CN112858659A - Sampling needle cleaning system, sample analyzer and immune luminescence analyzer - Google Patents
Sampling needle cleaning system, sample analyzer and immune luminescence analyzer Download PDFInfo
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- CN112858659A CN112858659A CN201911193459.7A CN201911193459A CN112858659A CN 112858659 A CN112858659 A CN 112858659A CN 201911193459 A CN201911193459 A CN 201911193459A CN 112858659 A CN112858659 A CN 112858659A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/023—Cleaning the external surface
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/027—Cleaning the internal surfaces; Removal of blockages
- B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
- B08B9/0321—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing using pressurised, pulsating or purging fluid
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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Abstract
The application discloses sampling needle cleaning system, sample analysis appearance and immunofluorescence analysis appearance, this sampling needle cleaning system includes: sampling needle, first washing liquid container, second washing liquid container and liquid extraction and push mechanism, wherein, set up the first washing liquid entry with the inside sampling channel intercommunication of sampling needle on the outer wall of sampling needle, liquid extraction and push mechanism are connected with first washing liquid container and second washing liquid container respectively, and further be connected with sampling channel through first washing liquid entry, be arranged in absorbing first washing liquid, second washing liquid from first washing liquid container, second washing liquid container respectively, and further push second washing liquid, first washing liquid in proper order in the sampling channel of sampling needle, in order to utilize in proper order the second washing liquid first washing liquid is right respectively the inner wall of sampling needle washs. Through the mode, the cleanliness of the inner wall of the sampling needle can be improved.
Description
Technical Field
The application relates to the technical field of medical equipment, in particular to a sampling needle cleaning system, a sample analyzer and an immune luminescence analyzer.
Background
Sampling needles are important components of sample analyzers, and are used primarily for collecting and dispensing samples during operation.
Typically, after the sample is collected and dispensed from the sampling needle, the sampling needle needs to be cleaned to reduce the risk of cross-contamination with the next sample collected due to insufficient cleanliness.
Disclosure of Invention
The main technical problem who solves of this application provides a sampling needle cleaning system, sample analysis appearance and immune luminescence analysis appearance, can improve the cleanliness of the inner wall of sampling needle.
In order to solve the technical problem, the application adopts a technical scheme that: the utility model provides a sampling needle cleaning system, set up on the outer wall of sampling needle with the first washing liquid entry of sampling passageway intercommunication of sampling needle, cleaning system includes: a first cleaning liquid container for containing a first cleaning liquid; the second cleaning liquid container is used for containing a second cleaning liquid, wherein the cleaning force of the second cleaning liquid is stronger than that of the first cleaning liquid; and the liquid extracting and pushing mechanism is respectively connected with the first cleaning liquid container and the second cleaning liquid container, is further connected with the sampling channel through the first cleaning liquid inlet, is used for respectively sucking the first cleaning liquid and the second cleaning liquid from the first cleaning liquid container and the second cleaning liquid container, and further sequentially pushes the second cleaning liquid and the first cleaning liquid into the sampling channel of the sampling needle so as to sequentially utilize the second cleaning liquid and the first cleaning liquid to respectively clean the inner wall of the sampling needle.
In order to solve the above technical problem, another technical solution adopted by the present application is: the utility model provides an immune luminescence analyzer, immune luminescence analyzer includes sampling needle and as above sampling needle cleaning system, wherein, set up on the outer wall of sampling needle with the first washing liquid entry of sampling channel intercommunication of sampling needle.
In order to solve the above technical problem, another technical solution adopted by the present application is: the sample analyzer comprises a sampling needle and the sampling needle cleaning system, wherein a first cleaning liquid inlet communicated with a sampling channel of the sampling needle is formed in the outer wall of the sampling needle.
The beneficial effect of this application is: different from the prior art, the sampling needle cleaning system comprises a sampling needle, a first cleaning liquid container, a second cleaning liquid container and a liquid extracting and pushing mechanism, in the working process, the liquid extracting and pushing mechanism is used for respectively absorbing the first cleaning liquid and the second cleaning liquid from the first cleaning liquid container and the second cleaning liquid container, and further pushing the second cleaning solution and the first cleaning solution into a sampling channel of the sampling needle in sequence, so that the inner wall of the sampling needle is firstly cleaned by the second cleaning solution with stronger cleaning force to clean the sample remained on the inner wall, then the inner wall is cleaned by first cleaning liquid with common cleaning force to clean the second cleaning liquid remained on the inner wall, thereby can carry out comparatively thorough washing to the inner wall of sampling needle to can improve the cleanliness of sampling needle inner wall.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts. Wherein:
FIG. 1 is a schematic structural diagram of an embodiment of a sampling needle cleaning system of the present application;
FIG. 2 is a schematic structural diagram of an embodiment of an immuno-luminescence analyzer of the present application;
FIG. 3 is a schematic diagram of the structure of an embodiment of the sample analyzer of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a sampling needle cleaning system according to the present application. It should be noted that the sampling needle cleaning system in the present embodiment may be used in a sample analyzer in the field of medical devices, such as an immune luminescence analyzer, a blood cell analyzer, and the like, and is not limited herein.
In the sample analyzer as described above, the sampling needle is an important component for collecting and distributing the sample, and specifically, the sampling needle is provided with a sampling channel (not shown) inside, and during the operation, the sampling needle collects the sample by penetrating into the sample, and after the sample is collected, the sample is temporarily stored in the sampling channel, so that even after the stored sample is distributed, some sample still remains on the outer wall 11 of the sampling needle and the inner wall of the sampling needle, and therefore, the outer wall 11 of the sampling needle and the inner wall of the sampling needle need to be cleaned, so as to improve the cleanliness of the sampling needle and reduce the risk of cross contamination during the repeated use of the sampling needle.
In the related art, after a sample is dispensed by a sampling needle, a certain amount of common cleaning liquid, such as sheath liquid, is sucked by a liquid extracting and pushing mechanism, and then the common cleaning liquid is pushed into a sampling channel of the sampling needle by the liquid extracting and pushing mechanism, so that the inner wall of the sampling needle is cleaned.
However, since the smoothness of the inner wall of the sampling needle is limited, after the sampling needle has been used to separate a sample, such as a whole blood sample, proteins in the blood sample are adsorbed on the inner wall of the sampling needle, so that the inner wall of the sampling needle is not easily cleaned. Therefore, in some application scenarios, the cleaning method cannot meet the requirement of the cleanliness of the sampling needle. For example, in an immuno-luminescence analysis instrument, if the sampling needle is not cleaned, the next sample will be detected when the next sample is dispensed, and the accuracy of the sample detection will be affected. That is, in such application scenarios, there is often a higher cleanliness requirement.
For this reason, the sampling needle cleaning system in the present embodiment may include the first cleaning liquid container 21, the second cleaning liquid container 22, and the liquid extracting and pushing mechanism.
The first cleaning liquid container 21 is used for containing a first cleaning liquid, the second cleaning liquid container 22 is used for containing a second cleaning liquid, and both the first cleaning liquid and the second cleaning liquid can be used for cleaning the inner wall and the inner wall of the sampling needle.
It should be noted that the cleaning force of the second cleaning liquid is stronger than that of the first cleaning liquid, for example, the first cleaning liquid may be used to wash the inner wall of the sampling needle or the residual sample on the inner wall by applying a certain washing force, and the second cleaning liquid may be used to dissolve the residual sample adsorbed on the inner wall of the sampling needle into the second cleaning liquid by further dissolving, so as to achieve the purpose of cleaning.
Specifically, the first cleaning solution may be a common cleaning solution as mentioned in the above-mentioned related art, such as a sheath solution, and the second cleaning solution may be a cleaning solution having a certain acid-base corrosiveness, such as a strong acid or strong alkaline cleaning solution, and the cleaning solution is not limited herein as long as it can satisfy the above-mentioned dissolving requirement.
The liquid extracting and pushing mechanism can be used for sucking and taking out corresponding cleaning liquid from the corresponding cleaning liquid container in the cleaning system and further pushing the cleaning liquid to a target position. The liquid drawing and pushing mechanism may be a syringe 23 as shown in fig. 1, but may have other forms in other embodiments as long as the liquid drawing and pushing can be achieved.
Specifically, the syringe 23 may be connected to the first cleaning liquid container 21 and the second cleaning liquid container 22, respectively, to suck the first cleaning liquid in the first cleaning liquid container 21 and the second cleaning liquid in the second cleaning liquid container 22; wherein, the outer wall 11 of the sampling needle is provided with a first cleaning solution inlet 111 communicated with the sampling channel, and further, the injector 23 can be connected with the sampling channel through the first cleaning solution inlet 111. It is to be noted that the above-mentioned connection can be realized by providing corresponding lines in the washing system.
Specifically, the injector 23 is configured to suck the first cleaning solution and the second cleaning solution from the first cleaning solution container 21 and the second cleaning solution container 22, respectively, and further push the second cleaning solution and the first cleaning solution into the sampling channel of the sampling needle in sequence, so that the inner wall of the sampling needle is cleaned by the second cleaning solution and the first cleaning solution in sequence, respectively.
It should be noted that, when the inner wall of the sampling needle is cleaned, the second cleaning solution is firstly used to clean the inner wall so as to dissolve protein impurities and the like adsorbed on the inner wall, and then the first cleaning solution is used to wash the first cleaning solution remained on the inner wall.
In this embodiment, a certain amount of the first cleaning solution may be first sucked by the syringe 23 and stored, and then a certain amount of the second cleaning solution may be sucked and stored; after the cleaning liquid is completely sucked, the syringe 23 further pushes the sucked second cleaning liquid and first cleaning liquid into the sampling channel of the sampling needle in sequence, so that the inner wall of the sampling needle is cleaned by the second cleaning liquid and the first cleaning liquid in sequence.
Of course, in other embodiments, a certain amount of the second cleaning solution may be sucked by the syringe 23, and then the sucked second cleaning solution may be pushed into the sampling channel of the sampling needle by the syringe 23 to perform the first cleaning; then, a certain amount of the first cleaning liquid is sucked by the syringe 23, and then the sucked first cleaning liquid is pushed into the sampling passage again, thereby performing the second cleaning.
It should be pointed out that, in this application above-mentioned mode, the inner wall of sampling needle washs through the stronger second washing liquid of clean dynamics earlier to wash the sample of remaining on the inner wall, then wash through the first washing liquid of ordinary clean dynamics again, with wasing the second washing liquid of remaining on the inner wall, thereby can carry out comparatively thorough washing to the inner wall of sampling needle, in order to improve the cleanliness of sampling needle inner wall.
Further, the cleaning system for the sampling needle may further include a cleaning swab 24, a liquid pump 25, a waste liquid container 26, and a pipeline connecting the various components of the cleaning system, and a valve disposed in the pipeline.
Wherein, the outer wall 11 of the sampling needle is also provided with a first waste liquid outlet 112 communicated with the sampling channel. When the cleaning system cleans the inner wall of the sampling needle, the generated waste liquid can be discharged from the first waste liquid outlet 112.
Further, the cleaning swab 24 defines a through groove (not shown), and the sidewall is opened with a second cleaning solution inlet 241 and a second waste liquid outlet 242 penetrating the sidewall and communicating with the through groove at an interval. The second cleaning liquid inlet 241 is configured to receive a first cleaning liquid for cleaning the outer wall 11 of the sampling needle, and the second waste liquid outlet 242 is configured to further discharge waste liquid generated by cleaning the inner wall of the sampling needle and waste liquid discharged from the first waste liquid outlet from the through groove of the cleaning swab 24. The second waste liquid outlet 242 is further communicated with the liquid pump 25, and the suction force of the liquid pump 25 generates a suction force to the waste liquid in the swab, thereby facilitating the discharge of the waste liquid from the second waste liquid outlet 242.
Specifically, when the inner wall of the sampling needle is cleaned, the second waste liquid outlet 242 is not lower than the first waste liquid outlet 112 and the second cleaning liquid inlet 241, so that the cleaning liquid and the waste liquid entering the through groove of the cleaning swab 24 receive an upward suction force to prevent the cleaning liquid and the waste liquid from flowing downward out of the through groove of the cleaning swab 24. It should be noted that references to "up," "down," "high," "low," etc. in this application are made in terms of the orientation of the various components under normal operating conditions.
The waste container 26 is further connected to the second waste outlet 242 for receiving and containing waste liquid generated during the washing process by the liquid pump 25. In one application scenario, the sampling needle cleaning system may not include the waste container 26 and may be additionally equipped only when needed, but is not limited thereto.
Wherein, on the cleaning liquid cleaning side of the cleaning system, the conduit may comprise: first line 271, second line 272, third line 273, fourth line 274, fifth line 275, sixth line 276, and seventh line 277, the valves may comprise: a first valve 281, a second valve 282, and a third valve 283, wherein all three valves are three-way valves.
Specifically, one end of the first pipe line 271 communicates with the syringe 23, one side of the first valve 281 is connected to the other end of the first pipe line 271, the other side is connected to one end of the second pipe line 272 and one end of the seventh pipe line 277, one side of the second valve 282 is connected to one end of the second pipe line 272 remote from the first valve 281, the other side is connected to one end of the third pipe line 273 and one end of the fourth pipe line 274, the other end of the third pipe line 273 remote from the second valve 282 communicates with the first cleaning liquid container 21, one side of the third valve 283 is connected to one end of the fourth pipe line 274 remote from the second valve 282, the other side is connected to one end of the fifth pipe line 275 and one end of the sixth pipe line 276, respectively, wherein the other end of the fifth pipe line 275 remote from the third valve 283 communicates with the second cleaning liquid container 22, and the other end of the sixth pipe line 283 communicates with the first cleaning liquid inlet 111 of the sampling needle, further, the other end of the seventh line 277 remote from the first valve 281 communicates with the second washing liquid inlet 241 of the washing swab 24.
On the waste liquid discharge side of the cleaning system, the conduit comprises a waste liquid conduit 278, one end of the waste liquid conduit 278 communicating with the second waste liquid outlet 242 of the cleaning swab 24 and the other end communicating with the waste liquid container 26, wherein the liquid suction pump 25 is arranged on the waste liquid conduit 278 for sucking waste liquid in the waste liquid conduit 278 and the channel through which the waste liquid conduit 278 passes in a direction towards the waste liquid container 26.
The working principle of the sampling needle cleaning system in the embodiment is respectively explained in the following two aspects of cleaning the inner wall of the sampling needle and cleaning the inner wall of the sampling needle:
when the inner wall of the sampling needle is cleaned, the first valve 281 and the second valve 282 are adjusted, so that the first valve 281 connects the first pipeline 271 with the second pipeline 272, the second valve 282 connects the second pipeline 272 with the third pipeline 273, and under the suction action of the syringe 23, the first cleaning liquid in the first cleaning liquid container 21 sequentially enters the syringe 23 along the third pipeline 273, the second valve 282, the second pipeline 272, the first valve 281 and the first pipeline 271 and is stored between the syringe 23 and the second valve 282; then, the second valve 282 and the third valve 283 are adjusted so that the second valve 282 communicates the second line 272 with the fourth line 274, the third valve 283 communicates the fourth line 274 with the fifth line 275, and further, under the suction action of the syringe 23, the second cleaning liquid in the second cleaning liquid container 22 enters along the fifth line 275 and the third valve 283 and is stored in the fourth line 274.
After the first and second cleaning liquids are completely sucked, the third valve 283 is further adjusted to communicate the fourth pipeline 274 with the sixth pipeline 276, then the second cleaning liquid stored in the fourth pipeline 274 enters the sampling channel through the first cleaning liquid inlet 111 along the third and sixth pipelines 283 and 276 in sequence under the pushing action of the injector 23, and cleans the inner wall of the sampling needle to dissolve the residual sample adsorbed on the inner wall of the sampling needle in the second cleaning liquid, and the first cleaning liquid stored between the injector 23 and the second valve 282 enters the sampling channel through the first cleaning liquid inlet 111 along the second, fourth and third pipelines 282, 283 and 276 in sequence, to further clean the inner wall of the sampling needle to flush the residual first cleaning liquid on the inner wall.
During the cleaning process, the liquid pump 25 is started, and under the action of the liquid pump 25, the waste liquid generated by cleaning the inner wall of the sampling needle is discharged into the through groove of the cleaning swab 24 outside the sampling needle through the first waste liquid outlet 112, and further enters the waste liquid pipeline 278 through the second waste liquid outlet 242 of the cleaning swab 24, and further enters the waste liquid container 26 along the waste liquid pipeline 278.
It should be noted that in some applications, if sufficient first cleaning fluid is stored between the syringe 23 and the second valve 282 before the outer wall 11 of the sampling needle is cleaned, no further suction through the syringe 23 may be required. Of course, if sufficient second cleaning liquid is stored in the fourth pipe 274 at the same time, it is not necessary to suck the second cleaning liquid any more.
In addition, the case where the first cleaning solution is stored between the syringe 23 and the second valve 282 may include that the first cleaning solution is stored in the syringe 23, or in both the syringe 23 and the first pipe 271, or in both the syringe 23, the first pipe 271 and the second pipe 272. Of course, further storage in the corresponding valve is also possible.
And the second cleaning solution is stored only in the fourth pipe 274. In this embodiment, since the second cleaning liquid is a corrosive strong alkali or strong acid cleaning liquid, the third valve 283 may be made of a corrosion-resistant material, and the length of the fourth pipeline 274 is set to be not less than a predetermined length so that the distance between the storage position of the second cleaning liquid sucked by the syringe 23 in the fourth pipeline 274 and the second valve 282 is not less than a predetermined distance in order to prevent the second cleaning liquid from contacting the second valve 282 connected to the fourth pipeline 274 or reduce the risk of the second cleaning liquid contacting the second valve 282.
The preset length may be set according to operation experience, installation of equipment, and size requirements, and is not particularly limited herein. In addition, the preset distance is not particularly limited in the present embodiment, as long as the second cleaning liquid stored in the fourth pipe 274 does not contact the second valve 282. Of course, in some application scenarios, the second valve 282 may also be made of a corrosion-resistant material, so as to prevent the second valve 282 from being damaged due to the contact between the second cleaning liquid and the second valve 282 under special circumstances.
When the outer wall 11 of the sampling needle is cleaned, the first valve 281 and the second valve 282 are adjusted so that the first valve 281 connects the first pipeline 271 with the second pipeline 272, the second valve 282 connects the second pipeline 272 with the third pipeline 273, and under the suction action of the syringe 23, the first cleaning solution in the first cleaning solution container 21 sequentially enters the syringe 23 along the third pipeline 273, the second valve 282, the second pipeline 272, the first valve 281, and the first pipeline 271, and is stored between the syringe 23 and the second valve 282.
After the first cleaning liquid is completely sucked, the first valve 281 is further adjusted to communicate the first pipeline 271 with the seventh pipeline 277, and then the first cleaning liquid stored between the syringe 23 and the first valve 281 enters the through groove of the cleaning swab 24 through the second cleaning liquid inlet 241 along the first valve 281 and the seventh pipeline 277 in sequence under the pushing action of the syringe 23, so that the outer wall 11 of the sampling needle is cleaned.
During the cleaning process, the liquid pump 25 is activated, and the waste liquid generated by cleaning the outer wall 11 of the sampling needle passes through the second waste liquid outlet 242 into the waste liquid pipeline 278 under the action of the liquid pump 25, and further enters the waste liquid container 26 along the waste liquid pipeline 278.
It should be noted that, when cleaning the outer wall 11 of the sampling needle, the cleaning swab 24 and/or the sampling needle may be controlled to perform a relative movement in the direction of elongation of the sampling needle, so that the outer wall 11 of the sampling needle may be cleaned more completely.
In addition, in some application scenarios, if the injector 23 and/or the first pipeline 271 have stored enough first cleaning solution before the outer wall 11 of the sampling needle is cleaned, the first cleaning solution can be pushed directly through the injector 23 to clean the outer wall 11 of the sampling needle without further sucking through the injector 23.
It should be noted that, when cleaning the sampling needle, the outer wall 11 of the sampling needle may be cleaned first, or the inner wall of the sampling needle may be cleaned first, and specifically, the cleaning may be performed according to the requirement, and is not limited herein.
Referring to fig. 2, the present application further provides an immunofluorescence analyzer, which includes a sampling needle 10, and a sampling needle 10 cleaning system 20 for cleaning the sampling needle 10.
The related structures, functions, and the like of the sampling needle 10 and the sampling needle 10 cleaning system 20 are the same as those of the embodiment of the sampling needle 10 cleaning system 20 in the present application, and the related details refer to the above embodiment, which is not described herein again.
Referring to fig. 3, the present application further provides a sample analyzer, which includes a sampling needle 30, and a sampling needle 30 cleaning system 40 for cleaning the sampling needle 30.
The related structures, functions, and the like of the sampling needle 30 and the sampling needle 30 cleaning system 40 are the same as those of the embodiment of the sampling needle 30 cleaning system 40 in the present application, and the related details refer to the above embodiment, which is not described herein again.
The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings of the present application or are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.
Claims (10)
1. The utility model provides a sampling needle cleaning system which characterized in that, set up on the outer wall of sampling needle with the first washing liquid entry of sampling channel intercommunication of sampling needle, cleaning system includes:
a first cleaning liquid container for containing a first cleaning liquid;
the second cleaning liquid container is used for containing a second cleaning liquid, wherein the cleaning force of the second cleaning liquid is stronger than that of the first cleaning liquid;
and the liquid extracting and pushing mechanism is respectively connected with the first cleaning liquid container and the second cleaning liquid container, is further connected with the sampling channel through the first cleaning liquid inlet, is used for respectively sucking the first cleaning liquid and the second cleaning liquid from the first cleaning liquid container and the second cleaning liquid container, and further sequentially pushes the second cleaning liquid and the first cleaning liquid into the sampling channel of the sampling needle so as to sequentially utilize the second cleaning liquid and the first cleaning liquid to respectively clean the inner wall of the sampling needle.
2. The cleaning system of claim 1, wherein the liquid extraction and pushing mechanism is a syringe, and wherein between the syringe and the first cleaning liquid container is disposed: the cleaning device comprises a first pipeline, a second pipeline, a third pipeline, a first valve and a second valve, wherein the first valve is connected between the first pipeline and the second pipeline, the second valve is connected between the second pipeline and the third pipeline, one end of the first pipeline, which is far away from the first valve, is communicated with an injector, and one end of the third pipeline, which is far away from the second valve, is communicated with a first cleaning liquid container;
when the injector sucks the first cleaning liquid, the first pipeline is communicated with the second pipeline through the first valve, and the second pipeline is communicated with the third pipeline through the second valve, so that the first cleaning liquid sequentially enters the injector along the third pipeline, the second valve, the second pipeline, the first valve and the first pipeline and is stored between the injector and the second valve.
3. The cleaning system according to claim 2, wherein a fourth line, a fifth line and a third valve are provided between the second valve and the second cleaning liquid container, the third valve is connected between the fourth line and the fifth line, an end of the fourth line remote from the third valve is connected to the second valve, and an end of the fifth line remote from the third valve is communicated with the second cleaning liquid container;
the second valve is a three-way valve, when the injector sucks the second cleaning liquid, the first valve communicates the first pipeline with the second pipeline, the second valve communicates the second pipeline with the fourth pipeline, and the third valve communicates the fourth pipeline with the fifth pipeline, so that the second cleaning liquid enters along the fifth pipeline and the third valve and is stored in the fourth pipeline.
4. The cleaning system of claim 3, wherein the second cleaning solution is a strong acid cleaning solution or a strong alkaline cleaning solution, and the third valve is made of a corrosion-resistant material.
5. The cleaning system of claim 3, wherein the length of the fourth line is no less than a preset length such that the second cleaning fluid drawn by the syringe is spaced no less than a preset distance from the second valve at a storage location within the fourth line.
6. The cleaning system of claim 3, wherein a sixth line is disposed between the third valve and the first cleaning fluid inlet of the sampling needle,
the third valve is a three-way valve, when the inner wall of the sampling needle is cleaned, the first pipeline is communicated with the second pipeline through the first valve, said second valve communicating said second line with said fourth line, said third valve communicating said fourth line with said sixth line, so that the second cleaning solution stored in the fourth pipeline enters the sampling channel along the third valve and the sixth pipeline in sequence and through the first cleaning solution inlet under the pushing of the injector, and the first cleaning solution stored between the injector and the second valve enters the sampling channel along the second valve, the fourth pipeline, the third valve and the sixth pipeline in sequence and through the first cleaning solution inlet, and cleaning the inner wall of the sampling needle by sequentially utilizing the second cleaning liquid and the first cleaning liquid.
7. The cleaning system according to claim 6, further comprising a cleaning swab, wherein the cleaning swab defines a through groove, and a second cleaning solution inlet penetrating through the sidewall and communicating with the through groove is formed on a sidewall of the cleaning swab, and the cleaning swab is configured to be sleeved around the sampling needle through the through groove to clean an outer wall of the sampling needle;
a seventh pipeline is arranged between the second cleaning liquid inlet and the first valve;
the first valve is a three-way valve, and when the outer wall of the sampling needle is cleaned, the first pipeline is communicated with the seventh pipeline through the first valve, so that the first cleaning liquid stored between the injector and the first valve sequentially enters the through groove along the first valve and the seventh pipeline and through the second cleaning liquid inlet under the pushing of the injector, and the outer wall of the sampling needle is cleaned.
8. The cleaning system according to claim 7, wherein a first waste liquid outlet connected to the sampling channel is formed in a side wall of the sampling needle, a second waste liquid outlet penetrating the side wall and communicating with the through groove is formed in a side wall of the cleaning swab, wherein the second waste liquid outlet is spaced from the second cleaning liquid inlet and is not lower than the second cleaning liquid inlet, and the first waste liquid outlet is located between the second cleaning liquid inlet and the second waste liquid outlet in a height direction of the sampling needle when the inner wall of the sampling needle is cleaned;
the cleaning system also comprises a waste liquid container, wherein a waste liquid pipeline for communicating the second waste liquid outlet and the waste liquid container and a liquid pump arranged on the waste liquid pipeline are arranged between the second waste liquid outlet and the waste liquid container;
when the inner wall of the sampling needle is cleaned, the generated waste liquid sequentially passes through the first waste liquid outlet, the second waste liquid outlet and the waste liquid pipeline and enters the waste liquid container under the action of the liquid extracting pump; when being right the outer wall of sampling needle washs under the effect of drawing liquid pump, the waste liquid that produces passes through in proper order the second waste liquid export waste liquid pipeline and get into the waste liquid container.
9. An immune luminescence analyzer, characterized in that, the immune luminescence analyzer includes sampling needle and the sampling needle cleaning system of any one of claims 1-8, wherein, offer the first washing liquid entry that communicates with the sampling channel of the sampling needle on the outer wall of the sampling needle.
10. A sample analyzer, comprising a sampling needle and the sampling needle cleaning system as claimed in any one of claims 1 to 8, wherein the outer wall of the sampling needle is provided with a first cleaning liquid inlet communicated with the sampling passage of the sampling needle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911193459.7A CN112858659B (en) | 2019-11-28 | 2019-11-28 | Sampling needle cleaning system, sample analyzer and immune luminescence analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911193459.7A CN112858659B (en) | 2019-11-28 | 2019-11-28 | Sampling needle cleaning system, sample analyzer and immune luminescence analyzer |
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| CN112858659A true CN112858659A (en) | 2021-05-28 |
| CN112858659B CN112858659B (en) | 2022-10-28 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113695322A (en) * | 2021-08-31 | 2021-11-26 | 中元汇吉生物技术股份有限公司 | Sampling needle cleaning device and cleaning method thereof |
| CN116893131A (en) * | 2023-09-11 | 2023-10-17 | 深圳市帝迈生物技术有限公司 | Flow type sample analyzer and flow chamber cleaning method |
| WO2023207207A1 (en) * | 2022-04-27 | 2023-11-02 | 深圳市帝迈生物技术有限公司 | Sample analysis apparatus and control method therefor |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0511059U (en) * | 1991-07-29 | 1993-02-12 | 日本分光株式会社 | Flow path cleaning device for auto sampler |
| CN206046598U (en) * | 2016-07-08 | 2017-03-29 | 深圳市朗辰医用设备有限公司 | A kind of breast milk composition analyser pipeline washing device |
| CN106546758A (en) * | 2016-09-28 | 2017-03-29 | 长春迪瑞医疗科技股份有限公司 | A kind of Full-automatic chemiluminescence immunoassay analysis meter and its liquid-way system |
| WO2019033312A1 (en) * | 2017-08-16 | 2019-02-21 | 北京普利生仪器有限公司 | Blood analyzer and control method therefor |
| CN110133314A (en) * | 2018-02-08 | 2019-08-16 | 成都深迈瑞医疗电子技术研究院有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN110434128A (en) * | 2018-05-02 | 2019-11-12 | 深圳开立生物医疗科技股份有限公司 | Sampling needle cleaning device and cleaning method |
-
2019
- 2019-11-28 CN CN201911193459.7A patent/CN112858659B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0511059U (en) * | 1991-07-29 | 1993-02-12 | 日本分光株式会社 | Flow path cleaning device for auto sampler |
| CN206046598U (en) * | 2016-07-08 | 2017-03-29 | 深圳市朗辰医用设备有限公司 | A kind of breast milk composition analyser pipeline washing device |
| CN106546758A (en) * | 2016-09-28 | 2017-03-29 | 长春迪瑞医疗科技股份有限公司 | A kind of Full-automatic chemiluminescence immunoassay analysis meter and its liquid-way system |
| WO2019033312A1 (en) * | 2017-08-16 | 2019-02-21 | 北京普利生仪器有限公司 | Blood analyzer and control method therefor |
| CN110133314A (en) * | 2018-02-08 | 2019-08-16 | 成都深迈瑞医疗电子技术研究院有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN110434128A (en) * | 2018-05-02 | 2019-11-12 | 深圳开立生物医疗科技股份有限公司 | Sampling needle cleaning device and cleaning method |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113695322A (en) * | 2021-08-31 | 2021-11-26 | 中元汇吉生物技术股份有限公司 | Sampling needle cleaning device and cleaning method thereof |
| WO2023207207A1 (en) * | 2022-04-27 | 2023-11-02 | 深圳市帝迈生物技术有限公司 | Sample analysis apparatus and control method therefor |
| CN116893131A (en) * | 2023-09-11 | 2023-10-17 | 深圳市帝迈生物技术有限公司 | Flow type sample analyzer and flow chamber cleaning method |
| CN116893131B (en) * | 2023-09-11 | 2024-02-20 | 深圳市帝迈生物技术有限公司 | Flow type sample analyzer and flow chamber cleaning method |
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