CN113056279A - 美洲大蠊提取物、其制剂以及它们的制备方法和应用 - Google Patents

美洲大蠊提取物、其制剂以及它们的制备方法和应用 Download PDF

Info

Publication number
CN113056279A
CN113056279A CN202080005893.2A CN202080005893A CN113056279A CN 113056279 A CN113056279 A CN 113056279A CN 202080005893 A CN202080005893 A CN 202080005893A CN 113056279 A CN113056279 A CN 113056279A
Authority
CN
China
Prior art keywords
ethanol
periplaneta americana
fresh
time
filtering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202080005893.2A
Other languages
English (en)
Other versions
CN113056279B (zh
Inventor
耿越飞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Liangshan Canonda Biological Raw Material Breeding Co ltd
Original Assignee
Liangshan Canonda Biological Raw Material Breeding Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liangshan Canonda Biological Raw Material Breeding Co ltd filed Critical Liangshan Canonda Biological Raw Material Breeding Co ltd
Publication of CN113056279A publication Critical patent/CN113056279A/zh
Application granted granted Critical
Publication of CN113056279B publication Critical patent/CN113056279B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Insects & Arthropods (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

本发明涉及医药技术领域,具体涉及一种美洲大蠊提取物、其制剂以及它们的制备方法和应用。本发明所述美洲大蠊提取物的制备方法包括如下步骤:1)采用新鲜美洲大蠊用乙醇浸泡;2)再加入乙醇回流提取,然后过滤、合并滤液;3)滤液浓缩为浸膏,即得。本发明方法使用乙醇等环保试剂、增加了美洲大蠊提取物的生物活性物质含量,节约了时间,人力物力,节约能源,降低生产成本;同时本发明获得美洲大蠊提取物具有更好的抗炎活性,具有更高含量的氨基酸。

Description

PCT国内申请,说明书已公开。

Claims (26)

  1. PCT国内申请,权利要求书已公开。
CN202080005893.2A 2019-10-11 2020-10-10 美洲大蠊提取物、其制剂以及它们的制备方法和应用 Active CN113056279B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019109615019 2019-10-11
CN201910961501 2019-10-11
PCT/CN2020/120079 WO2021068909A1 (zh) 2019-10-11 2020-10-10 美洲大蠊提取物、其制剂以及它们的制备方法和应用

Publications (2)

Publication Number Publication Date
CN113056279A true CN113056279A (zh) 2021-06-29
CN113056279B CN113056279B (zh) 2023-04-28

Family

ID=75437751

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080005893.2A Active CN113056279B (zh) 2019-10-11 2020-10-10 美洲大蠊提取物、其制剂以及它们的制备方法和应用

Country Status (6)

Country Link
US (1) US20220339205A1 (zh)
EP (1) EP4043020A4 (zh)
JP (1) JP7391204B2 (zh)
CN (1) CN113056279B (zh)
CA (1) CA3156271A1 (zh)
WO (1) WO2021068909A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114015126B (zh) * 2021-10-28 2022-08-30 南开大学 一种食品包装膜材料制备及应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1548058A (zh) * 2003-05-22 2004-11-24 福州金象中药制药有限公司 蜚蠊活成虫提取物的制备方法
CN101502534A (zh) * 2009-03-11 2009-08-12 黄少鉴 美洲大蠊药用物质的提取方法
US20130052273A1 (en) * 2008-12-17 2013-02-28 Funeng GENG Pharmaceutical composition comprising periplaneta americana or its ethanol extract and a method of using the same for treating inflammations
CN105878292A (zh) * 2015-09-24 2016-08-24 陈光健 一种美洲大蠊提取物及其制备工艺
CN109966319A (zh) * 2017-12-22 2019-07-05 四川好医生攀西药业有限责任公司 一种康复新液的原料及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1010828B (zh) * 1987-01-27 1990-12-19 大理医学院 一种治疗外伤创面药物的制备方法
CN1255117C (zh) 2003-04-30 2006-05-10 严少宏 美洲大蠊药用浸膏提取工艺
CN1961893A (zh) 2005-11-08 2007-05-16 肖小芹 美洲大蠊成虫提取物的制备方法
CN101077355A (zh) * 2006-05-22 2007-11-28 贵州联盛药业有限公司 双效天然澄清剂及其应用技术
CN100525781C (zh) 2006-09-30 2009-08-12 耿福能 美洲大蠊提取物、含该提取物的药物组合物及其制备方法
CN1943600B (zh) * 2006-10-17 2010-05-12 耿福能 含有美洲大蠊及其乙醇提取物的药物组合物及新用途
CN103446187B (zh) 2013-09-05 2015-08-26 陈光健 一种抗炎消肿的药物组合物及其制备方法和用途
CN104622910A (zh) 2013-11-08 2015-05-20 成都百草和济科技有限公司 美洲大蠊提取物的低温制备方法
CN106074614B (zh) 2016-06-21 2019-12-06 四川好医生攀西药业有限责任公司 美洲大蠊在制备治疗前列腺炎药物中的应用
CN107753535B (zh) 2017-02-21 2020-07-14 四川好医生攀西药业有限责任公司 一种治疗心脑血管疾病的药物组合物及其应用
CN109700832A (zh) 2017-10-25 2019-05-03 浙江京新药业股份有限公司 包含地衣芽孢杆菌和美洲大蠊提取物的药物组合物
CN109718252A (zh) * 2017-10-25 2019-05-07 浙江京新药业股份有限公司 美洲大蠊提取物在制备治疗和预防化疗致肠道黏膜炎药物中的应用
CN107929325B (zh) * 2017-11-29 2023-03-24 四川好医生攀西药业有限责任公司 一种含美洲大蠊的栓剂及其制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1548058A (zh) * 2003-05-22 2004-11-24 福州金象中药制药有限公司 蜚蠊活成虫提取物的制备方法
US20130052273A1 (en) * 2008-12-17 2013-02-28 Funeng GENG Pharmaceutical composition comprising periplaneta americana or its ethanol extract and a method of using the same for treating inflammations
CN101502534A (zh) * 2009-03-11 2009-08-12 黄少鉴 美洲大蠊药用物质的提取方法
CN105878292A (zh) * 2015-09-24 2016-08-24 陈光健 一种美洲大蠊提取物及其制备工艺
CN109966319A (zh) * 2017-12-22 2019-07-05 四川好医生攀西药业有限责任公司 一种康复新液的原料及其制备方法和应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
NA LI 等: "Protective effect of Periplaneta Americana extract in ulcerative colitis rats induced by dinitrochlorobenzene and acetic acid", 《PHARMACEUTICAL BIOLOGY》 *
耿巧玉 等: "美洲大蠊药效物质提取工艺优化", 《环球中医药》 *
耿巧玉: "美洲大蠊活性部位提取分离工艺优化与初步抗肿瘤作用研究" *
胡伯凯 等: "柿酒研究进展", 《贵州林业科技》 *

Also Published As

Publication number Publication date
EP4043020A1 (en) 2022-08-17
CN113056279B (zh) 2023-04-28
EP4043020A4 (en) 2023-11-22
CA3156271A1 (en) 2021-04-15
JP7391204B2 (ja) 2023-12-04
WO2021068909A1 (zh) 2021-04-15
JP2022551319A (ja) 2022-12-08
US20220339205A1 (en) 2022-10-27

Similar Documents

Publication Publication Date Title
CN108635375A (zh) 预防或治疗肝病和肝纤维化及改善肝功能的熊胆粉及用途
KR100699790B1 (ko) 댕댕이나무 추출물을 포함하는 간 질환 예방 및 치료효과를 가지는 약제학적 조성물
CN112057546A (zh) 一种蜂胶灵芝孢子粉组合物及其制备方法和应用
CN113056279A (zh) 美洲大蠊提取物、其制剂以及它们的制备方法和应用
JP2007526914A (ja) 魚腥草と徳利苺の実の抽出物とそれらのアレルギー疾患予防及び治療用組成物(ExtractsofHouttuyniacordataandRubuscoreanusandtheircompositionforpreventingandtreatingallergicdiseases)
CN112353734A (zh) 一种积雪草发酵产物的发酵方法及其在修复功效化妆品中的应用
CN111514174A (zh) 一种沙棘果结合态多酚的提取方法及其应用
CN113559152B (zh) 护肝中药组合物、饮品及其制备方法和应用
CN109248188A (zh) 一种金雀根提取物的制备方法及其应用
CN105362326B (zh) 一种从不结球白菜提取天然活性物质的方法及其应用
CN105030952B (zh) 一种组合物在制备预防尿结石药物中的应用
CN107890469A (zh) 一种抗脑缺血再灌注损伤的天然药物活性成分组合物及其制备方法与应用
CN107281317A (zh) 一种提高人体免疫力的口服液及其制备方法
ES2311086T3 (es) Esporas de ganoderma lucidum para el tratamiento de lupus eritematosos sistemico (sle).
CN104208683B (zh) 一种抗鸭病毒性疾病的药物组合物、冻干粉、制备方法及应用
CN106172255B (zh) 一种提高水蛭体内水蛭甲素含量的方法
CN1160095C (zh) 抗衰老养生膏及其制备方法
Nasution et al. The response of red ginger (Zinggiber officinalle var rubra) with various processing in broilers were infected by Eimeria tenella
CN109793235A (zh) 对化学性肝损伤有辅助保护作用口服液及其制备方法
CN116687994B (zh) 一种金银花在制备降低川乌毒性药物方面的用途
CN116474014B (zh) 一种治疗鸡组织滴虫病的中药组合物及其制备方法
TWI846046B (zh) 毛木耳多醣體萃取物及其用於製備促進傷口癒合之醫藥組成物的用途
CN111700903B (zh) 一种紫菜多糖的应用及紫菜多糖的制备方法
Adeoye et al. Effect of white cabbage (Brassica oleracea) aqueous extract on oxidative stress in pre-diabetes–induced male albino rats
CN114042133A (zh) 一种组合物及其制备方法与应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant