medicaments are combined to play a role in clearing heat, eliminating phlegm, reducing lung qi, stopping cough and asthma and eliminating all symptoms, and the Chinese medicinal preparation has the advantages of low cost, low toxicity, high cure rate, no medicament resistance, stable effect and the like for treating the piglet pneumonia. The composition is simple, safe and effective, avoids drug residue, ensures the food safety problem, and is convenient for large-scale popularization in animal production.
Description
Technical Field
The invention belongs to the technical field of veterinary medicines, and particularly relates to a traditional Chinese medicine composition for treating pneumonia of livestock and poultry, and a preparation method of the traditional Chinese medicine composition.
Background
Pig pneumonia is one of the most common infectious diseases, is generally caused by pathogens such as streptococcus pneumoniae, Actinobacillus pleuropneumoniae, staphylococcus aureus, pseudomonas aeruginosa, escherichia coli, porcine respiratory reproductive syndrome virus, influenza virus and the like, causes great harm to the breeding industry, particularly the bacterial pneumonia is on the rise, more serious, the bacterial drug resistance is on the rise, particularly the Actinobacillus pleuropneumoniae (APP), common antimicrobial drugs such as B lactamase, gentamicin, micronomicin, spectinomycin, florfenicol, doxycycline, sulfonamides and the like have little curative effect, but no effective drugs are used for preventing and treating at present, the existence of multiple pathogens causes cause poor prevention effect of vaccines, and the pneumonia caused by mixed bacterial and toxic infection becomes one of important factors of pig farm loss, therefore, the search for safe, reliable, inexpensive and effective therapeutic drugs is a problem to be solved. The traditional Chinese medicine for preventing and treating pneumonia of livestock and poultry has the advantages of being long-term in China, obvious in curative effect, few in toxic and side effects, high in curative effect, low in drug resistance, lasting in effect and free of residues. Therefore, in the aspect of treating pneumonia of livestock and poultry.
Disclosure of Invention
The invention aims to provide a novel traditional Chinese medicine composition for treating pneumonia of livestock and poultry, and the traditional Chinese medicine composition has an obvious treatment effect.
The invention relates to a traditional Chinese medicine composition for treating pneumonia of livestock and poultry, which is characterized by being prepared from the following raw material medicines in parts by weight: 7-22 parts of pinellia ternate, 3-15 parts of almond, 6-13 parts of mangnolia officinalis, 9-20 parts of scutellaria baicalensis, 3-12 parts of oriental wormwood, 7-15 parts of ephedra, 6-13 parts of coix seed and 7-16 parts of fructus amomi.
The livestock and poultry pneumonia for treating livestock and poultry pneumonia preferably comprises the following components in proportion:
pinellia ternate 12 parts, almond 8 parts, magnolia officinalis 9 parts, scutellaria baicalensis 12 parts, oriental wormwood 9 parts, ephedra 10 parts, coix seed 6 parts and cardamon seed 10 parts.
The extraction method of the traditional Chinese medicine composition for treating the pneumonia of the livestock and poultry comprises the following steps:
mixing the raw materials with water according to the weight ratio of 1: 8, soaking for 30 minutes, then boiling for 1 hour, then filtering, mixing the filter residue and water according to the ratio of 1: 5 for 45 minutes, combining the liquid medicines of the two times, concentrating the liquid medicines until each milliliter of the liquid medicines is equivalent to 1 gram of the crude drug.
Square solution: infectious respiratory diseases such as porcine infectious pleuropneumonia and the like are clinically manifested by fever (increased body temperature), cough and asthma, dyspnea, or symptoms such as phlegm and saliva, red mouth, rapid pulse (accelerated heartbeat), yellow or greasy tongue coating and the like. The traditional Chinese veterinarian distinguishes the syndrome of lung heat cough and asthma caused by excessive lung heat, pathogenic heat attacking the lung and lung failing to disperse and descend, and is suitable for clearing heat and ventilating the lung, relieving cough and asthma, regulating qi and resolving phlegm.
The lung governs qi and governs respiration, mainly disperses, purifies and descends, is delicate organ, does not resist cold and heat, heat pathogen forces lung, and lung loses and descends, so cough and dyspnea occur, the scutellaria baicalensis enters lung meridian due to bitter cold, is the essential drug for clearing lung heat since ancient times, especially the scorched scutellaria baicalensis is of great importance for old age, has special potency, and clears lung heat to solve the main contradiction. The bitter apricot kernels are bitter, sweet and warm, enter the lung, descend the lung qi and are used as ministerial drugs for relieving cough and asthma.
Hou Po regulates qi and dries dampness, Yin Chen is bland to excrete dampness, phlegm is produced by dampness, and phlegm is produced by dampness accumulation, and is decocted by heat, so heat phlegm is produced. In ancient times: the expression "treating phlegm well but not treating phlegm but treating qi, regulating qi flow and regulating body fluids , and eliminating phlegm by regulating body fluids and dampness". Magnolia officinalis can dry dampness and resolve phlegm as well as regulate qi and resolve phlegm, Artemisia capillaris can eliminate dampness and reduce phlegm generation, and promote urination, so that damp-heat evil is relieved through urination.
The medicines are combined to clear heat, remove phlegm, lower lung qi and relieve cough and asthma, and all symptoms are extinguished.
The invention takes APP as a representative, establishes an animal infection model, evaluates the curative effect of the traditional Chinese medicine composition consisting of pinellia ternate, almond, mangnolia officinalis, scutellaria baicalensis, oriental wormwood, ephedra, coix seed, fructus amomi rotundus and the like, and the result proves that the effect is exact:
1 research on treatment effect of traditional Chinese medicine on piglet infection APP
1.1 establishment of piglet pneumonia model
Experimental grouping and model preparation: the 34 mice were randomly divided into 4 groups, which were respectively a treatment group of the present invention, an enrofloxacin treatment group, an infection control group, and a healthy control group, and each group was 5, 21, and 3 mice. In addition to the healthy control group, 4mL of the solution containing 8X 10 was added to the nasal cavity8APP with CFU in log phase. When piglets developed overt clinical symptoms, the administration was immediately performed according to table 1.
Table 1: experimental pig grouping and processing method
1.2 Compound Observation of clinical symptoms of piglets infected with pneumonia
Piglets were closely observed at the 2h infection, and clinical symptoms included: mental state, activity, appetite, respiratory rate, type of breathing, presence or absence of cough, presence or absence of vomiting, nasal secretion, ocular secretion, stool shape, presence or absence of cyanosis of the skin. The clinical symptoms of the piglets begin to be scored 6h after toxin attacking, and the clinical symptoms of anorexia, depression, body temperature rise, depression and the like are found in the compound treatment group, the enrofloxacin group and the infection control group in the 6 h. However, the treatment group of the present invention showed a significant improvement at 48h and returned to normal at 72h, and clinical symptoms were significantly reduced and recovered more rapidly in comparison with the infected group (fig. 1). Meanwhile, compared with the enrofloxacin treatment group, the compound treatment group has no significant difference (P is more than 0.05), which shows that the treatment group can effectively relieve the clinical symptoms of the pneumonia of the swine and has certain treatment effect.
1.3 the treatment group of the invention influences the body temperature change of the piglets infected with pneumonia
Body temperature changes after pneumonia infection of piglets are shown in fig. 2. According to the figure 2, the body temperature of the treatment group and the enrofloxacin treatment group is obviously lower than that of the infection group within 12-72 h, and the body temperature shows a descending trend. After the toxin is attacked, the body temperature of each group of piglets rises rapidly within 0-6 h, and the body temperature of the administration treatment group begins to fall after 6h, wherein the body temperature of the treatment group slightly rises within 24-48 h, but the clinical symptoms are not obviously abnormal.
1.4 Effect of the treatment groups of the invention on weight gain of piglets infected with pneumonia
After the piglets are infected by the drug for 6 hours, the piglets are continuously treated by the drug for 5 days, and the weight change before and after the comparison test shows that the infected control group basically has no weight gain, but the mutual weight gain rate difference between the treatment group and the enrofloxacin treatment group is not significant (P is more than 0.05), but the treatment group is extremely higher than the infected control group (P is less than 0.05). See table 2.
Table 2: weight gain of piglets in each group
# indicates significant difference compared to healthy control group (P < 0.01); indicates significant differences compared to the infected group (P < 0.01).
1.5 Effect of the treatment group of the invention on the hematological index of the piglets infected with pneumonia
Compared with a healthy control group, the leukocyte, the neutrophil and the macrophage of piglets of the infected control group are obviously increased (P < 0.01), while the leukocyte, the neutrophil and the macrophage of piglets of the treatment group and the enrofloxacin group have smaller increase amplitude (P < 0.01) than that of a model group. See table 3.
Table 3: influence of the treatment group of the invention on the total number of inflammatory cells in blood of piglets infected with pneumonia
# indicates significant difference compared to healthy control group (P < 0.01); indicates significant differences compared to the infected control group (P < 0.01).
1.6 Effect of treatment groups of the invention on inflammatory cells in pneumonia-infected piglet BALF
Infection with APP causes the associated recruitment of inflammatory cells in the lung, which are mainly leukocytes, neutrophils, macrophages in BALF. Compared with a healthy control group, the white blood cells, the neutrophils and the macrophages of the mice of the infected control group are obviously increased (P < 0.05), while the white blood cells, the neutrophils and the macrophages of the mice of the treatment group and the enrofloxacin group have smaller increasing amplitude (P < 0.05) than that of the model group. Among them, macrophage decline is most pronounced. See table 4.
Table 4: effect of treatment groups of the invention on the Total number of inflammatory cells in pneumonia-infected piglet BALF
# indicates significant difference compared to the control group (P < 0.05); indicates significant differences compared to model groups (P < 0.05).
1.7 Effect of the treatment groups of the invention on Lung tissue pathology of piglets infected with pneumonia
Compared with the healthy control group, the lung of the group infected with the control group has obvious pathological changes, including inflammatory cells infiltrating into interstitial and alveolar cavities and the alveolar wall is thickened. For the invention treatment group and the enrofloxacin treatment group, the severity of lung tissue pathology is weaker than that of the infection control group, alveolar cavities are gradually clear, and inflammatory cell infiltration among lung tissues is obviously reduced. See fig. 3.
1.7 the effect of the invention on mortality of piglets infected with pneumonia:
table 5: effect on mortality of pneumonia infected piglets
The invention has the advantages that:
the invention is a pure Chinese medicinal preparation, the medicaments are combined to play a role in clearing heat, eliminating phlegm, reducing lung qi, stopping cough and asthma and eliminating all symptoms, and the Chinese medicinal preparation has the advantages of low cost, low toxicity, high cure rate, no medicament resistance, stable effect and the like for treating the piglet pneumonia. The composition is simple, safe and effective, avoids drug residue, ensures the food safety problem, and is convenient for large-scale popularization in animal production.
Description of the drawings:
FIG. 1: infected piglet clinical symptom score; (# # represents significant difference compared with healthy control group (P < 0.01); and represents significant difference compared with infection group (P < 0.01));
FIG. 2: mean body temperature profile of infected piglets; (# # represents significant difference compared with healthy control group (P < 0.01); and represents significant difference compared with infection group (P < 0.01));
FIG. 3, Effect of the invention on Lung tissue pathology in Pneumoniae infected pigs (HE X100); (A healthy control group; B infection control group; C enrofloxacin group; D compound treatment group).
Detailed Description
The present invention is further illustrated by the following examples, which do not limit the present invention in any way, and any modifications or changes that can be easily made by a person skilled in the art to the present invention will fall within the scope of the claims of the present invention without departing from the technical solution of the present invention.
Example 1
Mixing pinellia ternate 12 parts, almond 8 parts, mangnolia officinalis 9 parts, scutellaria baicalensis 12 parts, oriental wormwood 9 parts, ephedra 10 parts, coix seed 6 parts, cardamon seed 10 parts and water according to the weight ratio of 1: 8, soaking for 30 minutes, then boiling for 1 hour, then filtering, mixing the filter residue and water according to the ratio of 1: 5 for 45 minutes, combining the liquid medicines of the two times, concentrating the liquid medicines until each milliliter of the liquid medicines is equivalent to 1 gram of the crude drug.
Example 2
Mixing 7g of pinellia ternate, 3g of almond, 6g of mangnolia officinalis, 9g of scutellaria baicalensis, 3g of oriental wormwood, 7g of ephedra, 6g of coix seed, 7g of fructus amomi cardamomi and water according to the weight ratio of 1: 8, soaking for 30 minutes, then boiling for 1 hour, then filtering, mixing the filter residue and water according to the ratio of 1: 5 for 45 minutes, combining the liquid medicines of the two times, concentrating the liquid medicines until each milliliter of the liquid medicines is equivalent to 1 gram of the crude drug.
Example 3
Mixing pinellia ternate 22g, almond 15g, mangnolia officinalis 13g, scutellaria baicalensis 20g, oriental wormwood 12g, ephedra 15g, coix seed 13g, cardamon seed 16g and water according to the weight ratio of 1: 8, soaking for 30 minutes, then boiling for 1 hour, then filtering, mixing the filter residue and water according to the ratio of 1: 5 for 45 minutes, combining the liquid medicines of the two times, concentrating the liquid medicines until each milliliter of the liquid medicines is equivalent to 1 gram of the crude drug.
Claims (1)
1. An extraction method of a traditional Chinese medicine composition for treating pneumonia of livestock and poultry comprises the following steps: weighing 7-22 parts of pinellia ternate, 3-15 parts of almond, 6-13 parts of mangnolia officinalis, 9-20 parts of scutellaria baicalensis, 3-12 parts of oriental wormwood, 7-15 parts of ephedra, 6-13 parts of coix seed, 7-16 parts of fructus amomi and water according to a proportion of 1: 8, soaking for 30 minutes, then boiling for 1 hour, then filtering, mixing the filter residue and water according to the ratio of 1: 5 for 45 minutes, combining the liquid medicines of the two times, concentrating the liquid medicines until each milliliter of the liquid medicines is equivalent to 1 gram of the crude drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810246704.5A CN108159342B (en) | 2018-03-23 | 2018-03-23 | Traditional Chinese medicine composition for treating pneumonia of livestock and poultry and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810246704.5A CN108159342B (en) | 2018-03-23 | 2018-03-23 | Traditional Chinese medicine composition for treating pneumonia of livestock and poultry and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108159342A CN108159342A (en) | 2018-06-15 |
| CN108159342B true CN108159342B (en) | 2021-03-16 |
Family
ID=62511273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810246704.5A Active CN108159342B (en) | 2018-03-23 | 2018-03-23 | Traditional Chinese medicine composition for treating pneumonia of livestock and poultry and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108159342B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110075210A (en) * | 2019-05-20 | 2019-08-02 | 重庆三峡职业学院 | A kind of drug and preparation method thereof for treating beef cattle acute pneumonia |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432374A (en) * | 2013-09-10 | 2013-12-11 | 周冠旻 | Medicine for treating pneumonia of pig |
| CN105477231A (en) * | 2014-09-19 | 2016-04-13 | 蔡卫进 | Traditional Chinese medicine prescription for treating pulmonary abscess |
-
2018
- 2018-03-23 CN CN201810246704.5A patent/CN108159342B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432374A (en) * | 2013-09-10 | 2013-12-11 | 周冠旻 | Medicine for treating pneumonia of pig |
| CN105477231A (en) * | 2014-09-19 | 2016-04-13 | 蔡卫进 | Traditional Chinese medicine prescription for treating pulmonary abscess |
Non-Patent Citations (5)
| Title |
|---|
| 三仁汤治疗湿温高热不退的临床运用;叶洪等;《广州医药》;20021231(第02期);第58-59页 * |
| 中西医对照治疗小儿肺炎痰热壅肺证80例;胥丹桂;《南京中医药大学学报(自然科学版)》;19980531(第03期);第188页 * |
| 中西医结合治疗猪传染性胸膜肺炎;张忠花;《中兽医医药杂志》;20051230(第06期);第45-46页 * |
| 从治疗两例"发烧待查"病例谈伏暑晚发;任旭;《北京中医》;19870625(第03期);第51-52页 * |
| 肺炎冲剂治疗小儿支气管肺炎临床及实验研究;段琚华等;《中国中医急症》;20020228(第01期);第7-8页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108159342A (en) | 2018-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102198236B (en) | Chinese medicine composition for treating acute sinusitis and preparation method thereof | |
| CN103211997B (en) | Antibacterial and antiviral traditional Chinese medicine composition and preparation method thereof | |
| CN111298048A (en) | Traditional Chinese medicine composition for treating novel coronavirus pneumonia and application thereof | |
| CN105560372A (en) | Traditional Chinese medicine spray for treating rhinitis and preparation method thereof | |
| CN103721103B (en) | Medicine being used for the treatment of pig erysipelas and preparation method thereof | |
| CN1251732C (en) | Chinese medicine for treating intrapulmonic infection and SARS | |
| CN105168807B (en) | The Chinese medicine composition and preparation method thereof for treating pig blue-ear disease | |
| CN108159342B (en) | Traditional Chinese medicine composition for treating pneumonia of livestock and poultry and preparation method | |
| WO2020155318A1 (en) | Traditional chinese medicine preparation for treatment of bacterial respiratory tract disease in livestock and production technique thereof | |
| CN105709081B (en) | Pharmaceutical composition for treating infectious rhinitis of chicken, application and feed thereof | |
| CN105688157A (en) | Traditional Chinese medicine compound preparation for resisting swine influenza virus and preparing method thereof | |
| CN103070813A (en) | Toothpaste applicable to chronic sinusitis patients | |
| CN105535406A (en) | Traditional Chinese medicine composition for preventing and treating livestock respiratory disease | |
| CN113559205B (en) | Traditional Chinese medicine composition for treating infantile common cold and application | |
| CN110354215B (en) | Traditional Chinese medicine composition and medicine for treating cough caused by lung yin deficiency with dampness and preparation method of traditional Chinese medicine composition and medicine | |
| CN107362271A (en) | A kind of Chinese medicine composition for treating breathing problem and preparation method thereof | |
| CN101209293A (en) | Chinese medicinal granule with heat-clearing, detoxication, wind-expelling and cold-expelling efficacy | |
| CN1872192A (en) | A medication composition,and preparation method | |
| CN111632092A (en) | Traditional Chinese medicine formula for preventing and treating respiratory diseases of livestock and poultry and application thereof | |
| CN113750182A (en) | Medicinal and edible composition for preventing and treating gout as well as preparation method and application thereof | |
| CN104274750A (en) | Traditional Chinese medicinal composition for treating acute bronchitis and upper respiratory infection | |
| CN1219527C (en) | Ointment for curing acne and its preparation method | |
| CN104587346A (en) | Lozenge indicated to patients with chronic sinusitis | |
| CN114392310B (en) | Anti-inflammatory antipruritic skin-moistening traditional Chinese medicine external preparation and preparation method and application thereof | |
| CN105688171B (en) | Feed additive for chicks and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |