CN207851094U - A kind of digestion instrument automatic sampling device - Google Patents
A kind of digestion instrument automatic sampling device Download PDFInfo
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- CN207851094U CN207851094U CN201820284062.3U CN201820284062U CN207851094U CN 207851094 U CN207851094 U CN 207851094U CN 201820284062 U CN201820284062 U CN 201820284062U CN 207851094 U CN207851094 U CN 207851094U
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Abstract
The utility model is related to a kind of digestion instrument automatic sampling devices.Including a multiple-way valve group, multiple-way valve group includes five branches, and the public passage of kinetic pump connecting multi-channel valve group, the first branch of sampling probe connecting multi-channel valve group, stripping rotor are connected to by the 4th branch of liquid supplementation channel connecting multi-channel valve group, the 5th branch of multiple-way valve group with extraneous air by the second branch of return connecting multi-channel valve group, third branch, the fluid infusion slot of note sample needle connecting multi-channel valve group.The digestion instrument automatic sampling device of the utility model can realize that kinetic pump is connected to corresponding pipeline under different condition, it is fast accurately finished the operations such as automatic sampling, automatic liquid supply, automatic-discharging pipeline, automatic detergent line during the automatic sampling of dissolution experiment, meet sampling requirement of the pharmacopeia to dissolution experiment, accomplish the accurate, reliable, efficient of sampling, avoids adjacent sample point contaminated samples.
Description
Technical field
The utility model is related to drug test equipment correlative technology field, concretely relates to a kind of digestion instrument and take automatically
Sampling device.
Background technology
The sample technology of the drug-elutings experimentation such as tablet, capsule and particle, either in synchronized sampling, sampling
Presently, there are certain defect in terms of accuracy, sampling automatic positioning and fluid infusion accuracy, it is mainly manifested in：
1. the sampling moment error sampled manually is larger, sampling probe when cannot achieve synchronized sampling, and sampling manually
There is also large errors for position；
2. automatic sampling, sample position cannot achieve automatic positioning, and sampling pipe dead volume causes sampling amount inaccurate；
3. automatic sampling process can not all empty pipeline remaining sample, adjacent samples cross-infection is caused, sample is not
Accurately；
4. automatic sampling can not automatic liquid supply or covered fluid temperature cannot be satisfied pharmacopoeial requirements.
Utility model content
For the deficiency of the prior art, the utility model provides a kind of digestion instrument automatic sampling device.
The specific technical solution of the digestion instrument automatic sampling device of the utility model is as follows：
A kind of digestion instrument automatic sampling device comprising a multiple-way valve group；The multiple-way valve group includes passing through
The first branch that sampling line is connected with sampling probe, the second branch that stripping rotor is connected to by circuit lines, by noting sample
Needle is connected to the third branch of sample collection device, is connected to the 4th branch and extraneous air of fluid infusion slot by replenishing line
5th branch of connection and the public passage for being connected to kinetic pump；The kinetic pump is connected with the kinetic pump for driving its operation
Driving device；The sampling probe is set in sampling needle lifting drive module；The note sample needle is set to note sample needle lifting driving
In module；The sample collection device is connected with sample collection device movement drive module；Also, the multiple-way valve group,
The power pump drive, the sampling needle lifting drive module, the note sample needle lifting drive module and the sample are received
Acquisition means movement drive module is connected with the control system of the digestion instrument.
The digestion instrument automatic sampling device of the utility model can be to multiple-way valve group by using above-mentioned technical proposal
It switches over, different branches is made to be connected to public passage, to realize, kinetic pump is connected to corresponding pipeline under different condition,
Automatic sampling, automatic liquid supply, automatic-discharging pipeline, automatic clear is fast accurately finished during the automatic sampling of dissolution experiment
The operations such as pipeline are washed, meets sampling requirement of the pharmacopeia to dissolution experiment, accomplishes the accurate, reliable, efficient of sampling, avoid adjacent
Sample point contaminated samples.
According to a preferred embodiment, the multiple-way valve group is five-way electromagnetic valve；The kinetic pump is injection
Pump.
According to a preferred embodiment, the power pump drive is stepper motor.
According to a preferred embodiment, the sampling needle lifting drive module includes the lead screw being vertically arranged and institute
State the sampling probe crane and be connected with the lead screw that the nut slider, middle part that lead screw is connected are connected with the nut slider
The first driving motor connect；The sampling probe is set to sampling probe crane both sides；Also, first driving motor connects
It is connected to the control system of the digestion instrument so that under the control of the control system of the digestion instrument, first driving motor
The lead screw can be driven to rotate, and then drive the nut slider and sampling probe crane lifting, to make described take
Sample needle can move up and down.
According to a preferred embodiment, the note sample needle lifting drive module includes the second driving motor, second same
Step band, the second synchronizing wheel and note sample needle framed bent；The note sample needle framed bent passes through second synchronous belt and second synchronizing wheel
It is connected with second driving motor；The note sample needle is set on the note sample needle framed bent；Also, the second driving electricity
Machine is connected to the control system of the digestion instrument so that under the control of the control system of the digestion instrument, second driving
Motor can drive the note sample needle to move up and down by second synchronous belt and second synchronizing wheel.
According to a preferred embodiment, sample collection device movement drive module include third driving motor,
Third synchronous belt and third synchronizing wheel；The sample collection device passes through the third synchronous belt and the third synchronizing wheel and institute
Third driving motor is stated to be connected；Also, the third driving motor is connected to the control system of the digestion instrument so that in institute
Under the control for stating the control system of digestion instrument, the third driving motor can be same by the third synchronous belt and the third
Step wheel drives the sample collection device to move horizontally.
According to a preferred embodiment, the sample collection device includes multiple test tubes and for placing the test tube
Rack for test tube；The rack for test tube is connected by the third synchronous belt and the third synchronizing wheel with the third driving motor
It connects.
Compared with prior art, the digestion instrument automatic sampling device of the utility model has the advantages that：
The digestion instrument automatic sampling device of the utility model can switch over multiple-way valve group, make different branches
It is connected to public passage, to realize, kinetic pump is connected to corresponding pipeline under different condition, in the automatic sampling of dissolution experiment
It is fast accurately finished the operations such as automatic sampling, automatic liquid supply, automatic-discharging pipeline, automatic detergent line in the process, meets medicine
Allusion quotation accomplishes the accurate, reliable, efficient of sampling, avoids adjacent sample point contaminated samples to the sampling requirement of dissolution experiment.
Description of the drawings
Fig. 1 is the structure diagram of the utility model digestion instrument automatic sampling device
Fig. 2 is the connection relation signal of each branch of multiple-way valve group in the utility model digestion instrument automatic sampling device
Figure；
Fig. 3 is the structural schematic diagram that needle lifting drive module is sampled in the utility model digestion instrument automatic sampling device；
Fig. 4 is the structural schematic diagram that sample needle lifting drive module is noted in the utility model digestion instrument automatic sampling device；
Fig. 5 is the structural representation of sample collection device movement drive module in the utility model digestion instrument automatic sampling device
Figure.
Reference numerals list
100- multiple-way valve groups, the 101- first branchs, 102- the second branches, 103- third branches, the 4th branches of 104-,
The 5th branches of 105-, 200- power pump drives, 301- sampling lines, 302- circuit lines, 303- replenishing lines, 400- take
Sample needle, 500- note sample needle, 600- fluid infusion slots, 700- kinetic pumps, 800- sampling needle lifting drive modules, 801- lead screws, 802- spiral shells
Female sliding block, 803- sampling probe cranes, the first driving motors of 804-, 900- note sample needle lifting drive module, and 901- second drives
Motor, the second synchronous belts of 902-, the second synchronizing wheels of 903-, 1000- sample collection devices move drive module, and 1001- thirds are driven
Dynamic motor, 1002- third synchronous belts, 1003- third synchronizing wheels, 1100- sample collection devices, 1101- test tubes, 1102- test tubes
Frame, 10- extraneous airs, 20- stripping rotors.
Specific implementation mode
The digestion instrument automatic sampling device of the utility model is described in detail below in conjunction with the accompanying drawings.
Fig. 1 to Fig. 5 shows a kind of preferred embodiment of the utility model digestion instrument automatic sampling device.
As shown in Figures 1 to 5, a kind of digestion instrument automatic sampling device comprising a multiple-way valve group 100.Wherein, more
Channel valve group 100 includes the first branch 101 being connected with sampling probe 400 by sampling line 301, passes through circuit lines
302 are connected to the second branch 102 of stripping rotor, are connected to the third branch of sample collection device 1100 by noting sample needle 500
103, the 4th branch 104 of fluid infusion slot 600, the 5th branch 105 being connected to extraneous air 10 are connected to by replenishing line 303
With the public passage 106 for being connected to kinetic pump 700.
Preferably, five-way electromagnetic valve may be used in multiple-way valve group 100.Syringe pump may be used in kinetic pump 700.
Kinetic pump 700 is connected with the power pump drive 200 for driving its operation.Preferably, kinetic pump driving dress
It can be driving motor to set 200.Further, power pump drive 200 can be stepper motor.
Multiple-way valve group 100 is connected with the control system of digestion instrument.Under the control of the control system of digestion instrument, five
Three-way electromagnetic valve can carry out the switching of different pipeline branches automatically under the control of control information, be moved under different condition to realize
Power pump can be connected to corresponding pipeline；And under the control of the control system of digestion instrument, power pump drive 200 drives
Kinetic pump 700 works, and carries out extraction, the injection of sample, realizes automatic sampling；Alternatively, carrying out automatic liquid supply, automatic-discharging pipe
The operations such as road, automatic detergent line.
Sampling probe 400 is set in sampling needle lifting drive module 800.Preferably, 8 or 12 settings of sampling probes 400
In in sampling needle lifting drive module 800, it is formed as sampling probe row.
Preferably, as shown in figure 3, sampling needle lifting drive module 800 includes the lead screw 801 being vertically arranged and lead screw 801
The sampling probe crane 803 and be connected with lead screw 801 that the nut slider 802 that is connected, middle part are connected with nut slider 802
The first driving motor 804.Sampling probe 400 is set to 803 both sides of sampling probe crane.Also, the first driving motor 804 connects
To the control system of digestion instrument so that under the control of the control system of digestion instrument, the first driving motor 804 can drive lead screw
801 rotations, and then nut slider 802 and sampling probe crane 803 is driven to lift, to enable sampling probe 400 to move up and down.
Specifically, 803 middle part of sampling probe crane is fixedly connected with nut slider 802, nut slider 802 is inserted in lead screw
801, lead screw 801 is connect with the first driving motor 804, and sampling probe and circuit needle are installed in 803 both sides of sampling probe crane, and first drives
The dynamic work of motor 804 drives lead screw 801 to rotate, and lead screw 801 drives nut slider 802 to slide up and down, and the drive of nut slider 802 takes
Sample needle lifting frame 803 moves up and down, and makes sampling probe that can be automatically lowered predeterminated position every time, to make sample position realize
Automatic positioning.
Preferably, the first driving motor 804 can be stepper motor.
In addition, sampling needle lifting drive module 800 can also be made of linear motor and sampling probe crane 803.Straight line
Motor is connected with sampling probe crane 803 so that linear motor can drive sampling probe crane 803 to move up and down, and make to take
Sample needle can be automatically lowered predeterminated position every time, to make sample position realize automatic positioning.
Note sample needle 500 is set in note sample needle lifting drive module 900.
Preferably, as shown in figure 4, note sample needle lifting drive module 900 includes the second driving motor 901, the second synchronous belt
902, the second synchronizing wheel 903 and note sample needle framed bent 904.Note sample needle framed bent 904 passes through the second synchronous belt 902 and the second synchronizing wheel
903 are connected with the second driving motor 901；Note sample needle 500 is set on note sample needle framed bent 904.Also, the second driving motor
901 are connected to the control system of digestion instrument so that under the control of the control system of digestion instrument, the second driving motor 901 can
Note sample needle 500 is driven to move up and down by the second synchronous belt 902 and the second synchronizing wheel 903.
Specifically, note sample needle 500 is connected by pipeline with third branch 103,8 or 12 note sample needles 500 are fixed on
It notes on sample needle framed bent 904, note sample needle framed bent 904 passes through the second synchronous belt 902, the second synchronizing wheel 903 and the second driving motor 901
Connection, the second driving motor 901 make note sample needle exist by the second synchronous belt 902, the second synchronizing wheel 903 driving note sample needle lifting
The into or out sample collection device of appropriate time point.
Preferably, the second driving motor 901 or stepper motor.
Note sample needle lifting drive module 900 can also be made of linear motor and note sample needle framed bent 904.Note sample needle framed bent
904 are connected with linear motor so that linear motor can drive note sample needle framed bent 904 to move up and down, so that note sample needle
Lifting, make note sample needle in due course between put into or out sample collection device.
Sample collection device is connected with sample collection device movement drive module 1000.
Preferably, sample collection device 1100 includes multiple test tubes 1101 and the rack for test tube 1102 for holding test tubes.Examination
Pipe support 1102 is connected by third synchronous belt 1002 and third synchronizing wheel 1003 with third driving motor 1001.
Preferably, as shown in figure 5, sample collection device movement drive module 1000 includes third driving motor 1001, the
Three synchronous belts 1002 and third synchronizing wheel 1003.Sample collection device 1100 passes through third synchronous belt 1002 and third synchronizing wheel
1003 are connected with third driving motor 1001.Also, third driving motor 1001 is connected to the control system of digestion instrument so that
Under the control of the control system of digestion instrument, third driving motor 1001 can pass through third synchronous belt 1002 and third synchronizing wheel
1003 drive sample collection devices 1100 move horizontally, and sample is enable to inject corresponding test tube row the inside.
In addition, sample collection device movement drive module 1000 can also by third driving motor 1001, driving gear and
Rack is constituted.Rack is set to 1102 bottom of rack for test tube, by driving gear to be connected with third driving motor 1001 so that
Third driving motor 1001 enables sample by driving gear and rack that sample collection device 1100 can be driven to move horizontally
Inject corresponding test tube row the inside.
Preferably, third driving motor 1001 or stepper motor.
The course of work of the digestion instrument automatic sampling device of the utility model is as follows：
1. sampling before moment point 30 seconds, under the control of the control system of digestion instrument, in sampling needle lifting drive module 800
The first driving motor 804 driving sampling probe be automatically lowered the predeterminated position in stripping rotor 20；The control system control of digestion instrument
The public passage of five-way electromagnetic valve processed and first branch unicom；
2. under the control of the control system of digestion instrument, power pump drive 200 drives kinetic pump 700 to work, and passes through
Sampling probe drawing liquid (for rinsing rinse pipeline) from stripping rotor, then digestion instrument control system control five-way electromagnetic valve public affairs
Common road and the second branch unicom, power pump drive 200 drive kinetic pump 700 to work, the liquid that kinetic pump is extracted
Stripping rotor 20 is returned along return 302；
3. digestion instrument control system controls the public passage and first branch unicom of five-way electromagnetic valve again, then control is dynamic
Power pump drive 200 drives kinetic pump 700 formally to extract stripping rotor sample solution；Pass through above-mentioned technical proposal can solve hand
The sampling moment error of dynamic sampling is larger, when cannot achieve synchronized sampling, and sampling manually the position of sampling probe there is also compared with
The problem of big error；
4. the public passage and third branch unicom of the control system control five-way electromagnetic valve of digestion instrument, note sample needle lifting drive
The dynamic model driving of the second driving motor 901 note sample needle in the block enters waste liquid tank, and then power pump drive 200 drives kinetic pump
700 work, kinetic pump 700 first inject 2ml or 3ml primary filtrates toward waste liquid tank, then note sample needle and rise to leave waste liquid tank；Sampling
Needle lifting frame leaves stripping rotor under the driving of the first driving motor 804 and rises to origin position；
5. sample collection device moves the third driving motor 1001 in drive module and drives sample collection device movement, make
Corresponding test tube row is moved to the underface of note sample needle, then notes sample needle and is lowered to test tube in the driving of the second driving motor 901
It is interior；Power pump drive 200 drives kinetic pump to pass through the interior liquid of pump and notes sample needle tubing road injecting tube；
6, after cuvette sample has been injected, the public passage and the 5th branch of the control system control five-way electromagnetic valve of digestion instrument
Unicom, power pump drive 200 drive kinetic pump to extract 5ml air；
7. digestion instrument control system control five-way electromagnetic valve public passage again with third branch unicom, kinetic pump drive
Dynamic device 200 drives kinetic pump 700, and the emptying rate of liquid in injection pipeline is completed sample and taken into test tube using the air of absorption
Sample；To solve the problems, such as to cause sampling amount inaccurate because of sampling pipe dead volume；
8. the public passage and the 4th branch unicom of the control system control five-way electromagnetic valve of digestion instrument, kinetic pump driving dress
It sets 200 driving kinetic pumps 700 and extracts covering liquid from fluid infusion slot 600；
9. the public passage and first branch unicom of the control system control five-way electromagnetic valve of digestion instrument, kinetic pump driving dress
It sets 200 driving kinetic pumps 700 and the covering liquid of extraction is discharged into respective stripping rotor by sampling line and sampling probe；Then power
Pump drive 200 drives kinetic pump 700 from sampling pipe back suction, the residual liquid in sampling pipe is drawn back same in kinetic pump
When extract air；
10. the public passage and the second branch unicom of the control system control five-way electromagnetic valve of digestion instrument, kinetic pump driving
Device 200 drives kinetic pump 700 to work, by pump liquid and air stripping rotor is discharged by circuit, and will be returned by air
Road empties；Pipeline remaining sample can not all be emptied to solve automatic sampling process, cause adjacent samples cross-infection,
Sample is inaccurate and automatic sampling can not automatic liquid supply or covered fluid temperature cannot be satisfied a series of of pharmacopoeial requirements
Problem.
By above step, the digestion instrument automatic sampling device of the utility model complete automatic sampling, automatic liquid supply, from
Actions, the entire operation process precise and high efficiencies such as dynamic rinse emptying pipeline are reliable.
Multiple-way valve group 100 includes five branches in the digestion instrument automatic sampling device of the present embodiment, and kinetic pump 700 connects
Connect the public passage 106 of multiple-way valve group 100, the first branch 101 of 400 connecting multi-channel valve group 100 of sampling probe, dissolution
The second branch 102, note sample needle 500 connecting multi-channel valve group of the cup by 302 connecting multi-channel valve group 100 of return
100 third branch 103, fluid infusion slot 600 pass through the 4th branch 104 of 303 connecting multi-channel valve group 100 of liquid supplementation channel, more
5th branch 105 of channel valve group 100 is connected to extraneous air；Under the control of the control system of digestion instrument, multiple valve
Door group 100 can carry out different pipeline switchings, and to realize, syringe pump can be connected to corresponding pipeline under different condition, real
The extraction or injection of existing sample；And it can be fast accurately finished in dissolution is tested by using above-mentioned technical proposal automatic
The operations such as sampling, automatic liquid supply, automatic-discharging pipeline, automatic detergent line meet pharmacopeia to the sampling requirement of dissolution experiment, do
To the accurate, reliable, efficient of sampling；The automatic of the dissolution testings instrument such as tablet, capsule, particle is can be applied to take
Sample.
It should be noted that all features disclosed in this specification or disclosed all methods or in the process the step of,
Other than mutually exclusive feature and/or step, it can combine in any way.
In addition, above-mentioned specific embodiment is exemplary, those skilled in the art can be in the utility model disclosure
Inspiration under find out various solutions, and these solutions also belong to the open scope of the utility model and fall into this reality
Within novel protection domain.It will be understood by those skilled in the art that the utility model specification and its attached drawing are explanation
Property and not constitute limitations on claims.The scope of protection of the utility model is limited by claim and its equivalent.
Claims (7)
1. a kind of digestion instrument automatic sampling device, which is characterized in that it includes a multiple-way valve group (100)；
The multiple-way valve group (100) includes the first branch being connected with sampling probe (400) by sampling line (301)
(101), it is connected to the second branch (102) of stripping rotor (20) by circuit lines (302), is connected to by noting sample needle (500)
The third branch (103) of sample collection device (1100), the 4th that fluid infusion slot (600) is connected to by replenishing line (303)
Road (104), the 5th branch (105) being connected to extraneous air (10) and the public passage (106) for being connected to kinetic pump (700)；
The kinetic pump (700) is connected with the kinetic pump drive module (200) for driving its operation；The sampling probe (400)
It is set in sampling needle lifting drive module (800)；The note sample needle (500) is set to note sample needle lifting drive module (900)
On；The sample collection device is connected with sample collection device movement drive module (1000)；
Also, the multiple-way valve group (100), the kinetic pump drive module (200), the sampling needle lifting drive module
(800), the note sample needle lifting drive module (900) and the sample collection device movement drive module (1000) with it is described
The control system of digestion instrument is connected.
2. digestion instrument automatic sampling device according to claim 1, which is characterized in that the multiple-way valve group (100)
For five-way electromagnetic valve；The kinetic pump (700) is syringe pump.
3. digestion instrument automatic sampling device according to claim 1 or 2, which is characterized in that the kinetic pump drive module
(200) it is stepper motor.
4. digestion instrument automatic sampling device according to claim 1 or 2, which is characterized in that the sampling needle lifting driving
Module (800) include the lead screw (801) being vertically arranged, the nut slider (802) being connected with the lead screw (801), middle part with
The sampling probe crane (803) that the nut slider (802) is connected and the first driving electricity being connected with the lead screw (801)
Machine (804)；
The sampling probe (400) is set to sampling probe crane (803) both sides；
Also, first driving motor (804) is connected to the control system of the digestion instrument so that in the control of the digestion instrument
Under the control of system processed, first driving motor (804) can drive the lead screw (801) to rotate, and then drive the spiral shell
Female sliding block (802) and the sampling probe crane (803) lifting, to make the sampling probe (400) that can move up and down.
5. digestion instrument automatic sampling device according to claim 1 or 2, which is characterized in that the note sample needle lifting driving
Module (900) includes the second driving motor (901), the second synchronous belt (902), the second synchronizing wheel (903) and note sample needle framed bent
(904)；
The note sample needle framed bent (904) passes through second synchronous belt (902) and second synchronizing wheel (903) and described second
Driving motor (901) is connected；The note sample needle (500) is set on the note sample needle framed bent (904)；
Also, second driving motor (901) is connected to the control system of the digestion instrument so that in the control of the digestion instrument
Under the control of system processed, second driving motor (901) can be synchronous with described second by second synchronous belt (902)
Wheel (903) drives the note sample needle (500) to move up and down.
6. digestion instrument automatic sampling device according to claim 1 or 2, which is characterized in that the sample collection device moves
Dynamic drive module (1000) includes third driving motor (1001), third synchronous belt (1002) and third synchronizing wheel (1003)；
The sample collection device (1100) passes through the third synchronous belt (1002) and the third synchronizing wheel (1003) and institute
Third driving motor (1001) is stated to be connected；
Also, the third driving motor (1001) is connected to the control system of the digestion instrument so that in the digestion instrument
Under the control of control system, the third driving motor (1001) can pass through the third synchronous belt (1002) and the third
Synchronizing wheel (1003) drives the sample collection device (1100) to move horizontally.
7. digestion instrument automatic sampling device according to claim 6, which is characterized in that the sample collection device (1100)
Rack for test tube including multiple test tubes (1101) and for placing the test tube；
The rack for test tube drives electricity by the third synchronous belt (1002) and the third synchronizing wheel (1003) with the third
Machine (1001) is connected.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820284062.3U CN207851094U (en) | 2018-02-28 | 2018-02-28 | A kind of digestion instrument automatic sampling device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820284062.3U CN207851094U (en) | 2018-02-28 | 2018-02-28 | A kind of digestion instrument automatic sampling device |
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| CN207851094U true CN207851094U (en) | 2018-09-11 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108333381A (en) * | 2018-02-28 | 2018-07-27 | 深圳市锐拓仪器设备有限公司 | A kind of digestion instrument automatic sampling device |
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2018
- 2018-02-28 CN CN201820284062.3U patent/CN207851094U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108333381A (en) * | 2018-02-28 | 2018-07-27 | 深圳市锐拓仪器设备有限公司 | A kind of digestion instrument automatic sampling device |
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