CN112931872A - 一种杞菊咀嚼软胶囊及其制备方法 - Google Patents
一种杞菊咀嚼软胶囊及其制备方法 Download PDFInfo
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- CN112931872A CN112931872A CN202110339628.4A CN202110339628A CN112931872A CN 112931872 A CN112931872 A CN 112931872A CN 202110339628 A CN202110339628 A CN 202110339628A CN 112931872 A CN112931872 A CN 112931872A
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- chrysanthemum
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Abstract
本申请公开了一种杞菊咀嚼软胶囊及其制备方法，包括枸杞籽油10‑60份，菊花提取物16‑36份，维生素A 0.16‑0.24份，维生素E 4‑12份，β‑胡萝卜素0.16‑0.24份，牛磺酸0.16‑0.3份。本申请采用枸杞为主要原料，添加维生素A、菊花提取物以及眼部所需的维生素和微量元素，不仅能够益精明目，并且解决了服用人群吞服的困难问题，易于食用，食用时可随取随用，胶皮完全密封，可在口中咬破咀嚼并且迅速溶化，在咀嚼的同时，可驱除口气、清新口腔和保护牙齿。可通过调整胶皮口味，改善入口营养原料的口感，口感俱佳，从而容易被消费者喜爱，同时，保持内容物的营养功效，延伸枸杞深加工的方向，提高枸杞的利用率。
Description
技术领域
本申请涉及胶囊领域，尤其涉及一种杞菊咀嚼软胶囊及其制备方法。
背景技术
枸杞子为常用滋补类中药材，药用始见于《神农本草经》。《中国药典》收载的枸杞子为宁夏枸杞(Lycium barbarismL.)的干燥成熟果实。枸杞子有补肝、益肾、明目的功能，用于治疗虚劳精亏、腰膝酸痛、眩晕耳鸣、内热消渴、血虚痿黄、目眩不明等症。随着人民生活水平的提高，食疗意识的增强。
随着智能手机和电子产品的发展，长时间使用电子屏幕已经是许多人生活中的一部分，用眼的负担日益加重，出现视物模糊、视物不能持久、看东西出现双影儿(复视)、眼睛又干又涩、眼睛酸胀、有烧灼感、流泪。甚至还有头晕头痛、恶心呕吐、记忆力减退和焦虑烦躁等全身性症状。这些症状就是我们所说的视疲劳，它已经成为困扰学生和年轻白领的非常普遍的亚健康问题。
并且在现有的药物或保健品服用的过程中吞服较为困难，所以需要一种杞菊咀嚼软胶囊及其制备方法，解决上述问题。
发明内容
本申请提供了一种杞菊咀嚼软胶囊及其制备方法，解决了现有技术中眼睛干涩、酸胀、有烧灼感、流泪，服药困难的问题。
本申请提供了一种杞菊咀嚼软胶囊，包括枸杞籽油10-60份，菊花提取物16-36份，维生素A 0.16-0.24份，维生素E 4-12份，β-胡萝卜素0.16-0.24份，牛磺酸0.16-0.3份。
一种杞菊咀嚼软胶囊的制备方法，包括下列方法：
a、枸杞干果或鲜果在除杂后清洗或浸泡，将清洗或浸泡后的枸杞干果、鲜果进行打浆分离出种籽，并将种籽清洗后自然晾干，将种籽粉碎后放入超临界二氧化碳设备中萃取出枸杞油；
b、将菊花粉碎后经水提取、浓缩、喷雾干燥得到菊花提取物；
c、将果胶、明胶、调味剂、色素和纯净水加入化胶罐混匀，开启真空泵脱泡，搅拌10分钟后关闭搅拌，胶液用60目滤袋过滤，形成液体物料，至50℃-55℃保温备用；
d、将枸杞籽油、维生素A和维生素E加入配置罐内，搅拌混和均匀，加入牛磺酸、菊花提取物与液体物料混匀，搅拌30分钟，加入胶体磨中研磨，过100目筛，研磨过程中注意观察料液性状，将胶液送至软胶囊机，采用软胶囊机将配制好的液体物料定量压注包封于胶膜内，压制过程中将胶液在50℃-55℃内保温；
e、成型后的杞菊咀嚼软胶囊经定型、打磨、晾干后进行包装。
进一步的，一种杞菊咀嚼软胶囊的制备方法，所述菊花提取物采用菊花原料加1：6～1：8纯净水提取2次，每次30分钟，合并提取液过滤，滤液采用双效真空浓缩至1：1，喷雾干燥，得菊花提取物。提取物过80—100目筛，水分控制在5％以内。
由以上技术方案可知，本申请提供了一种杞菊咀嚼软胶囊及其制备方法，采用枸杞为主要原料，添加维生素A、菊花提取物以及眼部所需的维生素和微量元素，不仅能够益精明目，并且解决了服用人群吞服的困难。改变了食用保健食品的心理感受，不再像“吃药”一样食用软胶囊。胶皮使内容物完全密封，可在口中咬破咀嚼并且迅速溶化，在咀嚼的同时，可驱除口气、清新口腔和保护牙齿。可通过调整胶皮口味，改善载入的所有营养原料的口感，使之美味，从而容易被消费者喜爱，同时，保持内容物的营养功效。
附图说明
为了更清楚地说明本申请的技术方案，下面将对实施案例中所需要使用的附图作简单地介绍，显而易见地，对于本领域普通技术人员而言，在不付出创造性劳动性的前提下，还可以根据这些附图获得其他的附图。
图1为本申请工艺流程示意图。
具体实施方式
为了使本技术领域的人员更好地理解本申请中的技术方案，下面将结合附图，对本申请实施例中的技术方案进行清楚、完整地描述。
参见图1
由以上技术方案可知，一种杞菊咀嚼软胶囊，包括枸杞籽油10-60份，菊花提取物16-36份，维生素A 0.16-0.24份，维生素E 4-12份，β-胡萝卜素0.16-0.24份，牛磺酸0.16-0.3份。
一种杞菊咀嚼软胶囊的制备方法，包括下列方法：
a、枸杞干果或鲜果在除杂后清洗或浸泡，将清洗或浸泡后的枸杞干果、鲜果进行打浆分离出种籽，并将种籽清洗后自然晾干，将种籽粉碎后放入超临界二氧化碳设备中萃取出枸杞油；
b、将菊花粉碎后经水提取、浓缩、喷雾干燥得到菊花提取物，菊花提取物主要活性成分为黄酮类和酚类化合物。具有扩张冠状动脉、降低血压、预防高血脂、抗菌、抗病毒、抗炎、抗衰老等多种生理活性，能够有效的中和枸杞带来的上火现象；
c、将果胶、明胶、调味剂、色素和纯净水加入化胶罐混匀，处理过程中先加入定量纯净水至化胶罐内，加热罐内纯净水，待化胶罐内纯净水温度达50℃-60℃时，易于溶解果胶和，明胶，避免在搅拌过程出现结块的现象，开启搅拌机，缓缓加入果胶、明胶、调味剂原辅料，溶解效果好，且效率高，罐内明胶完全吸水膨胀，搅拌均匀，待胶液温度达到65℃-70℃时，开启真空泵脱泡，将色素加入化胶罐，此时搅拌后的色素更加均匀，搅拌10分钟后关闭搅拌。胶液用60目滤袋过滤，提高口感，避免结块引起的口感不佳，至50℃-55℃保温备用，形成液体物料，保持形成液体物料的流动性，便于后期其他物质的溶解；
d、将枸杞籽油、维生素A和维生素E加入配置罐内，搅拌混和均匀，在加入前需过100目筛，避免搅拌时结块，影响品质；牛磺酸、菊花提取物过100目筛，与液体物料混匀，搅拌30分钟，加入胶体磨中研磨，过100目筛，研磨过程中注意观察料液性状，不能发生结块，且料液颜色均匀，形成胶液，将胶液送至软胶囊机，采用软胶囊机将配制好的液体物料定量压注包封于胶膜内，压制过程中对胶液在50℃-55℃内保温，避免结块；
e、成型后的杞菊咀嚼软胶囊经定型、打磨、晾干后进行包装，晾干过程中将压制的杞菊咀嚼软胶囊放入干燥转笼进行干燥，在20℃-25℃下干燥7-15小时，再将转笼取出的胶丸放于带筛网的干燥车上干燥，在20℃-25℃下干燥7-15小时，期间每隔3小时翻丸一次，使干燥均匀，防止粘连，采用超声波软胶囊清洗机，用95％乙醇清洗胶丸，将洗后的胶丸放于带筛网的干燥车上，摊平，在18℃-26℃干燥6-8小时，挥去乙醇；期间每隔3小时翻丸一次，使干燥均匀，防止粘连，干燥后，检查胶丸质量，即可收丸。
优选的，所述菊花提取物采用菊花原料加1：6～1：8纯净水提取2次，每次30分钟，合并提取液过滤，滤液采用双效真空浓缩至1：1，喷雾干燥，得菊花提取物；提取物过80—100目筛，水分控制在5％以内。
枸杞性平，味甘。滋补肝肾，益精明目。用于虚劳精亏、腰膝酸痛、眩晕耳鸣、内热消渴、血虚萎黄、目昏不明。
枸杞油中主要成分亚油酸可降低血浆中的胆固醇，防止动脉粥样硬化，防止高血脂，并能促进儿童大脑发育。亚油酸属“不饱和脂肪酸”，属人体必须脂肪酸。不饱和脂肪酸在人体内不能合成，只能从植物油中摄取；磷脂对儿童大脑发育有很好效果，辅助治疗冠心病，参于脑营养物质的代谢，对X射线损伤的皮肤有修复作用；维生素E抗衰老，防止心血管疾病，同时能促进维生素A发挥缓解视疲劳的功能；β-胡萝卜素为主要的维生素A源物质，是一种最常见的维生素A补充剂，构成视觉细胞内的感光物质，有效促进健康及细胞发育，预防先天不足。根据大量文献研究结果表明，枸杞油从枸杞种籽中萃取，是综合枸杞子所有生物信息、营养成份的最精华部分。枸杞油中含有大量的维生素E、胡萝卜素、亚油酸等活性物质，不但可以直接参与体内氧化性物质结合，还可以有效的激活体内的超氧化物歧化酶(SOD)，延长细胞在体内的老化时间，从而达到延缓人体衰老速度；胡萝卜素可以维持眼睛和皮肤的健康，改善夜盲症、皮肤粗糙的状况，有助于身体免受自由基的伤害。对维持机体健康、提高机体防御体系进而防止机体衰老方面有良好的效果。
菊花提取物:菊花具有良好的药用价值，具有散风清热，平肝明目的功效。用于风热感冒，头痛眩晕，目赤肿痛，眼目昏花。现代研究表明，菊花含黄酮类、胆碱、氨基酸、绿原酸、维生素A、维生素B族、微量元素硒、镍、锰等，具有清热解毒、平肝、降血压抗衰老、促进胆固醇分解的作用，是各类人群喜欢的茶饮。
维生素A：维生素A是一类具有全反式视黄醇活性的脂溶性维生素，它是一种β-芷相酮类衍生物，机体的正常代谢离不开它的参与。维生素A的重要生理功能是维护角膜的正常结构，维持视网膜的正常功能，对于维持正常视力有重要作用。维生素A还可以调节眼睛的发育及眼表上皮细胞的正常分化，研究发现，维生素A参与结膜分化，对角膜糖蛋白合成及能量代谢起作用，同时也能够调控角膜表皮生长因子受体基因的表达，从而促进角膜生长或修复。
亚油酸、胡萝卜素、维生素E、维生素B、维生素C和钙、磷、铁等，具有延缓人体衰老，维持眼睛和皮肤的健康，改善夜盲症、皮肤粗糙的状况，有助于身体免受自由基的伤害。维生素A维护角膜的正常结构，维持视网膜的正常功能，对于维持正常视力有重要作用。菊花具有清热解毒、平肝、降血压、抗衰老、促进胆固醇分解的作用。枸杞和菊花中所含有的微量元素是人体所需要的，在此基础上添加维生素A、维生素E和牛磺酸可营养视网膜，快速缓解视疲劳，用于视力功能下降、近视及弱视人群及长期操作电脑、接触智能手机的人群。
在制作工艺方面，采用二氧化碳超临界萃取技术，保留了原料中所含的营养物质，采用咀嚼软胶囊剂型，改变了以往吞服的方式，同时咀嚼软胶囊将突破内载油性营养物质的限制，将更多非油性营养物质载入，此举将极大地降低企业的生产成本。该剂型可解决服用人群吞服困难，具有独特的咀嚼性，可利用胶皮的配方清新口气、改善内容物的口感，彰显内容物独特的风味。
本领域技术人员在考虑说明书及实践这里公开的申请后，将容易想到本申请的其它实施方案。本申请旨在涵盖本申请的任何变型、用途或者适应性变化，这些变型、用途或者适应性变化遵循本申请的一般性原理并包括本申请未公开的本技术领域中的公知常识或惯用技术手段。说明书和实施例仅被视为示例性的，本申请的真正范围由权利要求指出。
应当理解的是，本申请并不局限于上面已经描述并在附图中示出的精确结构，并且可以在不脱离其范围进行各种修改和改变。以上所述的本申请实施方式并不构成对本申请保护范围的限定。
Claims (3)
1.一种杞菊咀嚼软胶囊，其特征在于，包括枸杞籽油10-60份，菊花提取物16-36份，维生素A 0.16-0.24份，维生素E 4-12份，β-胡萝卜素0.16-0.24份，牛磺酸0.16-0.3份。
2.根据权利要求1所述的一种杞菊咀嚼软胶囊的制备方法，其特征在于，包括下列方法：
a、枸杞干果或鲜果在除杂后清洗或浸泡，将清洗或浸泡后的枸杞干果、鲜果进行打浆分离出种籽，并将种籽清洗后自然晾干，将种籽粉碎后放入超临界二氧化碳设备中萃取出枸杞籽油；
b、将菊花粉碎后经水提取、浓缩、喷雾干燥得到菊花提取物；
c、将果胶、明胶、调味剂、色素和纯净水加入化胶罐混匀，开启真空泵脱泡，搅拌10分钟后关闭搅拌，胶液用60目滤袋过滤，形成液体物料，至50℃-55℃保温备用；
d、将枸杞籽油、维生素A和维生素E加入配置罐内，搅拌混和均匀，加入牛磺酸、菊花提取物与液体物料混匀，搅拌30分钟，加入胶体磨中研磨，过100目筛，研磨过程中注意观察料液性状，将胶液送至软胶囊机，采用软胶囊机将配制好的液体物料定量压注包封于胶膜内，压制过程中将胶液在50℃-55℃内保温；
e、成型后的杞菊咀嚼软胶囊经定型、打磨、晾干后进行包装。
3.根据权利要求2所述的一种杞菊咀嚼软胶囊的制备方法，其特征在于，所述菊花提取物采用菊花原料加1：6～1：8纯净水提取2次，每次30分钟，合并提取液过滤，滤液采用双效真空浓缩至1：1，喷雾干燥，得菊花提取物；提取物过80—100目筛，水分控制在5％以内。
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