CN208705287U - The glycolated hemoglobin analysis of detection accuracy can be improved - Google Patents
The glycolated hemoglobin analysis of detection accuracy can be improved Download PDFInfo
- Publication number
- CN208705287U CN208705287U CN201821427777.6U CN201821427777U CN208705287U CN 208705287 U CN208705287 U CN 208705287U CN 201821427777 U CN201821427777 U CN 201821427777U CN 208705287 U CN208705287 U CN 208705287U
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- China
- Prior art keywords
- valve
- pressure pump
- pump
- mobile phase
- direction changeover
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Links
- 108010054147 Hemoglobins Proteins 0.000 title claims abstract description 13
- 102000001554 Hemoglobins Human genes 0.000 title claims abstract description 13
- 238000001514 detection method Methods 0.000 title claims abstract description 11
- 238000005070 sampling Methods 0.000 claims description 17
- 238000003860 storage Methods 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 11
- 239000002699 waste material Substances 0.000 claims description 8
- 238000004140 cleaning Methods 0.000 claims description 6
- 238000009826 distribution Methods 0.000 abstract description 5
- 102000017011 Glycated Hemoglobin A Human genes 0.000 abstract description 4
- 108010014663 Glycated Hemoglobin A Proteins 0.000 abstract description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model discloses a kind of glycolated hemoglobin analysis that detection accuracy can be improved, equipped with the high-pressure pump to connect respectively with the outlet of two mobile phases and the mixer to connect with two high pressure pump outlets, two mobile phase ratio distribution in the unit time are completed by the flow velocity of two high-pressure pumps of control, no setting is required degasser and proportion magnetic valve, not only simplify device structure, and the problems such as overcoming the inaccurate distribution of mobile phase ratio present in the prior art and poor repeatability, improve the accuracy of glycosylated hemoglobin analysis.
Description
Technical field
The utility model relates to a kind of glycolated hemoglobin analysis, especially a kind of structure is simple, it is quasi- that detection can be improved
The glycolated hemoglobin analysis of true property.
Background technique
Glycosylated hemoglobin is glucose and hemoglobin cross-linking products in blood, when the concentration of glucose in blood is higher
When, it is also just relatively high that human body is formed by saccharification hemoglobin content.Therefore, glycosylated hemoglobin as diabetes screening,
Diagnosis, glycemic control, efficacy assessment effective Testing index, be widely used in clinic.Existing HbAle egg
The principle of white analyzer is identical as high performance liquid chromatograph, and structure is provided with three-way switch valve, and three-way switch valve is respectively with
One syringe pump, the second syringe pump, first liang of direction changeover valve and sampling valve (six tunnel switching valves) connect, with first liang of direction changeover valve phase
It is connected to cleaning liquid storage tank and second liang of direction changeover valve, sampling valve is connected by two direction changeover valve of third with sample introduction needle；There are two if
Mobile phase storage tank, two mobile phase storage tanks pass sequentially through degasser, proportion magnetic valve and a high-pressure pump, and (double plunger is in parallel past
Multiple pump) connect, the output of high-pressure pump passes sequentially through pressure transmitter again, pot strainer connects with sampling valve, and sampling valve leads to again
Chromatographic column is crossed to connect with detector.Existing glycolated hemoglobin analysis is worked in high-pressure pump for mobile phase distribution method
Each channel opening time for the ratio control proportion magnetic valve that the unit time of journey sets according to mobile phase, there are the following problems:
1. due to double plunger and plunger rod that connection reciprocating pump convexity wheel drives is within the unit time and non-continuous imbibition, i.e.,
Make during suction, the movement of plunger rod be also it is nonlinear, aspirate mobile phase speed will appear acceleration, at the uniform velocity and slow down
Three phases, therefore proportion magnetic valve each channel unlatching period appears in above-mentioned different phase, in addition also by response time shadow
It rings, not can guarantee the accuracy and repeatability of mobile phase ratio distribution；If the unlatching period of proportion magnetic valve and double plunger are simultaneously
Cam rotation period in connection reciprocating pump is consistent, then can generate covibration, and then form larger noise, can equally reduce detection
As a result accuracy.
2. mobile phase can generate biggish bubble in the handoff procedure of proportion magnetic valve, into can then be accounted in high-pressure pump
According to flowing phase space, mobile phase ratio is caused to distribute misalignment, therefore need that degasser is arranged before proportion magnetic valve, leads to equipment
Structure is relative complex.
Summary of the invention
The utility model is to solve above-mentioned technical problem present in the prior art, and providing one kind can be improved detection standard
The glycolated hemoglobin analysis of true property.
The technical solution of the utility model is: a kind of glycolated hemoglobin analysis that detection accuracy can be improved,
Equipped with three-way switch valve, three-way switch valve respectively with the first syringe pump, the second syringe pump, first liang of direction changeover valve and sampling valve phase
It connects, is connected to cleaning liquid storage tank and second liang of direction changeover valve with first liang of direction changeover valve, the sampling valve is cut by the way that third two is logical
It changes valve to connect with sample introduction needle, second liang of direction changeover valve connects with the first high-pressure pump and the second high pressure pump inlet respectively, described
The outlet of first high-pressure pump and the second high-pressure pump is connected by waste collection control valve with waste liquid barrel；With the entrance of the first high-pressure pump
It is also connected to the first mobile phase storage tank, is also connected to the second mobile phase storage tank, first high pressure with the entrance of the second high-pressure pump
The outlet of pump and the second high-pressure pump also connects with mixer, and the outlet of the mixer passes through pressure transmitter, pot strainer
Connect with sampling valve, the sampling valve is connected by chromatographic column with detector.
The utility model be equipped with the high-pressure pump that connects respectively with the outlet of two mobile phases and with two high pressure pump outlet phases
The mixer connect completes two mobile phase ratio distribution in the unit time by the flow velocity of two high-pressure pumps of control, and no setting is required
Degasser and proportion magnetic valve not only simplify device structure, and overcome mobile phase ratio present in the prior art
The problems such as distributing inaccurate and poor repeatability improves the accuracy of glycosylated hemoglobin analysis.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model embodiment.
Specific embodiment
The glycolated hemoglobin analysis that detection accuracy can be improved of the utility model is equipped with three-way switch valve 1, threeway
Switching valve 1 connects with the first syringe pump 2,3, first liang of direction changeover valves 4 of the second syringe pump and sampling valve 5 respectively, the first syringe pump 2
It is different from 3 capacity of the second syringe pump；Cleaning liquid storage tank 6 and second liang of direction changeover valve 7, institute are connected to first liang of direction changeover valve 4
State sampling valve 5 and connected with sample introduction needle 9 by two direction changeover valve 8 of third, second liang of direction changeover valve 7 respectively with the first high-pressure pump
10 and 11 entrance of the second high-pressure pump connect, the outlet of first high-pressure pump 10 and the second high-pressure pump 11 passes through waste collection and controls
Valve 12 connects with waste liquid barrel 13；It is also connected to the first mobile phase storage tank 14 with the entrance of the first high-pressure pump 10, with the second high-pressure pump
11 entrance is also connected to the second mobile phase storage tank 15, the outlet of first high-pressure pump 10 and the second high-pressure pump 11 also with mix
Device 16 connects, and the outlet of the mixer 16 is connected by pressure transmitter 17, pot strainer 18 with sampling valve 5, it is described into
Sample valve 5 is connected by chromatographic column 19 with detector 20.
When detection, second liang of direction changeover valve 7 is closed, the first high-pressure pump 10 and the second high-pressure pump 11 extract the first flowing respectively
Mobile phase in phase storage tank 14 and the second mobile phase storage tank 15 controls the flow velocity of the first high-pressure pump 10 and the second high-pressure pump 11, i.e.,
The amount for entering two mobile phases of mixer in the control unit time is proportionally required, realizes the proportional assignment of the two.It
Afterwards by entering detector 20 after pressure transmitter 17, pot strainer 18, sampling valve 5, chromatographic column 19.It can be according to requiring to set
First syringe pump 2 or the work of the second syringe pump 3, extract blood sample by sample introduction needle 9, are mixed into color by sampling valve 5 and mobile phase
Column is composed, detector detection is entered back into.When needing to clean equipment, it can control first liang of direction changeover valve, 4, second liang of direction changeover valves 7
And two direction changeover valve 8 of third, cleaning solution is extracted by the first syringe pump 2 or the second syringe pump 3 and cleans sample introduction needle 9, by the first high pressure
Pump 10 and the second high-pressure pump 11 extract cleaning solution respectively and clean to the other parts of glycolated hemoglobin analysis, open useless
Liquid collects control valve 12, collects waste liquid by waste liquid barrel 13.
Claims (1)
1. a kind of glycolated hemoglobin analysis that detection accuracy can be improved is equipped with three-way switch valve (1), three-way switch valve
(1) connect respectively with the first syringe pump (2), the second syringe pump (3), first liang of direction changeover valve (4) and sampling valve (5), with first
Two direction changeover valves (4) are connected to cleaning liquid storage tank (6) and second liang of direction changeover valve (7), and the sampling valve (5) is logical by third two
Switching valve (8) connects with sample introduction needle (9), it is characterised in that: second liang of direction changeover valve (7) respectively with the first high-pressure pump (10)
And second high-pressure pump (11) entrance connect, the outlet of first high-pressure pump (10) and the second high-pressure pump (11) passes through waste collection
Control valve (12) connects with waste liquid barrel (13)；It is also connected to the first mobile phase storage tank (14) with the entrance of the first high-pressure pump (10),
The second mobile phase storage tank (15), first high-pressure pump (10) and the second high pressure are also connected to the entrance of the second high-pressure pump (11)
The outlet of pump (11) also connects with mixer (16), and the outlet of the mixer (16) passes through pressure transmitter (17), online mistake
Filter (18) connects with sampling valve (5), and the sampling valve (5) is connected by chromatographic column (19) with detector (20).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821427777.6U CN208705287U (en) | 2018-09-03 | 2018-09-03 | The glycolated hemoglobin analysis of detection accuracy can be improved |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821427777.6U CN208705287U (en) | 2018-09-03 | 2018-09-03 | The glycolated hemoglobin analysis of detection accuracy can be improved |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208705287U true CN208705287U (en) | 2019-04-05 |
Family
ID=65945795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821427777.6U Withdrawn - After Issue CN208705287U (en) | 2018-09-03 | 2018-09-03 | The glycolated hemoglobin analysis of detection accuracy can be improved |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208705287U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109060992A (en) * | 2018-09-03 | 2018-12-21 | 大连技嘉科技有限公司 | The glycolated hemoglobin analysis of detection accuracy can be improved |
-
2018
- 2018-09-03 CN CN201821427777.6U patent/CN208705287U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109060992A (en) * | 2018-09-03 | 2018-12-21 | 大连技嘉科技有限公司 | The glycolated hemoglobin analysis of detection accuracy can be improved |
| CN109060992B (en) * | 2018-09-03 | 2024-02-27 | 苏州博睿嘉晟医疗科技有限公司 | Glycosylated hemoglobin analyzer capable of improving detection accuracy |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200610 Address after: 215011 building 2-2-211, No.2, Peiyuan Road, high tech Zone, Suzhou City, Jiangsu Province Patentee after: Suzhou Borui Jiasheng Medical Technology Co.,Ltd. Address before: 116000 north side of No. 20, AI Xian street, hi tech Industrial Park, Dalian, Liaoning. Patentee before: DALIAN JIJIA TECHNOLOGY Co.,Ltd. |
|
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20190405 Effective date of abandoning: 20240227 |
|
| AV01 | Patent right actively abandoned |
Granted publication date: 20190405 Effective date of abandoning: 20240227 |