KR101222708B1 - Health foods composition for improving the skin - Google Patents
Health foods composition for improving the skin Download PDFInfo
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- KR101222708B1 KR101222708B1 KR1020100092207A KR20100092207A KR101222708B1 KR 101222708 B1 KR101222708 B1 KR 101222708B1 KR 1020100092207 A KR1020100092207 A KR 1020100092207A KR 20100092207 A KR20100092207 A KR 20100092207A KR 101222708 B1 KR101222708 B1 KR 101222708B1
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- skin
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- mixed
- functional food
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- 235000013402 health food Nutrition 0.000 title claims 2
- 230000006872 improvement Effects 0.000 claims abstract description 15
- 235000013376 functional food Nutrition 0.000 claims abstract description 14
- 241000167550 Centella Species 0.000 claims abstract description 12
- 235000014360 Punica granatum Nutrition 0.000 claims abstract description 12
- 235000002789 Panax ginseng Nutrition 0.000 claims abstract description 11
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- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 description 1
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- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
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- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
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- 235000021018 plums Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
Abstract
본 발명은 피부 개선용 건강 기능성 식품 조성물에 관한 것으로서,
병풀, 석류, 매실을 일정 비율로 혼합 조성하여 추출한 혼합 추출물에 홍삼 농축액을 함유시킨 천연 복합 추출물로 피부 개선용 건강 기능성 식품 조성물을 제조함으로써,
스트레스로 상하기 쉬운 피부의 긴장을 진정시킴과 동시에, 피로를 회복시키고, 피부 보습을 강화시켜, 피부 노화를 효과적으로 방지할 수 있는 피부 개선용 건강 기능성 식품 조성물을 제공할 수 있도록 한 것이다.The present invention relates to a health functional food composition for skin improvement,
By preparing a health functional food composition for skin improvement with a natural complex extract containing red ginseng concentrate in a mixed extract extracted by mixing the composition of Centella, pomegranate and plum at a certain ratio,
At the same time to relax the tension of the skin susceptible to stress, to restore fatigue and to strengthen the skin moisturizing, to provide a healthy functional food composition for skin improvement that can effectively prevent skin aging.
Description
본 발명은 피부 개선용 건강 기능성 식품 조성물에 관한 것이다.
The present invention relates to a health functional food composition for skin improvement.
사람의 피부는 나이가 들어감에 따라, 내적으로는 노화의 진행으로 인해 신진 대사를 조절하는 각종 호르몬의 분비가 감소함과 동시에, 면역 세포의 기능과 세포들의 활성이 저하되어 생체에 필요한 면역 및 생체 단백질의 생합성이 줄어들게 되며,As the human skin ages, internal aging progresses, the secretion of various hormones that regulate metabolism decreases, and the function and function of cells of the immune cells is reduced, resulting in the immunity and vitality of the body. Reduce the biosynthesis of proteins,
외적으로는 오존층 파괴로 인하여 태양 광선에 자외선의 함량이 증가하게 되고 환경 오염이 더욱 심화됨에 따라 자유 라디칼 및 유해 활성 산소 등이 증가함으로써,Externally, due to the destruction of the ozone layer, the amount of ultraviolet rays in the sun's rays increases, and as the pollution becomes more severe, free radicals and harmful active oxygen increase,
피부의 주름이 증가할 뿐만 아니라, 기미, 주근깨, 검버섯이 증가하는 등의 여러 가지 변화가 끊임없이 일어나게 되어, 피부의 기능 저하와 함께, 시각적인 아름다움이 감소하게 된다.
In addition to the increase in wrinkles of the skin, various changes such as the increase in the appearance of spots, freckles, mushrooms, etc. occur constantly, and with the deterioration of the skin function, the visual beauty is reduced.
그리고 이러한 피부 주름은 일반적으로 피부의 수분 함유량과 콜라겐의 함유량, 외부 환경에 대한 면역 작용 능력 등의 여러 가지 요소들에 의해 생성되는 것으로 알려져 있으며, 이 중 피부 주름 형성에 가장 큰 영향을 미치는 것은 콜라겐이다.
In addition, the skin wrinkles are generally produced by various factors such as the moisture content of the skin, the collagen content, and the ability of the immune function to the external environment. Among them, collagen has the greatest effect on the skin wrinkle formation. to be.
콜라겐은 피부의 유연성을 주는 섬유 조직으로서, 진피 조직의 약 70 % 를 차지하는 주요 구성 요소이다. 콜라겐 섬유의 폴리펩타이드 사슬은 섬유아세포의 과립형질세망 내에서 양 끝에 확장펩타이드(telopeptide)를 가지고 있는 상태로 합성된 뒤, 3 중 나선 구조로 조합된 프로콜라겐 형태로 세포 밖으로 분비된다. 이렇게 분비된 프로콜라겐은 특정 효소에 의해 확장펩타이드가 절단되어 트로포콜라겐이 생성되고 이들은 세포외 기질에서 서로 조합되어 콜라겐 섬유로 합성된다.
Collagen is a fibrous tissue that gives skin flexibility and is a major component of about 70% of dermal tissue. Polypeptide chains of collagen fibers are synthesized in the fibroblast granular reticulum with the extended peptides (telopeptide) at both ends, and then secreted out of the cells in the form of a procollagen combined into a triple helix structure. The secreted procollagen is digested with an extended peptide by a specific enzyme to produce tropocollagen, which is combined with each other in the extracellular matrix and synthesized into collagen fibers.
이러한 콜라겐 섬유의 합성은 피부 노화가 진행되면서 급격히 저하하며, 또한 외부 환경에 의해 콜라겐 섬유가 변형되면서 피부에 주름이 많이 생성되고 깊어지게 된다. 이러한 콜라겐의 분해에는 콜라겐 분해효소인 콜라게나아제(collagenase)가 관여하는 것으로 알려져 있다.
Synthesis of such collagen fibers is rapidly degraded as the skin ages, and as the collagen fibers are deformed by the external environment, a lot of wrinkles are generated and deepened in the skin. The collagen is known to be involved in collagenase, which is a collagenase.
이와 같이 최근 피부 주름 생성 원인 및 개선을 위하여 피부 생리학적 연구가 많이 행하여지고 있으며, 활성 산소 제거, 섬유아세포의 증식 및 콜라겐의 생합성 촉진 등을 통하여 피부 노화를 예방, 치료 또는 지연시킬 수 있다.
As described above, a lot of skin physiological studies have been conducted for the cause and improvement of skin wrinkles, and skin aging can be prevented, treated or delayed through removal of free radicals, growth of fibroblasts and promotion of collagen biosynthesis.
이러한 해결 방안으로 화장품과 같은 외용적 방법에 의한 피부 상태 개선과 함께, 식이 섭취에 의한 피부 개선 효과를 나타내는 물질에 대한 연구가 활발히 진행되고 있다.
In order to solve such a problem, research on substances exhibiting skin improvement effects by dietary intake as well as skin condition improvement by external methods such as cosmetics have been actively conducted.
본 발명은 이와 같은 피부 상태 개선을 위한 건강 기능성 식품에 관하여 연구된 것으로서,The present invention has been studied with respect to the health functional food for improving such a skin condition,
본 발명의 목적은 스트레스로 상하기 쉬운 피부의 긴장을 진정시킴과 동시에, 피로를 회복시키고, 피부 보습을 강화시켜, 피부 노화를 방지할 수 있는 피부 개선용 건강 기능성 식품 조성물을 제공할 수 있도록 하는 데 있다.An object of the present invention is to soothe the tension of the skin susceptible to stress, at the same time to restore fatigue, enhance skin moisturizing, to provide a health functional food composition for skin improvement that can prevent skin aging have.
이를 위하여 본 발명은,To this end,
병풀, 석류, 매실을 일정 비율로 혼합 조성하여 추출한 혼합 추출물에 홍삼 농축액을 함유시킨 천연 복합 추출물로 피부 개선용 건강 기능성 식품 조성물을 제조함으로써,By preparing a health functional food composition for skin improvement with a natural complex extract containing red ginseng concentrate in the mixed extract extracted by mixing and mixing Centella, pomegranate and plum at a certain ratio,
스트레스로 상하기 쉬운 피부의 긴장을 진정시킴과 동시에, 피로를 회복시키고, 피부 보습을 강화시켜, 피부 노화를 효과적으로 방지할 수 있는 피부 개선용 건강 기능성 식품 조성물을 제공할 수 있도록 한 것을 특징으로 한다.
It is characterized in that it is possible to provide a healthy functional food composition for skin improvement that can soothe tension of the skin which is easily damaged by stress and at the same time recover fatigue and strengthen skin moisturizing, effectively preventing skin aging.
본 발명의 피부 개선용 건강 기능성 식품 조성물은,Health functional food composition for skin improvement of the present invention,
천연 식물 복합 추출물로서, 스트레스로 상하기 쉬운 피부의 긴장을 진정시킴과 동시에, 피로를 회복시키고, 피부 보습을 강화시켜, 피부 노화를 효과적으로 방지할 수 있는 피부 개선용 건강 기능성 식품 조성물을 제공할 수 있는 효과가 있다.
As a natural plant complex extract, it is possible to provide a healthy functional food composition for skin improvement that can soothe the tension of the skin, which is susceptible to stress, to restore fatigue, enhance skin moisturization, and effectively prevent skin aging. It works.
이하 본 발명을 구체적으로 설명한다.
Hereinafter, the present invention will be described in detail.
먼저, 본 발명에 따른 피부 개선용 건강 기능성 식품 조성물의 주성분인 병풀과 석류 및 매실은 연구 결과, 다음과 같은 효능이 있음이 밝혀졌다.
First, the centella, pomegranate and plum, which are the main components of the functional food composition for skin improvement according to the present invention, have been found to have the following effects.
1. 병풀1. Centella
- 피부 진정-Soothing skin
- 보습- Moisturizing
- 아시아티코사이드(asiaticoside) 에 의한 콜라겐 합성Collagen synthesis by asiaticoside
- 피부 각질 주기 조절에 관여-Involved in skin keratin cycle control
- 항염, 항균, 상처 치유
-Anti-inflammatory, antibacterial, wound healing
2. 석류2. Pomegranate
- 껍질의 타닌 성분이 에너지대사 촉진, 피로 회복에 도움-Tannins in the shell help promote energy metabolism and recover from fatigue
- 씨앗에 함유된 천연식물성 에스트로겐에 의해 콜라겐 합성, 피부 미용, 노화에 도움
-Natural plant estrogen in seeds helps collagen synthesis, skin beauty and aging
3. 매실3. Plum
- 알칼리성 식품-Alkaline foods
- 다량의 유기산 함유, 정신적인 스트레스와 피로회복, 정장 작용-Contains large amount of organic acid, mental stress and fatigue recovery, formal action
- 구연산과 사과산이 풍부하여, 칼슘흡수 촉진-Rich in citric acid and malic acid, promoting calcium absorption
- 피크린 산, 카테킨 산 함유 해독, 살균 작용-Detoxification, bactericidal action containing picric acid and catechin acid
- 각종 유기산과 비타민이 혈액순환을 도와 피부 미용 작용
-Various organic acids and vitamins help blood circulation
이하, 본 발명에 따른 피부 개선용 건강 기능성 식품 조성물의 바람직한 실시예를 구체적으로 설명하면 다음과 같다.
Hereinafter, described in detail a preferred embodiment of the health functional food composition for skin improvement according to the present invention.
실시예 1
Example 1
1. 원료 혼합1. Raw material mixing
병풀을 60 ~ 80 % 의 주정 에탄올 용매에 10 % 함량으로 혼합한다.
Centella is mixed in 60-80% alcoholic ethanol solvent with 10% content.
2. 추출물 획득2. Obtaining Extract
상기 혼합된 원료를 교반기에서 상온으로 24 시간 추출하여 병풀 추출물을 획득하였다
The mixed raw material was extracted at room temperature for 24 hours in a stirrer to obtain Centella asiatica extract.
3. 여과3. Filtration
상기 병풀 추출물을 250 메쉬와 0.5 ㎛ 필터페이퍼로 여과하여 액상 추출물을 수득한다.
The centella extract is filtered through 250 mesh and 0.5 μm filter paper to obtain a liquid extract.
4. 농축4. Thickening
상기 여과된 액상 추출물을 회전 감압 농축기로 감압 농축한 뒤, 추출된 성분의 용해도를 높이기 위해 β-cyclodextrin 을 2 % 첨가하였다.
The filtered liquid extract was concentrated under reduced pressure with a rotary vacuum concentrator, and 2% of β-cyclodextrin was added to increase the solubility of the extracted components.
5. 동결 건조5. Freeze Drying
상기 농축이 끝난 병풀 추출물을 동결 건조하여 분말 상태로 제조하였다.
The concentrated Centella asiatica extract was freeze-dried to prepare a powder.
6. 식품 조성물 1 의 제조6. Preparation of Food Composition 1
상기 제조된 병풀 추출물을 증류수에 0.1 내지 5 % 의 비율로 첨가하고, 여기에 고형분 60 % 의 홍삼 농축액을 0.1 내지 2 % 의 비율로 첨가한 후, 혼합하여 식품 조성물 1 을 제조하였다.
The prepared Centella asiatica extract was added to distilled water at a ratio of 0.1 to 5%, and a red ginseng concentrate having a solid content of 60% was added at a ratio of 0.1 to 2%, and then mixed to prepare a food composition 1.
실시예 2
Example 2
1. 원료 혼합1. Raw material mixing
석류를 60 ~ 80 % 의 주정 에탄올 용매에 10 % 함량으로 혼합한다.
Pomegranate is mixed in a 60% to 80% alcohol ethanol solvent in 10% content.
2. 추출물 획득2. Obtaining Extract
상기 혼합된 원료를 교반기에서 상온으로 24 시간 추출하여 석류 추출물을 획득하였다
The mixed raw material was extracted at room temperature for 24 hours in a stirrer to obtain a pomegranate extract.
3. 여과3. Filtration
상기 석류 추출물을 250 메쉬와 0.5 ㎛ 필터페이퍼로 여과하여 액상 추출물을 수득한다.
The pomegranate extract is filtered through 250 mesh and 0.5 μm filter paper to obtain a liquid extract.
4. 농축4. Thickening
상기 여과된 액상 추출물을 회전 감압 농축기로 감압 농축한 뒤, 추출된 성분의 용해도를 높이기 위해 β-cyclodextrin 을 2 % 첨가하였다.
The filtered liquid extract was concentrated under reduced pressure with a rotary vacuum concentrator, and 2% of β-cyclodextrin was added to increase the solubility of the extracted components.
5. 동결 건조5. Freeze Drying
상기 농축이 끝난 석류 추출물을 동결 건조하여 분말 상태로 제조하였다.
The concentrated pomegranate extract was freeze-dried to prepare a powder.
6. 식품 조성물 2 의 제조6. Preparation of Food Composition 2
상기 제조된 석류 추출물을 증류수에 0.1 내지 5 % 의 비율로 첨가하고, 여기에 고형분 60 % 의 홍삼 농축액을 0.1 내지 2 % 의 비율로 첨가한 후, 혼합하여 식품 조성물 2 를 제조하였다.
The pomegranate extract prepared above was added to distilled water at a ratio of 0.1 to 5%, and a red ginseng concentrate having a solid content of 60% was added at a ratio of 0.1 to 2%, and then mixed to prepare a food composition 2.
실시예 3
Example 3
1. 원료 혼합1. Raw material mixing
매실을 60 ~ 80 % 의 주정 에탄올 용매에 10 % 함량으로 혼합한다.
Plum is mixed in 60-80% alcoholic ethanol solvent in 10% content.
2. 추출물 획득2. Obtaining Extract
상기 혼합된 원료를 교반기에서 상온으로 24 시간 추출하여 매실 추출물을 획득하였다
The mixed raw material was extracted for 24 hours at room temperature in a stirrer to obtain a plum extract
3. 여과3. Filtration
상기 매실 추출물을 250 메쉬와 0.5 ㎛ 필터페이퍼로 여과하여 액상 추출물을 수득한다.
The plum extract is filtered through 250 mesh and 0.5 μm filter paper to obtain a liquid extract.
4. 농축4. Thickening
상기 여과된 액상 추출물을 회전 감압 농축기로 감압 농축한 뒤, 추출된 성분의 용해도를 높이기 위해 β-cyclodextrin 을 2 % 첨가하였다.
The filtered liquid extract was concentrated under reduced pressure with a rotary vacuum concentrator, and 2% of β-cyclodextrin was added to increase the solubility of the extracted components.
5. 동결 건조5. Freeze Drying
상기 농축이 끝난 매실 추출물을 동결 건조하여 분말 상태로 제조하였다.
The concentrated plum extract was freeze-dried to prepare a powder.
6. 식품 조성물 3 의 제조6. Preparation of Food Composition 3
상기 제조된 매실 추출물을 증류수에 0.1 내지 5 % 의 비율로 첨가하고, 여기에 고형분 60 % 의 홍삼 농축액을 0.1 내지 2 % 의 비율로 첨가한 후, 혼합하여 식품 조성물 3 을 제조하였다.
The plum extract prepared above was added to distilled water at a ratio of 0.1 to 5%, and a red ginseng concentrate having a solid content of 60% was added at a ratio of 0.1 to 2% and then mixed to prepare a food composition 3.
실시예 4
Example 4
1. 원료 혼합1. Raw material mixing
병풀과 석류, 매실을 다음의 표 1 에 기입된 함량으로 혼합하여 60 ~ 80 % 의 주정 에탄올 용매에 10 % 함량으로 혼합한다.
Centella, pomegranate, and plum are mixed in the amounts listed in Table 1 below, and mixed with 60% to 80% alcohol ethanol solvent in 10% content.
성분명
Ingredients
함유량(중량 %)
Content (weight%)
병풀
Centella
30 ~ 60
30 to 60
석류
Pomegranate
20 ~ 40
20 to 40
매실
plum
20 ~ 40
20 to 40
2. 추출물 획득2. Obtaining Extract
상기 혼합된 원료를 교반기에서 상온으로 24 시간 추출하여 혼합 추출물을 획득하였다
The mixed raw material was extracted at room temperature for 24 hours in a stirrer to obtain a mixed extract.
3. 여과3. Filtration
상기 혼합 추출물을 250 메쉬와 0.5 ㎛ 필터페이퍼로 여과하여 액상 추출물을 수득한다.
The mixed extract was filtered through 250 mesh and 0.5 μm filter paper to obtain a liquid extract.
4. 농축4. Thickening
상기 여과된 액상 추출물을 회전 감압 농축기로 감압 농축한 뒤, 추출된 성분의 용해도를 높이기 위해 β-cyclodextrin 을 2 % 첨가하였다.
The filtered liquid extract was concentrated under reduced pressure with a rotary vacuum concentrator, and 2% of β-cyclodextrin was added to increase the solubility of the extracted components.
5. 동결 건조5. Freeze Drying
상기 농축이 끝난 혼합 추출물은 동결 건조하여 분말 상태로 제조하였다.
The concentrated mixed extract was freeze-dried to prepare a powder.
6. 식품 조성물 4 의 제조6. Preparation of Food Composition 4
상기 제조된 혼합 추출물을 증류수에 0.1 내지 5 % 의 비율로 첨가하고, 여기에 고형분 60 % 의 홍삼 농축액을 0.1 내지 2 % 의 비율로 첨가한 후, 혼합하여 식품 조성물 4 를 제조하였다.
The mixed extract prepared above was added to distilled water at a ratio of 0.1 to 5%, and a red ginseng concentrate having a solid content of 60% was added at a ratio of 0.1 to 2% and then mixed to prepare a food composition 4.
시험예Test Example
실시예 1 - 4 를 통하여 제조된 식품 조성물 1 - 4 를 대상으로 관련 시험을 실시하였다.
Related tests were conducted on the food compositions 1-4 prepared through Examples 1-4.
1. 세포 독성 시험1. Cytotoxicity Test
96 - 웰 플레이트(well plate)에 정상인의 피부 섬유아세포(Human dermal fibroblast)를 동일량을 접종한 후, 실시예 1 - 4 를 농도별로 처리하여 37 ℃ 5 % CO2 의 조건에서 24 시간 동안 배양하였다. 배양이 끝난 세포에 MTS 용액을 첨가하여 2 시간 배양 후, ELISA 측정기를 이용하여 490 nm 에서 흡광도를 측정하였다.
After inoculating the 96-well plate with the same amount of normal dermal fibroblasts (Human dermal fibroblast), and treated with Examples 1 to 4 by concentration incubated for 24 hours at 37 ℃ 5% CO 2 conditions It was. After incubation for 2 hours by adding the MTS solution to the cultured cells, the absorbance was measured at 490 nm using an ELISA meter.
시료
sample
세포 생존 비율(%)
Cell survival rate (%)
대조군
Control group
100.0
100.0
실시예 1 의 식품 조성물 1 (0.001%)
Food Composition 1 of Example 1 (0.001%)
94.4
94.4
실시예 1 의 식품 조성물 1 (0.01%)
Food Composition 1 of Example 1 (0.01%)
98.6
98.6
실시예 1 의 식품 조성물 1 (0.1%)
Food Composition 1 of Example 1 (0.1%)
102.7
102.7
실시예 2 의 식품 조성물 2 (0.001%)
Food Composition 2 of Example 2 (0.001%)
91.5
91.5
실시예 2 의 식품 조성물 2 (0.01%)
Food Composition 2 of Example 2 (0.01%)
92.2
92.2
실시예 2 의 식품 조성물 2 (0.1%)
Food Composition 2 of Example 2 (0.1%)
92.3
92.3
실시예 3 의 식품 조성물 3 (0.001%)
Food Composition 3 of Example 3 (0.001%)
93.0
93.0
실시예 3 의 식품 조성물 3 (0.01%)
Food Composition 3 of Example 3 (0.01%)
95.4
95.4
실시예 3 의 식품 조성물 3 (0.1%)
Food Composition 3 of Example 3 (0.1%)
95.6
95.6
실시예 4 의 식품 조성물 4 (0.001%)
Food Composition 4 of Example 4 (0.001%)
101.6
101.6
실시예 4 의 식품 조성물 4 (0.01%)
Food Composition 4 of Example 4 (0.01%)
103.8
103.8
실시예 4 의 식품 조성물 4 (0.1%)
Food Composition 4 of Example 4 (0.1%)
107.1
107.1
상기 표 2 에 나타난 바와 같이, 실시예 1 은 세포 증식에 효과적이며, 실시예 2 와 3 은 세포 증식의 효능은 미비하였으나, 독성이 거의 없는 것으로 나타났다. 병풀과 석류, 매실이 혼합 추출된 혼합 추출물에 홍삼 농축액이 혼합된 실시예 4 는 적은 농도에서도 세포 증식 효과를 보였으며, 독성 효과는 나타내지 않았다.
As shown in Table 2, Example 1 is effective for cell proliferation, and Examples 2 and 3 are insignificant in efficacy, but little toxicity. Example 4 in which the red ginseng concentrate was mixed in the mixed extract of Centella, pomegranate, and plum was mixed, and showed a cell proliferation effect even at a small concentration, but did not show a toxic effect.
2. 항산화능 시험2. Antioxidant Activity Test
실시예 1 - 4 의 항산화 효과를 알아보기 위해 DPPH 를 이용한 자유라디칼 소거능 시험을 진행하였다. DPPH 용액이 처리된 96 - 웰 플레이트에 실시예 1 - 4 를 첨가한 후, 30 분간 반응시키고 ELISA 측정기로 517 nm 에서 흡광도를 측정하였다.
In order to examine the antioxidant effects of Examples 1-4, free radical scavenging ability test using DPPH was conducted. After adding Examples 1-4 to a 96-well plate treated with DPPH solution, the reaction was carried out for 30 minutes and the absorbance was measured at 517 nm with an ELISA meter.
상기 표 3 에서 알 수 있듯이, 실시예 4 의 경우 다른 실시예 1 - 3 에 비해 자유라디칼 소거능이 약 15 % 증가함을 확인할 수 있다. 따라서 병풀, 석류, 매실의 개별 추출물보다 혼합 추출물로 제조되었을 때, 항산화능이 증가함을 확인할 수 있다.
As can be seen in Table 3, in the case of Example 4, it can be seen that free radical scavenging ability is increased by about 15% compared to other Examples 1 to 3. Therefore, it can be seen that the antioxidant activity is increased when the extract is prepared from the extract of the centella, pomegranate, plum.
3. 콜라겐 합성능 촉진3. Promote collagen synthesis
48 - 웰 플레이트에 정상인의 피부 섬유아세포를 동일량 접종한 후, 실시예 1 - 4 를 처리하여 37 ℃ 5 % CO2 의 조건에서 48 시간 동안 배양하였다. 48 시간 배양 후, 배양 상층액을 수집한 후, 제 1 형 프로콜라겐 생성량을 ELISA 키트(Takara MK101)를 이용하여 측정하였다.
After 48-well plates were inoculated with the same amount of normal skin fibroblasts, Examples 1-4 were treated and incubated for 48 hours at 37 ° C. 5% CO 2. After 48 hours of incubation, the culture supernatant was collected, and the type 1 procollagen production was measured using an ELISA kit (Takara MK101).
시료
sample
프로콜라겐 생성량 (%)
Procollagen Production (%)
대조군
Control group
100.0
100.0
실시예 1
Example 1
124.2
124.2
실시예 2
Example 2
116.9
116.9
실시예 3
Example 3
103.4
103.4
실시예 4
Example 4
139.0
139.0
병풀과 석류, 매실이 혼합 추출된 혼합 추출물에 홍삼 농축액이 혼합된 실시예 4 의 경우, 상기 표 4 에서와 같이, 다른 실시예에 비해 콜라겐 생성량이 더욱 증가함을 확인할 수 있다. 따라서 병풀과 석류, 매실의 혼합 추출물과 홍삼 농축액의 혼합은 콜라겐 생성을 크게 촉진하여 주름 개선과 노화 방지에 효과적임을 알 수 있다.
In the case of Example 4 in which the red ginseng concentrate was mixed in the mixed extract of the centellae, pomegranate and plums, the collagen production amount was further increased as compared with the other examples. Therefore, it can be seen that the mixture of Centella, pomegranate, and plum extract and red ginseng concentrate are very effective in improving wrinkle generation and preventing aging.
제조예
Manufacturing example
상기와 같이 제조된 본 발명의 식품 조성물은 일반적인 환이나 음료, 티백 차, 인스턴트 차, 드링크제, 과립, 정제 또는 캡슐의 형태로 제형화되어 사용된다.The food composition of the present invention prepared as described above is used in the form of a general pill or beverage, tea bag tea, instant tea, drink, granules, tablets or capsules.
Claims (4)
석류 20 - 40 중량 % 와;
매실 20 - 40 중량 % ;
를 60 ~ 80 % 의 주정 에탄올 용매에 10 % 함량으로 혼합하여 추출한 혼합 추출물에 홍삼 농축액을 함유시킨 천연 복합 추출물로 이루어진 것을 특징으로 하는 피부 개선용 건강 기능성 식품 조성물.Centella 30-60 wt%;
20-40% by weight pomegranate;
Plum 20-20% by weight;
Skin functional health food composition for improving skin, characterized in that consisting of a natural complex extract containing red ginseng extract in a mixed extract extracted by mixing in 60 to 80% alcoholic ethanol solvent of 10% content.
상기 혼합 추출물은 전체 중량의 0.1 내지 5 % 함유하는 것을 특징으로 하는 피부 개선용 건강 기능성 식품 조성물.The method of claim 1,
The mixed extract contains 0.1 to 5% of the total weight of the health functional food composition for skin improvement.
상기 홍삼 농축액은 전체 중량의 0.1 내지 2 % 함유하는 것을 특징으로 하는 피부 개선용 건강 기능성 식품 조성물.
The method of claim 1,
The red ginseng concentrate is 0.1 to 2% of the total weight of the health functional food composition, characterized in that it contains.
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| KR20160011536A (en) | 2014-07-22 | 2016-02-01 | (주) 건강사랑 | Composition for improving skin condition comprising pomegranate concentrate as active ingredient |
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| JP5288573B1 (en) | 2012-11-02 | 2013-09-11 | 独立行政法人情報通信研究機構 | Olfactory display and incense source cartridge used therefor |
| KR20160133331A (en) | 2015-05-12 | 2016-11-22 | 주식회사 슈퍼내츄럴스 | Green tea composition comprising rubus suavissimus s. lee |
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|---|---|---|---|---|
| KR930012029A (en) * | 1991-12-20 | 1993-07-20 | 김정순 | Method of manufacturing acne and cosmetic poison treatment using ginseng extract and centella extract |
| KR20080101821A (en) * | 2008-08-27 | 2008-11-21 | 김선일 | Cosmetic included to flos |
| KR20090034241A (en) * | 2007-10-02 | 2009-04-07 | 동국대학교 산학협력단 | A method for fermentation of natural plants and herbal medicines, a fermented product prepared therefrom and a paharmaceutical composition, a cosmetic compositon and a food composition comprising the product |
| KR20100101258A (en) * | 2009-03-09 | 2010-09-17 | 주식회사 엘씨에스바이오텍 | Methods for fermentation of natural plants or herbal medicines and fermented products using the same methods |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR930012029A (en) * | 1991-12-20 | 1993-07-20 | 김정순 | Method of manufacturing acne and cosmetic poison treatment using ginseng extract and centella extract |
| KR20090034241A (en) * | 2007-10-02 | 2009-04-07 | 동국대학교 산학협력단 | A method for fermentation of natural plants and herbal medicines, a fermented product prepared therefrom and a paharmaceutical composition, a cosmetic compositon and a food composition comprising the product |
| KR20080101821A (en) * | 2008-08-27 | 2008-11-21 | 김선일 | Cosmetic included to flos |
| KR20100101258A (en) * | 2009-03-09 | 2010-09-17 | 주식회사 엘씨에스바이오텍 | Methods for fermentation of natural plants or herbal medicines and fermented products using the same methods |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160011536A (en) | 2014-07-22 | 2016-02-01 | (주) 건강사랑 | Composition for improving skin condition comprising pomegranate concentrate as active ingredient |
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