CN109444450A - A kind of whole blood sample automatic sampling apparatus - Google Patents
A kind of whole blood sample automatic sampling apparatus Download PDFInfo
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- CN109444450A CN109444450A CN201811609671.2A CN201811609671A CN109444450A CN 109444450 A CN109444450 A CN 109444450A CN 201811609671 A CN201811609671 A CN 201811609671A CN 109444450 A CN109444450 A CN 109444450A
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- sample
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- blood sample
- whole blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1418—Depression, aspiration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
- G01N2001/386—Other diluting or mixing processes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Hydrology & Water Resources (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention relates to a kind of whole blood sample automatic sampling apparatus, it may include sample disc, shaft, drive motor, barcode recognizer, sampling assemble, wash needle assemblies and controller, sample disc is removably attached in shaft and circumferentially have multiple elastic clamping grooves, elastic clamping groove is for clamping the sample cell for accommodating blood sample to be detected, drive motor and shaft are drivingly connected and are run according to the instruction of controller, barcode recognizer is mounted to the sample cell bar code in alignment sample disc, to identify bar code and be sent to controller, sampling assemble includes sampling probe and actuating mechanism, actuating mechanism is acted according to controller order-driven sampling probe, sampling probe is from extraction blood sample in the sample cell for being located at sampling station and injects in integrated reagent card accordingly, needle assemblies are washed for sufficiently washing to the inside and outside wall of sampling probe, eliminate the intersection of sample room Pollution.The present invention can be realized multitube whole blood sample and be automatically performed standing, identification, uniform, sampling and sample-adding.
Description
Technical field
The present invention relates to blood testing equipment fields, more particularly to a kind of whole blood sample automatic sampling apparatus.
Background technique
In to samples such as human vein blood, peripheral bloods in the instant detection process of object, need directly to use whole blood sample
Sample detection.Traditional instant detection manual operations, adds whole blood sample, therefore there is no problem by hand.
It is numerous based on China human mortality, it is often overstaffed in scenes such as situation of all-level hospitals outpatient service, emergency treatment, department's outpatient services.By
Limited in the critical or time limit leave of absence to attend to public affairs of the pain of disease, the state of an illness, patient often expect it is vertical etc. can examine and can control, this is real
It needs.The method of traditional diagnostic check serum, plasma sample, can not achieve vertical etc. can survey of detection immediately can examine and can control.?
This numerous samples, numerous indexs scene under realize that high-throughput full-automatic detection immediately is very important.
Different from serum (slurry) sample, whole blood sample standing is easy to be layered.And whole blood sample detection has to protect
It is uniform representative to demonstrate,prove sample, it is necessary to need before sample detection uniform to sample.That is, between sample stands, mixes, samples
The automation process for realizing linkage, can realize the uniform sampling of whole blood sample and detection.Therefore, it is necessary to a realization whole blood samples
It stands, identification, mix, the device of sampling and sample-adding realizes this process.
Summary of the invention
The present invention is intended to provide a kind of whole blood sample that can be realized stands, identification, mixes, the whole blood sample of sampling and sample-adding
Automatic sampling apparatus.For this purpose, the specific technical solution that the present invention uses is as follows:
A kind of whole blood sample automatic sampling apparatus, it may include sample disc, shaft, drive motor, barcode recognizer, sampling
Component washes needle assemblies and controller, and the sample disc is removably attached in shaft and circumferentially have multiple elasticity
Clip slot, the elastic clamping groove drive for clamping the sample cell for accommodating blood sample to be detected, the drive motor and the shaft
It connects and is run according to the instruction of the controller, the barcode recognizer is mounted to the sample cell being aligned in the sample disc
Bar code, to identify bar code and be sent to the controller, the sampling assemble includes sampling probe and actuating mechanism, the cause
The movement of motivation structure sampling probe according to the controller order-driven, the sampling probe is from the sample cell for being located at sampling station
It extracts blood sample and injects in the integrated Reagent Tube of corresponding integrated reagent card, the needle assemblies of washing are for the inside and outside wall to sampling probe
Sufficiently washing, eliminates the cross contamination of sample room.
Further, the whole blood sample automatic sampling apparatus further includes protection plate, and the protection plate and the sample disc are coaxial
And the sample disc is surrounded, the side of the protection plate opens up a sample tap, the sample disc on the position of the sampling station
It rotates so that sample cell to be detected is directed at the sample tap.
Further, the barcode recognizer is fixed on the outside of the protection plate, in the previous station of sampling station
Position.
Further, the sampling probe includes metal needle tubing and piston, and the metal needle interior wall is smooth, the piston cloth
It sets and is equipped with cleaning solution channel in the metal needle tubing and in its piston rod.
Further, the actuating mechanism includes plunger actuation component and three shaft mechanical arms, the plunger actuation component
For linear reciprocating actuating member, the metal needle tubing is fixed on the three shaft mechanicals arm.
Still further, the plunger actuation component is electric pushrod.
Further, it is described wash needle assemblies include inner wall washing pipeline, outer wall washing liquid pipeline, bottle for handling liquid toilet or cosmetic substance, lotion pumps,
Rinse bath, waste pipe, waste liquid bottle and waste drains pump, inner wall washing pipeline one end is connected to the cleaning solution channel, another
The outlet at end and the lotion pumps, outer wall washing pipeline one end are connected to the flushing liquid injection port in the rinse bath,
The outlet of the other end and the lotion pumps, the import of the lotion pumps are connected to the bottle for handling liquid toilet or cosmetic substance, and the rinse bath gives up
Liquid outlet is connected to the waste liquid bottle by the waste pipe and the waste drains pump.
Still further, the rinse bath is funnel-shaped, the side rinsed liquid injection port and be arranged in the rinse bath
On, the waste liquid outlet is arranged in bottom.
Still further, the quantity for rinsing liquid injection port is two or four, is arranged symmetrically in the rinse bath
On side.
The present invention by adopting the above technical scheme, when having the beneficial effect that the present invention can fully ensure that sampling, sample
It is uniform and representative；And by the measuring samples detection project before sampling, integrated, whole blood sample is mixed integrally joins with sample introduction
Dynamic identification and operation, improve detection efficiency, guarantee testing process reliability.
Detailed description of the invention
To further illustrate that each embodiment, the present invention are provided with attached drawing.These attached drawings are that the invention discloses one of content
Point, mainly to illustrate embodiment, and the associated description of specification can be cooperated to explain the operation principles of embodiment.Cooperation ginseng
These contents are examined, those of ordinary skill in the art will be understood that other possible embodiments and advantages of the present invention.In figure
Component be not necessarily to scale, and similar component symbol is conventionally used to indicate similar component.
Fig. 1 is the schematic diagram of whole blood sample automatic sampling apparatus of the invention；
Fig. 2 is the sample disc structural schematic diagram of whole blood sample automatic sampling apparatus shown in FIG. 1；
Fig. 3 is the protection plate structural schematic diagram of whole blood sample automatic sampling apparatus shown in FIG. 1.
Specific embodiment
Now in conjunction with the drawings and specific embodiments, the present invention is further described.
Referring to figs. 1 to 3, a kind of whole blood sample automatic sampling apparatus may include sample disc 1, protection plate 2, shaft 3, drive motor
4, barcode recognizer 5, sampling assemble, wash needle assemblies and controller (not shown) etc..
Sample disc 1 can be made of stainless steel metal material, disk sample, can unload and load after a upper disk has detected and not examine
The sample disc of sample.That is, sample disc 1 is removably secured (for example, passing through bolt) in shaft 3.Sample disc 1 is by bottom disk 11
It is constituted with parallel circle 12.There are several engraved structures of equal distribution on bottom disk 11, flexible clip slot 13 on engraved structure, with
Clamp sample cell 10.Engraved structure identify the bar code on sample cell 10 can by barcode recognizer 5.
Protection plate 2 is coaxial with sample disc 1 and surrounds sample disc 1, is formed by continuously closing edge sealing (side) 21 and bracket 22.Envelope
Side 21 is equipped with sample tap 23 on the position of sampling station, and the upper cover (rubber stopper) of sample cell 10 is passed in and out for sampling probe 61.It takes
Sample mouth 23 is less than the rubber stopper of sample cell 10, takes away so that sample cell 10 is barred from protection plate 2 without being sampled needle 61.Bracket 22
Between be engraved structure, the engraved structure is corresponding with the engraved structure in sample disc 1, so that barcode recognizer 5 can recognize
Bar code on sample cell 10 to be detected.It should be noted that in other embodiments, protection plate 2 also can be omitted.
Shaft 3 and drive motor 4 are drivingly connected.Drive motor 4 is electrically connected with the controller, the instruction issued according to controller
Operation.Specifically, on the one hand after the bar code that barcode recognizer 5 reads sample cell 10,4 drive shaft 3 of drive motor (and because
This sample disc 1) a few are rotated with fast speed, so that the blood sample in sample cell 10 is uniformly mixed, sampled for next station；Separately
On the one hand, after sample cell 10 samples, the rotation of 4 drive shaft 3 (and therefore sample disc 1) of drive motor will be to
The sample cell 10 of detection rotates forward to sampling station.
Barcode recognizer 5 is fixed on the outside of protection plate, in the position of the previous station of sampling station.Barcode recognizer
The bar code of 5 identification measuring samples pipes 10 is simultaneously sent to controller, and controller obtains project to be checked according to received bar code,
On the one hand start integrated reagent card 8 and load integrated varieties of reagent corresponding with project to be checked and quantity, on the other hand starting driving
Motor 4 rotates measuring samples pipe 10, is uniformly mixed the blood sample in sample cell 10.
The sampling assemble be one can three-dimensional motion the accurate automatic sucking of energy and filling whole blood sample metal needle knot
Structure, including sampling probe 61 and actuating mechanism 62.61 intensity of sampling probe is sufficiently high, can pierce sample quality control 10 rubber stopper and from its
Middle extraction whole blood sample.61 inner wall smooth of sampling probe, capable of washing, not adsorption sample ingredient.Specifically, sampling probe 61 includes metal
Needle tubing 611 and piston 612, piston 612 are arranged in metal needle tubing 611 and are equipped with cleaning solution channel in its piston rod 613
614.Therefore, washing lotion can enter metal needle tubing 611 from cleaning solution channel 614, to clean to 611 inner wall of metal needle tubing.
The movement of the sampling probe 61 according to the controller order-driven of actuating mechanism 62, sampling probe 61 sample the sample of station from being located at
Blood sample is extracted in pipe 10 and is injected in the integrated Reagent Tube of corresponding integrated reagent card 8.It is all same patient in integrated reagent card 8
The sample index to be detected, therefore to same integrated reagent card 8 other integrated Reagent Tubes sample when, it is not necessary to washing take
Sample needle 61 can so be saved the time.Specifically, actuating mechanism 62 includes plunger actuation component 621 and three shaft mechanical arms 622,
In, plunger actuation component 621 is linear reciprocating actuating member (for example, electric putter), and metal needle tubing 611 is fixed on three axis
On mechanical arm 622, three shaft mechanical arms 622 are controlled by controller, and therefore, it is dynamic that metal needle tubing 611 can complete sampling, washing etc.
Make.
The needle assemblies of washing eliminate the cross contamination of sample room for sufficiently washing to the inside and outside wall of sampling probe.Specifically,
The needle assemblies of washing include inner wall washing pipeline 71, outer wall washing liquid pipeline 72, bottle for handling liquid toilet or cosmetic substance 73, lotion pumps 74, rinse bath 75, give up
Fluid catheter 76, waste liquid bottle 77 and waste drains pump 78 etc..Inner wall washing pipeline 71, cleaning solution channel 614, bottle for handling liquid toilet or cosmetic substance 73 and lotion pumps 74
For being washed to 61 inner wall of sampling probe.Outer wall washing pipeline 72, rinse bath 75, bottle for handling liquid toilet or cosmetic substance 73 and lotion pumps 74 are used for taking
61 outer wall of sample needle is washed.
Rinse bath 75, which is equipped with, rinses liquid injection port 751 and waste liquid outlet 752, and washing lotion is sprayed from liquid injection port 751 is rinsed, to sampling
61 outer wall of needle is washed, waste liquid from waste liquid outlet 752 leave rinse bath 75 drain into via waste pipe 76 and waste drains pump 78 it is useless
In liquid bottle 77.In the shown embodiment, rinse bath 75 is funnel-shaped, and two flushing liquid injection ports 751 are arranged symmetrically in rinse bath 751
Side on, waste liquid outlet 752 is arranged in bottom.Certainly, rinse bath 75 is not limited to shown configuration, for example, rinsing liquid injection port 751
Quantity can be four or more.
Now briefly explain the course of work of whole blood sample automatic sampling apparatus of the invention.Sample cell 10 will be installed
Sample disc 1 passes through on bolt fixed rotating shaft 3；When the rotation of sample cell 10 in sample disc 1 to 5 corresponding position of barcode recognizer
When, barcode recognizer 5 reads the sample cell bar code and is sent to controller, and controller identifies the item to be checked of corresponding sample
Mesh, starting integrated card loads the integrated reagent of project to be checked, and send to designated position；Meanwhile sample disc 1 quickly rotates for several weeks simultaneously
Advance to sampling station；Sampling assemble movement, the blood of sample cell 10 is extracted by several times and is injected into the corresponding of integrated reagent card 8
In integrated Reagent Tube；After one sample of the completion all sampling of project to be checked, sampling probe 61 is moved to by three shaft mechanical arms
In rinse bath 75, starts lotion pumps, the inside and outside wall of sampling probe is sufficiently washed；Sampling probe 61 returns to sampling station, waits next
The detection of sample cell samples；After so completing whole disk sample disc sample detection, sample disc is removed, it is to be checked to change another
Sample disc executes the sample-adding sampling of new sample disk.
Although specifically showing and describing the present invention in conjunction with preferred embodiment, those skilled in the art should be bright
It is white, it is not departing from the spirit and scope of the present invention defined by the appended claims, it in the form and details can be right
The present invention makes a variety of changes, and is protection scope of the present invention.
Claims (9)
1. a kind of whole blood sample automatic sampling apparatus, which is characterized in that including sample disc, shaft, drive motor, bar code recognition
Device, sampling assemble wash needle assemblies and controller, and the sample disc is removably attached in shaft and circumferentially have more
A elastic clamping groove, the elastic clamping groove is for clamp the sample cell for accommodating blood sample to be detected, the drive motor and described turn
Axis is drivingly connected and is run according to the instruction of the controller, and the barcode recognizer is mounted to be aligned in the sample disc
Sample cell bar code, to identify bar code and be sent to the controller, the sampling assemble includes sampling probe and actuating mechanism,
The movement of actuating mechanism sampling probe according to the controller order-driven, the sampling probe sample the sample of station from being located at
Blood sample is extracted in quality control and is injected in the integrated Reagent Tube of corresponding integrated reagent card, and the needle assemblies of washing are for sampling probe
Inside and outside wall sufficiently washs, and eliminates the cross contamination of sample room.
2. whole blood sample automatic sampling apparatus as described in claim 1, which is characterized in that further include protection plate, the protection plate with
The sample disc is coaxial and surrounds the sample disc, and the side of the protection plate opens up a sampling on the position of the sampling station
Mouthful, the sample disc rotates so that sample cell to be detected is directed at the sample tap.
3. whole blood sample automatic sampling apparatus as claimed in claim 2, which is characterized in that the barcode recognizer is fixed on
On the outside of the protection plate, in the position of the previous station of sampling station.
4. whole blood sample automatic sampling apparatus as described in claim 1, which is characterized in that the sampling probe includes metal needle tubing
And piston, the metal needle interior wall is smooth, and the piston is arranged in the metal needle tubing and is equipped in its piston rod and washes
Wash liquid channel.
5. whole blood sample automatic sampling apparatus as claimed in claim 4, which is characterized in that the actuating mechanism includes that piston causes
Dynamic component and three shaft mechanical arms, the plunger actuation component are linear reciprocating actuating member, and the metal needle tubing is fixed on institute
It states on three shaft mechanical arms.
6. whole blood sample automatic sampling apparatus as claimed in claim 5, which is characterized in that the plunger actuation component is electronic
Push rod.
7. whole blood sample automatic sampling apparatus as claimed in claim 4, which is characterized in that the needle assemblies of washing include that inner wall is clear
Pipeline, outer wall washing liquid pipeline, bottle for handling liquid toilet or cosmetic substance, lotion pumps, rinse bath, waste pipe, waste liquid bottle and waste drains pump are washed, the inner wall is clear
It washes pipeline one end to be connected to the cleaning solution channel, the outlet of the other end and the lotion pumps, the outer wall washing pipeline
One end is connected to the flushing liquid injection port in the rinse bath, the outlet of the other end and the lotion pumps, the lotion pumps
Import is connected to the bottle for handling liquid toilet or cosmetic substance, and the waste liquid outlet of the rinse bath is connected to institute by the waste pipe and the waste drains pump
State waste liquid bottle.
8. whole blood sample automatic sampling apparatus as claimed in claim 7, which is characterized in that the rinse bath is funnel-shaped, institute
It states flushing liquid injection port to be arranged on the side of the rinse bath, the waste liquid outlet is arranged in bottom.
9. whole blood sample automatic sampling apparatus as claimed in claim 8, which is characterized in that it is described rinse liquid injection port quantity be
It two or four, is arranged symmetrically on the side of the rinse bath.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811609671.2A CN109444450B (en) | 2018-12-27 | 2018-12-27 | Whole blood sample autoinjection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811609671.2A CN109444450B (en) | 2018-12-27 | 2018-12-27 | Whole blood sample autoinjection device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109444450A true CN109444450A (en) | 2019-03-08 |
| CN109444450B CN109444450B (en) | 2022-05-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811609671.2A Active CN109444450B (en) | 2018-12-27 | 2018-12-27 | Whole blood sample autoinjection device |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110567761A (en) * | 2019-10-08 | 2019-12-13 | 全椒先奇医药科技有限公司 | Assay sample collection device for hospital |
| CN110672373A (en) * | 2019-09-30 | 2020-01-10 | 广东工业大学 | Medical chemical examination sampling device and sampling method thereof |
| CN113188879A (en) * | 2021-04-26 | 2021-07-30 | 苏州德运康瑞生物科技有限公司 | Automatic sampling device of blood cell capture staining instrument |
| CN113419073A (en) * | 2020-03-30 | 2021-09-21 | 厦门先明生物技术有限公司 | High-flux full-automatic micro-fluidic fluorescence immunoassay device |
| CN115166278A (en) * | 2022-09-07 | 2022-10-11 | 武汉贝宁科技有限公司 | Adhesive performance detection equipment and detection method |
| CN115266647A (en) * | 2022-08-04 | 2022-11-01 | 长春星锐智能化科技有限公司 | Full-automatic turbidity sampling device and using method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113188879A (en) * | 2021-04-26 | 2021-07-30 | 苏州德运康瑞生物科技有限公司 | Automatic sampling device of blood cell capture staining instrument |
| CN115266647A (en) * | 2022-08-04 | 2022-11-01 | 长春星锐智能化科技有限公司 | Full-automatic turbidity sampling device and using method |
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| Publication number | Publication date |
|---|---|
| CN109444450B (en) | 2022-05-17 |
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