CN112881722A - Sample adding needle cleaning liquid path and blood detection instrument - Google Patents
Sample adding needle cleaning liquid path and blood detection instrument Download PDFInfo
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- CN112881722A CN112881722A CN201911209230.8A CN201911209230A CN112881722A CN 112881722 A CN112881722 A CN 112881722A CN 201911209230 A CN201911209230 A CN 201911209230A CN 112881722 A CN112881722 A CN 112881722A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/023—Cleaning the external surface
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/027—Cleaning the internal surfaces; Removal of blockages
- B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
- B08B9/0321—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing using pressurised, pulsating or purging fluid
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
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Abstract
The invention provides a blood detection instrument and a sampling needle cleaning liquid path, wherein the sampling needle cleaning liquid path is used for cleaning the inner wall and/or the outer wall of a sampling needle, and comprises a liquid power device, a selection valve, a first liquid suction pipeline, a first liquid pushing pipeline, a second liquid pushing pipeline, a sixth pipeline and a cleaning swab; the first liquid suction pipeline is connected with the hydraulic power device through a reversing valve; the first liquid pushing pipeline is connected with the sample adding needle through the gate valve; the second liquid pushing pipeline is connected with the liquid inlet end of the cleaning swab through the selective valve; the sixth pipeline is connected with the liquid outlet end of the cleaning swab; the hydrodynamic device is used for: absorbing diluent through a first liquid absorbing pipeline; conveying the diluent to the sampling needle through a first liquid pushing pipeline so as to clean the inner wall of the sampling needle; and the diluent is transmitted to the liquid inlet end of the cleaning swab through the second liquid pushing pipeline so as to clean the outer wall of the sampling needle.
Description
Technical Field
The invention relates to the technical field of medical detection and analysis, in particular to a sample adding needle cleaning solution path and blood detection instrument.
Background
Blood routine and CRP have become the most common combination modality for diagnosis (outpatient) at the early stage of infection.
Among many symptoms of viral infection such as respiratory tract infection and fever, serum amyloid a (saa) is a marker that can be significantly elevated upon viral infection, and has recently come into widespread use for diagnosis of infection.
Among the blood detecting instrument, the application of sample needle can realize that blood sample inhales appearance, divides blood, also can be used to realize the application of sample of reagent simultaneously, and a needle is dual-purpose, can effectively promote sample detection speed, uses the application of sample needle to accomplish simultaneously and adds the action of test agent, can effectively practice thrift reagent cost, avoids reagent to persist in the pipeline for a long time and rotten.
In order to guarantee that the next sample is not carried and polluted in the blood detection and analysis, the inner wall and the outer wall of the sample adding needle need to be cleaned so as to avoid interference on the detection of the next sample.
However, the existing cleaning solution path has a complex structure and a poor cleaning effect, and particularly for the sample adding needle of the latex reagent for detecting the specific protein, the cleaning effect of the conventional diluent is poor, the sample adding needle contacts the specific protein latex reagent for a long time, a large amount of protein antibodies can be attached to the outer wall of the inner wall of the needle, the existing cleaning mode cannot meet the cleaning requirement, and the sample adding needle has great carrying pollution.
Disclosure of Invention
The invention provides a sample adding needle cleaning liquid path and a blood detection instrument, and aims to solve the technical problem that the structure of the existing sample adding needle cleaning liquid path is complex in the prior art.
In order to solve the technical problems, the invention adopts a technical scheme that: providing a cleaning liquid path for a sampling needle:
the sample adding needle cleaning liquid path is used for cleaning the inner wall and/or the outer wall of the sample adding needle, and comprises a liquid power device, a gating valve, a first liquid absorbing pipeline, a first liquid pushing pipeline, a second liquid pushing pipeline, a sixth pipeline and a cleaning swab;
the first liquid suction pipeline is connected with the hydraulic power device through the reversing valve;
the first liquid pushing pipeline is connected with the sample adding needle through the gate valve;
the second liquid pushing pipeline is connected with the liquid inlet end of the cleaning swab through the selective valve;
the sixth pipeline is connected with the liquid outlet end of the cleaning swab;
the hydrodynamic device is used for:
absorbing diluent through the first liquid absorbing pipeline;
conveying the diluent to the sample adding needle through the first liquid pushing pipeline so as to clean the inner wall of the sample adding needle;
and transmitting the diluent to the liquid inlet end of the cleaning swab through the second liquid pushing pipeline so as to clean the outer wall of the sample adding needle.
In order to solve the technical problem, the invention adopts another technical scheme that: providing a blood detection instrument, wherein the blood detection instrument comprises a control analysis module, a sample collection and distribution module, a blood routine measurement module, a specific protein detection module and the sample adding needle cleaning liquid path which are electrically connected;
the sample collection and distribution module is used for collecting blood samples and distributing the blood samples to the blood routine measurement module and the specific protein detection module, and the sample collection and distribution module comprises the sample adding needle;
the specific protein detection module is used for testing specific protein parameters of the blood sample;
the blood routine measurement module is used for testing blood routine parameters of the blood sample.
The invention has the beneficial effects that: different from the situation of the prior art, in the blood detection instrument provided by the invention, the sample adding needle can realize sample sucking and blood separation of a blood sample, and can also be used for sample adding of a reagent, and the sample detection speed can be effectively increased by using one needle for two purposes; the action of adding the reagent is finished by using the sample adding needle, so that the reagent cost can be effectively saved, and the reagent is prevented from being remained in the pipeline for a long time and deteriorating. The sample adding needle cleaning liquid path provided by the invention is simple in structure, comprehensive in function and good in cleaning effect.
The diluent is matched with the cleaning swab to clean the outer wall of the inner wall of the sampling needle, and the mode is suitable for the working condition that the requirement on the cleaning effect is relatively low and extra cleaning liquid is not needed for cleaning; and the sample adding needle moves to the position of the cleaning cup, and the diluent injector sucks and spits cleaning liquid in the cleaning cup to complete cleaning of the inner wall and the outer wall of the sample adding needle. This mode is applicable to and has higher expectations to the cleaning performance, and ordinary diluent washs and can't satisfy the requirement, needs to use extra washing liquid to carry out abluent operating mode. The two cleaning modes can be combined to complete cleaning simultaneously.
The sample adding needle cleaning liquid path provided by the invention integrates two cleaning modes, can be flexibly combined and applied according to specific cleaning requirements, saves cost and resources, and meets the cleaning requirements; the inner wall and the outer wall of the sample adding needle are sucked and discharged in the cleaning cup, the height of the cleaning outer wall can be designed and changed according to actual requirements, the volume of the cleaning cup or the liquid level height of cleaning liquid in the cup can be flexibly adjusted, and various working condition requirements can be met; when the diluent syringe sucks and spits the washing, can adjust the gear of diluent syringe according to the cleaning strength demand, can realize multiple operating mode demand: fast suction and fast push, slow suction and slow push, fast suction and slow push, slow suction and fast push and the like.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the invention, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:
fig. 1 is a schematic view of a liquid path structure of a cleaning liquid path of a sampling needle according to an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive work based on the embodiments of the present invention, are within the scope of the present invention.
It should be noted that, if directional indications (such as up, down, left, right, front, and back … …) are involved in the embodiment of the present invention, the directional indications are only used to explain the relative positional relationship between the components, the movement situation, and the like in a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indications are changed accordingly.
In addition, if there is a description of "first", "second", etc. in an embodiment of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.
Referring to fig. 1, an embodiment of the present invention provides a cleaning liquid path for a sample application needle, the cleaning liquid path is used to clean an inner wall and/or an outer wall of the sample application needle 1, and the cleaning liquid path for the sample application needle includes a liquid power device, a gate valve, a first liquid suction pipeline, a first liquid pushing pipeline, a second liquid pushing pipeline, a sixth pipeline (T10, T11), and a cleaning swab 3.
First imbibition pipeline passes through the switching-over valve to be connected with liquid power device, and first liquid pushing pipe way passes through the gating valve to be connected with application of sample needle 1, and the second liquid pushing pipe way passes through the gating valve to be connected with the feed liquor end of washing swab 3, and sixth pipeline (T10, T11) is connected with the play liquid end of washing swab 3, and liquid power device is used for: the diluent is absorbed by the first liquid absorbing pipeline, the diluent is transmitted to the sample adding needle through the first liquid pushing pipeline so as to clean the inner wall of the sample adding needle, and the diluent is transmitted to the liquid inlet end of the cleaning swab through the second liquid pushing pipeline so as to clean the outer wall of the sample adding needle. The use of the washing swab 3 for washing the outer wall of the sampling needle is well known in the art, and therefore the structure of the washing swab 3 is not described in the present application.
Referring to fig. 1, in an embodiment, the fluid power device includes a first fluid power device 4, the selection valve includes a first selection valve LV02 and a second selection valve LV03, the first suction fluid line includes a first line T4 and a third line T5, the first line T4 connects the first fluid power device 4 with a first direction valve LV02, the third line T5 connects with a first direction valve LV02, the first push fluid line includes a second line T6 and a fourth line T8, the second line T6 connects the first direction valve LV02 with a second direction valve LV03, the fourth line T8 connects the second direction valve LV03 with the sampling needle 1, the second push fluid line includes a fifth line T7, and the fifth line T7 connects the second direction valve LV03 with the inlet of the cleaning swab 3.
Referring to fig. 1, in another embodiment, the fluid power device includes a first fluid power device 4 and a third fluid power device (not shown in the figure), the gate valve includes a first gate valve LV02 and a fifth gate valve (not shown in the figure), the first liquid suction pipeline includes two ways, the first fluid power device 4 and the third fluid power device respectively suck the diluent through one of the ways, the third fluid power device sucks the diluent and transmits the diluent to the sample application needle through the first liquid pushing pipeline to clean the inner wall of the sample application needle 1, and the first fluid power device 4 sucks the diluent and transmits the diluent to the liquid inlet end of the cleaning swab through the second liquid pushing pipeline to clean the outer wall of the sample application needle.
The present embodiment differs from the previous embodiment in that: and an independent liquid power device and a selection valve are separately provided for cleaning the diluent on the inner wall of the sample adding needle 1.
Referring to fig. 1, the embodiment of the invention provides a cleaning solution path for a sample injection needle, which is used to clean an inner wall and/or an outer wall of the sample injection needle 1.
The sample adding needle cleaning liquid path comprises a first liquid power device 4, a first optional valve LV02, a second optional valve LV03, a first pipeline T4, a second pipeline T6, a third pipeline T5, a fourth pipeline T8, a fifth pipeline T7, a sixth pipeline (T10, T11) and a cleaning swab 3. The first pipeline T4 connects the first hydrodynamic device 4 with the first option valve LV02, the second pipeline T6 connects the first option valve LV02 with the second option valve LV03, one end of the third pipeline T5 is connected with the first option valve LV02, the other end of the third pipeline T5 is connected with the diluent bottle 7, the fourth pipeline T8 connects the second option valve LV03 with the sample adding needle 1, the fifth pipeline T7 connects the second option valve LV03 with the liquid inlet end of the cleaning swab 3, and the sixth pipeline (T10, T11) is connected with the liquid outlet end of the cleaning swab 3.
The first hydraulic power unit 4 is used for:
the diluent is sucked by the first pipeline T4, the first gate valve LV02 and the third pipeline T5, and the first liquid power device 4 is also used for transmitting the diluent to the sampling needle 1 by the second pipeline T6, the second gate valve LV03 and the fourth pipeline T8 so as to clean the inner wall of the sampling needle 1.
And the diluent is transmitted to the liquid inlet end of the cleaning swab 3 through the second pipeline T6, the second gating valve LV03 and the fifth pipeline T7 so as to clean the outer wall of the sampling needle 1.
Specifically, the first selecting valve LV02 and the second selecting valve LV03 are three-way selecting valves, a common end of the first selecting valve LV02 is connected to the first hydraulic power device 4 through a first pipeline T4, a normally closed end of the first selecting valve LV02 is connected to a common end of the second selecting valve LV03 through a second pipeline T6, a normally open end of the first selecting valve LV02 is connected to a third pipeline T5, a normally open end of the second selecting valve LV03 is connected to the sample adding needle 1 through a fourth pipeline T8, and a normally closed end of the second selecting valve LV03 is connected to the liquid inlet end of the cleaning swab 3 through a fifth pipeline T7.
Before the diluent is transmitted to the sample application needle 1 through the second pipeline T6, the second gate valve LV03 and the fourth pipeline T8 to clean the inner wall of the sample application needle 1, the needle tip of the sample application needle 1 is located near the liquid outlet end of the cleaning swab 3 to discharge liquid through the liquid outlet end of the cleaning swab 3. When the diluent is transmitted to the liquid inlet end of the cleaning swab 3 through the second pipeline T6, the second gate valve LV03 and the fifth pipeline T7 to clean the outer wall of the sampling needle 1, the sampling needle 1 moves axially relative to the cleaning swab 3. The specific structure of the cleaning swab 3 can refer to the prior art, and the structure does not relate to the invention point, so that the detailed description is omitted in the present application.
In addition, the loading needle cleaning fluid path provided by the application further comprises a third gate valve LV04, a waste liquid pump PP01 and a seventh pipeline T14.
The sixth pipeline (T10, T11) connects the outlet end of the washing swab 3 with the input end of the waste liquid pump PP01, the third gate valve LV04 is connected on the sixth pipeline (T10, T11), specifically can be located between the pipelines T10, T11, the output end of the waste liquid pump PP01 is connected with one end of the seventh pipeline T14, and the other end of the seventh pipeline T14 is connected with the waste liquid barrel 9.
When the diluent is transmitted to the sampling needle 1 through the second pipeline T6, the second gate valve LV03 and the fourth pipeline T8 to clean the inner wall of the sampling needle 1 and transmitted to the liquid inlet end of the cleaning swab 3 through the second pipeline T6, the second gate valve LV03 and the fifth pipeline T7 to clean the outer wall of the sampling needle 1, the third gate valve LV04 is in a conducting state after being electrified, and the waste liquid pump PP01 is electrified to collect the cleaning waste liquid and discharge the cleaning waste liquid to the waste liquid tank 9 through the seventh pipeline T14. The third gate valve LV04 may be a two-way gate valve, and is in a cut-off state when not powered on.
In order to improve the cleaning effect, aiming at the substances which are difficult to clean by adopting the diluent, the sample adding needle can be cleaned by adopting a special cleaning solution. Correspondingly, the cleaning liquid path of the sampling needle further comprises a cleaning cup 6, a second liquid power device 5, a fourth selector valve LV01, an eighth pipeline T1, a ninth pipeline T2, a tenth pipeline T3 and an eleventh pipeline (T12 and T13).
The eighth pipeline T1 connects the second liquid power device 5 with the fourth selective valve LV01, one end of the ninth pipeline T2 with the fourth selective valve LV01, the other end of the ninth pipeline T2 with the cleaning liquid bottle 8, the tenth pipeline T3 connects the fourth selective valve LV01 with the liquid inlet end of the cleaning cup 6, and the eleventh pipeline (T12, T13) with the liquid outlet end of the cleaning cup 6.
The second liquid power means 5 are intended to:
and cleaning liquid is sucked through an eighth pipeline T1, a fourth option valve LV01 and a ninth pipeline T2.
Cleaning liquid is injected into the cleaning cup 6 through the eighth pipeline T1, the fourth optional valve LV01 and the tenth pipeline T3.
The first hydraulic power unit 4 is also adapted to:
the cleaning liquid in the cleaning cup 6 is sucked and spitted through the first pipeline T4, the first gate valve LV02, the second pipeline T6, the second gate valve LV03, the fourth pipeline T8 and the sampling needle 1 so as to clean the inner wall and the outer wall of the sampling needle.
The fourth selective valve LV01 is a three-way selective valve, a common end of the fourth selective valve LV01 is connected with the second liquid power device 5 through an eighth pipeline T1, a normally open end of the fourth selective valve LV01 is connected with the ninth pipeline T2, and a normally closed end of the fourth selective valve LV01 is connected with a liquid inlet end of the cleaning cup 6.
The first hydrodynamic device 4 continues to be used for:
absorbing diluent through a first liquid absorbing pipeline;
conveying a diluent to the sample adding needle 1 through a first liquid pushing pipeline so as to clean the inner wall of the sample adding needle 1;
and the diluent is transmitted to the liquid inlet end of the cleaning swab 3 through a second liquid pushing pipeline so as to clean the outer wall of the sampling needle 1.
I.e. a second diluent wash is performed. The whole process comprises three times of cleaning, and the sequence is as follows: the first time of dilution washing, cleaning solution washing, the second time of dilution washing, wherein the second time of dilution washing is in order to clear away remaining cleaning solution when wasing the cleaning solution.
In addition, the sampling needle cleaning liquid path further comprises a fifth selector valve LV05 and shares the waste liquid pump PP01 and the seventh line T14.
Wherein, the eleventh pipeline (T12, T13) connects the liquid outlet end of the cleaning cup 6 with the input end of the waste liquid pump PP01, the fifth gate valve LV05 is connected on the eleventh pipeline (T12, T13), which can be located between the pipelines T12, T13, the pipeline T11 and the pipeline T13 are connected with the input end of the waste liquid pump PP01 through the three-way joint 10. The fifth gate valve LV05 is a two-way gate valve, and is in a cut-off state when not powered on, and the first and second hydraulic power devices 4 and 5 are syringes or fixed displacement pumps.
The embodiment of the invention also provides a blood detection instrument, which comprises a control analysis module, a sample collection and distribution module, a blood routine measurement module, a specific protein detection module and the sample adding needle cleaning liquid path which are electrically connected, wherein the sample collection and distribution module is used for collecting blood samples and distributing the blood samples to the blood routine measurement module and the specific protein detection module, the sample collection and distribution module comprises a sample adding needle 1, the specific protein detection module is used for testing specific protein parameters, and the blood routine measurement module is used for testing blood routine parameters of the blood samples.
The sample adding needle cleaning liquid path provided by the embodiment of the invention is integrated to realize two cleaning modes:
the diluent is matched with the cleaning swab 3 to clean the outer wall of the inner wall of the sample adding needle 1.
Secondly, the sample adding needle 1 moves to the position of the cleaning cup 6, and the diluent injector 4 sucks and spits cleaning liquid in the cleaning cup 6 to complete cleaning of the outer wall of the inner wall of the sample adding needle 1.
Above two kinds of modes can wash application of sample needle 1 simultaneously, reach double cleaning performance, also can be according to concrete demand, and the application of sample needle 1 of independent action, or use cleaning mode (r), reach demand cleaning performance.
The sample adding needle (sampling needle or reagent needle, which can absorb blood sample or absorb corresponding reagent, such as hemolytic reagent or antibody reagent) cleaning liquid path integrating two cleaning modes comprises a cleaning swab 3, a diluent injector 4, a cleaning liquid injector 5, a cleaning cup 6, a diluent bottle 7, a cleaning liquid bottle 8, a waste liquid barrel 9, a three-way selector valve LV01, a three-way selector valve LV02, a three-way selector valve LV03, a two-way selector valve LV04, a two-way selector valve LV05, a three-way joint 10 and corresponding pipelines.
The cleaning liquid injector 5 is connected with the public end of the three-way selector valve LV01, the normally closed end of the three-way selector valve LV01 is connected with the cleaning cup 6, the normally open end of the three-way selector valve LV01 is connected with the cleaning liquid bottle 7, and the cleaning liquid injector 5 can suck liquid and discharge liquid, and the three-way selector valve LV01 can complete the addition of the cleaning liquid in the cleaning cup 6.
The diluent injector 4 is connected with the common end of the three-way selector valve LV02, the normally closed end of the three-way selector valve LV02 is connected with the common end of the three-way selector valve LV03, the normally open end of the three-way selector valve LV02 is connected with the diluent bottle 7, the normally open end of the three-way selector valve LV03 is connected with the sample adding needle 1, the normally closed end of the three-way selector valve LV03 is connected with the liquid inlet of the cleaning swab 3, the liquid absorption and the liquid discharge of the diluent injector 4 are realized through the switching of the passages of the three-way selector valve LV02, the liquid absorption of the diluent is realized, and the switching of the passages of the three-way selector valve LV03 is matched, so that the first cleaning: the diluent cooperates with the cleaning swab 3 to clean the inner wall and the outer wall of the sample adding needle 1.
The liquid outlet end of the cleaning cup 6 is connected with one end of a two-way selective valve LV05, the other end of the two-way selective valve LV05 is connected with one branch port of a three-way joint 10, the liquid outlet end of the cleaning swab 3 is connected with one end of the two-way selective valve LV04, the other end of the two-way selective valve LV04 is connected with the other branch port of the three-way joint 10, a main port of the three-way joint 10 is connected with the input end of a waste liquid pump PP01, the output end of the waste liquid pump PP01 is connected with a waste liquid barrel 9 through a pipeline T14, the waste liquid pump PP01 provides power, and collection of waste liquid.
Two cleaning modes are specifically realized as follows.
In the mode of firstly, the diluent is matched with the cleaning swab 3 to clean the outer wall of the inner wall of the sample adding needle 1.
The specific process is as follows:
the three-way selector valve LV02 is not electrified, the diluent injector 4 sucks quantitative diluent through the pipeline T5 and stores the diluent in the diluent injector 4, the three-way selector valve LV02 is electrified, the three-way selector valve LV03 is not electrified, the needle tip of the sample injection needle 1 to be cleaned moves to the cleaning swab 3 (the needle tip of the sample injection needle 1 is positioned near the liquid outlet end of the cleaning swab 3), the diluent injector 4 pushes liquid through the pipeline T8, the two-way selector valve LV04 is synchronously electrified, the waste liquid pump PP01 is electrified, and in the process of pushing liquid by the diluent injector 4, the waste liquid pump PP01 finishes collection of cleaning waste liquid through the pipeline T10, and cleaning of the inner wall of the sample injection needle 1 cleaned by the diluent is finished.
The three-way selector valve LV02 is not electrified, the diluent injector 4 sucks quantitative diluent and stores the diluent in the diluent injector 4, the three-way selector valve LV02 is electrified, the three-way selector valve LV03 is electrified, the diluent injector 4 synchronously moves axially relative to the cleaning swab 3 in the liquid pushing process through the pipeline T7, and in the synchronous operation, the two-way selector valve LV04 is electrified synchronously, the waste liquid pump PP01 is electrified, and the waste liquid pump PP01 finishes the collection of cleaning waste liquid through the pipeline T10, so that the cleaning of the outer wall of the diluent cleaning sample needle 1 is finished.
Mode two, application of sample needle 1 moves to and washs cup 6 position, and the washing liquid in the washing cup 6 is inhaled to the diluent syringe and is vomited, accomplishes the washing to application of sample needle 1 inner wall outer wall, and the concrete process is as follows:
the three-way selector valve LV01 is not electrified, the cleaning liquid injector 5 absorbs quantitative cleaning liquid through the pipeline T2 and stores the cleaning liquid in the cleaning liquid injector 5, the three-way selector valve LV01 is electrified, the cleaning liquid injector 5 pushes the cleaning liquid through the pipeline T3 and injects the quantitative cleaning liquid into the cleaning cup 6, the sample adding needle 1 to be cleaned moves to the cleaning cup 6 in the horizontal direction and moves downwards in the vertical direction to a proper cleaning liquid level (ensuring that the sample adding needle 1 is immersed into the cleaning liquid in the cleaning cup 6 to have a high enough height and increase the contact area), the three-way selector valve LV02 is electrified, the three-way selector valve LV03 is not electrified, the diluent injector 4 absorbs quantitative cleaning liquid at a certain level through the sample adding needle 1 (ensuring that the absorbed liquid is stored in the pipeline T9 and is not only the selector valve LV03 and the pipeline T9 multiplexes with the pipe T8 but not an entity pipeline, and only indicates the state when the cleaning liquid is absorbed), and the cleaning, guarantee the cleaning performance, then 4 flowing back of diluent syringe, get back to the washing cup 6 with the washing liquid discharge in application of sample needle 1 and pipeline T9, 4 repeated imbibitions of diluent syringe spit the washing liquid, realize the effect of 1 inner wall outer walls of application of sample needle of washing liquid washing. Meanwhile, the liquid suction and liquid pushing gears of the diluent injector 4 can be controlled, and different cleaning effects can be realized by different gears. In the liquid pushing process, the cleaning liquid in the cleaning cup 6 forms a swirling flow cleaning effect.
After the cleaning solution cleans the sample adding needle 1, the cleaning solution on the inner wall and the outer wall of the sample adding needle 1 can be removed by using the diluent. Specifically, the diluent injector 4 sucks quantitative diluent through a pipeline T5, the diluent is stored in the diluent injector 4, the needle tip of the sampling needle 1 moves to the position of the cleaning swab 3, and in synchronization with the above, the three-way selecting valve LV02 is powered on, the three-way selecting valve LV03 is powered on, the diluent injector 4 pushes the diluent through the pipeline T7, the sampling needle 1 axially moves relative to the cleaning swab 3 in the vertical direction to clean the outer wall of the sampling needle 1, when the needle tip of the sampling needle 1 moves to the liquid outlet end of the cleaning swab 3, the three-way selecting valve LV02 is powered on, the three-way selecting valve LV03 is not powered on, the diluent injector 4 continues to push the diluent through the pipeline T8, and the cleaning liquid remaining on the inner wall of the sampling needle 1 is cleaned.
And finally, electrifying the three-way valve LV05, electrifying the waste liquid pump PP01, and emptying the waste liquid in the cleaning cup 6. The diluent injector 4 sucks quantitative diluent through a pipeline T5, the quantitative diluent is stored in the diluent injector 4, the sample adding needle 1 moves to the cleaning cup 6 again, then the three-way selector valve LV02 is electrified, the diluent injector 4 pushes the diluent through a pipeline T8, and the quantitative diluent is injected into the cleaning cup 6 to serve as base liquid.
The second cleaning mode of the sample adding needle 1 is completed by the operation: namely, the sample adding needle 1 moves to the position of the cleaning cup 6, and the diluent injector 4 sucks and spits the cleaning liquid in the cleaning cup 6 to complete the cleaning of the inner wall and the outer wall of the sample adding needle 1.
The washing operation includes a first washing with a diluent, and an intermediate washing with a second diluent, but those skilled in the art may wash with only the first diluent, only the intermediate washing, only the first washing with the diluent and only the intermediate washing, or both the first washing with the diluent and the intermediate washing with the intermediate washing, depending on the actual conditions.
Wherein the cleaning strength of the cleaning solution to a specific substance is greater than that of the diluent, and the specific substance can be a combination of immunoreaction or a reaction residue.
In the blood detection instrument provided by the invention, the sample adding needle 1 can realize sample suction and blood separation of a blood sample, and can also be used for realizing sample adding of a reagent, and one needle has two purposes, so that the sample detection speed can be effectively improved, and the sample adding needle 1 is used for completing the action of adding the reagent, so that the reagent cost can be effectively saved, and the reagent is prevented from being deteriorated due to long-time retention in a pipeline. Of course, the sample addition needle 1 may be used only for aspirating and separating a blood sample, a separate reagent needle may be used for adding and distributing a reagent, and the reagent needle may be cleaned by the above-described cleaning liquid path.
Adopt the diluent cooperation to wash swab 3 and accomplish the washing to 1 inner wall outer wall of application of sample needle, this mode is applicable to and requires relatively lowly to the cleaning performance, need not to use the abluent operating mode of extra washing liquid, and application of sample needle 1 removes to wasing cup 6 position, and the washing liquid in the dilution syringe 4 imbibition washing cup 6 accomplishes the washing to 1 inner wall outer wall of application of sample needle. This mode is applicable to and has higher expectations to the cleaning performance, and ordinary diluent washs and can't satisfy the requirement, needs to use extra washing liquid to carry out abluent operating mode.
The sampling needle cleaning liquid path provided by the invention integrates two cleaning modes, can be flexibly combined and applied according to specific cleaning requirements, saves cost and resources, and meets the cleaning requirements at the same time, the inner wall and the outer wall of the sampling needle 1 are sucked and discharged in the cleaning cup 6, the height of the cleaning outer wall can be designed and changed according to actual requirements, the volume of the cleaning cup 6 or the liquid level height of cleaning liquid in the cup can be flexibly adjusted, various working condition requirements can be met, when the diluent injector 4 is sucked and discharged for cleaning, the gear of the diluent injector 4 can be adjusted according to the cleaning strength requirements, and various working condition requirements can be realized: fast suction and fast push, slow suction and slow push, fast suction and slow push, slow suction and fast push and the like.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by using the contents of the present specification and the accompanying drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. The utility model provides a application of sample needle cleaning solution way which characterized in that:
the sample adding needle cleaning liquid path is used for cleaning the inner wall and/or the outer wall of the sample adding needle, and comprises a liquid power device, a gating valve, a first liquid absorbing pipeline, a first liquid pushing pipeline, a second liquid pushing pipeline, a sixth pipeline and a cleaning swab;
the first liquid suction pipeline is connected with the hydraulic power device through the reversing valve;
the first liquid pushing pipeline is connected with the sample adding needle through the gate valve;
the second liquid pushing pipeline is connected with the liquid inlet end of the cleaning swab through the selective valve;
the sixth pipeline is connected with the liquid outlet end of the cleaning swab;
the hydrodynamic device is used for:
absorbing diluent through the first liquid absorbing pipeline;
conveying the diluent to the sample adding needle through the first liquid pushing pipeline so as to clean the inner wall of the sample adding needle;
and transmitting the diluent to the liquid inlet end of the cleaning swab through the second liquid pushing pipeline so as to clean the outer wall of the sample adding needle.
2. The cleaning solution path for the sampling needle according to claim 1, characterized in that:
the hydrokinetic device comprises a first hydrokinetic device;
the selective valve comprises a first selective valve and a second selective valve;
the first liquid suction pipeline comprises a first pipeline and a third pipeline, the first pipeline connects the first hydraulic power device with the first reversing valve, and the third pipeline is connected with the first reversing valve;
the first liquid pushing pipeline comprises a second pipeline and a fourth pipeline, the second pipeline connects the first reversing valve with the second reversing valve, and the fourth pipeline connects the second reversing valve with the sample adding needle;
the second liquid pushing pipeline comprises a fifth pipeline, and the fifth pipeline connects the second reversing valve with the liquid inlet end of the cleaning swab;
the first selective valve and the second selective valve are both three-way selective valves;
the public end of the first option valve is connected with the first hydraulic power device through the first pipeline;
the normally closed end of the first option valve is connected with the public end of the second option valve through the second pipeline;
the normally open end of the first option valve is connected with the third pipeline;
the normally open end of the second selector valve is connected with the sampling needle through the fourth pipeline;
and the normally closed end of the second selection valve is connected with the liquid inlet end of the cleaning swab through the fifth pipeline.
3. The cleaning solution path for the sampling needle according to claim 1, characterized in that:
before the diluent is transmitted to the sample adding needle through the first liquid pushing pipeline to clean the inner wall of the sample adding needle, the needle point of the sample adding needle is positioned at the liquid outlet end of the cleaning swab to discharge liquid through the liquid outlet end of the cleaning swab;
when the second liquid pushing pipeline transmits the diluent to the liquid inlet end of the cleaning swab to clean the outer wall of the sample adding needle, the sample adding needle moves axially relative to the cleaning swab.
4. The cleaning solution path for the sampling needle according to claim 2, characterized in that:
the sample adding needle cleaning liquid path also comprises a third gating valve, a waste liquid pump and a seventh pipeline;
the sixth pipeline connects the liquid outlet end of the cleaning swab with the input end of the waste liquid pump;
the third gate valve is connected to the sixth pipeline;
the output end of the waste liquid pump is connected with the seventh pipeline;
when the diluent is transmitted to the sample adding needle through the second pipeline, the second gate valve and the fourth pipeline to clean the inner wall of the sample adding needle and the diluent is transmitted to the liquid inlet end of the cleaning swab through the second pipeline, the second gate valve and the fifth pipeline to clean the outer wall of the sample adding needle, the third gate valve is in a conducting state after being electrified, and meanwhile, the waste liquid pump is electrified to collect cleaning waste liquid and discharge the cleaning waste liquid through the seventh pipeline.
5. The cleaning solution path for the sampling needle according to claim 2, characterized in that: the sample adding needle cleaning liquid path also comprises a cleaning cup, a second liquid power device, a fourth gating valve, an eighth pipeline, a ninth pipeline, a tenth pipeline and an eleventh pipeline;
the eighth pipeline is used for connecting the second liquid power device with the fourth selective valve;
the ninth pipeline is connected with the fourth gate valve;
the tenth pipeline connects the fourth gate valve with the liquid inlet end of the cleaning cup;
the eleventh pipeline is connected with the liquid outlet end of the cleaning cup;
the second liquid power device is used for:
sucking cleaning liquid through the eighth pipeline, the fourth gate valve and the ninth pipeline;
injecting the cleaning liquid into the cleaning cup through the eighth pipeline, the fourth option valve and the tenth pipeline;
the first hydrodynamic device is further configured to:
and sucking and spitting the cleaning liquid in the cleaning cup through the first pipeline, the first gate valve, the second pipeline, the second gate valve, the fourth pipeline and the sample adding needle so as to clean the inner wall and the outer wall of the sampling needle.
6. The loading needle cleaning solution path of claim 5, wherein the first hydrodynamic device continues to:
absorbing diluent through the first liquid absorbing pipeline;
conveying the diluent to the sample adding needle through the first liquid pushing pipeline so as to clean the inner wall of the sample adding needle;
and transmitting the diluent to the liquid inlet end of the cleaning swab through the second liquid pushing pipeline so as to clean the outer wall of the sample adding needle.
7. The cleaning solution path for the sampling needle according to claim 5, wherein:
the fourth gate valve is a three-way gate valve;
the public end of the fourth selective valve is connected with the second liquid power device through the eighth pipeline;
the normally open end of the fourth option valve is connected with the ninth pipeline;
and the normally closed end of the fourth selective valve is connected with the liquid inlet end of the cleaning cup.
8. The cleaning solution path for the sampling needle according to claim 5, wherein:
the sample adding needle cleaning liquid path also comprises a fifth gating valve, a waste liquid pump and a seventh pipeline;
the eleventh pipeline connects the liquid outlet end of the cleaning cup with the input end of the waste liquid pump
The fifth gate valve is connected to the eleventh pipeline;
and the output end of the waste liquid pump is connected with the seventh pipeline.
9. The cleaning solution path for the sampling needle according to claim 1, characterized in that:
the hydraulic power device comprises a first hydraulic power device and a third hydraulic power device;
the selective valve comprises a first selective valve and a fifth selective valve;
the first liquid suction pipeline comprises two paths, and the first hydraulic power device and the third hydraulic power device respectively suck diluent through one path;
after the third liquid power device sucks the diluent, the diluent is transmitted to the sample adding needle through the first liquid pushing pipeline so as to clean the inner wall of the sample adding needle;
the first liquid power device sucks the diluent and then transmits the diluent to the liquid inlet end of the cleaning swab through the second liquid pushing pipeline so as to clean the outer wall of the sample adding needle.
10. A blood testing apparatus, comprising: the blood detection instrument comprises a control analysis module, a sample collection and distribution module, a blood routine measurement module, a specific protein detection module and a sample adding needle cleaning liquid path according to any one of claims 1-9 which are electrically connected;
the sample collection and distribution module is used for collecting blood samples and distributing the blood samples to the blood routine measurement module and the specific protein detection module, and the sample collection and distribution module comprises the sample adding needle;
the specific protein detection module is used for testing specific protein parameters of the blood sample;
the blood routine measurement module is used for testing blood routine parameters of the blood sample.
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| CN201911209230.8A CN112881722A (en) | 2019-11-30 | 2019-11-30 | Sample adding needle cleaning liquid path and blood detection instrument |
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| CN201911209230.8A CN112881722A (en) | 2019-11-30 | 2019-11-30 | Sample adding needle cleaning liquid path and blood detection instrument |
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| CN112881722A true CN112881722A (en) | 2021-06-01 |
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| CN201911209230.8A Pending CN112881722A (en) | 2019-11-30 | 2019-11-30 | Sample adding needle cleaning liquid path and blood detection instrument |
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