CN113151261B - 反义寡核苷酸作为tgf-r信号传导的抑制剂 - Google Patents

反义寡核苷酸作为tgf-r信号传导的抑制剂 Download PDF

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CN113151261B
CN113151261B CN202110048326.1A CN202110048326A CN113151261B CN 113151261 B CN113151261 B CN 113151261B CN 202110048326 A CN202110048326 A CN 202110048326A CN 113151261 B CN113151261 B CN 113151261B
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lna
seq
nucleotides
antisense oligonucleotide
region
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CN113151261A (zh
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M·霍斯巴赫
M·克兰普特
H-L·阿尔斯
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Neurovision Pharma GmbH
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CN202110048326.1A 2014-11-16 2015-11-16 反义寡核苷酸作为tgf-r信号传导的抑制剂 Active CN113151261B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14193368.9 2014-11-16
EP14193368.9A EP3020813A1 (en) 2014-11-16 2014-11-16 Antisense-oligonucleotides as inhibitors of TGF-R signaling
PCT/EP2015/076730 WO2016075339A1 (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling
CN201580056200.1A CN107002082B (zh) 2014-11-16 2015-11-16 反义寡核苷酸作为tgf-r信号传导的抑制剂

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Publication number Priority date Publication date Assignee Title
EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
WO2019010226A1 (en) * 2017-07-03 2019-01-10 The Regents Of The University Of California CHEMICALLY MODIFIED MICROARN-214 ANTISENS AND USE THEREOF FOR THE TREATMENT OF HEMORRHAGIC RECTOCOLITE AND PROCTITE
BR112020008478A2 (pt) * 2017-11-01 2020-10-20 Editas Medicine, Inc. métodos, composições e componentes para edição de crispr-cas9 de tgfbr2 em células t para imunota-rapia
WO2019122279A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorodithioate internucleoside linkage
WO2019122282A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
CN111448316B (zh) * 2017-12-22 2025-02-14 罗氏创新中心哥本哈根有限公司 新的硫代亚磷酰胺
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