CN211877889U - Chromatograph-mass spectrometer - Google Patents
Chromatograph-mass spectrometer Download PDFInfo
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- CN211877889U CN211877889U CN202020296871.3U CN202020296871U CN211877889U CN 211877889 U CN211877889 U CN 211877889U CN 202020296871 U CN202020296871 U CN 202020296871U CN 211877889 U CN211877889 U CN 211877889U
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- 238000004949 mass spectrometry Methods 0.000 claims abstract description 25
- 239000007788 liquid Substances 0.000 claims abstract description 17
- 239000002699 waste material Substances 0.000 claims abstract description 16
- 238000004140 cleaning Methods 0.000 claims abstract description 5
- 239000012530 fluid Substances 0.000 claims description 3
- 230000001066 destructive effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 abstract description 9
- 238000012423 maintenance Methods 0.000 abstract description 8
- 238000001819 mass spectrum Methods 0.000 description 10
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Abstract
The utility model provides a chromatographic-mass spectrometry combined device, which comprises a chromatographic column, a detector and a mass spectrometer; a plurality of buffer units for enriching and storing the sample discharged from the detector; the first switching unit is used for enabling the outlet of the detector to be selectively communicated with each temporary storage unit; the driving unit is used for sending the samples in each temporary storage unit to the second switching unit; the second switching unit is used for enabling the sample conveyed to the second switching unit to selectively communicate the mass spectrometer and the waste liquid pool; the waste liquid pool is used for containing a sample or a cleaning liquid. The utility model has the advantages of low maintenance cost, high detection efficiency, accurate result and the like.
Description
Technical Field
The utility model relates to a mass spectrometry, in particular to chromatogram mass spectrum allies oneself with uses device.
Background
The ultraviolet detector is used as a detector commonly matched with the liquid chromatogram, and has low maintenance cost and wide application range. But the application of uv detectors has limitations:
1. the mobile phase without background absorption is selected as far as possible, otherwise, larger background absorption is easily generated, and the quantitative accuracy is lower when trace substances are detected.
2. The uv detector cannot completely distinguish between substances having absorption peaks of similar frequencies, and further detection by mass spectrometry is required. The existing chromaticness detection method generally only has the function of solvent delay, a specific substance needing to be detected cannot be selected, and all components in a sample must be subjected to mass spectrometry. However, mass spectrometers are prone to contamination, require vacuum during maintenance, and are complex in procedure. That is, the existing chromatography-mass spectrometry combination not only improves the maintenance cost of the mass spectrum, reduces the service life of the mass spectrum, but also reduces the analysis efficiency.
SUMMERY OF THE UTILITY MODEL
For solving not enough among the above-mentioned prior art scheme, the utility model provides a maintenance volume is little, detection efficiency is high, the accurate chromatogram-mass spectrum combined use device of result.
The utility model aims at realizing through the following technical scheme:
the device comprises a chromatographic column, a detector and a mass spectrometer; the chromatography-mass spectrometry combined device comprises:
a plurality of buffer units for enriching and storing the sample discharged from the detector;
the first switching unit is used for enabling the outlet of the detector to be selectively communicated with each temporary storage unit;
the driving unit is used for sending the samples in the temporary storage units to the second switching unit;
a second switching unit for selectively communicating the sample delivered to the second switching unit with the mass spectrometer and the waste liquid pool;
a waste reservoir for holding a sample or a cleaning fluid.
Compared with the prior art, the utility model discloses the beneficial effect who has does:
1. the maintenance amount is small;
only target components exceeding a threshold value in an analysis sample after chromatographic analysis enter a mass spectrum, and non-target components in the sample cannot enter the mass spectrum analysis, so that the frequency of mass spectrum pollution is reduced, and the mass spectrum maintenance amount and the maintenance cost are reduced;
2. the detection efficiency is high;
the content of the target component is obtained by using the detector, if the content exceeds the threshold value, the target component in the temporary storage unit is required to be conveyed to mass spectrometry, namely whether mass spectrometry is required to be sent or not is determined according to the detection result of the chromatogram, so that the mass spectrometry result is more direct and clear, the data processing steps are reduced, and the detection efficiency is improved;
3. the detection result is accurate;
target components in the sample are enriched through the enrichment column and then enter mass spectrometry, so that the detection result is more accurate.
Drawings
The disclosure of the present invention will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only intended to illustrate the technical solution of the present invention and are not intended to limit the scope of the present invention. In the figure:
FIG. 1 is a simplified schematic diagram of a chromatography-mass spectrometry apparatus according to an embodiment of the present invention;
fig. 2 is another state diagram of a chromatography-mass spectrometry combination device according to an embodiment of the present invention.
Detailed Description
Fig. 1-2 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and reproduce the invention. For the purpose of teaching the present invention, some conventional aspects have been simplified or omitted. Those skilled in the art will appreciate variations or substitutions from these embodiments that will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Accordingly, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.
Example 1:
fig. 1-2 schematically show a simplified structure of a chromatography-mass spectrometry combination device according to embodiment 1 of the present invention, which, as shown in fig. 1-2, includes:
a chromatographic column 11, a detector 21 and a mass spectrometer 51, wherein the detector 21 is a non-destructive detector, such as an ultraviolet detector, a conductivity detector, a differential refraction detector or a fluorescence detector;
a plurality of buffer units 71-72 such as enrichment columns, the plurality of buffer units 71-72 for enriching and storing the sample discharged from the detector 21;
the first switching unit 31 is used for enabling the outlet of the detector 21 to be selectively communicated with each temporary storage unit 71-72, so that when the sample discharged by the detector 21 enters one temporary storage unit, the other temporary storage units are cleaned;
a driving unit 41-42, such as a pump, for sending the sample in each of the buffer units 71-72 to the second switching unit 33 and sending the cleaning liquid to the buffer units 71-72 at different times;
a second switching unit 33, the second switching unit 33 being for selectively communicating the mass spectrometer 51 and the waste liquid pool 61 with the sample delivered to the second switching unit 33;
a waste reservoir 61, said waste reservoir 61 for containing a sample or a cleaning fluid.
In order to enrich the sample, elute the enrichment column and wash the enrichment column in time, further, the chromatography-mass spectrometry combination device further comprises:
the flow path selection units 32 and 34 are respectively provided with the temporary storage units 71 to 72; the flow path selection units 32 and 34 are respectively connected with the first switching unit 31, the waste liquid pool 61 and the second switching unit 33; the outlet of the first switching unit 31 is selectively communicated with and without the waste liquid tank 61 through the temporary storage units 71-72 by switching of the flow path selection unit, and the driving units 41-42 are selectively communicated with and without the second switching unit 33 through the temporary storage units 71-72.
Example 2:
according to the utility model discloses embodiment 1's chromatogram mass spectrum allies oneself with application example of device.
In this application example, as shown in fig. 1-2, the chromatographic column 11 employs a liquid chromatographic separation column to separate an input liquid sample; the detector 21 is a nondestructive conductivity detector; the first switching unit 31 and the second switching unit 33 respectively adopt four-way valves, and the first flow path selecting unit 32 and the second flow path selecting unit 34 both adopt six-way valves; the temporary storage units 71-72 adopt enrichment columns which are respectively arranged between two ports of the first flow path selection unit 32 and the second flow path selection unit 34; the four ports of the first switching unit 31 are connected to the detector 21, the first flow path selection unit 32, the third pump 43, and the second flow path selection unit 34, respectively; the port of the first flow path selection unit 32 is connected to the waste liquid tank 61, the first pump 41, the second switching unit 33, and the first switching unit 31; the port of the second switching unit 33 is connected to the mass spectrometer 51, the waste liquid pool 61, the first flow path selection unit 32, and the second flow path selection unit 34; the second pump 42, the waste liquid tank 61, the first switching unit 31, and the second switching unit 33 are connected to ports of the second flow path selecting unit 34.
The working state of the chromatography-mass spectrometry device in this embodiment is:
initial state: as shown in fig. 1, ab-bit communication and cd-bit communication of the first switching unit 31; the ab bit of the first flow path selection unit 32 is communicated with the cd bit of the second flow path selection unit 34, and the ef bit is communicated with the cd bit; the ad bit of the second switching unit 33 is communicated, and the bc bit is communicated;
and (4) termination state: as shown in fig. 2, the first switching unit and the second switching unit remain unchanged; the af bit, bc bit and de bit of the first and second flow path selection units 34 are communicated.
Example 3:
according to the utility model discloses embodiment 1's chromatogram mass spectrum allies oneself with application example of device is different with embodiment 2:
the first switching unit adopts a three-way valve, and a third pump is omitted.
Claims (9)
1. The device comprises a chromatographic column, a detector and a mass spectrometer; the method is characterized in that: the chromatography-mass spectrometry combined device comprises:
a plurality of buffer units for enriching and storing the sample discharged from the detector;
the first switching unit is used for enabling the outlet of the detector to be selectively communicated with each temporary storage unit;
the driving unit is used for sending the samples in the temporary storage units to the second switching unit;
a second switching unit for selectively communicating the sample delivered to the second switching unit with the mass spectrometer and the waste liquid pool;
a waste reservoir for holding a sample or a cleaning fluid.
2. The chromatography-mass spectrometry combination apparatus of claim 1, wherein: the temporary storage unit is an enrichment column.
3. The chromatography-mass spectrometry combination apparatus of claim 1, wherein: the chromatography-mass spectrometry device further comprises:
the temporary storage units are respectively arranged on the flow path selection units; the flow path selection unit is respectively connected with the first switching unit, the waste liquid pool and the second switching unit.
4. The chromatography-mass spectrometry combination apparatus of claim 3, wherein: the driving unit adopts a pump and is communicated with the flow path selection unit.
5. The chromatography-mass spectrometry combination apparatus of claim 3, wherein: the outlet of the first switching unit is selectively communicated with the waste liquid pool through and without the temporary storage unit through the switching of the flow path selection unit, and the driving unit is selectively communicated with the second switching unit through and without the temporary storage unit.
6. The chromatography-mass spectrometry combination apparatus of claim 1, wherein: the driving unit is communicated with the first switching unit.
7. The chromatography-mass spectrometry combination apparatus of claim 1, wherein: the detector is a non-destructive detector.
8. The chromatography-mass spectrometry combination apparatus of claim 7, wherein: the detector is an electrical conductivity detector or a differential refraction detector or a fluorescence detector or an ultraviolet detector.
9. The chromatography-mass spectrometry combination apparatus of claim 3, wherein: the first switching unit, the second switching unit and the flow path selection unit all adopt multi-way valves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020296871.3U CN211877889U (en) | 2020-03-11 | 2020-03-11 | Chromatograph-mass spectrometer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020296871.3U CN211877889U (en) | 2020-03-11 | 2020-03-11 | Chromatograph-mass spectrometer |
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| Publication Number | Publication Date |
|---|---|
| CN211877889U true CN211877889U (en) | 2020-11-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202020296871.3U Active CN211877889U (en) | 2020-03-11 | 2020-03-11 | Chromatograph-mass spectrometer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112595789A (en) * | 2020-12-17 | 2021-04-02 | 广州禾信仪器股份有限公司 | Multifunctional gas chromatography-mass spectrometry device and analysis method |
| CN113899598A (en) * | 2021-09-25 | 2022-01-07 | 杭州谱育科技发展有限公司 | Atmospheric navigation monitoring system and method |
-
2020
- 2020-03-11 CN CN202020296871.3U patent/CN211877889U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112595789A (en) * | 2020-12-17 | 2021-04-02 | 广州禾信仪器股份有限公司 | Multifunctional gas chromatography-mass spectrometry device and analysis method |
| CN112595789B (en) * | 2020-12-17 | 2021-10-15 | 广州禾信仪器股份有限公司 | Multifunctional gas chromatography-mass spectrometry device and analysis method |
| CN113899598A (en) * | 2021-09-25 | 2022-01-07 | 杭州谱育科技发展有限公司 | Atmospheric navigation monitoring system and method |
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Address after: West side of 1st floor, 1st floor, Building A, No. 288 Jingu Middle Road (East), Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee after: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region after: China Address before: Room 304, D Building, Kexin Building, 655 Xueshi Road, Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee before: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region before: China |
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