CN108845056A - A kind of on-line automatic pretreating device of aflatoxin based on flow path switching - Google Patents
A kind of on-line automatic pretreating device of aflatoxin based on flow path switching Download PDFInfo
- Publication number
- CN108845056A CN108845056A CN201810872220.1A CN201810872220A CN108845056A CN 108845056 A CN108845056 A CN 108845056A CN 201810872220 A CN201810872220 A CN 201810872220A CN 108845056 A CN108845056 A CN 108845056A
- Authority
- CN
- China
- Prior art keywords
- way valves
- sample
- flow path
- path switching
- line automatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930195730 Aflatoxin Natural products 0.000 title claims abstract description 32
- 239000005409 aflatoxin Substances 0.000 title claims abstract description 32
- XWIYFDMXXLINPU-UHFFFAOYSA-N Aflatoxin G Chemical compound O=C1OCCC2=C1C(=O)OC1=C2C(OC)=CC2=C1C1C=COC1O2 XWIYFDMXXLINPU-UHFFFAOYSA-N 0.000 title claims abstract description 31
- 239000000523 sample Substances 0.000 claims abstract description 53
- 238000004140 cleaning Methods 0.000 claims abstract description 29
- 239000012488 sample solution Substances 0.000 claims abstract description 28
- 238000005191 phase separation Methods 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 11
- 239000002699 waste material Substances 0.000 claims description 6
- 239000000945 filler Substances 0.000 claims description 4
- 230000002572 peristaltic effect Effects 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 3
- 238000005213 imbibition Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 238000004458 analytical method Methods 0.000 abstract description 11
- 238000012545 processing Methods 0.000 abstract description 7
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 3
- 238000002203 pretreatment Methods 0.000 description 7
- 238000001514 detection method Methods 0.000 description 6
- 239000007791 liquid phase Substances 0.000 description 5
- QRARGUIFAGCOOA-UHFFFAOYSA-N aspertoxin Chemical compound O1C2=C(C3(C=COC3O3)O)C3=CC(OC)=C2C(=O)C2=C1C=CC=C2OC QRARGUIFAGCOOA-UHFFFAOYSA-N 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 3
- 238000009795 derivation Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 3
- 235000017060 Arachis glabrata Nutrition 0.000 description 2
- 244000105624 Arachis hypogaea Species 0.000 description 2
- 235000010777 Arachis hypogaea Nutrition 0.000 description 2
- 235000018262 Arachis monticola Nutrition 0.000 description 2
- 241000209140 Triticum Species 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 239000012149 elution buffer Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 235000020232 peanut Nutrition 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000228197 Aspergillus flavus Species 0.000 description 1
- 241000228230 Aspergillus parasiticus Species 0.000 description 1
- 208000003643 Callosities Diseases 0.000 description 1
- PQMOXTJVIYEOQL-UHFFFAOYSA-N Cumarin Natural products CC(C)=CCC1=C(O)C(C(=O)C(C)CC)=C(O)C2=C1OC(=O)C=C2CCC PQMOXTJVIYEOQL-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- FSOGIJPGPZWNGO-UHFFFAOYSA-N Meomammein Natural products CCC(C)C(=O)C1=C(O)C(CC=C(C)C)=C(O)C2=C1OC(=O)C=C2CCC FSOGIJPGPZWNGO-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028520 Mycotoxicosis Diseases 0.000 description 1
- 231100000006 Mycotoxicosis Toxicity 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000082085 Verticillium <Phyllachorales> Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 125000004852 dihydrofuranyl group Chemical class O1C(CC=C1)* 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
Abstract
A kind of on-line automatic pretreating device of aflatoxin based on flow path switching, including the changeable flow path being made of two multiple-way valves, I, two multiple-way valve II, syringe pump and multiple sample solutions, cleaning solution, pretreatment column is connected in two multiple-way valves I, quantitative loop is connected in two multiple-way valves II, two multiple-way valves I are connected between syringe pump and two multiple-way valves II；When changeable flow path cleaning finishes sample introduction, switch the access of two multiple-way valves, I, two multiple-way valve II, sample solution successively passes through syringe pump, two multiple-way valves I and pretreatment column, two multiple-way valves II and quantitative loop and completes sample introduction；Two II switched paths of multiple-way valve after completion sample introduction utilize flowing phase separation to carry out sample sample presentation.The utilization rate of processing sample can be improved in the present invention；The dosage for reducing reagent reduces the cost of analysis.
Description
Technical field
The invention belongs to technical field of chromatographic analysis, and in particular to a kind of aflatoxin based on flow path switching is online certainly
Dynamic pretreating device.
Background technique
In chromatographic analysis system, if having interfering substance in delivery sample or testing sample solution or being not intended to
Impurity composition when, the detection characteristic and precision of sample can be seriously affected, in some instances it may even be possible to cause sample to be tested detection failure.
Aflatoxin (AFT) is the similar compound of a kind of chemical structure, is the derivative of dihydrofuran cumarin.It is yellow
Aspertoxin is mainly the secondary metabolite generated by aspergillus flavus aspergillus parasiticus, is occurred in damp-heat area food and feed yellow
The probability highest of aspertoxin.They are present in soil, animals and plants, in various nuts, be especially easy pollution peanut, corn,
The grain oil products such as rice, soybean, wheat are that mycotoxicosis is maximum, mould to human health risk one kind extremely outstanding
Verticillium toxin.Therefore, its detection efficiently and quickly is identified, to guarantee people's life health and safe important in inhibiting.
Detection, the analysis of aflatoxin, traditional processing mode is all first to handle sample introduction again, the processing utilization rate of sample
Only 1% or so, utilization rate is lower, reagent dosage is big, analysis cost is high.
Disclosed in Chinese patent (Authorization Notice No. CN202522549U) " a kind of Full-automatic aflatoxin analytic system ",
Including：One Full-automatic solid phase extraction system is used to carry out Solid Phase Extraction；One two six-way valves, in be equipped with a trapping column, two
There are six mouth, trapping column is connected between third mouth and the 6th mouthful position six-way valve tool, the 5th mouthful of connection full-automatic solid phase
The output of extracting system, the 4th mouthful of one waste liquid bottle of connection；One highly effective liquid phase chromatographic system a comprising liquid-phase chromatographic column, a column
Deriving device, one first infusion pump and a fluorescence detector, liquid-phase chromatographic column are connected with the first of two six-way valves afterwards, and first
Second mouthful of infusion pump and two six-way valves is connected, the post-column derivation device and the liquid-phase chromatographic column phase
Even, for carrying out post-column derivation to chromatography column effluent, the fluorescence detector is connected with the post-column derivation device, uses
In progress fluorescence detection.
The analysis system uses switching valve and trapping column, and a Full-automatic solid phase extraction system and one are equipped with automatic column
The highly effective liquid phase chromatographic system of deriving device and fluorescence detector carries out online afterwards, by the automation for controlling software realization system
Analysis operation.Wherein, full-automatic extraction equipment is equivalent to the pre-processing device of aflatoxins toxin sample solution, but the processing side
Formula is complex, and limited to the cleaning of extraction equipment, therefore, still remains the lower problem of sample utilisation.
Summary of the invention
The present invention is a kind of on-line automatic pretreating device of aflatoxin based on flow path switching, for aflatoxin
The particularity of pre-treatment realizes a kind of new on-line automatic pretreating device based on flow path switching, utilizes aflatoxin and base
The matrix of aflatoxin in complicated substrate is eliminated, realizes the online of various samples by reservation difference of the body on pretreatment column
Pretreatment.
In order to achieve the object of the present invention, using following technical scheme：
A kind of on-line automatic pretreating device of aflatoxin based on flow path switching, including by two multiple-way valve I, two
The changeable flow path that multiple-way valve II, syringe pump and multiple sample solutions, cleaning solution are constituted, the sample solution and cleaning solution switching
It is completed by matched device with sample introduction function, syringe pump carries out imbibition and sample introduction switching by triple valve, described more than two
It is connected with pretreatment column in port valve I, quantitative loop is connected in two multiple-way valves II, two multiple-way valves I are connected on syringe pump and two
Between the multiple-way valve II of position；The sample solution, the outlet of cleaning solution and syringe pump inlet communication, the outlet two of syringe pump
Position I entrance of multiple-way valve；When changeable flow path cleaning finishes sample introduction, switch the access of two multiple-way valves, I, two multiple-way valve II, sample
Product solution successively passes through syringe pump, two multiple-way valves I and pretreatment column, two multiple-way valves II and quantitative loop and completes sample introduction；
Two II switched paths of multiple-way valve after completion sample introduction utilize flowing phase separation to carry out sample sample presentation.
In order to further realize the purpose of the present invention, following technical scheme can also be used：
A kind of on-line automatic pretreating device of aflatoxin based on flow path switching as described above, the pretreatment column
For Multifunctional cleanup column or immune affinity column.
A kind of on-line automatic pretreating device of aflatoxin based on flow path switching as described above, the pretreatment column
In be provided with the filler of filtration.
A kind of on-line automatic pretreating device of aflatoxin based on flow path switching as described above, two multi-pass
I, two multiple-way valve II of valve is two ten-way valves or two six-way valves.
A kind of on-line automatic pretreating device of aflatoxin based on flow path switching according to claim 1,
It is characterized in that, two multiple-way valves, I, two II access of multiple-way valve is switched to Electronic control.
A kind of on-line automatic pretreating device of aflatoxin based on flow path switching as described above, two multi-pass
I, two multiple-way valve II of valve, which corresponds on the position mouthful that cleaning solution cleaning is discharged, connects collection vessel.
A kind of on-line automatic pretreating device of aflatoxin based on flow path switching as described above, the collection vessel
For waste liquid bottle.
A kind of on-line automatic pretreating device of aflatoxin based on flow path switching as described above, two multi-pass
Valve I, which is connected with, carries out reversed regenerated peristaltic pump for pretreatment column.
Compared with prior art, the beneficial effects of the invention are as follows：
1, the utilization rate of processing sample can be improved in the present invention, this pretreating device only handles the sample of the ul rank of analysis
Product, sample utilisation are high；The dosage for reducing reagent reduces the cost of analysis.
2, pretreatment column can need to select Multifunctional cleanup column or immune affinity column according to sample.Pretreatment column is repeatable
It uses, and renewable；And the use of consumptive material in analytic process is reduced, it further reduces the cost.
3, two multiple-way valves of the invention, I, two multiple-way valve II can use two ten-way valves, two six-way valves or class
The function is realized like multiple valve groups conjunction of effect, with a variety of pretreatment technologies of compatibility and a variety of processing modes；Meanwhile it can basis
The difference of sample matrices, flexible combination collocation use, to guarantee the efficiency and sample utilisation of processing.
Detailed description of the invention
Fig. 1 is system composition schematic diagram of the invention.
Appended drawing reference：1- sample solution 1,2- sample solution 2,3- sample solution 3,4- cleaning solution, 5- syringe pump, 6- threeway
Valve, bis- multiple-way valves I of 7-, 71- pretreatment column, bis- multiple-way valves II of 8-, 81- quantitative loop, 9- chromatographic column, 10- detector, 11-
Sample introduction pipeline, 12- peristaltic pump, 13- waste liquid bottle.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, below in conjunction with attached drawing of the invention, to this hair
Bright technical solution is clearly and completely described, it is clear that and described embodiments are some of the embodiments of the present invention, without
It is whole embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not before making creative work
Every other embodiment obtained is put, shall fall within the protection scope of the present invention.
As shown in Figure 1, a kind of on-line automatic pre-treatment dress of aflatoxin based on flow path switching disclosed in the present embodiment
It sets, it is changeable including what is be made of two multiple-way valves, I 7, two multiple-way valves II 8, syringe pump 5 and multiple sample solutions, cleaning solution 4
Flow path.
Sample solution, cleaning solution 4 are arranged in the import of syringe pump 5, sample solution and cleaning solution switching by it is mating have into
The device of sample function is completed, and syringe pump carries out imbibition by triple valve and sample introduction switches, and passes through existing switching device, such as three
Port valve 6 and control unit cooperation, realize cleaning and respectively sample introduction.It is connected with pretreatment column 71 in two multiple-way valves I 7, two
Quantitative loop 81 is connected in multiple-way valve II 8.
Two multiple-way valves I 7 are connected between syringe pump 5 and two multiple-way valves II 8, sample solution, cleaning solution 4 outlet with
The inlet communication of syringe pump 5, two I 7 entrances of multiple-way valve of outlet of syringe pump 5, syringe pump 5 is by triple valve 6 to sample
Solution and cleaning solution 4 realize feed liquor switching.
When changeable flow path cleaning finishes sample introduction, switch the access of two multiple-way valves, I 7, two multiple-way valves II 8, sample is molten
Liquid successively passes through 71, two multiple-way valves II 8 of 5, two multiple-way valves I 7 of syringe pump and pretreatment column and quantitative loop 81 complete into
Sample.
Two II 8 switched paths of multiple-way valve after completion sample introduction send sample by sample introduction pipeline 11 using flowing phase separation
Sample detection, analysis, complete the automatic pre-treatment of sample.
Two multiple-way valves, I 7, two multiple-way valves II 8 are two ten-way valves or two six-way valves, and clean and arrange in cleaning solution 4
Collection vessel is connected on position mouthful out；Collection vessel uses waste liquid bottle, convenient for being collected to cleaning solution 4, emissions operation.
The state of two sets of two six-way valves in following embodiment is location A, dotted line with the display connection of solid line shown in Fig. 1
Display connection is B location.Two six-way valves are switched over by Electronic control in A, B location, to change sample solution, cleaning
The flow path of liquid 4.
Embodiment 1：
Sample relatively simple for matrixes such as peanut, wheat, corns, pretreatment column 71 uses Multifunctional cleanup column, right
Sample solution carries out purification post analysis.
As shown in Figure 1, sample solution has three tunnels, respectively sample solution 1, sample solution 2, sample solution 3, cleaning solution 4
For pure water, setting is arranged in 6 inlet side of triple valve, two multiple-way valves I 7 in 6 outlet side of triple valve, utilizes syringe pump 5 or multi-pass
Valve, autosampler complete the switching of three road sample solutions, cleaning solution 4.Chromatographic column 9 uses model C18 series filler, pre- to locate
It manages column 71 and uses SHAC-2 series filler.
In use, two multiple-way valves II 8 are located at position shown in Fig. 1 firstly, two multiple-way valves I 7 are shifted to B location
It is constant, pretreatment column 71, quantitative loop 81 etc. are cleaned using pure water；After cleaning, two multiple-way valves II 8 switch to B
Position, syringe pump 5 draw suitable sample solution, two multiple-way valves I 7 are then injected into, by the pretreatment of Multifunctional cleanup column
After column 71, into the quantitative loop 81 of two multiple-way valves II 8；After completing sample introduction, two multiple-way valves II 8 switch to location A, then
Sample is separated in the case where flowing phase separation by chromatographic column 9, is analyzed into fluorescence detector 10.
Embodiment 2：
The sample relative complex for matrix, pretreatment column 71 use immune affinity column or have the pre-treatment of similar function
Column carries out purification post analysis to sample solution.
As shown in Figure 1, before syringe pump 5 and two multiple-way valves, I 7, two multiple-way valves II 8 are same as Example 1.
In use, two multiple-way valves II 8 are located at shown in Fig. 1 A firstly, two multiple-way valves I 7 are switched to B location
It sets, syringe pump 5 draws appropriate amount of sample, the aflatoxin for being then injected into two I 7 cocurrents of multiple-way valve through pre-treatment column, in sample
It is pretreated the absorption of column 71；Syringe pump 5 sucks suitable elution buffer, is then injected into two multiple-way valves I 7 and pre-treatment column
It is sufficiently displaced from original sample.Static 1min elutes elution buffer sufficiently the aflatoxin that pre-treatment is adsorbed,
Two multiple-way valves II 8 switch to B location, and syringe pump 5 continues buffer elution liquid being pushed into two multiple-way valves II 8 and its quantitative loop
In.After completing sample introduction, two multiple-way valves II 8 switch to location A, carry out analysis detection.
Two multiple-way valves I 7 switch to location A, and peristaltic pump 12 provides regenerated liquid, reversed flushing is carried out to pretreatment column 71
Regeneration；Regenerated liquid after flushing, in the correspondence position of location A mouthful, is collected into waste liquid bottle 13 by two multiple-way valves I 7.
The technology contents of the not detailed description of the present invention are well-known technique.
Claims (8)
1. a kind of on-line automatic pretreating device of aflatoxin based on flow path switching, including by two multiple-way valves more than I, two
Port valve II, syringe pump and multiple sample solutions, cleaning solution constitute changeable flow path, the sample solution and cleaning solution switching by
The matched device with sample introduction function is completed, and syringe pump carries out imbibition by triple valve and sample introduction switches, which is characterized in that institute
It states and is connected with pretreatment column in two multiple-way valves I, quantitative loop is connected in two multiple-way valves II, two multiple-way valves I are connected on note
It penetrates between pump and two multiple-way valves II；The sample solution, the outlet of cleaning solution and syringe pump inlet communication, syringe pump go out
Mouth two I entrances of multiple-way valve of connection；When changeable flow path cleaning finishes sample introduction, switch two multiple-way valves, I, two multiple-way valve II
Access, it is complete that sample solution successively passes through syringe pump, two multiple-way valves I and pretreatment column, two multiple-way valves II and quantitative loop
At sample introduction；Two II switched paths of multiple-way valve after completion sample introduction utilize flowing phase separation to carry out sample sample presentation.
2. a kind of on-line automatic pretreating device of aflatoxin based on flow path switching according to claim 1, special
Sign is that the pretreatment column is Multifunctional cleanup column or immune affinity column.
3. a kind of on-line automatic pretreating device of aflatoxin based on flow path switching according to claim 1 or 2,
It is characterized in that, the filler of filtration is provided in the pretreatment column.
4. a kind of on-line automatic pretreating device of aflatoxin based on flow path switching according to claim 1, special
Sign is that two multiple-way valves, I, two multiple-way valve II is two ten-way valves or two six-way valves.
5. a kind of on-line automatic pretreating device of aflatoxin based on flow path switching according to claim 1, special
Sign is that two multiple-way valves, I, two II access of multiple-way valve is switched to Electronic control.
6. a kind of on-line automatic pretreating device of aflatoxin based on flow path switching according to claim 1, special
Sign is that two multiple-way valves, I, two multiple-way valve II, which corresponds on the position mouthful that cleaning solution cleaning is discharged, connects collection vessel.
7. a kind of on-line automatic pretreating device of aflatoxin based on flow path switching according to claim 6, special
Sign is that the collection vessel is waste liquid bottle.
8. a kind of on-line automatic pretreating device of aflatoxin based on flow path switching according to claim 1, special
Sign is that two multiple-way valves I, which are connected with, carries out reversed regenerated peristaltic pump for pretreatment column.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810872220.1A CN108845056A (en) | 2018-08-02 | 2018-08-02 | A kind of on-line automatic pretreating device of aflatoxin based on flow path switching |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810872220.1A CN108845056A (en) | 2018-08-02 | 2018-08-02 | A kind of on-line automatic pretreating device of aflatoxin based on flow path switching |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108845056A true CN108845056A (en) | 2018-11-20 |
Family
ID=64195349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810872220.1A Pending CN108845056A (en) | 2018-08-02 | 2018-08-02 | A kind of on-line automatic pretreating device of aflatoxin based on flow path switching |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108845056A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109738410A (en) * | 2019-01-29 | 2019-05-10 | 依利特(苏州)分析仪器有限公司 | It is a kind of for detecting the automation equipment and method of mycotoxin |
| CN112557537A (en) * | 2020-11-30 | 2021-03-26 | 姚凡 | Mycotoxin automatic checkout device |
| CN114994223A (en) * | 2022-04-29 | 2022-09-02 | 天津博纳艾杰尔科技有限公司 | Automatic sample injection liquid path system and automatic sample injection method |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101513576A (en) * | 2009-02-19 | 2009-08-26 | 浙江大学 | On-line film abstractor combined with ion chromatography |
| CN103235074A (en) * | 2013-03-30 | 2013-08-07 | 浙江大学 | High performance liquid chromatography online analysis method and application thereof |
| JP2015015118A (en) * | 2013-07-04 | 2015-01-22 | 株式会社日立ハイテクノロジーズ | Sample introduction device |
| CN204989120U (en) * | 2015-08-03 | 2016-01-20 | 上海磐合科学仪器股份有限公司 | Mycotoxin pretreatment and online sampling device |
| CN105891391A (en) * | 2016-06-29 | 2016-08-24 | 天津博纳艾杰尔科技有限公司 | Automatic sampling device |
| CN106153785A (en) * | 2015-04-09 | 2016-11-23 | 上海磐合科学仪器股份有限公司 | A kind of online sample introduction of aflatoxin analyzes method |
| CN106290603A (en) * | 2016-07-19 | 2017-01-04 | 浙江树人大学 | A kind of utilize Vavle switching method to detect the inorganic anion in plant, organic acid and the method for three kinds of phytochemicalss and application simultaneously |
| CN106645502A (en) * | 2017-02-27 | 2017-05-10 | 天津出入境检验检疫局动植物与食品检测中心 | Ion chromatograph based on multi-valve switching and for offline and online analysis and detection method of ion chromatograph |
| CN206876657U (en) * | 2017-05-11 | 2018-01-12 | 中国科学院西北高原生物研究所 | A kind of Accelerate solvent extraction instrument LC-MS instrument combined apparatus |
| CN208636264U (en) * | 2018-08-02 | 2019-03-22 | 山东省农业科学院农业质量标准与检测技术研究所 | A kind of on-line automatic pretreating device of aflatoxin based on flow path switching |
-
2018
- 2018-08-02 CN CN201810872220.1A patent/CN108845056A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101513576A (en) * | 2009-02-19 | 2009-08-26 | 浙江大学 | On-line film abstractor combined with ion chromatography |
| CN103235074A (en) * | 2013-03-30 | 2013-08-07 | 浙江大学 | High performance liquid chromatography online analysis method and application thereof |
| JP2015015118A (en) * | 2013-07-04 | 2015-01-22 | 株式会社日立ハイテクノロジーズ | Sample introduction device |
| CN106153785A (en) * | 2015-04-09 | 2016-11-23 | 上海磐合科学仪器股份有限公司 | A kind of online sample introduction of aflatoxin analyzes method |
| CN204989120U (en) * | 2015-08-03 | 2016-01-20 | 上海磐合科学仪器股份有限公司 | Mycotoxin pretreatment and online sampling device |
| CN105891391A (en) * | 2016-06-29 | 2016-08-24 | 天津博纳艾杰尔科技有限公司 | Automatic sampling device |
| CN106290603A (en) * | 2016-07-19 | 2017-01-04 | 浙江树人大学 | A kind of utilize Vavle switching method to detect the inorganic anion in plant, organic acid and the method for three kinds of phytochemicalss and application simultaneously |
| CN106645502A (en) * | 2017-02-27 | 2017-05-10 | 天津出入境检验检疫局动植物与食品检测中心 | Ion chromatograph based on multi-valve switching and for offline and online analysis and detection method of ion chromatograph |
| CN206876657U (en) * | 2017-05-11 | 2018-01-12 | 中国科学院西北高原生物研究所 | A kind of Accelerate solvent extraction instrument LC-MS instrument combined apparatus |
| CN208636264U (en) * | 2018-08-02 | 2019-03-22 | 山东省农业科学院农业质量标准与检测技术研究所 | A kind of on-line automatic pretreating device of aflatoxin based on flow path switching |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109738410A (en) * | 2019-01-29 | 2019-05-10 | 依利特(苏州)分析仪器有限公司 | It is a kind of for detecting the automation equipment and method of mycotoxin |
| CN109738410B (en) * | 2019-01-29 | 2021-11-12 | 依利特(苏州)分析仪器有限公司 | Automated device and method for detecting mycotoxins |
| CN112557537A (en) * | 2020-11-30 | 2021-03-26 | 姚凡 | Mycotoxin automatic checkout device |
| CN114994223A (en) * | 2022-04-29 | 2022-09-02 | 天津博纳艾杰尔科技有限公司 | Automatic sample injection liquid path system and automatic sample injection method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108845056A (en) | A kind of on-line automatic pretreating device of aflatoxin based on flow path switching | |
| CN102262060A (en) | Method and device for analyzing heavy metal elements by on-line enrichment and atomic absorption spectrum | |
| CN103235074B (en) | High performance liquid chromatography online analysis method and application thereof | |
| CN208636264U (en) | A kind of on-line automatic pretreating device of aflatoxin based on flow path switching | |
| CN101726437A (en) | On-line enrichment system of organic pollutants in water body | |
| CN105606753A (en) | FAE (field assisted extraction)-separation and enrichment-chromatographic analysis on-line combination equipment | |
| CN104034817A (en) | Ion chromatography on-line pretreatment for measuring glyphosate in genetically modified soybean oil | |
| CN102967495B (en) | Sample pretreatment device and sample treatment method | |
| CN107589190A (en) | The double SPE high performance liquid chromatography on-line coupling equipment of large volume sample injection | |
| CN109959741B (en) | Dual-channel online analysis pretreatment and offline analysis integrated liquid chromatograph and application method thereof | |
| CN109959742B (en) | Online analysis pretreatment and offline analysis integrated liquid chromatograph and use method thereof | |
| CN210690498U (en) | Chromatographic system for alternately and reversely cleaning chromatographic column by counting | |
| CN211877889U (en) | Chromatograph-mass spectrometer | |
| CN209858493U (en) | Dual-channel online analysis pretreatment and offline analysis integrated liquid chromatograph | |
| JPS6250659A (en) | Introducing method for sample into liquid chromatography | |
| CN209858494U (en) | Online analysis pretreatment and offline analysis integrated liquid chromatograph | |
| CN207457159U (en) | More flux liquid-phase chromatographic column circle irrigation systems | |
| CN209858497U (en) | Pretreatment and analysis integrated device for online detection of benzo (a) pyrene in hot-pressed vegetable oil | |
| CN202886166U (en) | Sample pretreatment device | |
| CN110286175A (en) | A kind of multidimensional on-line solid phase extraction liquid-chromatography apparatus | |
| CN110286173A (en) | Liquid-chromatography apparatus is used in a kind of detection of blood concentration | |
| CN113341030A (en) | High-throughput liquid chromatography-mass spectrometry system and separation and analysis method | |
| CN110455942A (en) | A kind of online Ultra Performance Liquid Chromatography instrument of three-dimensional | |
| CN208705287U (en) | The glycolated hemoglobin analysis of detection accuracy can be improved | |
| CN101982769B (en) | Cutting, sub-sampling and purifying device and method for gel chromatography purifying system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20231018 Address after: 250100 No. 23788, Gongye North Road, Licheng District, Jinan City, Shandong Province Applicant after: SHANDONG ACADEMY OF AGRICULTURAL SCIENCES Applicant after: QINGDAO SHENGHAN CHROMATOGRAPHY TECHNOLOGY Co.,Ltd. Address before: 250100 No. 202 industrial North Road, Shandong, Ji'nan Applicant before: INSTITUTE OF QUALITY STANDARDS & TESTING TECHNOLOGY FOR AGRO-PRODUCTS OF SHANDONG ACADEMY OF AGRICULTURAL SCIENCES Applicant before: QINGDAO XINGUANG ZHIYUAN ENVIRONMENT TECHNOLOGY Co.,Ltd. |