CN113166052A - 一种n-乙烯基吡咯烷酮单体的阻聚剂及其应用 - Google Patents

一种n-乙烯基吡咯烷酮单体的阻聚剂及其应用 Download PDF

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Publication number
CN113166052A
CN113166052A CN201880016117.5A CN201880016117A CN113166052A CN 113166052 A CN113166052 A CN 113166052A CN 201880016117 A CN201880016117 A CN 201880016117A CN 113166052 A CN113166052 A CN 113166052A
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China
Prior art keywords
polymerization inhibitor
vinyl pyrrolidone
polymerization
monomer
pyrrolidone monomer
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CN201880016117.5A
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English (en)
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CN113166052B (zh
Inventor
孙旭东
牛磊
张森林
李海朋
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Boai Xinkaiyuan Pharmaceutical Co ltd
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BOAI NKY PHARMACEUTICALS Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/38—Polymerisation using regulators, e.g. chain terminating agents, e.g. telomerisation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/38—Polymerisation using regulators, e.g. chain terminating agents, e.g. telomerisation
    • C08F2/40—Polymerisation using regulators, e.g. chain terminating agents, e.g. telomerisation using retarding agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Polymerisation Methods In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pyrrole Compounds (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)

Abstract

本发明属于化学试剂技术领域，具体公开一种N‑乙烯基吡咯烷酮单体的阻聚剂及其应用。该阻聚剂选自无机弱酸钾盐和/或有机酸钾盐；将阻聚剂加入N‑乙烯基吡咯烷酮单体中，在惰性气体保护下密封保存，所述阻聚剂的添加量为N‑乙烯基吡咯烷酮单体质量的0.005‑0.2%。将本发明的阻聚剂直接按比例投加至N‑乙烯基吡咯烷酮单体中，可抑制N‑乙烯基吡咯烷酮单体的自聚，延长保质期，且极大程度的降低单体色度和毒性，在溶液聚合时可直接使用，不需除去阻聚剂，且阻聚剂亦不影响聚合溶液的色度。

Description

PCT国内申请，说明书已公开。

Claims (8)

  1. PCT国内申请，权利要求书已公开。
CN201880016117.5A 2018-11-27 2018-11-27 一种n-乙烯基吡咯烷酮单体的阻聚剂及其应用 Active CN113166052B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/117618 WO2020107197A1 (zh) 2018-11-27 2018-11-27 一种n-乙烯基吡咯烷酮单体的阻聚剂及其应用

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CN113166052A true CN113166052A (zh) 2021-07-23
CN113166052B CN113166052B (zh) 2023-04-04

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US (1) US20210040125A1 (zh)
EP (1) EP3738951B1 (zh)
CN (1) CN113166052B (zh)
ES (1) ES2933348T3 (zh)
WO (1) WO2020107197A1 (zh)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102267942A (zh) * 2011-08-12 2011-12-07 鲁东大学 一种制备3-氨基-4-甲基吡啶的方法
CN103012235A (zh) * 2012-12-13 2013-04-03 中盐安徽红四方股份有限公司 N-乙烯基吡咯烷酮精馏阻聚方法
US20150307466A1 (en) * 2014-04-29 2015-10-29 Basf Se Process for the distillation of a mixture comprising a cyclic n-vinylamide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1270805B (de) * 1955-12-27 1968-06-20 Gen Aniline & Film Corp Stabilisieren von polymeren N-Vinyl-2-pyrrolidonen
US5416258A (en) * 1994-01-14 1995-05-16 Betz Laboratories, Inc. Methods for inhibiting ethylenically unsaturated monomers
US5534564A (en) * 1994-12-13 1996-07-09 Isp Investments Inc. Process for the color stabilization of an aqueous N-vinyl heterocyclic copolymer solution
US5691462A (en) * 1996-09-10 1997-11-25 Isp Investments Inc. Stabilized vinyl ether composition
DE19906316A1 (de) * 1999-02-16 2000-08-17 Basf Ag Stabilisierte Zusammensetzungen von O- und N-Vinylverbindungen und Verwendung von Ammoniumsalzen als Stabilisierungsmittel
US6447649B1 (en) * 2000-07-24 2002-09-10 Ge Betz, Inc. Polymerization inhibitor for vinyl-containing materials
JP2004345994A (ja) * 2003-05-21 2004-12-09 Nippon Shokubai Co Ltd Ｎ−ビニル−２−ピロリドンの精製方法
US20090088579A1 (en) * 2005-04-11 2009-04-02 Nippon Shokubai Co., Ltd. Production Method of N-Vinyl-2-Pyrrolidone
US9090526B2 (en) * 2011-06-13 2015-07-28 Nalco Company Synergistic combination for inhibiting polymerization of vinyl monomers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102267942A (zh) * 2011-08-12 2011-12-07 鲁东大学 一种制备3-氨基-4-甲基吡啶的方法
CN103012235A (zh) * 2012-12-13 2013-04-03 中盐安徽红四方股份有限公司 N-乙烯基吡咯烷酮精馏阻聚方法
US20150307466A1 (en) * 2014-04-29 2015-10-29 Basf Se Process for the distillation of a mixture comprising a cyclic n-vinylamide

Also Published As

Publication number Publication date
EP3738951B1 (en) 2022-09-14
ES2933348T3 (es) 2023-02-06
WO2020107197A1 (zh) 2020-06-04
CN113166052B (zh) 2023-04-04
EP3738951A1 (en) 2020-11-18
US20210040125A1 (en) 2021-02-11
EP3738951A4 (en) 2021-04-14

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Address after: 454450 No. 1888, Cultural Road (eastern section), Poai County, Jiaozuo, Henan

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Address before: 454450 No. 1888, Cultural Road (eastern section), Poai County, Jiaozuo, Henan

Patentee before: BOAI NKY MEDICAL HOLDINGS Ltd.

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