CY1121110T1 - Αντινοηματικα-ολιγονουκλεοτιδια ως παρεμποδιστες σηματοδοτησης tgf-r - Google Patents

Αντινοηματικα-ολιγονουκλεοτιδια ως παρεμποδιστες σηματοδοτησης tgf-r

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Publication number
CY1121110T1
CY1121110T1 CY181101402T CY181101402T CY1121110T1 CY 1121110 T1 CY1121110 T1 CY 1121110T1 CY 181101402 T CY181101402 T CY 181101402T CY 181101402 T CY181101402 T CY 181101402T CY 1121110 T1 CY1121110 T1 CY 1121110T1
Authority
CY
Cyprus
Prior art keywords
tgf
oligonucletoids
anto
signs
signaling inhibitors
Prior art date
Application number
CY181101402T
Other languages
Greek (el)
English (en)
Inventor
Markus Hossbach
Monika Krampert
Hans-Lothar Arth
Original Assignee
Neurovision Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurovision Pharma GmbH filed Critical Neurovision Pharma GmbH
Publication of CY1121110T1 publication Critical patent/CY1121110T1/el

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    • A61K31/7125Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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CY181101402T 2014-11-16 2018-12-28 Αντινοηματικα-ολιγονουκλεοτιδια ως παρεμποδιστες σηματοδοτησης tgf-r CY1121110T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14193368.9A EP3020813A1 (en) 2014-11-16 2014-11-16 Antisense-oligonucleotides as inhibitors of TGF-R signaling
PCT/EP2015/076730 WO2016075339A1 (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

Publications (1)

Publication Number Publication Date
CY1121110T1 true CY1121110T1 (el) 2019-12-11

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CY181101402T CY1121110T1 (el) 2014-11-16 2018-12-28 Αντινοηματικα-ολιγονουκλεοτιδια ως παρεμποδιστες σηματοδοτησης tgf-r

Country Status (22)

Country Link
US (4) US11213541B2 (https=)
EP (3) EP3020813A1 (https=)
JP (2) JP6832285B2 (https=)
KR (2) KR102417601B1 (https=)
CN (2) CN113151261B (https=)
AU (3) AU2015345006B2 (https=)
BR (1) BR112017006201B1 (https=)
CA (2) CA3201845C (https=)
CL (2) CL2017001233A1 (https=)
CY (1) CY1121110T1 (https=)
DK (1) DK3218488T3 (https=)
ES (1) ES2705066T3 (https=)
HU (1) HUE041793T2 (https=)
IL (2) IL251565B (https=)
MX (2) MX2017006369A (https=)
MY (1) MY181404A (https=)
PL (1) PL3218488T3 (https=)
PT (1) PT3218488T (https=)
RU (1) RU2717454C2 (https=)
SG (1) SG11201703127SA (https=)
TR (1) TR201900844T4 (https=)
WO (1) WO2016075339A1 (https=)

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EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
WO2019010226A1 (en) * 2017-07-03 2019-01-10 The Regents Of The University Of California CHEMICALLY MODIFIED MICROARN-214 ANTISENS AND USE THEREOF FOR THE TREATMENT OF HEMORRHAGIC RECTOCOLITE AND PROCTITE
BR112020008478A2 (pt) * 2017-11-01 2020-10-20 Editas Medicine, Inc. métodos, composições e componentes para edição de crispr-cas9 de tgfbr2 em células t para imunota-rapia
WO2019122279A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorodithioate internucleoside linkage
WO2019122282A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
CN111448316B (zh) * 2017-12-22 2025-02-14 罗氏创新中心哥本哈根有限公司 新的硫代亚磷酰胺
MA53924A (fr) 2018-05-22 2021-08-25 Ionis Pharmaceuticals Inc Modulateurs de l'expression d'apol1
US20210292358A1 (en) * 2018-07-31 2021-09-23 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
EP3830101B1 (en) * 2018-07-31 2025-11-19 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
CA3130431A1 (en) * 2019-02-20 2020-08-27 Roche Innovation Center Copenhagen A/S Phosphonoacetate gapmer oligonucleotides
JP2023548597A (ja) * 2020-10-29 2023-11-17 エー. ガルシア-ブランコ,マリアーノ がんを処置するための可溶性インターロイキン-7受容体(sIL7R)変調療法
CN114588160A (zh) * 2020-12-07 2022-06-07 四川大学华西医院 具有抗肺纤维化作用的次黄碱衍生物
CN113992687B (zh) * 2021-12-28 2022-04-08 浙江宇视科技有限公司 智能业务集群调度方法、装置、电子设备及存储介质
KR20250158048A (ko) 2023-03-03 2025-11-05 아스널 바이오사이언시스, 인크. Psma 및 ca9을 표적으로 하는 시스템
WO2025254160A1 (ja) * 2024-06-05 2025-12-11 湧永製薬株式会社 TGF-βシグナル阻害剤又は抗線維化剤のスクリーニング方法

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