CN113230183A - Preparation with skin cell repairing active protein peptide and preparation method thereof - Google Patents
Preparation with skin cell repairing active protein peptide and preparation method thereof Download PDFInfo
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- CN113230183A CN113230183A CN202110523387.9A CN202110523387A CN113230183A CN 113230183 A CN113230183 A CN 113230183A CN 202110523387 A CN202110523387 A CN 202110523387A CN 113230183 A CN113230183 A CN 113230183A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a preparation with skin cell repairing activity protein peptide, which comprises the following components in parts by weight: 8-12 parts of sodium hyaluronate, 8-12 parts of hydrolyzed hyaluronic acid, 5-9 parts of glycerol, 15-19 parts of collagen peptide, 15-19 parts of deep sea fish skin peptide, 6-10 parts of resveratrol, 20-24 parts of plant extract, 18-22 parts of auxiliary material and 150 parts of deionized water; according to the invention, the plant extract is used for supplementing moisture to the skin, so that the effects of moisturizing and moistening the skin are achieved; the palmitoyl tripeptide-5 in the auxiliary materials can help the skin to supplement collagen, improve the elasticity of the face and obviously reduce facial wrinkles, and meanwhile, the palmitoyl tripeptide-5 also has the characteristics of enhancing cell activity, improving the water content of the skin, enhancing the skin luster and improving the skin color; therefore, when the preparation with the skin cell repairing activity protein peptide is added into cosmetics, damaged skin can be repaired, and the activity of skin cells is improved.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a preparation with skin cell repairing activity protein peptide and a preparation method thereof.
Background
With the passing of years, the physiological function of the human body is continuously eliminated, and the signs of skin aging of people are more and more obvious; with the continuous degeneration of physiological functions, the collagen generating capacity is greatly reduced, the internal structure of the skin is collapsed, and the skin becomes loose.
In order to improve the elasticity of skin, cosmetics with the activity of repairing skin cells are more and more favored by people, the existing cosmetics containing protein peptides can only temporarily improve the elasticity of skin, can not repair damaged skin and can not activate the activity of skin cells, and therefore, a preparation with the activity of repairing skin cells protein peptides is developed.
Disclosure of Invention
The invention aims to provide a preparation with skin cell repairing active protein peptide and a preparation method thereof, which aim to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a preparation with skin cell repairing activity protein peptide comprises the following components in parts by weight: 8-12 parts of sodium hyaluronate, 8-12 parts of hydrolyzed hyaluronic acid, 5-9 parts of glycerol, 15-19 parts of collagen peptide, 15-19 parts of deep sea fish skin peptide, 6-10 parts of resveratrol, 20-24 parts of plant extract, 18-22 parts of auxiliary material and 150 parts of deionized water.
The plant extract is prepared from the following raw materials in parts by weight: 3-7 parts of noni extract, 3-7 parts of gamboge extract, 3-7 parts of purslane extract, 3-7 parts of centella asiatica extract and 3-7 parts of aloe extract.
Wherein the preparation method of the plant extract comprises the following steps:
firstly, selecting sufficient noni fruit extract, gamboge fruit extract, purslane extract, centella extract and aloe extract, then respectively grinding the noni fruit extract, gamboge fruit extract, purslane extract, centella extract and aloe extract by using a grinder, and respectively filtering the ground noni fruit extract, gamboge fruit extract, purslane extract, centella extract and aloe extract by using a 800-mesh stainless steel filter screen;
and step two, respectively weighing the filtered noni extract, the garcinia cambogia extract, the purslane extract, the centella asiatica extract and the aloe extract powder in parts by weight, then adding the weighed noni extract, the garcinia cambogia extract, the purslane extract, the centella asiatica extract and the aloe extract powder into a stirrer, and stirring for 10-15 minutes by the stirrer to uniformly mix the noni extract, the garcinia cambogia extract, the purslane extract, the centella asiatica extract and the aloe extract powder together to obtain the plant extract.
The auxiliary materials are prepared from the following raw materials in parts by weight: 54-8 parts of palmitoyl tripeptide, 4-8 parts of glabridin, 4-8 parts of astaxanthin and 4-8 parts of thickening agent.
The thickening agent is prepared from the following raw materials in parts by weight: 1-5 parts of xanthan gum and 1-5 parts of coconut oil.
A preparation method of a preparation with skin cell repairing activity protein peptide comprises the following steps:
s1, respectively weighing sodium hyaluronate, hydrolyzed hyaluronic acid, glycerol and deionized water in parts by weight, sequentially adding the weighed sodium hyaluronate, hydrolyzed hyaluronic acid, glycerol and deionized water into a reaction kettle, and stirring for 20-25 minutes through the reaction kettle to uniformly mix the sodium hyaluronate, the hydrolyzed hyaluronic acid and the glycerol into water;
s2, respectively weighing collagen peptide, deep sea fish skin peptide and resveratrol according to parts by weight, sequentially adding the weighed collagen peptide, deep sea fish skin peptide and resveratrol into a reaction kettle, adjusting the temperature of the reaction kettle to 120-140 ℃, and stirring for 20-25 minutes through the reaction kettle to uniformly mix the collagen peptide, deep sea fish skin peptide and resveratrol into the mixed liquid obtained in S1;
s3, weighing the plant extracts according to the parts by weight, adding the weighed plant extracts into a reaction kettle, and stirring for 15-20 minutes through the reaction kettle at the temperature of 120-140 ℃ so that the plant extracts are uniformly mixed into the mixed liquid obtained in the step S2;
s4, respectively weighing palmitoyl tripeptide-5, glabridin, astaxanthin and a thickening agent in parts by weight, sequentially adding the weighed palmitoyl tripeptide-5, glabridin, astaxanthin and thickening agent into a reaction kettle, adjusting the temperature of the reaction kettle to 230-260 ℃, and stirring for 35-40 minutes through the reaction kettle to uniformly mix the raw materials in the reaction kettle together to obtain the preparation with the skin cell repairing active protein peptide.
Compared with the prior art, the invention has the beneficial effects that:
according to the preparation method, sodium hyaluronate, hydrolyzed hyaluronic acid, glycerol, collagen peptide, deep-sea fish skin peptide, resveratrol, plant extracts, auxiliary materials and deionized water are uniformly mixed together through a scientific and reasonable ratio, and the preparation with the skin cell repairing active protein peptide is prepared through a series of processes; the plant extract is used for supplementing water to the skin, so that the effects of moisturizing and moistening the skin are achieved; the palmitoyl tripeptide-5 in the auxiliary materials can help the skin to supplement collagen, improve the elasticity of the face and obviously reduce facial wrinkles, and meanwhile, the palmitoyl tripeptide-5 also has the characteristics of enhancing cell activity, improving the water content of the skin, enhancing the skin luster and improving the skin color; therefore, when the preparation with the skin cell repairing activity protein peptide is added into cosmetics, damaged skin can be repaired, and the activity of skin cells is improved.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Embodiment 1, the present invention provides a technical solution: a preparation with skin cell repairing activity protein peptide comprises the following components in parts by weight: 9 parts of sodium hyaluronate, 9 parts of hydrolyzed hyaluronic acid, 7 parts of glycerol, 16 parts of collagen peptide, 16 parts of deep sea fish skin peptide, 8 parts of resveratrol, 21 parts of plant extract, 18 parts of auxiliary material and 130 parts of deionized water.
The plant extract is prepared from the following raw materials in parts by weight: 4 parts of noni extract, 4 parts of gamboge extract, 4 parts of purslane extract, 4 parts of centella extract and 5 parts of aloe extract.
The preparation method of the plant extract comprises the following steps:
firstly, selecting sufficient noni fruit extract, gamboge fruit extract, purslane extract, centella extract and aloe extract, then respectively grinding the noni fruit extract, gamboge fruit extract, purslane extract, centella extract and aloe extract by using a grinder, and respectively filtering the ground noni fruit extract, gamboge fruit extract, purslane extract, centella extract and aloe extract by using a 800-mesh stainless steel filter screen;
and step two, respectively weighing the filtered noni extract, the garcinia cambogia extract, the purslane extract, the centella asiatica extract and the aloe extract powder in parts by weight, then adding the weighed noni extract, the garcinia cambogia extract, the purslane extract, the centella asiatica extract and the aloe extract powder into a stirrer, and stirring for 10-15 minutes by the stirrer to uniformly mix the noni extract, the garcinia cambogia extract, the purslane extract, the centella asiatica extract and the aloe extract powder together to obtain the plant extract.
The auxiliary materials are prepared from the following raw materials in parts by weight: 54 parts of palmitoyl tripeptide, 4 parts of glabridin, 5 parts of astaxanthin and 5 parts of thickening agent.
The thickening agent is prepared from the following raw materials in parts by weight: 2 parts of xanthan gum and 3 parts of coconut oil.
A preparation method of a preparation with skin cell repairing activity protein peptide comprises the following steps:
s1, respectively weighing sodium hyaluronate, hydrolyzed hyaluronic acid, glycerol and deionized water in parts by weight, sequentially adding the weighed sodium hyaluronate, hydrolyzed hyaluronic acid, glycerol and deionized water into a reaction kettle, and stirring for 20-25 minutes through the reaction kettle to uniformly mix the sodium hyaluronate, the hydrolyzed hyaluronic acid and the glycerol into water;
s2, respectively weighing collagen peptide, deep sea fish skin peptide and resveratrol according to parts by weight, sequentially adding the weighed collagen peptide, deep sea fish skin peptide and resveratrol into a reaction kettle, adjusting the temperature of the reaction kettle to 120-140 ℃, and stirring for 20-25 minutes through the reaction kettle to uniformly mix the collagen peptide, deep sea fish skin peptide and resveratrol into the mixed liquid obtained in S1;
s3, weighing the plant extracts according to the parts by weight, adding the weighed plant extracts into a reaction kettle, and stirring for 15-20 minutes through the reaction kettle at the temperature of 120-140 ℃ so that the plant extracts are uniformly mixed into the mixed liquid obtained in the step S2;
s4, respectively weighing palmitoyl tripeptide-5, glabridin, astaxanthin and a thickening agent in parts by weight, sequentially adding the weighed palmitoyl tripeptide-5, glabridin, astaxanthin and thickening agent into a reaction kettle, adjusting the temperature of the reaction kettle to 230-260 ℃, and stirring for 35-40 minutes through the reaction kettle to uniformly mix the raw materials in the reaction kettle together to obtain the preparation with the skin cell repairing active protein peptide.
Embodiment 2, the present invention provides a technical solution: a preparation with skin cell repairing activity protein peptide comprises the following components in parts by weight: 11 parts of sodium hyaluronate, 11 parts of hydrolyzed hyaluronic acid, 7 parts of glycerol, 16 parts of collagen peptide, 16 parts of deep sea fish skin peptide, 9 parts of resveratrol, 23 parts of plant extract, 21 parts of auxiliary material and 140 parts of deionized water.
The plant extract is prepared from the following raw materials in parts by weight: 5 parts of noni extract, 5 parts of gamboge extract, 4 parts of purslane extract, 4 parts of centella extract and 5 parts of aloe extract.
The preparation method of the plant extract is basically the same as that of the preparation of the plant extract in example 1, and the difference is only that the mixture ratio of the components is different.
The auxiliary materials are prepared from the following raw materials in parts by weight: 55 parts of palmitoyl tripeptide, 5 parts of glabridin, 5 parts of astaxanthin and 6 parts of thickening agent.
The thickening agent is prepared from the following raw materials in parts by weight: 3 parts of xanthan gum and 3 parts of coconut oil.
The preparation method of the preparation with the skin cell repairing active protein peptide is basically the same as that of the preparation with the skin cell repairing active protein peptide in the embodiment 1, and the difference is only that the mixture ratio of the components is different.
Embodiment 3, the present invention provides a technical solution: a preparation with skin cell repairing activity protein peptide comprises the following components in parts by weight: 12 parts of sodium hyaluronate, 12 parts of hydrolyzed hyaluronic acid, 9 parts of glycerol, 19 parts of collagen peptide, 19 parts of deep sea fish skin peptide, 10 parts of resveratrol, 24 parts of plant extract, 22 parts of auxiliary material and 150 parts of deionized water.
The plant extract is prepared from the following raw materials in parts by weight: 6 parts of noni extract, 4 parts of gamboge extract, 6 parts of purslane extract, 4 parts of centella extract and 4 parts of aloe extract.
The preparation method of the plant extract is basically the same as that of the preparation of the plant extract in example 1, and the difference is only that the mixture ratio of the components is different.
The auxiliary materials are prepared from the following raw materials in parts by weight: 56 parts of palmitoyl tripeptide, 4 parts of glabridin, 5 parts of astaxanthin and 7 parts of thickening agent.
The thickening agent is prepared from the following raw materials in parts by weight: xanthan gum 4 parts and coconut oil 3 parts.
The preparation method of the preparation with the skin cell repairing active protein peptide is basically the same as that of the preparation with the skin cell repairing active protein peptide in the embodiment 1, and the difference is only that the mixture ratio of the components is different.
In conclusion, the preparation with the skin cell repairing activity is prepared by uniformly mixing sodium hyaluronate, hydrolyzed hyaluronic acid, glycerin, collagen peptide, deep sea fish skin peptide, resveratrol, plant extracts, auxiliary materials and deionized water together according to a scientific and reasonable proportion through a series of procedures, the preparation method is simple, and the collagen peptide, the deep sea fish skin peptide and the resveratrol have synergistic effect, so that the collagen lost in the body can be timely supplemented, the blood circulation is accelerated, and nutrition is provided for cells; the plant extract is used for supplementing water to the skin, so that the effects of moisturizing and moistening the skin are achieved; the palmitoyl tripeptide-5 in the auxiliary materials can help the skin to supplement collagen, improve the elasticity of the face and obviously reduce facial wrinkles, and meanwhile, the palmitoyl tripeptide-5 also has the characteristics of enhancing cell activity, improving the water content of the skin, enhancing the skin luster and improving the skin color; therefore, when the preparation with the skin cell repairing activity protein peptide is added into cosmetics, damaged skin can be repaired, and the activity of skin cells is improved.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. A preparation with skin cell repairing activity protein peptide is characterized by comprising the following components in parts by weight: 8-12 parts of sodium hyaluronate, 8-12 parts of hydrolyzed hyaluronic acid, 5-9 parts of glycerol, 15-19 parts of collagen peptide, 15-19 parts of deep sea fish skin peptide, 6-10 parts of resveratrol, 20-24 parts of plant extract, 18-22 parts of auxiliary material and 150 parts of deionized water.
2. The preparation of protein peptide with skin cell repairing activity according to claim 1, wherein: the plant extract is prepared from the following raw materials in parts by weight: 3-7 parts of noni extract, 3-7 parts of gamboge extract, 3-7 parts of purslane extract, 3-7 parts of centella asiatica extract and 3-7 parts of aloe extract.
3. The preparation of protein peptide with skin cell repairing activity according to claim 2, wherein: the preparation method of the plant extract comprises the following steps:
firstly, selecting sufficient noni fruit extract, gamboge fruit extract, purslane extract, centella extract and aloe extract, then respectively grinding the noni fruit extract, gamboge fruit extract, purslane extract, centella extract and aloe extract by using a grinder, and respectively filtering the ground noni fruit extract, gamboge fruit extract, purslane extract, centella extract and aloe extract by using a 800-mesh stainless steel filter screen;
and step two, respectively weighing the filtered noni extract, the garcinia cambogia extract, the purslane extract, the centella asiatica extract and the aloe extract powder in parts by weight, then adding the weighed noni extract, the garcinia cambogia extract, the purslane extract, the centella asiatica extract and the aloe extract powder into a stirrer, and stirring for 10-15 minutes by the stirrer to uniformly mix the noni extract, the garcinia cambogia extract, the purslane extract, the centella asiatica extract and the aloe extract powder together to obtain the plant extract.
4. The preparation of protein peptide with skin cell repairing activity according to claim 3, wherein: the auxiliary materials are prepared from the following raw materials in parts by weight: 54-8 parts of palmitoyl tripeptide, 4-8 parts of glabridin, 4-8 parts of astaxanthin and 4-8 parts of thickening agent.
5. The preparation of the protein peptide with skin cell repairing activity according to claim 4, wherein: the thickening agent is prepared from the following raw materials in parts by weight: 1-5 parts of xanthan gum and 1-5 parts of coconut oil.
6. The preparation method of the preparation of the protein peptide with the skin cell repairing activity according to any one of claims 1 to 5, which is characterized by comprising the following steps:
s1, respectively weighing sodium hyaluronate, hydrolyzed hyaluronic acid, glycerol and deionized water in parts by weight, sequentially adding the weighed sodium hyaluronate, hydrolyzed hyaluronic acid, glycerol and deionized water into a reaction kettle, and stirring for 20-25 minutes through the reaction kettle to uniformly mix the sodium hyaluronate, the hydrolyzed hyaluronic acid and the glycerol into water;
s2, respectively weighing collagen peptide, deep sea fish skin peptide and resveratrol according to parts by weight, sequentially adding the weighed collagen peptide, deep sea fish skin peptide and resveratrol into a reaction kettle, adjusting the temperature of the reaction kettle to 120-140 ℃, and stirring for 20-25 minutes through the reaction kettle to uniformly mix the collagen peptide, deep sea fish skin peptide and resveratrol into the mixed liquid obtained in S1;
s3, weighing the plant extracts according to the parts by weight, adding the weighed plant extracts into a reaction kettle, and stirring for 15-20 minutes through the reaction kettle at the temperature of 120-140 ℃ so that the plant extracts are uniformly mixed into the mixed liquid obtained in the step S2;
s4, respectively weighing palmitoyl tripeptide-5, glabridin, astaxanthin and a thickening agent in parts by weight, sequentially adding the weighed palmitoyl tripeptide-5, glabridin, astaxanthin and thickening agent into a reaction kettle, adjusting the temperature of the reaction kettle to 230-260 ℃, and stirring for 35-40 minutes through the reaction kettle to uniformly mix the raw materials in the reaction kettle together to obtain the preparation with the skin cell repairing active protein peptide.
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2021
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| CN112120956A (en) * | 2020-10-28 | 2020-12-25 | 广州安若希医药科技有限公司 | Polypeptide composition for repairing damaged skin |
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Application publication date: 20210810 |