MX2017006369A - Oligonucleotidos antisentido como inhibidores de la señalizacion del tgf-r. - Google Patents

Oligonucleotidos antisentido como inhibidores de la señalizacion del tgf-r.

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Publication number
MX2017006369A
MX2017006369A MX2017006369A MX2017006369A MX2017006369A MX 2017006369 A MX2017006369 A MX 2017006369A MX 2017006369 A MX2017006369 A MX 2017006369A MX 2017006369 A MX2017006369 A MX 2017006369A MX 2017006369 A MX2017006369 A MX 2017006369A
Authority
MX
Mexico
Prior art keywords
antisense
oligonucleotides
tgf
inhibitors
signaling
Prior art date
Application number
MX2017006369A
Other languages
English (en)
Spanish (es)
Inventor
Hossbach Markus
Krampert Monika
Lothar Arth Hans-
Original Assignee
Neurovision Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurovision Pharma GmbH filed Critical Neurovision Pharma GmbH
Publication of MX2017006369A publication Critical patent/MX2017006369A/es

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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)

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  • Orthopedic Medicine & Surgery (AREA)
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MX2017006369A 2014-11-16 2015-11-16 Oligonucleotidos antisentido como inhibidores de la señalizacion del tgf-r. MX2017006369A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14193368.9A EP3020813A1 (en) 2014-11-16 2014-11-16 Antisense-oligonucleotides as inhibitors of TGF-R signaling
PCT/EP2015/076730 WO2016075339A1 (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

Publications (1)

Publication Number Publication Date
MX2017006369A true MX2017006369A (es) 2018-02-16

Family

ID=51900289

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017006369A MX2017006369A (es) 2014-11-16 2015-11-16 Oligonucleotidos antisentido como inhibidores de la señalizacion del tgf-r.
MX2020011476A MX2020011476A (es) 2014-11-16 2017-05-16 Oligonucleótidos antisentido como inhibidores de la señalización del tgf-r.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020011476A MX2020011476A (es) 2014-11-16 2017-05-16 Oligonucleótidos antisentido como inhibidores de la señalización del tgf-r.

Country Status (22)

Country Link
US (4) US11213541B2 (https=)
EP (3) EP3020813A1 (https=)
JP (2) JP6832285B2 (https=)
KR (2) KR102417601B1 (https=)
CN (2) CN113151261B (https=)
AU (3) AU2015345006B2 (https=)
BR (1) BR112017006201B1 (https=)
CA (2) CA3201845C (https=)
CL (2) CL2017001233A1 (https=)
CY (1) CY1121110T1 (https=)
DK (1) DK3218488T3 (https=)
ES (1) ES2705066T3 (https=)
HU (1) HUE041793T2 (https=)
IL (2) IL251565B (https=)
MX (2) MX2017006369A (https=)
MY (1) MY181404A (https=)
PL (1) PL3218488T3 (https=)
PT (1) PT3218488T (https=)
RU (1) RU2717454C2 (https=)
SG (1) SG11201703127SA (https=)
TR (1) TR201900844T4 (https=)
WO (1) WO2016075339A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
WO2019010226A1 (en) * 2017-07-03 2019-01-10 The Regents Of The University Of California CHEMICALLY MODIFIED MICROARN-214 ANTISENS AND USE THEREOF FOR THE TREATMENT OF HEMORRHAGIC RECTOCOLITE AND PROCTITE
BR112020008478A2 (pt) * 2017-11-01 2020-10-20 Editas Medicine, Inc. métodos, composições e componentes para edição de crispr-cas9 de tgfbr2 em células t para imunota-rapia
WO2019122279A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorodithioate internucleoside linkage
WO2019122282A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
CN111448316B (zh) * 2017-12-22 2025-02-14 罗氏创新中心哥本哈根有限公司 新的硫代亚磷酰胺
MA53924A (fr) 2018-05-22 2021-08-25 Ionis Pharmaceuticals Inc Modulateurs de l'expression d'apol1
US20210292358A1 (en) * 2018-07-31 2021-09-23 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
EP3830101B1 (en) * 2018-07-31 2025-11-19 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
CA3130431A1 (en) * 2019-02-20 2020-08-27 Roche Innovation Center Copenhagen A/S Phosphonoacetate gapmer oligonucleotides
JP2023548597A (ja) * 2020-10-29 2023-11-17 エー． ガルシア－ブランコ，マリアーノ がんを処置するための可溶性インターロイキン－７受容体（ｓＩＬ７Ｒ）変調療法
CN114588160A (zh) * 2020-12-07 2022-06-07 四川大学华西医院 具有抗肺纤维化作用的次黄碱衍生物
CN113992687B (zh) * 2021-12-28 2022-04-08 浙江宇视科技有限公司 智能业务集群调度方法、装置、电子设备及存储介质
KR20250158048A (ko) 2023-03-03 2025-11-05 아스널 바이오사이언시스, 인크. Psma 및 ca9을 표적으로 하는 시스템
WO2025254160A1 (ja) * 2024-06-05 2025-12-11 湧永製薬株式会社 ＴＧＦ－βシグナル阻害剤又は抗線維化剤のスクリーニング方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997029782A1 (en) 1996-02-19 1997-08-21 Nycomed Imaging A/S Thermally stabilized contrast agent
US20030064944A1 (en) * 2001-06-21 2003-04-03 Isis Pharmaceuticals Inc. Antisense modulation of transforming growth factor beta receptor II expression
US9045518B2 (en) 2002-11-18 2015-06-02 Santaris Pharma A/S Amino-LNA, thio-LNA and alpha-L-oxy-LN
US20060229266A1 (en) * 2003-08-13 2006-10-12 Kumar Nalin M Silencing of tgf-beta receptor type II expression by sirna
AU2005210151B2 (en) * 2004-02-09 2010-07-01 Aigner, Ludwig Dr. Inhibitors of TGF-R signaling for treatment of CNS disorders
WO2007031091A2 (en) 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
JP5342881B2 (ja) 2006-01-27 2013-11-13 アイシス ファーマシューティカルズ， インコーポレーテッド ６−修飾された二環式核酸類似体
CA2648132C (en) 2006-04-03 2019-05-28 Santaris Pharma A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
AU2007249349B2 (en) 2006-05-11 2012-03-08 Isis Pharmaceuticals, Inc. 5'-Modified bicyclic nucleic acid analogs
EP2090127A2 (en) 2006-10-30 2009-08-19 Nokia Corporation Method, apparatus and system providing operator controlled mobility for user equipment
WO2008109546A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting tgfbr gene expression and uses thereof
EP2170917B1 (en) 2007-05-30 2012-06-27 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
EP2173760B2 (en) 2007-06-08 2015-11-04 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
CA2692579C (en) 2007-07-05 2016-05-03 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
US8546556B2 (en) 2007-11-21 2013-10-01 Isis Pharmaceuticals, Inc Carbocyclic alpha-L-bicyclic nucleic acid analogs
AU2009272841A1 (en) * 2008-07-15 2010-01-21 F. Hoffmann-La Roche Ag Compositions and methods for inhibiting expression of TGF-beta receptor genes
KR20120095397A (ko) * 2009-10-16 2012-08-28 글락소 그룹 리미티드 Ｈｂｖ 안티센스 억제제
EP2580326A1 (en) * 2010-06-11 2013-04-17 Antisense Pharma GmbH Method for selective oligonucleotide modification
US9115371B2 (en) * 2011-08-18 2015-08-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reduction of TGF beta signaling in myeloid cells in the treatment of cancer
CN104004762B (zh) * 2014-05-20 2016-03-30 南京医科大学附属南京儿童医院 Tgf-r反义序列及其在制备抗气道炎症反应药物中的应用
EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling

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