CN113144194B - 一种GP73抑制剂在制备治疗SARS-CoV-2肺炎及其并发症的药物中的应用 - Google Patents
一种GP73抑制剂在制备治疗SARS-CoV-2肺炎及其并发症的药物中的应用 Download PDFInfo
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- CN113144194B CN113144194B CN202110148016.7A CN202110148016A CN113144194B CN 113144194 B CN113144194 B CN 113144194B CN 202110148016 A CN202110148016 A CN 202110148016A CN 113144194 B CN113144194 B CN 113144194B
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Abstract
Description
GP73 siRNA | 序列5’-3’ |
siCtrl(SEQ ID No:1) | AUCACACCAACACAGGUCCTT |
SEQ ID No:1 | 275-CCUGGUGGCCUGUGUUAUUTT |
SEQ ID No:2 | 553-GCGAGAAGCUCAUUCGAGATT |
SEQ ID No:3 | 950-GCAGAAUGAGGAAACCAAUTT |
SEQ ID No:4 | 995-CCAACAGGCAUCCAUCCAATT |
SEQ ID No:5 | 1198-CAGGAGAUGAAUACGACAUTT |
SEQ ID No:6 | 1263-GCAGGGAAUGACAGAAAUATT |
SEQ ID No:7 | 1430-UGUGAAAUGGACAGCGAAATT |
SEQ ID No:8 | 1802-GCUCUUACCGUCAGCAUAATT |
SEQ ID No:9 | 2108-GCACCUAUGGUCUGUGUUUTT |
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CN202110148016.7A CN113144194B (zh) | 2021-02-03 | 2021-02-03 | 一种GP73抑制剂在制备治疗SARS-CoV-2肺炎及其并发症的药物中的应用 |
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Families Citing this family (1)
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CN115671284A (zh) * | 2021-07-28 | 2023-02-03 | 北京舜景生物医药技术有限公司 | Gp73作为非肥胖型非酒精性脂肪性肝病的治疗靶标、诊断标志物的应用 |
Citations (5)
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US5935822A (en) * | 1995-03-21 | 1999-08-10 | The Regents Of The University Of Colorado | Product and process for membrane and soluble polypeptide segregation |
CN1450164A (zh) * | 2003-06-11 | 2003-10-22 | 复旦大学 | 一种新型冠状病毒株及其医药用途 |
CN104940901A (zh) * | 2015-07-07 | 2015-09-30 | 中国人民解放军军事医学科学院生物工程研究所 | ERRα及其抑制剂在促进干扰素生成以及抑制病毒感染中的用途 |
CN110951756A (zh) * | 2020-02-23 | 2020-04-03 | 广州恩宝生物医药科技有限公司 | 表达SARS-CoV-2病毒抗原肽的核酸序列及其应用 |
CN112121168A (zh) * | 2020-04-09 | 2020-12-25 | 中国人民解放军军事科学院军事医学研究院 | 一种抑制剂在制备治疗SARS-CoV-2肺炎及其并发症的药物中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111450097A (zh) * | 2020-02-27 | 2020-07-28 | 中国人民解放军军事科学院军事医学研究院 | Abl酪氨酸激酶抑制剂在制备治疗冠状病毒所致疾病的药物中的应用 |
CN112111489A (zh) * | 2020-06-23 | 2020-12-22 | 深圳罗兹曼国际转化医学研究院 | 抑制SARS-COV-2病毒复制的shRNA及其应用 |
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Patent Citations (5)
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US5935822A (en) * | 1995-03-21 | 1999-08-10 | The Regents Of The University Of Colorado | Product and process for membrane and soluble polypeptide segregation |
CN1450164A (zh) * | 2003-06-11 | 2003-10-22 | 复旦大学 | 一种新型冠状病毒株及其医药用途 |
CN104940901A (zh) * | 2015-07-07 | 2015-09-30 | 中国人民解放军军事医学科学院生物工程研究所 | ERRα及其抑制剂在促进干扰素生成以及抑制病毒感染中的用途 |
CN110951756A (zh) * | 2020-02-23 | 2020-04-03 | 广州恩宝生物医药科技有限公司 | 表达SARS-CoV-2病毒抗原肽的核酸序列及其应用 |
CN112121168A (zh) * | 2020-04-09 | 2020-12-25 | 中国人民解放军军事科学院军事医学研究院 | 一种抑制剂在制备治疗SARS-CoV-2肺炎及其并发症的药物中的应用 |
Non-Patent Citations (6)
Title |
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Cholesterol Metabolism--Impact for SARS-CoV-2 Infection Prognosis, Entry, and Antiviral Therapies;Congwen Wei,等;《MedRxiv》;20200424;第1-25页 * |
GP73 is a glucogenic hormone regulating SARS-CoV-2-induced hyperglycemia;Luming Wan,等;《medRxiv》;20210503 * |
Gp73, a novel tgf-β target gene, provides selective regulation on smad and non-smad signaling pathways;Yang, X., 等;《Biochimica et Biophysica Acta (BBA) - Molecular Cell Research》;20190430;第1866卷(第4期);第588-597页 * |
HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry;Congwen Wei,等;《Nature Metabolism》;20201126;第2卷;第1391–1400页 * |
P73, a novel Golgi-localized protein upregulated by viral infection;Raleigh D.Kladney,等;《Gene》;20000516;第249卷(第1-2期);第53-65页 * |
乙型肝炎病毒对高尔基体糖蛋白-73表达的影响研究;刘兴辉,等;《中国卫生检验杂志》;20170131;第27卷(第1期);第49-51页 * |
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Inventor after: Wei Congwen Inventor after: Wan Luming Inventor after: Zhong Hui Inventor after: Zhang Yanhong Inventor after: Gao Qi Inventor after: Huang Linfei Inventor after: Yang Xiaopan Inventor after: Lin Changqing Inventor after: Sun Zhiwei Inventor before: Wei Congwen Inventor before: Zhang Yanhong Inventor before: Wan Luming Inventor before: Zhong Hui Inventor before: Gao Qi Inventor before: Huang Linfei Inventor before: Yang Xiaopan Inventor before: Lin Changqing Inventor before: Sun Zhiwei |
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