CN113100337A

CN113100337A - Application of red yeast rice residue product in preparation of feed

Info

Publication number: CN113100337A
Application number: CN202110527622.XA
Authority: CN
Inventors: 王学丰
Original assignee: Tianjin Zeyou Feed Sales Co ltd
Current assignee: Tianjin Zeyou Feed Sales Co ltd; Beijing Peking University WBL Biotech Co Ltd
Priority date: 2021-05-14
Filing date: 2021-05-14
Publication date: 2021-07-13

Abstract

The invention provides an application of a red yeast rice residue product for producing lipid-lowering medicines in the aspect of preparing feed or feed additives, wherein the red yeast rice residue product comprises the following components in parts by weight: the method comprises the steps of taking grain crops as raw materials, fermenting with monascus to produce monascus fermented substances, extracting medicinal lipid-lowering components with ethanol, and extracting residues of the lipid-lowering components. The feed or feed additive obtained by the invention can improve the immunity of animals and promote the growth of the animals.

Description

Application of red yeast rice residue product in preparation of feed

Technical Field

The invention relates to the technical field of feed preparation, in particular to application of a red yeast rice residue product in preparing feed.

Background

Monascus is the main strain for producing monascus wine, red yeast rice, functional red yeast rice and natural pigments, and has a long history of use. The red yeast rice has the characteristic of both medicine and food, and plays an important role in the extensive research of green health foods in recent years. The research shows that the monascus has lovastatin physiological active substances and can produce good medical and health care effects on the aspects of reducing blood fat, cholesterol, blood pressure, blood sugar, bacteria resistance and the like.

The prior method for extracting lovastatin active substances by adopting red yeast rice generally takes rice and the like as raw materials, fermentation products are generated by submerged fermentation of monascus, the products are extracted by ethanol to obtain medicinal lipid-lowering components lovastatin, the rest red yeast rice residues almost have no lovastatin, a large amount of red yeast rice residues are discarded as wastes, and the wastes are further subjected to deep treatment to avoid polluting the environment when being discarded, so that the waste treatment cost is increased, and the waste of resources is caused. Research shows that red yeast rice residue does not contain lovastatin, but also contains a large amount of fatty acid and polysaccharide components which are nutritional components with good effects of improving animal immunity and promoting animal growth, and the feed is not suitable for containing lovastatin lipid-lowering components in order to improve fattening rate of animal feeding.

At present, the fermented feed for animal breeding generally adopts microorganisms or complex enzyme as a biological feed starter strain for fermentation, but the fermented feed generally has the problems of low protein content, low energy feed ingredient, insufficient capability of degrading crude fibers of the fermented strain and the like, is not beneficial to the healthy growth and the rapid weight increment of animals, and has poor effects on the aspects of feed intake and digestion weight increment of the animals. How to feed intake of animals to feed and how to accelerate weight gain are one of the important contents of modern feed research.

Disclosure of Invention

The invention explores and successfully applies the red yeast rice residue product to the preparation of the feed or the feed additive, and proves that the feed or the feed additive produced by adopting the red yeast rice residue product as the raw material can improve the immunity of animals and promote the growth of the animals.

The invention firstly provides the application of the red yeast rice residue product in the preparation of feed or feed additives, wherein the red yeast rice residue product comprises the following components in parts by weight: the method comprises the steps of taking grain crops as raw materials, carrying out liquid fermentation on monascus to generate monascus fermentation substances, then extracting lipid-lowering components through ethanol, and extracting residues of the lipid-lowering components.

Wherein the grain crops are one or more of cereals, beans and potato crops, including wheat, rice, corn, soybean, potato, etc.; in the production of lovastatin-like substances, one or more of rice and soybean is preferably used, and at least 40% of rice is preferably used. In the fermentation process, the fermentation culture is preferably carried out at 7-38 ℃ for more than 4 days, and more preferably at 15-35 ℃ for more than 9 days; the ethanol extraction process adopts 60-98% ethanol decoction.

The red yeast dregs product can be prepared by self or purchased directly from a drug manufacturer of lovastatin active substances, the prior manufacturer adopting red yeast to extract the lovastatin active substances mainly utilizes the lovastatin and other substances in filtrate to further deeply process and produce drugs after the red yeast fermented substances are decocted by ethanol and filtered, and the residual residues can be applied to the invention. For example, the residual red yeast dregs product produced by Beijing Davweixin Biotechnology Limited for the lipid-lowering drug product Xuezhikang can be used in the invention.

Further, the preparation method of the monascus slag product applied to the feed or the feed additive comprises the following steps: adding other raw material components into the red yeast residue product according to the requirement, performing secondary fermentation by using lactic acid bacteria, saccharomycetes and bacillus, and taking the secondary fermentation product as a feed or feed additive product.

Wherein the other raw material components added into the red yeast rice residue product can comprise traditional Chinese medicine components (such as radix Codonopsis, radix astragali, etc.), energy and mineral feed components, molasses, etc.; as a preferable formula composition, the proportion of each component of the secondary fermentation raw material can be as follows: 50-99% of red yeast rice residue product, 1-10% of codonopsis pilosula, 1-10% of astragalus root, 1-20% of corn cob powder, 1-15% of hawthorn fruit powder, 1-10% of molasses and 0-50% of other feed raw materials; wherein, the other feed raw materials comprise one or more of grain raw grain, soybean meal, corn, fish meal, amino acid, miscellaneous meal, additives, whey powder, grease, meat and bone meal, grains and the like, which are all prepared into the conventional feed raw materials, namely the conventional feed raw materials can be added into the part and then are subjected to secondary fermentation together.

Wherein the mass ratio of the lactic acid bacteria, the yeast and the bacillus is preferably (1-3): (1-3): (1-3).

Wherein, the secondary fermentation process is preferably carried out for more than 2 days at the temperature of 5-40 ℃.

Further, the feed or feed additive prepared from the red yeast rice residue product can be used as a single feed for feeding 100%, and can also be mixed with corn, soybean meal and the like for feeding, and the addition amount of the product is preferably 5-30% during mixed feeding.

Compared with the prior art, the invention has the following beneficial effects:

(1) the monascus fermented soybean rice is used for increasing and improving the immunity components:

the red yeast rice residue product adopts grain crops such as soybean, rice and the like as raw materials, and the residue contains a large amount of protein, various vitamin mineral substances and other nutritional ingredients. The rice red yeast rice can produce coenzyme Q10 after fermentation, is an activator of cell metabolism and cell respiration, can improve mitochondrial respiration function, and promotes oxidative phosphorylation reaction. It is also a natural oxidant produced by cells, can inhibit the peroxidation of mitochondria and has the function of protecting the structural integrity of biological membranes. Has nonspecific enhancing effect on immunity, and can increase phagocytic rate of phagocyte, increase antibody production, improve T cell function, and improve animal disease resistance. Meanwhile, has the effects of strengthening spleen, promoting digestion, promoting blood circulation and removing blood stasis. Has good effects on food stagnation, abdominal fullness and distention, red and white diarrhea and the like of cultured animals. Solves the problem that the original fermented feed has insufficient capability of degrading crude fibers and is not beneficial to degrading and digesting the crude fibers in the fermented feed. Improving the feed intake and promoting the digestion and weight gain with poor effect. The soybean, rice and other ingredients are added, the protein content and the energy feed ratio are improved, the nutrition ratio of the fermented feed is improved, the problem that the animal is not beneficial to the healthy growth of the animal due to low protein content is solved; the energy feed has low components and is not beneficial to weight increment.

(2) The alcohol extraction method is used for removing components which are unfavorable for animal fattening and weight increasing, such as blood fat reduction and the like in the red yeast rice product:

the red yeast fermentation product contains two main substances, 1, lovastatin as the representative substance with the effects of reducing blood fat, reducing blood pressure, reducing blood fat and losing weight. 2, the gamma-aminobutyric acid represented by the red yeast polysaccharide and the gamma-aminobutyric acid can improve the immunity of livestock and poultry, improve the utilization rate of feed, promote the growth of livestock and poultry, improve the health condition of the livestock and poultry, improve the production performance, improve the quality of livestock and poultry meat and the like;

the red yeast polysaccharide has the effects of protecting liver, improving immunity and inhibiting tumor, and has a certain protection effect on infectious bronchitis of chicken, and also has a certain protection effect on protein oxidation injury. The fungus polysaccharide has the effects of improving the immunity of animals and resisting viruses;

by utilizing the characteristic that lovastatin substances are dissolved in alcohol and red yeast rice polysaccharide and gamma-aminobutyric acid substances are not dissolved in alcohol, and utilizing an alcohol extraction method, the components with the effects of reducing blood fat and losing weight represented by lovastatin in fermentation products are removed, and the function of improving immunity of the red yeast rice polysaccharide and the gamma-aminobutyric acid is fully exerted.

(3) And (3) secondary fermentation is carried out by using mixed bacteria, so that the components for promoting digestion and absorption are improved:

the lactobacillus, the saccharomycetes and the bacillus are mixed to prepare the anaerobic secondary fermented feed, the existence of the aerobic bacteria such as the saccharomycetes and the bacillus creates an anaerobic environment for the growth and the propagation of the lactobacillus, the lactobacillus produces lactic acid through mass propagation, the pH value is reduced, so that the fermented feed product has acid fragrance, and the feed is homogenized and fluffy after being fermented, so that the palatability of the feed is improved, and the feed intake is stimulated;

after the feed is fermented, a series of biochemical reactions are carried out, on the basis of the primary fermentation of the red yeast rice, the mixed bacteria are more suitable for the secondary fermentation, complex macromolecular organic matters such as cellulose, starch, protein and the like in the feed are further degraded into monosaccharide, disaccharide, oligosaccharide, amino acid and other small molecular substances which are easy to digest and absorb by animals, so that the digestibility of the feed is improved, the deep production and processing effect which cannot be achieved by feed machinery is achieved, and meanwhile, a large number of microbial strain cells with rich nutrition and useful metabolites can be generated and accumulated in the process of the feed fermentation, such as: amino acid, organic acid, vitamin, activated trace elements and special carbohydrate, and the feed is softened and becomes fragrant, and the nutrition is increased, so that the physical and chemical properties of the feed are changed, and the palatability, the digestibility, the absorptivity and the nutritive value of the feed are improved;

the fermented feed contains a large amount of beneficial live bacteria (mainly lactic acid bacteria) and metabolites thereof, and is beneficial to intestinal health (inhibiting growth of pathogenic bacteria, promoting intestinal microbial balance, promoting intestinal immune response, improving digestive absorption function, and promoting health and growth);

tests show that the immunity and disease resistance of sows, sows and newborn piglets fed with the fermented feed are improved. The literature also shows that the oral administration of lactic acid bacteria can improve the immunocompetence of human bodies and animal bodies, the number of lymphocytes in the blood of sows is obviously increased, and the morbidity of newborn piglets fed by the colostrums of the sows is also obviously reduced;

(4) the traditional Chinese medicine components are added to clear away heat and toxic materials and improve the disease resistance:

the Chinese herbal medicines selected from the fermented feed are based on qi and blood tonifying and immunity improving, have the effects of clearing heat, detoxifying, clearing damp, resisting bacteria and viruses and the like, and have good effects of preventing, treating and protecting health for various animal diseases. For example: radix astragali has effects of invigorating qi and blood, and enhancing immunity. Codonopsis pilosula can nourish blood, tonify qi, promote the production of body fluid, quench thirst, and treat inappetence, hypodynamia and diarrhea. The combined application can improve the immune function of the organism and enhance the disease resistance of the organism by regulating the immune function;

(5) energy and mineral feed ingredients, molasses and the like, and has balanced nutrition:

the corncobs and the jujubes are energy feeds with high sugar content, and have various trace elements, so that the corncobs and the jujubes can supplement balanced nutrition with high protein components such as rice, soybeans and the like, and simultaneously improve the taste and the feed intake; the molasses is mineral feed with extremely high sugar content, can supplement various vitamins and minerals, and can improve the immunity of animal organisms; the hawthorn is used as one of the additive components of mineral feed, can supplement components such as vitamins and organic acids, and can be matched with traditional Chinese medicines to have the effects of promoting digestion and absorption, improving the digestibility of protein and fat in the feed, enhancing the immunity of the digestive tract and the like.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate an embodiment of the invention and, together with the description, serve to explain the invention and not to limit the invention. In the drawings:

FIG. 1 is a process flow diagram of one embodiment of the present invention.

Detailed Description

For a better understanding of the present invention, reference is made to the following detailed description taken in conjunction with the accompanying drawings. Technical terms used in the following description have the same meanings as commonly understood by one of ordinary skill in the art to which the present invention belongs.

Firstly, the preparation of the feed or feed additive of the invention (figure 1)

(1) Moistening semen glycines or rice with water, adding Monascus, fermenting, and culturing at 7-38 deg.C for more than 4 days;

(2) extracting the fermented product with 60-98% ethanol, separating the filtrate, and collecting the residue as red rice residue product;

(3) the red yeast rice residue product is prepared from 50-99% of red yeast rice residue product, 1-10% of codonopsis pilosula, 1-10% of astragalus root, 1-20% of corncob powder, 1-15% of hawthorn powder and 1-10% of molasses by weight, wherein the red yeast rice residue product is prepared from (1-3): (1-3): (1-3) inoculating lactobacillus, saccharomycetes and bacillus in proportion, adjusting water content and mixing uniformly;

(4) subpackaging the uniformly mixed materials by using one-way breather valve fermentation bags, sealing and fermenting at constant temperature;

(5) the fermented product is sold as finished feed or feed additive.

Wherein, the red yeast rice residue product obtained in the step (2) can also be directly obtained by purchasing. For example, the compound can be purchased from Beijing Daweixin Biotechnology Co., Ltd, the company adopts the steps from (1) to (2) for production, the filtrate separated after ethanol extraction is used as the raw material for producing the blood fat reducing drug product 'Xuezhikang', and the residual red yeast dregs product can be used for preparing the feed or the feed additive.

Second, feed cultivation test evaluation

1. Red yeast rice feed/probiotic fermented feed breeding fattening pig test

Comparing the effect of the red yeast rice fermented feed and the effect of the conventional lactobacillus yeast fermented feed in pig breeding and fattening, and comparing the daily feed intake, the daily gain of 30 balances, the diarrhea rate and the feed conversion rate in tests.

(1) Materials and methods

The feed conditions of each group are as follows:

blank group: the fermented feed is not added, and only the conventional feed is used, and the mixture ratio is shown in table 1;

TABLE 1

Name of article	Ratio/(%)
		Corn (corn)	60
Bean pulp	15
		Wheat bran	10
Premix compound	5
		Auxiliary materials	10
Total up to	100

Red yeast rice fermented feed group: the red yeast rice fermented feed and the conventional feed used in the blank group are mixed according to the weight ratio of 1: 9, mixing, wherein the nutrient components of the red yeast rice fermented feed are shown in the table 2;

TABLE 2

Item	Unit of	Method	Results
				Protein	g/100g	First method of GB 5009.5-2016	14.5
Total sugar	g/100g	First method of GB 5009.9-2016	56.4
				Total amount of probiotic bacteria	Hundred million/g	GBT13093-2006	30
Lead (Pb)	mg/kg	The second method of GB 5009.12-2017,	not detected out
				Total arsenic (As)	mg/kg	The first article of GB 5009.11-2014,	not detected out
Total mercury (Hg)	mg/kg	The first article of GB 5009.17-2014,	not detected out
				Cadmium (Cd)	mg/kg	GB 5009.15-2014,	Not detected out
Aflatoxin	ug/kg	Third method of GB 5009.22-2016	Not detected out

Probiotic fermented feed group: the probiotic fermented feed and the conventional feed used in the blank group are mixed in a ratio of 1: 9, mixing, wherein the probiotic fermented feed comprises the following formula: corn 58.2%, soybean meal 31.5%, rapeseed meal 5%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, salt 0.3%, oil 2.5%, and probiotic 1kg is added to every 100 kg of feed, and the fermentation probiotic is prepared by mixing lactobacillus acidophilus, bacillus subtilis, enterococcus faecalis 1: 1: the formulation of 1, the nutrient components of the probiotic fermented feed are shown in table 3.

TABLE 3

Item	Unit of	Method	Results
				Protein	g/100g	First method of GB 5009.5-2016	12.5
Total sugar	g/100g	First method of GB 5009.9-2016	53.4
				Total amount of probiotic bacteria	Hundred million/g	GBT13093-2006)	28
Lead (Pb)	mg/kg	The second method of GB 5009.12-2017,	not detected out
				Total arsenic (As)	mg/kg	The first article of GB 5009.11-2014,	not detected out
Total mercury (Hg)	mg/kg	The first article of GB 5009.17-2014,	not detected out
				Cadmium (Cd)	mg/kg	GB 5009.15-2014,	Not detected out
Aflatoxin	ug/kg	Third method of GB 5009.22-2016	Not detected out

The experimental animals are selected to be healthy by long-white three-way hybridization with similar gestation times and weight (50 +/-5 kg), 90 pigs are randomly divided into 3 groups, and the three groups of feeds are respectively fed. The test pigs are all raised in the same fattening house, are immunized according to the immunization program of a pig farm, and are repelled according to the conventional program and method. The test pigs feed and drink water freely, the colony house is cleaned regularly every day, and the feeding management conditions of all groups are completely consistent except that the fermented feed is added in the test.

(2) Measurement items

i. Average daily food intake:

the feed is settled once every 10d in repeating group units, weighed and settled.

Daily food consumption is (initial weight of feed-weight of feed powder)/feeding days.

Average daily gain:

the weight is respectively weighed once at the beginning and the end of the test (early morning empty stomach), and the measurement index of the growth speed is the average daily gain of the growing-finishing pigs in a certain period, namely the average daily gain.

Average daily gain (g) ═ end weight-start weight/day of feed.

Feed conversion ratio iii

Means the amount of feed consumed per 1kg body weight gain during a period.

Feed conversion ratio (total feed consumption/(end weight-start weight) during the measurement period)

Diarrhea rate:

the number of diarrhea pigs in each group is recorded in detail every day during the test period, and the diarrhea rate of each group at the end of the test is counted.

Diarrhea determination criteria: the feces are unformed and the stacking height of the naturally excreted feces on the ground is less than 10 cm.

The diarrhea rate (%) is the total number of diarrhea in the experimental period/total number of the fed animals in the experimental period multiplied by 100%

(3) Results of the experiment

And calculating the average daily gain and the average daily feed intake by individuals, counting the feed conversion rate, and performing single-factor variance analysis and statistical treatment on the obtained data. The weight gain and feed intake data obtained are shown in table 4 and the diarrhea data are shown in table 5.

TABLE 4

TABLE 5

Item	Blank group	Probiotic fermented feed group	Red yeast rice fermented feed group
				Number of Total diarrhea	15	13	11
Mean diarrhea rate	0.17	0.14	0.12
				Rate of improvement		-13.33％	-26.67％

(4) Discussion of results

i. The average daily gain of the probiotic fermented feed group and the red yeast rice fermented feed group in the test period is respectively improved by 6.05 percent and 12.66 percent compared with the control group, the difference between the test red yeast rice fermented feed group and the control group is obvious (P is less than 0.05), and the average daily gain of the red yeast rice fermented feed group is also obviously improved compared with the probiotic fermented feed group.

And ii, the average daily food consumption in the test period of the probiotic fermented feed group and the red yeast rice fermented feed group are respectively increased by 4.66 percent and 6.56 percent compared with the control group, the difference between the red yeast rice fermented feed group and the control group is obvious (P is less than 0.05), and the red yeast rice fermented feed group is only increased by 1.9 percent compared with the probiotic fermented feed group.

Comparison of diarrhea rates: during the test period, compared with the control group, the probiotic fermented feed group and the red yeast rice fermented feed group have the diarrhea rate respectively reduced by 13.33 percent and 26.67 percent.

2. Red yeast rice feed/probiotic fermented feed breeding mutton sheep test

Comparing the effect of the red yeast rice fermented feed and the effect of the conventional lactobacillus yeast fermented feed for breeding the mutton sheep, comparing the daily feed intake, 60-balance daily gain and feed conversion rate in the experiment.

(1) Materials and methods

Feeding the feed and breeding the fattening pigs for each group.

The experimental animals selected 60 healthy sheep with similar weight and similar gestational frequency and weight (50 +/-5 kg), and were randomly divided into 2 groups of 60 days from 3 months to 1 to 4 months in 2020 for total. Respectively feeding the probiotic fermented feed and the red yeast rice fermented feed. The test sheep are all raised in the same fattening house, and are immunized according to the immunization program of the sheep farm and repelled according to the conventional program and method. Test sheep freely feed and drink water, and the colony house is regularly cleaned every day, and the feeding management conditions of all groups are completely consistent except that the test additives are different.

(2) Measurement items

The method is used for breeding fattening pigs.

(3) Experimental results and discussion

The results of the test period are shown in Table 6.

TABLE 6

Item	Probiotic fermented feed group	Red yeast rice fermented feed group
			Feed intake (kg/head)	59.15±5.72	67.31±6.14
Initial weight (kg)	28.32±2.68	28.44±2.37
			Terminal weight (kg)	42.37±4.34	45.61±4.72
Weight gain (kg)	15.04±2.35	17.17±2.69
			Daily gain (g/head)	234.17±23.27	286.17±26.32
Meat ratio of materials	4.21±0.34	3.92±0.41

Also, as can be seen from table 6, the red yeast rice fermented feed group can increase the average daily gain, feed conversion ratio and average daily feed intake of growing mutton sheep compared to the probiotic fermented feed group.

3. Red yeast rice feed/probiotic fermented feed breeding beef cattle test

Comparing the effect of the red yeast rice fermented feed and the effect of the conventional lactobacillus yeast fermented feed for cultivating beef cattle, comparing the daily feed intake, the daily gain of 30 balances and the feed conversion rate in an experiment.

(1) Materials and methods

Feeding the feed and breeding the fattening pigs for each group.

Experimental animals 10 simmental beef cattle of 12-13 months age were selected and randomly divided into 2 groups. Respectively feeding the probiotic fermented feed and the red yeast rice fermented feed. The test cattle were immunized according to the immunization program of the cattle farm and repelled according to the conventional program and method. Test cattle feed and drink water freely, the colony house is cleaned regularly every day, and the feeding management conditions of all groups are completely consistent except that the test additives are different.

(2) Experimental results and discussion

The results of the test period are shown in Table 7.

TABLE 7

Test period	Probiotic fermented feed group	Red yeast rice fermented feed group
			Height (cm)	98.67±1.53	100.00±2.00
Oblique length (cm)	106.33±1.52	110.23±6.66
			Chest circumference (cm)	109.14±1.12	112.32±4.93
Body weight (kg)	114.83±2.08	117.51±5.47

Also, as can be seen from table 7, the red yeast rice fermented feed group can increase the weight gain of the growing mutton sheep compared to the probiotic fermented feed group.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. An application of a red yeast rice residue product in preparing feed or feed additives is disclosed, wherein the red yeast rice residue product comprises: the method comprises the steps of fermenting grain crops serving as raw materials by using monascus to produce monascus fermented substances, extracting medicinal lipid-lowering components by using ethanol, and extracting residues of the lipid-lowering components.

2. The use of claim 1, wherein the food crop is one or more of cereals, beans, potatoes, including one or more of wheat, rice, corn, soybean, potato, preferably at least 40% rice;

in the fermentation process, the fermentation culture is preferably carried out at 7-38 ℃ for more than 4 days, and more preferably at 15-35 ℃ for more than 9 days;

the ethanol extraction process adopts 60-98% ethanol decoction.

3. The use of claim 1, wherein the preparation method of the monascus slag product applied to feed or feed additives comprises the following steps: adding other raw material components into the red yeast residue product according to the requirement, performing secondary fermentation by using lactic acid bacteria, saccharomycetes and bacillus, and taking the secondary fermentation product as a feed or feed additive product.

4. The use as claimed in claim 3, wherein said other raw material components added to the red yeast rice residue product include herbal ingredients, energy and mineral feed ingredients, and molasses.

5. The application of the method as claimed in claim 4, wherein the proportion of each component of the secondary fermentation raw materials is as follows: 5-99% of red yeast rice residue product, 1-10% of codonopsis pilosula, 1-10% of astragalus root, 1-40% of corncob powder, 1-15% of hawthorn powder, 1-50% of molasses and 0-50% of other feed raw materials; wherein the other feed raw materials comprise one or more of grain raw grain, soybean meal, corn, fish meal, amino acid, miscellaneous meal, additives, whey powder, oil, meat and bone meal, and grains.

6. Use according to claim 3, characterized in that the mass ratio of lactic acid bacteria, yeasts and bacilli is preferably (1-3): (1-3): (1-3).

7. The use according to claim 3, wherein the secondary fermentation is carried out at 5-40 ℃ for more than 2 days.

8. The use of claim 1, wherein the feed or feed additive prepared from the red yeast rice residue product is used as a single feed for 100% feeding, or is mixed with other feeds for feeding, and the addition amount of the feed or feed additive prepared from the red yeast rice residue product is 5-30% during mixed feeding.

9. The use according to claim 1, wherein the red yeast rice residue product is a residual red yeast rice residue product purchased from Beijing Davweixin Biotech limited for the production of a blood lipid lowering pharmaceutical product "Xuezhikang".