CN104083603A - Traditional Chinese medicine composition for preventing and treating swine infectious atrophic rhinitis and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for preventing and treating swine infectious atrophic rhinitis and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for preventing and treating swine infectious atrophic rhinitis, which is prepared from Chinese ephedra, asarum, radix angelicae, magnolia flower, cocklebur fruit, rhizoma anemarrhenae, platycodon grandiflorum, scutellaria baicalensis, coptis chinensis and fructus gardeniae. The traditional Chinese medicine composition can be powder. A preparation method of the traditional Chinese medicine composition comprises the steps of (1) selecting: removing impurities, stones, metals and non-medicinal parts; (2) washing: slowly pouring 2-3 folds of water into the raw materials by using an infiltration method so as to completely infiltrate the raw materials exactly; (3) baking: decompressing and drying at 40-70 DEG C till the drugs are completely baked; (4) crushing: crushing the baked drugs with a crusher; (5) passing through a sieve: filtering large particle substances with a 80-100-mesh sieve; and (6) packaging into bags: packaging into each bag of 100-200 g, so as to obtain the finished product of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention can effectively prevent and treat swine infectious atrophic rhinitis and the cure rate is more than 95%. The composition has the effects of clearing heat and drying dampness, nourishing yin and moistening dryness and ventilating the lung and smoothing orifices.
Description
Technical field
The invention belongs to herbal medicine formulation art, especially a kind of Chinese medicine composition of preventing and treating pig infectious atrophic rhinitis and preparation method thereof.
Background technology
Pig infectious atrophic rhinitis (AR) is a kind of porcine respiratory chronic infectious disease being caused by bronchus deteriorated blood bordetella bacilli (Bb) and toxigenic P.multocida (Pm).Wherein produce the Etiological that malicious pasteurella multocida is primary disease, bronchus deteriorated blood bordetella bacilli 1 phase bacterium is the cause of disease of a kind of less important, the mild of primary disease.Antibacterial mainly encroaches on upper respiratory tract.The pig at various ages has susceptibility, and in 1 week age, infection can cause pneumonia, acute death.1-2 month children pig in age is to the susceptible of primary disease.Early symptom is sneeze, rhinorrhea, occur serous catarrh and purulent rhinitis, and pig turbinates 3-4 week after morbidity starts atrophy, congestion, and dyspnea, facial deformation, there is tear speckle at canthus, also may translate into individually pneumonia or frontal sinusitis.The main harm of AR is to cause disease pig growth and development slow, and the feed conversion rate of pig is reduced more than 15%, causes huge economic loss to intensive pig production.The current clinical treatment of primary disease generally adopts intramuscular injection sulfa drugs or other antibiotics, as penicillin, and streptomycin and kanamycin etc., or in feedstuff, add antibiotic.But antibiotics ubiquity easily produces drug resistance and drug residue problem.
It is low that Chinese medicine has toxic and side effects, no drug residue, the advantage of environmental protection.Therefore develop treatment by Chinese herbs AR medicine, overcome the defect of above-mentioned chemical medicine class medicine, become China's pig industry and be badly in need of one of problem solving.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, a kind of good effect, no drug residue, safe and reliable pig Chinese medicine composition are provided.
Another technical problem that the present invention will solve is: a kind of Chinese medicine formula of preventing and treating pig infectious atrophic rhinitis is provided.
Another technical problem that the present invention will solve is: the preparation method that the powder of above-mentioned pig Chinese medicine composition is provided.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition of preventing and treating pig infectious atrophic rhinitis, is characterized in that: the raw material by following mass fraction is prepared from: Herba Ephedrae 10-20 part, Herba Asari 5-15 part, Radix Angelicae Dahuricae 5-15 part, Flos Magnoliae 5-10 part, Fructus Xanthii 5-10 part, Rhizoma Anemarrhenae 5-15 part, Radix Platycodonis 5-15 part, Radix Scutellariae 5-15 part, Rhizoma Coptidis 5-15 part, Fructus Gardeniae 5-15 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows:
20 parts, Herba Ephedrae, 10 parts of Herba Asaris, 10 parts of the Radixs Angelicae Dahuricae, 5 parts of Flos Magnoliaes, 5 parts of Fructus Xanthii, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Platycodoniss, 10 parts of Radix Scutellariaes, 10 parts of Rhizoma Coptidis, 10 parts of Fructus Gardeniaes.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form that contains or do not contain pharmaceutic adjuvant.
Further, described preparation can be powder.
Further, the preparation method of the powder of said composition is: (1) is selected: choose most impurity, stone and metal, remove non-medicinal part; (2) eluriate: use soaking method to make water reach medicine in blowing slowly with 2-3 times of water gaging permeable most; (3) dry: 40 DEG C of-70 DEG C of blood pressure lowerings are dry until dry completely; (4) pulverize: the medical material of oven dry is pulverized with pulverizer; (5) sieve: with 80-100 object sieve elimination large particulate matter; (6) be packaged into bag, every bag of 100-200g
,get product.
Advantage and good effect that the present invention has are:
(1) the present invention is according to tcm theory, science compatibility, retain the combined effect of Chinese medicinal formulae determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and use modern means of science and technology to the effective ingredient of most of medical material wherein carry out quantitatively, half-quantitative detection, through clinical verification determined curative effect, it is a kind of green veterinary drug of nuisanceless no drug residue.
(2) Chinese medicine ingredients that the present invention contains can effectively be prevented and treated pig infectious atrophic rhinitis, can reach more than 90%, in table 1 cure rate of the serious respiratory symptom of piglet.This prescription have heat clearing and damp drying, nourishing YIN to relieve dryness, lung qi dispersing sensible effect.Drug resistance and the residue problem of medicine in Carnis Sus domestica of chemicals have been avoided simultaneously.
(3) pharmacology of the each raw material of Chinese medicine of the present invention is:
Herba Ephedrae: relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, inducing diuresis to remove edema.
Herba Asari: the cold expelling that induces sweat, wind-expelling pain-stopping, sensible, warming the lung to resolve fluid-retention.
The Radix Angelicae Dahuricae: the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.
Flos Magnoliae: dispersing wind-cold, clearing the nasal passage.
Fructus Xanthii: dispersing wind-cold, clearing the nasal passage, wind-damp dispelling, pain relieving.
The Rhizoma Anemarrhenae: clearing away heat-fire is nourshing Yin and drynsessmoistening prescription.
Radix Platycodonis: lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus.
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.
Fructus Gardeniae: pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.
Among formula, Herba Asari, the Radix Angelicae Dahuricae, Flos Magnoliae, Fructus Xanthii is the cold expelling that induces sweat, the key medicine of clearing the nasal passage.Wherein the pungent loose temperature of Herba Asari is logical, and fragrance reaches thoroughly, loose ailment said due to cold or exposure, removing dampness is turbid, fragrance reaches thoroughly, clearing the nasal passage, conventional nasal obstruction, watery nasal discharge, the headache person who controls the Rhinological diseases such as nasal sinusitis, for controlling the good medicine of nasal sinusitis, and normal and the Radix Angelicae Dahuricae, Flos Magnoliae, Fructus Xanthii compatibility, heighten the effect of a treatment, and can effectively alleviate the watery nasal discharge of pig infectious atrophic rhinitis appearance, sneeze, the symptoms such as dyspnea.Herba Ephedrae, the Rhizoma Anemarrhenae, Radix Platycodonis compatibility, relieving the exterior syndrome by diaphoresis, nourishing YIN and moistening the lung, opens lung qi dispersing gas.Radix Platycodonis strengthens antiinflammatory and immunization in addition, in advance the generation of diseases prevention pig secondary pneumonia.In addition, Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae is heat clearing and damp drying, the good medicine of eliminating fire and detoxication.Chinese medical discrimination viewpoint think pig infectious atrophic rhinitis be in exopathogen, invade due to, Radix Scutellariae has the effect of clearing away heat-fire removing toxic substances, availablely controls the carbuncle sore tumefacting virus that fire-toxin is flourishing, and normal and Rhizoma Coptidis, Fructus Gardeniae compatibility.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
Prevent and treat a Chinese medicine powder for pig infectious atrophic rhinitis, the parts by weight of each raw material are as follows: 20 parts, Herba Ephedrae, 10 parts of Herba Asaris, 10 parts of the Radixs Angelicae Dahuricae, 5 parts of Flos Magnoliaes, 5 parts of Fructus Xanthii, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Platycodoniss, 10 parts of Radix Scutellariaes, 10 parts of Rhizoma Coptidis, 10 parts of Fructus Gardeniaes.Its preparation method is: (1) is selected: choose most impurity, stone and metal, remove non-medicinal part; (2) eluriate: make water reach medicine in blowing slowly with 2 times of water gagings use soaking methods permeable most; (3) dry: 65 DEG C of blood pressure lowerings are dry until dry completely; (4) pulverize: the medical material of oven dry is pulverized with pulverizer; (5) sieve: with 80 object sieve elimination large particulate matters; (6) be packaged into bag, every bag of 100g
,get product.
Embodiment 2
Prevent and treat a Chinese medicine powder for pig infectious atrophic rhinitis, the parts by weight of each raw material are as follows: 15 parts, Herba Ephedrae, 15 parts of Herba Asaris, 15 parts of the Radixs Angelicae Dahuricae, 10 parts of Flos Magnoliaes, 10 parts of Fructus Xanthii, 5 parts of the Rhizoma Anemarrhenaes, 5 parts of Radix Platycodoniss, 15 parts of Radix Scutellariaes, 5 parts of Rhizoma Coptidis, 5 parts of Fructus Gardeniaes.Its preparation method is: (1) is selected: choose most impurity, stone and metal, remove non-medicinal part; (2) eluriate: use soaking method to make water reach medicine in blowing slowly with 2-3 times of water gaging permeable most; (3) dry: 60 DEG C of blood pressure lowerings are dry until dry completely; (4) pulverize: the medical material of oven dry is pulverized with pulverizer; (5) sieve: with 100 object sieve elimination large particulate matters; (6) be packaged into bag, every bag of 200g
,get product.
Embodiment 3
Prevent and treat a Chinese medicine powder for pig infectious atrophic rhinitis, the parts by weight of each raw material are as follows: 10 parts, Herba Ephedrae, 5 parts of Herba Asaris, 5 parts of the Radixs Angelicae Dahuricae, 8 parts of Flos Magnoliaes, 7 parts of Fructus Xanthii, 15 parts of the Rhizoma Anemarrhenaes, 15 parts of Radix Platycodoniss, 5 parts of Radix Scutellariaes, 15 parts of Rhizoma Coptidis, 15 parts of Fructus Gardeniaes.Its preparation method is: (1) is selected: choose most impurity, stone and metal, remove non-medicinal part; (2) eluriate: use soaking method to make water reach medicine in blowing slowly with 2-3 times of water gaging permeable most; (3) dry: 65 DEG C of blood pressure lowerings are dry until dry completely; (4) pulverize: the medical material of oven dry is pulverized with pulverizer; (5) sieve: with 80 object sieve elimination large particulate matters; (6) be packaged into bag, every bag of 200g
,get product.
Clinical trial
Experiment 1:
100 of long plain boiled pork porkling pigs are bought on pig farm, Hebei province from other places, buy back about 7 days, and sneeze appears in indivedual piglets, and the symptoms such as rhinorrhea occur piglet nose, face extremely then, and sick pig spreads full group.Be diagnosed as after diagnosing pig infectious atrophic rhinitis.40 sick pigs are wherein used to the prepared product of embodiment 1, and every 100g spice 1kg, every day twice, treats five days.And wash nose with 0.1% potassium permanganate.Except the heavier piglet of symptom was processed the same day, second day sick pig symptom of medication alleviates greatly, within the 5th day, all cures afterwards, and cure rate reaches 97.5%.Another 30 give sulfamethazine, and wash nose with 0.1% potassium permanganate.Except the heavier piglet of symptom was processed the same day, medication starts onset for second day, and within the 5th day, jumpbogroup is cured, cure rate 92.3%.Another 30 give streptomycin, and wash nose with 0.1% potassium permanganate.Except the heavier piglet of symptom was processed the same day, medication starts onset for second day, and within the 5th day, jumpbogroup is cured, cure rate 93.3%.
Experimental results show that the obtained product curative effect of embodiment 1 is obviously better than the antibiotics of the treatment pig infectious atrophic rhinitis of commonly using on the market.
Experiment 2:
60 of ternary piglets are bought on pig farm, Guangdong Province from other places, buy back about 7 days, and pig spirit is depressed, the minimizing of searching for food, and initial just sneeze and nasal obstruction, have purulent nasal discharge to flow out.There is the sick pig in two to flow out blood from single-nostril.And then there is nose skin of face and subcutaneous tissue atrophy, and there is slight turbinates atrophy phenomenon, pig poor growth, efficiency of feed utilization obviously declines, and clinical diagnosis is pig infectious atrophic rhinitis.Wherein 20 use the obtained product of embodiment 1.Every 100g spice 1kg, every day twice, treats five days.And wash nose with 0.1% potassium permanganate.Except the heavier piglet of symptom was processed the same day, second day sick pig symptom of medication alleviates greatly, within the 5th day, all cures afterwards, and cure rate reaches 95%.Another 30 give sulfamethazine, and wash nose with 0.1% potassium permanganate.Except the heavier piglet of symptom was processed the same day, medication starts onset for second day, and within the 5th day, jumpbogroup is cured, cure rate 93.2%.Another 30 give streptomycin, and wash nose with 0.1% potassium permanganate.Except the heavier piglet of symptom was processed the same day, medication starts onset for second day, and within the 5th day, jumpbogroup is cured, cure rate 90.8%.
Experimental results show that the obtained product curative effect of embodiment 1 is obviously better than the antibiotics of the treatment pig infectious atrophic rhinitis of commonly using on the market.
Other result of the tests are in table 1.
Table 1
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiment according to limited range, therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (9)
1. prevent and treat the Chinese medicine composition of pig infectious atrophic rhinitis for one kind, it is characterized in that: the raw material by following mass fraction is prepared from: Herba Ephedrae 10-20 part, Herba Asari 5-15 part, Radix Angelicae Dahuricae 5-15 part, Flos Magnoliae 5-10 part, Fructus Xanthii 5-10 part, Rhizoma Anemarrhenae 5-15 part, Radix Platycodonis 5-15 part, Radix Scutellariae 5-15 part, Rhizoma Coptidis 5-15 part, Fructus Gardeniae 5-15 part.
2. the Chinese medicine composition of control pig infectious atrophic rhinitis according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
20 parts, Herba Ephedrae, 10 parts of Herba Asaris, 10 parts of the Radixs Angelicae Dahuricae, 5 parts of Flos Magnoliaes, 5 parts of Fructus Xanthii, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Platycodoniss, 10 parts of Radix Scutellariaes, 10 parts of Rhizoma Coptidis, 10 parts of Fructus Gardeniaes.
3. the Chinese medicine composition of control pig infectious atrophic rhinitis according to claim 1 and 2, is characterized in that: this Chinese medicine composition is the various conventional extract oral medicine dosage form that contains or do not contain pharmaceutic adjuvant.
4. the Chinese medicine composition of control pig infectious atrophic rhinitis according to claim 3, is characterized in that: described preparation can be powder.
5. a method of preparing the Chinese medicine composition of control pig infectious atrophic rhinitis as claimed in claim 4, is characterized in that: preparation method is: (1) is selected: choose most impurity, stone and metal, remove non-medicinal part; (2) eluriate: make water reach medicine in blowing slowly with certain water gaging use soaking method permeable most; (3) dry: blood pressure lowering is at a certain temperature dry until dry completely; (4) pulverize: the medical material of oven dry is pulverized with pulverizer; (5) sieve: with the sieve elimination large particulate matter of certain order number; (6) be packaged into bag, get product.
6. the preparation method of the Chinese medicine composition of control pig infectious atrophic rhinitis according to claim 5, is characterized in that: described elutriation water consumption is 2-3 times.
7. the preparation method of the Chinese medicine composition of control pig infectious atrophic rhinitis according to claim 5, is characterized in that: the dry temperature of blood pressure lowering is 40-70 DEG C.
8. the preparation method of the Chinese medicine composition of control pig infectious atrophic rhinitis according to claim 5, is characterized in that: the order number sieving is 80-100 order.
9. the preparation method of the Chinese medicine composition of control pig infectious atrophic rhinitis according to claim 5, is characterized in that: the specification of packaging is 100-200g/ bag.
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Cited By (5)
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| CN106689758A (en) * | 2017-03-06 | 2017-05-24 | 长沙瑞多康生物科技有限公司 | Feed for preventing swine infectious atrophic rhinitis |
| CN106819483A (en) * | 2017-03-06 | 2017-06-13 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention infectious atrophic rhinitis of pig |
| CN106880663A (en) * | 2017-03-06 | 2017-06-23 | 长沙瑞多康生物科技有限公司 | A kind of composition of prevention infectious atrophic rhinitis of pig |
| CN106901018A (en) * | 2017-03-06 | 2017-06-30 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention infectious atrophic rhinitis of pig |
| CN113244297A (en) * | 2021-06-16 | 2021-08-13 | 四川省羌山农牧科技股份有限公司 | Traditional Chinese medicine composition for treating swine infectious atrophic rhinitis and using method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106689758A (en) * | 2017-03-06 | 2017-05-24 | 长沙瑞多康生物科技有限公司 | Feed for preventing swine infectious atrophic rhinitis |
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| CN106901018A (en) * | 2017-03-06 | 2017-06-30 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention infectious atrophic rhinitis of pig |
| CN113244297A (en) * | 2021-06-16 | 2021-08-13 | 四川省羌山农牧科技股份有限公司 | Traditional Chinese medicine composition for treating swine infectious atrophic rhinitis and using method thereof |
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