CN107561198A - A kind of liquid chromatograph automatic sampler - Google Patents
A kind of liquid chromatograph automatic sampler Download PDFInfo
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- CN107561198A CN107561198A CN201710736196.4A CN201710736196A CN107561198A CN 107561198 A CN107561198 A CN 107561198A CN 201710736196 A CN201710736196 A CN 201710736196A CN 107561198 A CN107561198 A CN 107561198A
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Abstract
The present invention discloses a kind of liquid chromatograph automatic sampler, and it includes sample introduction path and six-way valve, and sample introduction path front end and end connect chromatographic column and liquid-feeding pump respectively, and sample introduction path includes sample introduction needle, the first pipeline, the needle stand of grafting sample introduction needle；Each port of six-way valve changes mutual connected state by passage switching, six-way valve includes the first port of connection liquid-feeding pump, the second port for connecting the first pipeline, the 3rd port for connecting needle stand, the 4th port for connecting chromatographic column, during sample introduction, first, second port connects, three, the 4th ports connect, liquid-feeding pump connects the first pipeline by first, second port, and needle stand connects chromatographic column by the three, the 4th ports.Compared to traditional injector, the present invention need not use quantitative loop to realize accurate sample introduction, and injector of the present invention can easily change sampling amount, eliminate the trouble of traditional injector dismounting quantitative loop, sample carryover can be also greatly reduced in injector of the present invention, and without cleaning repeatedly, sample introduction efficiency improves.
Description
Technical field
The present invention relates to chromatograph field, and in particular to a kind of liquid chromatograph automatic sampler.
Background technology
In recent years, liquid chromatograph is fast-developing to automation direction, the appearance of automatic sampler, greatly improves reality
Room efficiency is tested, alleviates human cost.Automatic sampler improves repeatable accuracy around sample carryover is reduced, and improves operating efficiency,
It is convenient, it is easy-to-use etc. to update.
Current automatic sampler is ensures repeatable accuracy, typically using the pipeline of a fixed volume for being referred to as quantitative loop
To realize.When needing to change the sample size of sample, it is necessary to change the quantitative loop of another volume.It is cumbersome to change process,
And it is easily damaged instrument.To reduce influence of the previous sample to one sample following, the automatic sampler requirement of liquid chromatograph
Extremely low sample carryover, current automatic sampler are to reduce sample carryover by cleaning sample introduction needle after sample introduction repeatedly.It is this
Mode was both time-consuming, also wasted solvent.
The sampling process and sample introduction process of the automatic sampler of existing liquid chromatograph are as depicted in figs. 1 and 2：During sampling,
Six-way valve 107 goes to sample position, that is, hole 101 connects with hole 102, and hole 103 connects with hole 104, and hole 105 connects with hole 106
It is logical.Syringe 110 is used for extracting sample, and the sample of sample bottle 109 flows to note by sample introduction needle 108, quantitative loop 113, threeway 114
Emitter 110.Sample is full of quantitative loop 113.
During sample introduction, six-way valve 107 goes to sample introduction position, that is, hole 102 connects with hole 103, and hole 104 connects with hole 105,
Hole 106 connects with hole 101.The mobile phase of pump 111 brings the sample in quantitative loop 113 into chromatographic column 112.Pin moves on to waste liquid pool
116, syringe 110 first shifts remaining sample onto waste liquid pool 116, and then, threeway 114 is switched to be connected with cleaning pump 115, clearly
Washing lotion is driven into sample introduction needle, to empty and clean the sample of sample introduction needle residual.
This input mode has 2 drawbacks：1, when needing to change the sample size of sample, it is necessary to change another volume
Quantitative loop.It is cumbersome to change process, and is easily damaged instrument；2, to reduce sample carryover, sample introduction needle must clean more repeatedly
It is secondary.This mode was both time-consuming, also wasted solvent..
Therefore, prior art also needs to further improve and develop.
The content of the invention
The invention aims to provide a kind of liquid chromatograph automatic sampler, it is intended to solve current liquid chromatograph
The problem of when the quantitative loop dismounting trouble and sample introduction needle developing fee of injector.
The present invention provides a kind of liquid chromatograph automatic sampler, wherein, including sample introduction path and six-way valve, the sample introduction
The front end and end of path connect chromatographic column and liquid-feeding pump respectively, and the sample introduction path includes sample introduction needle, the of connection sample introduction needle
One pipeline and the needle stand connected by sample introduction needle grafting with sample introduction needle；
The six-way valve is provided with multiple ports, and each port changes mutual connection by the switching of six-way valve internal channel
State, the six-way valve include the first port of connection liquid-feeding pump, the second port for connecting the first pipeline, connect the 3rd of needle stand
Port and the 4th port for connecting chromatographic column, during automatic sampler sample introduction, first port connects with second port, the 3rd port
Connected with the 4th port, the liquid-feeding pump connects the first pipeline with second port by first port, and the needle stand passes through the 3rd
Port connects chromatographic column with the 4th port.
Described liquid chromatograph automatic sampler, wherein, the automatic sampler also includes waste liquid path, the waste liquid
The front end and end of path connect waste liquid bottle and syringe respectively, the six-way valve also include connection syringe fifth port and
The 6th port of waste liquid bottle is connected, during automatic sampler sample introduction, fifth port connects with the 6th port, and the syringe passes through the
Five ports are connected waste liquid bottle with the 6th port.
Described liquid chromatograph automatic sampler, wherein, when automatic sampler samples, the six-way valve switches each port
Connected state before, second port connect with fifth port, the syringe is connected by second port with fifth port
Sample introduction needle, sample introduction needle are moved to sample bottle and the sample in pipette samples bottle under syringe controls, sample is entered sample introduction needle
In the first pipeline.
Described liquid chromatograph automatic sampler, wherein, the sample volume of automatic sampler sampling is less than the sample introduction
The inner volume sum of pin and the first pipeline.
Described liquid chromatograph automatic sampler, wherein, the syringe is to carry out accurate quantification absorption to sample
Syringe.
Described liquid chromatograph automatic sampler, wherein, the interface of sample introduction needle is provided with the top of the needle stand, it is described
Interface connects the 3rd port in sample introduction along needle stand internal run-through to needle stand bottom by the second pipeline.
Described liquid chromatograph automatic sampler, wherein, the interface position of the needle stand is provided with cooperation sample introduction needle
The sealing ring of grafting, the sealing ring holding sample introduction needle are plugged to the sealing state of interface after needle stand.
Described liquid chromatograph automatic sampler, wherein, when automatic sampler samples, six-way valve switches before each port
Connected state, first port is connected with the 4th port, the 3rd port connects with the 6th port.
Beneficial effect：The present invention provides a kind of liquid chromatograph automatic sampler, and compared to traditional injector, the present invention enters
Sample device need not be quantified using quantitative loop, but realize accurate sample introduction by syringe, so that injector of the present invention can be easily
Sample volume is changed, the trouble of traditional injector dismounting quantitative loop is eliminated, in addition, injector samples taken of the present invention is located at
In sample introduction needle and its connecting line, sample carryover can be substantially reduced by the continuous flushing of mobile phase, save and clean journey repeatedly
Sequence, cleaning solvent is saved, improved sample introduction efficiency.
Brief description of the drawings
Fig. 1 is the sampling structure schematic diagram of existing liquid chromatograph automatic sampler.
Fig. 2 is the sampling structure schematic diagram of existing liquid chromatograph automatic sampler.
Fig. 3 is the structural representation of liquid chromatograph automatic sampler in the specific embodiment of the invention.
Fig. 4 is the sampling structure schematic diagram of liquid chromatograph automatic sampler in the specific embodiment of the invention.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.It is based on
Embodiment in the present invention, the every other implementation that those skilled in the art are obtained under the premise of creative work is not made
Example, belongs to the scope of protection of the invention.
A kind of liquid chromatograph automatic sampler as shown in Figure 3, wherein, including sample introduction path and six-way valve 207, it is described
The front end and end of sample introduction path connect chromatographic column 212 and liquid-feeding pump 211 respectively, and the sample introduction path includes sample introduction needle 208, connected
The needle stand 217 for connecing the first pipeline 218 of sample introduction needle and being connected by sample introduction needle grafting with sample introduction needle.
Further, the six-way valve is provided with multiple ports, specifically, six-way valve includes six ports, in six-way valve
Set passage to connect adjacent both ends mouth, set rotor to realize that passage switches in six-way valve, so as to be made not by passage switching
Connected between same adjacent both ends mouth, six ports are symmetrical arranged around six-way valve rotor center of rotation.
In specific embodiment, the six-way valve includes the first port 202 of connection liquid-feeding pump, connects the second of the first pipeline
Port 203, the 3rd port 206 for connecting needle stand and the 4th port 201 for connecting chromatographic column, during automatic sampler sample introduction, first
Port 202 connects with second port 203, and the 3rd port 206 connects with the 4th port 201, and the liquid-feeding pump passes through first port
202 connect the first pipeline 218 with second port 203, and the needle stand 217 connects color by the 3rd port 206 with the 4th port 201
Compose post.
Specifically, the liquid-feeding pump 211 connects first port 202 by the 3rd pipeline 221, the chromatographic column 212 passes through
4th pipeline 222 connects the 4th port 201.
Specifically, be provided with the interface of sample introduction needle at the top of the needle stand, the interface is along needle stand internal run-through to pin
Seat bottom, and the 3rd port is connected by the second pipeline 223 in sample introduction.It is preferred that the interface position of the needle stand is set
The sealing ring for coordinating sample introduction needle grafting is equipped with, the sealing ring holding sample introduction needle is plugged to the sealing state of interface after needle stand.
Therefore, when six-way valve switching channel to sample introduction pattern, sample introduction needle is plugged in needle stand, and sample intake passage is formed：Send
Liquid pump is connected to sample introduction needle and needle stand through first port with connecting the first pipeline after second port, and further passes through phase
The 3rd port and the 4th port of connection are communicated to chromatographic column.After sample intake passage is formed, the mobile phase first end of liquid-feeding pump output
Mouth sequentially enters the first pipeline, sample introduction needle and needle stand with second port, and flows into chromatographic column behind the 3rd port and the 4th port,
The sample in sample introduction needle and the first pipeline flows into chromatographic column by mobile phase simultaneously.
Each sample chromatographic column analysis time in a few minutes to dozens of minutes, within this time, mobile phase is necessary
Ensure constantly to flow into, originally the first pipeline equipped with sample and sample introduction needle pin are under the continuous flushing of mobile phase, sample therein
Product all pour chromatographic column, can greatly reduce residual.If necessary to change sample size, then it need to only change the extraction amount of syringe
.
In addition, the automatic sampler also includes waste liquid path, the front end and end of the waste liquid path connect useless respectively
Liquid bottle 216 and syringe 210, the six-way valve also include the fifth port 204 and connection waste liquid bottle 216 of connection syringe 210
The 6th port 205.Specifically, the syringe 210 connects fifth port 204, the waste liquid bottle by the 5th pipeline 225
216 connect the 6th port 205 by the 6th pipeline 224.During automatic sampler sample introduction, after the switching of six-way valve passage, sample intake passage
While formation, fifth port 204 connects with the 6th port 205, so that waste fluid channel is formed, the syringe 210 passes through
Fifth port 204 is connected waste liquid bottle 216 with the 6th port 205.Thus during feeder, syringe is resetted, and waste liquid is noted
Enter waste liquid bottle.
As shown in figure 3, when automatic sampler samples, the six-way valve switches the connected state before each port, makes second
Port 203 connects with fifth port 204, and first port 202 connects with the 4th port 201, the 3rd port 206 and the 6th port
205 connections.Sampling path is formed, the syringe 210 is connected the first pipeline with fifth port 204 by second port 203
Sample introduction needle 208 on 218, sample introduction needle 208 are moved to sample bottle 209 and the sample in pipette samples bottle 209 under syringe 210 controls
Product, sample is set to enter in the pipeline 218 of sample introduction needle 208 and first.
In preferred embodiment, the sample volume of automatic sampler sampling is less than the sample introduction needle and the inner volume of the first pipeline
Sum.Sample sucks sample introduction needle and the first pipeline, and the segment space of the first pipeline is filled by sample.Also, the syringe is
The syringe of accurate quantification absorption is carried out to sample.Sample size is accurately controlled by syringe
The present invention provides a kind of liquid chromatograph automatic sampler, and compared to traditional injector, injector of the present invention need not
Quantified using quantitative loop, but accurate sample introduction is realized by syringe, so that injector of the present invention can easily change sample
Sampling amount, eliminate the trouble of traditional injector dismounting quantitative loop, in addition, injector samples taken of the present invention be located at sample introduction needle and
In its connecting line, sample carryover can be substantially reduced by the continuous flushing of mobile phase, save cleaning procedure repeatedly, saved
Cleaning solvent, improve sample introduction efficiency.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
The present invention is described in detail, it will be understood by those within the art that：It still can be to foregoing each implementation
Technical scheme described in example is modified, or carries out equivalent substitution to which part technical characteristic；And these modification or
Replace, the essence of appropriate technical solution is departed from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (8)
- A kind of 1. liquid chromatograph automatic sampler, it is characterised in that including sample introduction path and six-way valve, the sample introduction path Front end and end connect chromatographic column and liquid-feeding pump respectively, the sample introduction path include sample introduction needle, the first pipeline for connecting sample introduction needle, And the needle stand connected by sample introduction needle grafting with sample introduction needle；The six-way valve is provided with multiple ports, and each port changes mutual connected state by the switching of six-way valve internal channel State, the six-way valve include the first port of connection liquid-feeding pump, connect the second port of the first pipeline, connect the 3rd end of needle stand Mouthful and connection chromatographic column the 4th port, during automatic sampler sample introduction, first port connects with second port, the 3rd port with 4th port connects, and the liquid-feeding pump connects the first pipeline with second port by first port, and the needle stand passes through the 3rd end Mouth connects chromatographic column with the 4th port.
- 2. liquid chromatograph automatic sampler according to claim 1, it is characterised in that the automatic sampler also includes Waste liquid path, the front end and end of the waste liquid path connect waste liquid bottle and syringe respectively, and the six-way valve also includes connection 6th port of the fifth port of syringe and connection waste liquid bottle, during automatic sampler sample introduction, fifth port connects with the 6th port Logical, the syringe is connected waste liquid bottle by fifth port with the 6th port.
- 3. liquid chromatograph automatic sampler according to claim 2, it is characterised in that when automatic sampler samples, institute The connected state before each port of six-way valve switching is stated, second port connects with fifth port, makes the syringe by second Port is connected sample introduction needle with fifth port, and sample introduction needle is moved to sample bottle and the sample in pipette samples bottle under syringe controls, Sample is set to enter in sample introduction needle and the first pipeline.
- 4. liquid chromatograph automatic sampler according to claim 3, it is characterised in that the sample of automatic sampler sampling Volume is less than the sample introduction needle and the inner volume sum of the first pipeline.
- 5. liquid chromatograph automatic sampler according to claim 3, it is characterised in that the syringe is to enter to sample The syringe that row accurate quantification is drawn.
- 6. liquid chromatograph automatic sampler according to claim 1, it is characterised in that be provided with the top of the needle stand into The interface of sample pin, the interface pass through the second pipeline connection the in sample introduction along needle stand internal run-through to needle stand bottom Three ports.
- 7. liquid chromatograph automatic sampler according to claim 6, it is characterised in that the interface position of the needle stand The sealing ring for coordinating sample introduction needle grafting is provided with, the sealing ring holding sample introduction needle is plugged to the sealing shape of interface after needle stand State.
- 8. liquid chromatograph automatic sampler according to claim 1, it is characterised in that when automatic sampler samples, six Port valve switches the connected state before each port, first port is connected with the 4th port, the 3rd port connects with the 6th port.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710736196.4A CN107561198A (en) | 2017-08-24 | 2017-08-24 | A kind of liquid chromatograph automatic sampler |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710736196.4A CN107561198A (en) | 2017-08-24 | 2017-08-24 | A kind of liquid chromatograph automatic sampler |
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| CN201710736196.4A Pending CN107561198A (en) | 2017-08-24 | 2017-08-24 | A kind of liquid chromatograph automatic sampler |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109100458A (en) * | 2018-10-16 | 2018-12-28 | 安徽皖仪科技股份有限公司 | Chromatography autosampler and automatic sampling method |
| CN112198261A (en) * | 2020-11-02 | 2021-01-08 | 山东悟空仪器有限公司 | Sample introduction method of suction type sample injector, suction type sample injector and liquid chromatograph |
| CN112362794A (en) * | 2020-11-10 | 2021-02-12 | 山东悟空仪器有限公司 | Sample feeder, full-loop sample feeding method, liquid analysis method and liquid chromatography system |
| CN112379032A (en) * | 2020-10-26 | 2021-02-19 | 安徽皖仪科技股份有限公司 | Automatic sample injector, liquid chromatograph and sample injection method of liquid chromatograph |
| CN112485356A (en) * | 2020-12-08 | 2021-03-12 | 山东悟空仪器有限公司 | Pre-loading sample injector for high performance liquid chromatograph, high performance liquid chromatograph and pre-loading sample control method thereof |
| WO2021103658A1 (en) * | 2019-11-25 | 2021-06-03 | 清华大学 | Automatic sample injection and analysis device for multiple samples |
| CN114609312A (en) * | 2022-03-22 | 2022-06-10 | 苏州艾迪迈医疗科技有限公司 | Sample introduction structure and method for sample pretreatment device to chromatographic analysis device |
| CN114923993A (en) * | 2022-04-15 | 2022-08-19 | 华南理工大学 | Liquid chromatography system based on pre-column online derivation method and use method |
| CN114994223A (en) * | 2022-04-29 | 2022-09-02 | 天津博纳艾杰尔科技有限公司 | Automatic sample injection liquid path system and automatic sample injection method |
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| CN101609075A (en) * | 2009-07-20 | 2009-12-23 | 浙江出入境检验检疫局检验检疫技术中心 | The sampling device of high performance liquid chromatography-tandem mass instrument |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109100458A (en) * | 2018-10-16 | 2018-12-28 | 安徽皖仪科技股份有限公司 | Chromatography autosampler and automatic sampling method |
| WO2021103658A1 (en) * | 2019-11-25 | 2021-06-03 | 清华大学 | Automatic sample injection and analysis device for multiple samples |
| CN112379032A (en) * | 2020-10-26 | 2021-02-19 | 安徽皖仪科技股份有限公司 | Automatic sample injector, liquid chromatograph and sample injection method of liquid chromatograph |
| CN112198261A (en) * | 2020-11-02 | 2021-01-08 | 山东悟空仪器有限公司 | Sample introduction method of suction type sample injector, suction type sample injector and liquid chromatograph |
| CN112362794A (en) * | 2020-11-10 | 2021-02-12 | 山东悟空仪器有限公司 | Sample feeder, full-loop sample feeding method, liquid analysis method and liquid chromatography system |
| CN112485356A (en) * | 2020-12-08 | 2021-03-12 | 山东悟空仪器有限公司 | Pre-loading sample injector for high performance liquid chromatograph, high performance liquid chromatograph and pre-loading sample control method thereof |
| CN114609312A (en) * | 2022-03-22 | 2022-06-10 | 苏州艾迪迈医疗科技有限公司 | Sample introduction structure and method for sample pretreatment device to chromatographic analysis device |
| CN114923993A (en) * | 2022-04-15 | 2022-08-19 | 华南理工大学 | Liquid chromatography system based on pre-column online derivation method and use method |
| CN114923993B (en) * | 2022-04-15 | 2023-06-20 | 华南理工大学 | Liquid chromatography system based on pre-column online derivatization method and application method |
| CN114994223A (en) * | 2022-04-29 | 2022-09-02 | 天津博纳艾杰尔科技有限公司 | Automatic sample injection liquid path system and automatic sample injection method |
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Application publication date: 20180109 |