CN204116358U - There is the platelet aggregation instrument of sample preprocessing - Google Patents

There is the platelet aggregation instrument of sample preprocessing Download PDF

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Publication number
CN204116358U
CN204116358U CN201420103804.XU CN201420103804U CN204116358U CN 204116358 U CN204116358 U CN 204116358U CN 201420103804 U CN201420103804 U CN 201420103804U CN 204116358 U CN204116358 U CN 204116358U
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China
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sample
cup
test
arranges
platelet aggregation
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Expired - Lifetime
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CN201420103804.XU
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Chinese (zh)
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陈生
肖继昌
王顺义
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Shandong Tailixin Medical Technology Co ltd
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BEIJING TAILI KANGXIN TECHNOLOGY Co Ltd
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Abstract

The utility model relates to a kind of platelet aggregation instrument with sample preprocessing, its support is provided with automatic control circuit, testing stand is arranged test machine core apparatus, test cup dish device, sample disc device, reagent bottle device, cleaning disc device, support side arranges modular centrifuge apparatus; Arrange sample needle device, reagent needles device above testing stand and grab cup device, this sample needle device, reagent needles device and grab cup device and be arranged on a running gear, running gear comprises longitudinal traveling mechanism and horizontal travel mechanism.The utility model by platelet poor plasma preparation, platelet rich plasma preparation, automatic sample, automatically detect, cleaning automatically, a complete set of integration procedure of removal waste fluid is on an instrument, improve the test speed of clinical examination greatly, avoid the contact of operating personnel and blood sample, improve the accuracy of testing result.

Description

There is the platelet aggregation instrument of sample preprocessing
Technical field
The utility model relates to a kind of platelet aggregation instrument with sample preprocessing, for blood platelet Performance Detection.This gathering instrument is provided with automatic control circuit, test machine core apparatus, test cup dish device, sample disc device, reagent bottle device, cleaning disc device, modular centrifuge apparatus, sample needle device, reagent needles device and grabs cup device.
Background technology
Chinese patent 90207370.2 discloses intelligent blood platelet gathering instrument, comprises complete machine and is made up of power supply, temperature-adjusting circuit, photoelectric switching circuit, amplifying circuit, programmable amplifying circuit, analog to digital conversion circuit, data converting circuit, imput output circuit, display, keyboard, printer, stirring motor and basic calculating system.Make central processing unit by 8-bit microprocessor, control each several part, there is the functions such as the automatic zero set (AZS) of test blood plasma, stirring, reporting printing and displaying time.Adopt micro computer special circuit by various corresponding control program solidification in integrated circuits, solve automatic zero set (AZS), automatic zero set (AZS) is carried out to different test sample blood plasma; Automatic driving stirring motor, and can by the gathering curve of test and laboratory report automatic printing, copy and automatically show the time at that time.But this patent once only can be measured a blood sample, belong to the category of hand dipping, not only can cause the prolongation of test period, also can because of artificial negligence of operation, affect the accuracy of test result, operating personnel are contaminated because directly contacting with blood sample of patient.Therefore, need to propose a kind of platelet aggregation instrument with sample preprocessing.
Summary of the invention
The purpose of this utility model is to provide a kind of platelet aggregation instrument with sample preprocessing, the testing stand of its support is arranged test machine core apparatus, test cup dish device, sample disc device, reagent bottle device, cleaning disc device, the side of support arranges modular centrifuge apparatus; Sample needle device, reagent needles device are set above testing stand and grab cup device, this sample needle device, reagent needles device and grab cup device and be arranged on a running gear.Step with centrifugal separation of the present utility model, load procedure, testing procedure, cleaning step complete automatically by instrument, improve test speed and the accuracy of clinical examination greatly.
The purpose of this utility model is realized by following technical proposals: a kind of platelet aggregation instrument with sample preprocessing, there is a support, described support is provided with automatic control circuit, the testing stand of described support is arranged test machine core apparatus, test cup dish device, sample disc device, reagent bottle device, cleaning disc device, the side of described support arranges modular centrifuge apparatus; Be provided with multiple magnetic stirring apparatus in described test machine core apparatus, be provided with lighting transistor circuit and photoelectric switching circuit around this magnetic stirring apparatus; Described sample disc device arranges multiple sample cup; Described reagent bottle device bottom arranges semiconductor cooling device; Described cleaning disc device comprises cleaning fluid bottle and waste collection bottle; Described modular centrifuge apparatus comprises a base, described base is fixed a medical supercentrifuge; Arrange sample needle device, reagent needles device above the testing stand of described support and grab cup device, this sample needle device, reagent needles device and grab cup device and be arranged on a running gear, this running gear comprises longitudinal traveling mechanism and horizontal travel mechanism.
The utility model compared with prior art tool has the following advantages:
1, the utility model by platelet poor plasma preparation, platelet rich plasma preparation, automatic sample, automatically detect, cleaning automatically, a complete set of integration procedure of removal waste fluid is on an instrument, improve the test speed of clinical examination greatly, shorten the time waiting for testing result.
2, former test tube (blood sampling test tube) sample with whole blood is placed on platelet aggregation instrument by the utility model, carry out automatic preparation and the automatic sample of platelet poor plasma and platelet rich plasma, avoid the contact of operating personnel and blood sample, improve the speed of detection and the accuracy of testing result.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the utility model is described in further detail.
Fig. 1 is right TV structure schematic diagram of the present utility model;
Fig. 2 of the present utility modelly faces structural representation;
Fig. 3 is plan structure figure of the present utility model;
Fig. 4 is the structural representation of test cup of the present utility model;
Fig. 5 is structural representation of grabbing cup device of the present utility model;
Fig. 6 is the structural representation of sample needle device of the present utility model.
Embodiment
Embodiment one:
See Fig. 1 to Fig. 6, (Fig. 1 is partial sectional view, show the situation of horizontal travel mechanism), (Fig. 3 is the vertical view of Fig. 2, the layout scenarios of display testing stand), platelet aggregation instrument of the present utility model, there is a support 1, support is provided with automatic control circuit (in figure not display), in this automatic control circuit, corresponding program is installed, microcomputer (single chip circuit), the testing stand 101 of support arranges test machine core apparatus 3, test cup dish device 2, sample disc device 6, reagent bottle device 5, cleaning disc device 4, the side of described support arranges modular centrifuge apparatus 7, be provided with five magnetic stirring apparatuses in described test machine core apparatus, be provided with lighting transistor circuit and photoelectric switching circuit (test machine core apparatus adopts photoelectric turbidimetry test circuit) around this magnetic stirring apparatus, described test cup dish device arranges 40 test cups 201, the described test cup dish device left side arranges a useless cup aperture 102, and below useless cup aperture, (below testing stand) arranges useless cup disposable box, described sample disc device is arranged 60 sample cups (for placing blood plasma to be tested), described reagent bottle device bottom arranges semiconductor cooling device, described cleaning disc device comprises cleaning fluid bottle and waste collection bottle, described modular centrifuge apparatus comprises a base 701, and described base is fixed a medical supercentrifuge 702, the medical supercentrifuge left side arranges blood-taking tube support 703, sample needle device 9, reagent needles device 10 are set above the testing stand of described support and grab cup device 8, this sample needle device, reagent needles device and grab cup device and be arranged on a running gear 11, this running gear comprises longitudinal traveling mechanism 111 and horizontal travel mechanism 112.Sample needle 901 in sample needle device is connected with the automatic detergent line of an automatic sample pipeline and a sample needle, and the reagent needles 902 in described reagent needles device is connected with the automatic detergent line of a reagent needles.
In the present embodiment, photoelectric turbidimetry test circuit adopts prior art, is not described in detail.Control of the present utility model adopts Computer Control Technology, and its automatic control circuit belongs to routine techniques means, is not described in detail.
In the present embodiment, each magnetic stirring apparatus in test machine core apparatus is provided with test cup aperture (for putting into test cup 201), below test cup, disk is set, a stirring rod (little bar magnet) is added in test cup, magnetic agitation motor drives disc rotation, little bar magnet rotates thereupon, realizes stirring the test plasma in test cup.This magnetic stirring apparatus belongs to prior art, is not described in detail.In the present embodiment, magnetic stirring apparatus disclosed in Chinese patent ZL02265972.2 can also be adopted to the stirring of test plasma.
See Fig. 3, in the present embodiment, sample disc device 6 is arranged 60 sample cup aperture positions, sample cup aperture position is by lineament layout, insert the sample cup 601 preserving PRP or PPP (i.e. platelet rich plasma or platelet poor plasma) in sample cup aperture respectively, sample needle can draw detection plasma sample from sample cup.After 60 sample cups exhaust, whole dish upgrades.
In the present embodiment, reagent bottle device top arranges reagent bottle hole, and its interpolation installed reagents bottle, preserves platelet aggregation in reagent bottle.In order to meet the temperature requirement of platelet aggregation, described reagent bottle device bottom arranges semiconductor cooling device; This refrigerating plant is made up of refrigeration circuit, heat radiator and fan, and refrigerating plant belongs to prior art, is not described in detail.
In the present embodiment, cleaning disc device is provided with service sink, and service sink is used for the cleaning of sample needle and reagent needles.Service sink inside arranges two pin hole shape rinse baths and waste collection mouth, and bottom arranges waste collection bottle, and waste collection mouth is communicated with waste collection bottle.The waste liquid that sample needle device, reagent needles device produce can be discharged in waste collection bottle, unified collection.Cleaning disc device belongs to prior art, is not described in detail.
In the present embodiment, medical supercentrifuge is commercially available BY-G20 type desk type high speed normal temperature hydro-extractor, and hydro-extractor is made up of shell, rotating part and electric control system.During machine operation, under motor drives, rotating head carrying sample separation High Rotation Speed, the test tube symmetry that blood sample is housed puts into the adapter of rotating head, and described test tube is medical institutions' test tube for blood samples.In the present embodiment, the base of described modular centrifuge apparatus arranges Rapid Combination mechanism.See Fig. 1 and Fig. 3, the base 701 of modular centrifuge apparatus and support 1 arrange multiple pin-and-hole (in figure not display), mount pin screw assembly 103 (four pins are combined on one block of plate) on this pin-and-hole.Modular centrifuge apparatus relies on the support Rapid Combination of pin assembly and platelet aggregation instrument.Rapid Combination mechanism can also adopt the array mode of dovetail groove and lock pin; Support 1 arranges dovetail groove, base 701 arranges dovetail.Rely on Rapid Combination mechanism can realize the Fast Installation Sum decomposition of modular centrifuge apparatus and support, be convenient to decompose transport and assembling use, both can be separated use with support and also can combinationally use.
In the present embodiment, sample needle device, reagent needles device and grab cup device and be arranged on a running gear 11, this running gear comprises longitudinal traveling mechanism 111 and horizontal travel mechanism 112.(length direction of the platelet aggregation instrument of Fig. 3 display is for longitudinal) longitudinal traveling mechanism comprises longitudinal rail, stepper motor, synchronous cog belt, longitudinal bracket of walking, and longitudinally walking bracket and synchronous cog belt fixedly mount; (Width of the platelet aggregation instrument of Fig. 3 display is for horizontal) horizontal travel mechanism comprises cross slide way, stepper motor, synchronous cog belt, horizontal bracket of walking, and laterally walking bracket and synchronous cog belt fixedly mount; Sample needle device, reagent needles device and grab cup device be fixed on horizontal travel mechanism transverse direction walking bracket on, horizontal travel mechanism be fixed on longitudinal traveling mechanism longitudinal direction walking bracket on.Sample needle device, reagent needles device arrange vertically to travel mechanism separately, and driving sample needle 901, reagent needles 902 move up and down respectively, and this vertically comprises stepper motor, synchronous cog belt, synchronous pulley to travel mechanism.Sample needle device comprises sample needle, flexible pipe, solenoid valve, suction pumps, measuring element; Reagent needles device comprises reagent needles, flexible pipe, solenoid valve, suction pumps, measuring element; Sample needle device, reagent needles device belong to prior art category, are not described in detail.Described cup device of grabbing comprises vertically to driving mechanism, vertically to bracket 803, describedly vertically install gripping arm 802 to bracket base, and described gripping arm bottom level arranges four fingers and grabs cupule 801.
See Fig. 4, in the present embodiment, test cup 201 has a transparent test cup 203, test cup top arranges the link 202 protruding cup, this link 202 is grabbed cupule 801 with four described fingers and is matched, four refer to grab cupule above two refer to insert edge on link in fork-shaped, four to refer to grab cupule below two refers to insert in fork-shaped edge under link and just can complete and grabs a glass action reliably.
The course of work of the present utility model is as follows:
A, use blood sampling test tube gather patient blood samples's (gathering by examination criteria consumption, normally 5ml), carry out anti-freezing process, generate anticoagulated whole blood to this blood sample; In the present embodiment, patient blood samples carries out anti-freezing with blood anticoagulant 3.8% (concentration) sodium citrate, and the ratio of anti-coagulants and blood is 1: 9; This job step is completed by the blood sampling department of medical institutions.
B, by anticoagulated whole blood centrifugal treating, prepare platelet rich plasma; Loaded in the position, corresponding test tube hole in adapter by the test tube that anticoagulated whole blood is housed, the coordinate of position, test tube hole has been preset in the program in automatic control circuit.Operate by operating personnel the setting that microcomputer completes cuvette sample number, described sample number can be electronic marker, makes position, each test tube hole one_to_one corresponding in each sample number and test tube basket.Carry out centrifugal treating by medical supercentrifuge, first with first gear speed centrifugal (centrifugation time 30-60 second, centrifugal force 2000g-3000g), be separated preparation PRP (i.e. platelet rich plasma); Order sample needle draws a certain amount of platelet rich plasma from described test tube, is injected in the sample cup in sample disc device, arranges sample number, makes the sample number of each sample cup corresponding with test tube.Then automatically sample needle is cleaned, described automatic cleaning sample needle, according to pre-set program, use the clean water sample needle in washer bottle, sample needle is after each pipette samples completes an application of sample action, all the clear water can introduced in washer bottle cleans automatically, and the waste liquid that cleaning produces is injected in the waste collection bottle of cleaning disc device by sample needle.
C, medical supercentrifuge with second speed centrifugal (centrifugal 100-200 second, centrifugal force 7000g-8000g), are separated preparation PPP (i.e. platelet poor plasma) again.Order sample needle draws a certain amount of platelet poor plasma from described test tube, is injected in the sample cup in sample disc device, arranges sample number;
D, the platelet aggregation prepared put into the reagent bottle device assembling instrument, be 3-10umol/1 by liquid concentration, reagent dosage 5--10ul, derivant also can use the one in ADR (adrenal gland), COL (collagen), ARA (arachidonic acid), RIS (ristomycin).
E, order are grabbed cup device and from test cup dish device, are taken out test cup put it in test machine core apparatus; Order sample needle is pressed examination criteria consumption and is drawn platelet poor plasma from described sample cup, inject test cup, start magnetic stirring apparatus platelet poor plasma is stirred, detect light path system automatically read platelet poor plasma sample transmission data and be stored in microcomputer, then automatically clean sample needle; In the present embodiment, platelet poor plasma consumption is 300ul, automatic cleaning sample needle is according to pre-set program, use the washing lotion cleaning sample needle in washer bottle, sample needle is after each pipette samples completes an application of sample action, all can clean, the waste liquid that cleaning produces is injected in the waste collection bottle of cleaning disc device by sample needle.After test procedure completes, capture in the lump together with blood plasma discarded in cup and stirring rod and lose in useless cup box.
F, order are grabbed cup device and from test cup dish device, are taken out test cup put it in test machine core apparatus; Order sample needle is pressed examination criteria consumption and is drawn platelet rich plasma from described sample cup, inject test cup, start magnetic stirring apparatus platelet rich plasma is stirred, detect light path system and automatically read platelet rich plasma sample transmission data and be stored in microcomputer; Automatic cleaning sample needle; In the present embodiment, platelet rich plasma consumption is 300ul.
G, order sample needle are pressed examination criteria consumption and are drawn platelet aggregation from reagent bottle device, inject test cup, start magnetic stirring apparatus platelet rich plasma and platelet aggregation are uniformly mixed, detection light path system reads the platelet rich plasma sample transmission data in the platelet aggregation forming process in the stipulated time automatically, describing aggregation curve and store, then with grabbing cup device, test cup crawl being lost in useless cup box; In the present embodiment, platelet aggregation consumption is 5ul.
H, calculate the platelet aggregation rate of tested blood sample, the measurement result of Platelet is generated test report according to inputted patient information.
In the present embodiment, measured data are processed and all belongs to proven technique content, be not described in detail at this.

Claims (3)

1. one kind has the platelet aggregation instrument of sample preprocessing, there is a support, described support is provided with automatic control circuit, it is characterized in that: the testing stand of described support is arranged test machine core apparatus, test cup dish device, sample disc device, reagent bottle device, cleaning disc device, the side of described support arranges modular centrifuge apparatus; Be provided with multiple magnetic stirring apparatus in described test machine core apparatus, be provided with lighting transistor circuit and photoelectric switching circuit around this magnetic stirring apparatus; Described sample disc device arranges multiple sample cup; Described reagent bottle device bottom arranges semiconductor cooling device; Described cleaning disc device comprises cleaning fluid bottle and waste collection bottle; Described modular centrifuge apparatus comprises a base, described base is fixed a medical supercentrifuge; Arrange sample needle device, reagent needles device above the testing stand of described support and grab cup device, this sample needle device, reagent needles device and grab cup device and be arranged on a running gear, this running gear comprises longitudinal traveling mechanism and horizontal travel mechanism.
2. the platelet aggregation instrument with sample preprocessing according to claim 1, is characterized in that: the base of described modular centrifuge apparatus arranges Rapid Combination mechanism.
3. the platelet aggregation instrument with sample preprocessing according to claim 2, it is characterized in that: described grab cup device comprise vertically to driving mechanism, vertically to bracket, described vertically to bracket base installation gripping arm, described gripping arm bottom level arranges four fingers and grabs cupule.
CN201420103804.XU 2014-03-07 2014-03-07 There is the platelet aggregation instrument of sample preprocessing Expired - Lifetime CN204116358U (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105571903A (en) * 2016-02-04 2016-05-11 南昌大学第二附属医院 Automatic sampling device for neutral desorption and ionization mass spectrum analyzing method
CN105954239A (en) * 2016-04-26 2016-09-21 中国人民武装警察部队总医院 Method for detecting platelet aggregation function
CN107014990A (en) * 2017-05-15 2017-08-04 深圳麦科田生物医疗技术有限公司 Full-automatic thrombus elastic force measuring device
CN107966580A (en) * 2017-12-26 2018-04-27 江苏柯伦迪医疗技术有限公司 A kind of fast automatic biochemical detection system and method for application bar formula detection card
CN108786179A (en) * 2018-08-31 2018-11-13 中触媒新材料股份有限公司 A kind of full-automatic part collection device of column chromatography for separation and method
CN108802416A (en) * 2017-05-05 2018-11-13 北京普利生仪器有限公司 The sample adding device and sample analyser of sample analyser
CN114675041A (en) * 2021-08-06 2022-06-28 中睿医学(山东)科技有限公司 Full-automatic platelet aggregation instrument and control method thereof

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105571903A (en) * 2016-02-04 2016-05-11 南昌大学第二附属医院 Automatic sampling device for neutral desorption and ionization mass spectrum analyzing method
CN105571903B (en) * 2016-02-04 2018-05-08 南昌大学第二附属医院 A kind of neutrality solution smokes automatic sampling apparatus and ionization mass spectrometry method
CN105954239A (en) * 2016-04-26 2016-09-21 中国人民武装警察部队总医院 Method for detecting platelet aggregation function
CN108802416A (en) * 2017-05-05 2018-11-13 北京普利生仪器有限公司 The sample adding device and sample analyser of sample analyser
CN107014990A (en) * 2017-05-15 2017-08-04 深圳麦科田生物医疗技术有限公司 Full-automatic thrombus elastic force measuring device
CN107966580A (en) * 2017-12-26 2018-04-27 江苏柯伦迪医疗技术有限公司 A kind of fast automatic biochemical detection system and method for application bar formula detection card
CN108786179A (en) * 2018-08-31 2018-11-13 中触媒新材料股份有限公司 A kind of full-automatic part collection device of column chromatography for separation and method
CN114675041A (en) * 2021-08-06 2022-06-28 中睿医学(山东)科技有限公司 Full-automatic platelet aggregation instrument and control method thereof

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Date Code Title Description
C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20191209

Address after: 264200 Room B0407-0411, Innovation Base No. 213-3, Torch Road, Gao District, Weihai City, Shandong Province

Patentee after: SHANDONG TAILIXIN MEDICAL TECHNOLOGY CO.,LTD.

Address before: 100085, building 2, building 35, No. 518, East Road, Haidian District, Beijing, 2

Patentee before: BEIJING TAILI KANGXIN TECHNOLOGY Co.,Ltd.

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CX01 Expiry of patent term

Granted publication date: 20150121